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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopy显示文摘瞄准:为在活体内评估一根最新发达的手持的共焦的探针在啮齿类动物的完全的胃肠道的显微镜的成像。方法:一根新奇僵硬共焦的探针(直径 7 公里) 为 fluorophore 刺激用 488 nm 单身者线激光在人为使用与类似于灵活 endomicroscopy 系统的光特征被设计。轻排放在 505 ~ 750 nm 被检测。看法的地多样地是 475 妈妈 475 妈妈。光片厚度是有 0.7 妈妈的侧面的分辨率的 7 妈妈。在不同深度(到 250 妈妈的表面) 的表面下的连续图象多样地在 1024 点在实时被产生由在轻轻的、稳定的接触把探查放到织物上的 1024 个象素(0.8 frames/s ) 。织物标本为组织病理学说的关联被取样。结果:食管,胃,小并且大肠和中央,肝,胰和胆囊是在在 n = 的高分辨率的视觉 ised 在活体内 48 个鼠标。有共焦的微型显微镜学探查的实时显微镜的成像是容易的完成。不同染色协议(荧光黄,吖啶黄,标记 FITC 的葡聚糖和 L。可食用嗯植物凝血素) 织物的每个加亮的特定的方面,和在活体内成像与常规组织学最优地相关。在活体内血流监视把功能的质量加到词法成像。结论:共焦的显微镜学是在甚至表面下的织物结构的高分辨率允许完全的官方补给的道的可视化的可行在活体内。在这研究评估的新共焦的探查设计与腹腔镜检查兼容并且显著地扩展可能的应用的地到 intra 腹的机关。它允许新在活体内染色和申请选择的立即的测试因此在病人从动物研究允许快速的转移到临床的使用。 | Martin Goetz Beena Memadathil Stefan Biesterfeld Constantin Schneider Sebastian Gregor Peter R Galle Markus F Neurath Ralf Kiesslich | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 3 | Microstructure-based Fatigue Modeling of Cast A356- T6 Alloy显示文摘 | D L McDowell K Gall M F Horstemeyer | 2003 | Engineering Fracture Mechanics2003，70，1： | 1 |
| 4 | Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis显示文摘 | Daubiné F Le Gall C Gasser J | 2007 | J Natl Cancer Inst2007，99，4： | 1 |
| 5 | New advances in understanding the molecular biology of plant-potyvirus ineraction 显示文摘 | REVERS F GALL O L CANDRESSE T | 1999 | Molecular Plant-Microbe Interactions1999，12，5： | 1 |
| 6 | Atomistic simulations on the tensile debonding of an aluminum-silicon interface显示文摘 | Gall K Horstemeyer M F Schilfgaarde M V Baskes M I | 2000 | J Mech Phys Solids2000，48，： | 1 |
| 7 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 8 | The debonding and fracture of Si particle during the fatigue of a cast Al-Si alloy显示文摘 | Gall K Yang N Horstemeyer M F | 1999 | Metall Trans A1999，30，： | 1 |
| 9 | Microstructure-based fatigue modeling of cast A356-T6 alloy显示文摘 | McDowell D L Gall K Horstemeyer M F | 2003 | Engineering Fracture Mechanics2003，70，： | 1 |
| 10 | Cutting edge: TGF-beta induces a regulatory phenotype in CD4^+ CD25^- T cells through Foxp3 induction and down-regulation of Smad 7显示文摘 | Fantini M C Becker C Monteleone G Pallone F Galle P R Neuratb M F | 2004 | J Inmmnol2004，172，51： | 1 |
| 11 | A new simplified acute physiology score (SAPA Ⅱ) based on a European/ North American multicenter study显示文摘 | Le GALL J R LEMESHOW S SAULNIER F | 1993 | JAMA1993，270，： | 1 |
| 12 | Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis 显示文摘 | Daubin~ F Le Gall C Gasser J | 2007 | J Natl Cancer Inst2007，99，4： | 1 |
| 13 | A new Simplified Acute Physiology Score ( SAPS l/ ) based on a European/North American multicenter study 显示文摘 | Le Gall JR Lemeshow S Saulnier F | 1993 | JAIVIA1993，270，： | 1 |
| 14 | Promondia: a Java-based framework for real-time group communication in the Web 显示文摘 | Gall U Hauck F J | 1997 | Computer networks and ISDN systems1997，29，8： | 1 |
| 15 | Development of a computational hydrodynamic model for a biomimetic underwater autonomous vehicle显示文摘 | GALLS S F REDINIOTIS O K | 2007 | AIAA Journal2007，45，5： | 1 |
| 16 | The genome sequence of Drosophila melanogaster显示文摘 | Adams M D Celniker S E Holt R A Evans C A Gocayne J D Amanatides P G Scherer S E Li P W Hoskins R A Galle R F | | 0，，： | 1 |
| 17 | A new Simplified Acute Physiology Score (SAPS Ⅱ) based on a European/North American muhicenter study显示文摘 | Le Gall J R Lemeshow S Saulnier F | 1993 | JAMA1993，270，24： | 1 |
| 18 | Characteristics of water re- pellent spraying mortar显示文摘 | GALL G GERDES A WITFMANN F H | 1999 | International Conference on Materials Sci- ence and Restoration MSR 99 Aedificatio Publishers1999，1999，： | 1 |
| 19 | A new Simplified Acute Physiology Score (SAPS Ⅱ) based on a European/North American multicenter study显示文摘 | Le Gall JR Lemeshow S Saulnier F | | 0，，： | 1 |
| 20 | Maternal and cord blood LC-HRMS metabolomics reveal alterations in energy and polyamine metabolism,and oxidative stress in very-low birth weight infants显示文摘 | Alexandre-Gouabau MC Courant F Moyon T Küster A Le Gall G Tea I | 2013 | J Proteome Res2013，12，6： | 1 |
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