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| 1 | Oxaliplatin and 5-fluorouracil hepatic infusion with lipiodolized chemoembolization in large hepatocellular carcinoma显示文摘AIM: To investigate transarterial chemoembolization(TACE) with hepatic infusion of oxaliplatin and 5-fluorouracil and Lipiodol chemoembolization in large hepatocellular carcinoma(HCC).METHODS: In this retrospective study, 132 patients with unresectable HCCs larger than 10 cm were treated with hepatic infusion of oxaliplatin and 5-fluorouracil followed by Lipiodol chemoembolization. The primary endpoint was overall survival(OS). Sixteen-week disease-control rate, time to progression(TTP), and major complications were also studied. Univariate and multivariate analyses were performed to identify prognostic factors affecting OS and TTP.RESULTS: A total of 319 procedures were performed in the 132 patients. Eleven(8.3%) patients received radical resection following TACE treatment(median time to initial TACE 4.3 ± 2.3 mo). The median OS and TTP were 10.3 and 3.0 mo respectively, with a 50.0% 16-wk disease-control rate. Major complications were encountered in 6.0%(8/132) of patients following TACE and included serious jaundice in 1.5%(2/132) patients, aleukia in 1.5%(2/132), and hepatic failure in 3.0%(4/132). One patient died within one month due to serious hepatic failure and severe sepsis after receiving the second TACE. The risk factor associated with TTP was baseline alpha-fetoprotein level, and vascular invasion was an independent factor related to OS.CONCLUSION: Hepatic infusion of oxaliplatin and 5-fluorouracil followed by lipiodolized-chemoembolization is a safe and promising treatment for patients with HCCs larger than 10 cm in diameter. | Jing-Huan Li Xiao-Ying Xie Lan Zhang Fan Le Ning-Ling Ge Li-Xin Li Yu-Hong Gan Yi Chen Ju-Bo Zhang Tong-Chun Xue Rong-Xin Chen Jing-Lin Xia Bo-Heng Zhang Sheng-Long Ye Yan-Hong Wang Zheng-Gang Ren | 2015 | World Journal of Gastroenterology2015，21，13： | 6 |
| 2 | Natural YMDD-motif mutants affect clinical course of lamivudine in chronic hepatitis B显示文摘AIM:To investigate the prevalence of nature tyrosinemethionine-aspartic acid-aspartic acid motif mutations in chronic hepatitis B(CHB)patients and to evaluate the efficacy of lamivudine.METHODS:A total of 1268 CHB patients were recruited from the outpatient and inpatient departments of six centers.Tyrosine-methionine-aspartic acid-aspartic acid(YMDD)mutations were analyzed using the hepatitis B virus(HBV)drug resistance line probe assay.Forty voluntary patients were selected from those with positive or negative natural YMDD mutations to undergo treatment with lamivudine.RESULTS:YMDD mutations were detected in 288(22.71%)of the 1268 CHB patients.Multivariate analysis revealed that the patients’HBV DNA level(P=0.0282)and hepatitis B e antigen status(P=0.0133)were also associated with natural YMDD mutations.The rates of normalization of alanine aminotransferase levels and HBV DNA nondetection at 6,24,36,and 48 wk were compared between the patients with natural YMDD mutations and those without,and the differences were not significant.However,there was a significant difference in the cumulative emergence rates of virological breakthrough at 48 wk in the patients with natural YMDD mutations and those without(32.5%vs 12.5%,P=0.032).CONCLUSION:Naturally occurring YMDD mutationsare detectable in a large proportion of CHB patients;breakthrough hepatitis tended to occur in patients with natural YMDD mutations. | You-Wen Tan Yun Ye Guo-Hong Ge Wei Zhao Jian-He Gan Yun Zhao Zhi-Lin Niu Dong-Jun Zhang Li Chen Xue-Jun Yu Li-Jun Yang | 2015 | World Journal of Gastroenterology2015，21，7： | 4 |
| 3 | Processing,Quality,Safety,and Acceptance of Meat Analogue Products显示文摘Rapid global population growth has caused an increasing need for products containing protein.Meat products are the most common high-protein food source,but impact the environment,cause animal welfare issues,and raise public health concerns.Consumer health and food safety are paramount to the food industry.Both the scientists and food industry are actively seeking plant proteins to substitute for animal-sourced proteins.Plant proteins have a well-balanced amino acid composition,and exhibit great potential for replacing meat via the development of healthy,high-protein,low-saturated fat,cholesterol-free,and nutritionally similar meat-like products.Generally,meat analogue formulations are specially designed and processing conditions are optimized to obtain the texture and bite of real animal meat.This article focuses on plant-based meat analogues,and covers aspects regarding processing,products,quality,and nutritional and structural modifications.Product safety consciousness and consumer acceptance are also discussed.Challenges and perspectives for future research concerning nonmeat products are presented. | Cuixia Sun Jiao Ge Jun He Renyou Gan Yapeng Fang | 2021 | Engineering2021，7，5： | 4 |
| 4 | The Science Operations and Data Center (SODC) of the ASO-S mission显示文摘A ground data analysis center is very important to the success of a mission.We introduce the Science Operations and Data Center(SODC)for the ASO-S mission,which consists of a scientific operation subcenter,a data management subcenter,a data analysis subcenter and a user service subcenter.The mission planning process,instrument observation modes and the data volume are presented.We describe the data flow and processing procedures from spacecraft telemetry to high-level science data,and the long-term archival as well.The data policy and distributions are also briefly introduced. | Yu Huang Hui Li Wei-Qun Gan You-Ping Li Jiang-Tao Su Yuan-Yong Deng Li Feng Yang Su Wei Chen Shi-Jun Lei Ying Li Yun-Yi Ge Ying-Na Su Si-Ming Liu Jing-Jing Zang Zun-Lei Xu Xian-Yong Bai Jing-Wei Li | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 3 |
| 5 | Absolute Stability of General Lurie Control Systems with Multi-Nonlinear Feedback Terms | Zuo Xin GAN Wei Gao GE Institute of Systems Science, Chinese Academy of Sciences, Beijing 100080, P. R. China Department of Applied Mathematics, Beijing Institute of Technology, Beijing 100081, P. R. China | 2001 | Acta Mathematica Sinica,English Series2001，17，4： | 2 |
| 6 | Study of severe and rare complications of transarterial chemoembolization (TACE) for liver cancer显示文摘 | Jinglin Xia Zhenggang Ren Shenglong Ye Dilip Sharma Zhiying Lin Yuhong Gan Yi Chen Ninglin Ge Zengchen Ma Zhiquan Wu Jia Fan Lunxiu Qin Xinda Zhou Zhaoyou Tang Binghui Yang | 2006 | European Journal of Radiology2006，，3： | 2 |
| 7 | Pilomatrixoma:calcifying epitheliomaofMalherbe 显示文摘 | Stone GE Done gan JO Simpson WA | 1990 | OtolaryngolHeadNeckSurg1990，102，6： | 1 |
| 8 | Vacuum pyrolysis of waste print circuit board显示文摘 | Gan Ge Chen Lieqiang Peng Shaohong | 2005 | Journal of Coal Science and Engineering2005，11，1： | 1 |
| 9 | Robust absolute stability of general Lurie type nonlinear control systems显示文摘 | GAN Z Ge W Zhao S | 1999 | Mathematics Applications1999，12，1： | 1 |
| 10 | The design of HEPS global timing system显示文摘Purpose The high energy photon source(HEPS)is a 4th generation synchrotron light source under construction by the institute of high energy physics.The accelerator complex consists of a 500-MeV Linac,a full-energy synchrotron booster,a 6-GeV synchrotron storage ring(SR),and three e-beam transport lines for injection and extraction among accelerators.A global timing system(GTS)covers the timing needs for all accelerator,beamline,and experiment systems.The GTS is designed to coordinate the injection processes and various measurements and protections.Most systems require that the RMS jitter of the GTS signal is less than 30 ps,while the trigger jitters for the electron gun and SR injection and extraction kickers are less than 10 ps.Method The HEPS GTS is an event-based timing system based on MicroTCA.4 hardware architecture.The MicroTCA.4300 series products from the micro-research Finland Oy are implemented in the HEPS GTS system.Results and conclusions The RMS jitter,integrated from 1 Hz to 10 MHz,of the 166.6 MHz event clock is 5.489 ps.The RMS jitter of TTL outputs is less than 30 ps.This paper reports the design of the HEPS GTS,which satisfies all of the HEPS physics requirements for timing with preliminary test results shown. | Fang Liu Ge Lei Zhe Duan Cai Meng Chenyan Lu Yanhua Shao Xinpeng Ma Nan Gan Yuemei Peng Jianshe Cao Chungming Chu Yanfeng Sui Jingyi Li IHEP | 2021 | Radiation Detection Technology and Methods2021，5，3： | 1 |
| 11 | Lyapunov functional for multiple delay general Lur 'e control systems with multiple nonlinearities 显示文摘 | Gan Z X Ge W G | 2001 | J of Mathematics Analysis and Applications2001，259，2： | 1 |
| 12 | Time-course analysis of counts anddegranulation of mast cells during early intestinal ischemia- reperfu-sion injury in mice显示文摘 | Ge M Gan X Liu D | 2013 | Mol Med Rep2013，8，2： | 1 |
| 13 | Geochronology of the Mesozoic volcanic rocks in the Great Xing'an Range, northeastern China: Implications for subduction! induced delamination 显示文摘 | Zhang J H Gan S Ge W C | 2010 | Chemical Geology2010，276，： | 1 |
| 14 | Blockade of lysophosphatidic acid receptors LPAR1/3 ameliorates lung fibrosis induced by irradiation显示文摘 | Lu Gan Jian-Xin Xue Xin Li De-Song Liu Yan Ge Pei-Yan Ni Lin Deng You Lu Wei Jiang | 2011 | Biochemical and Biophysical Research Communications2011，，1： | 1 |
| 15 | Lyapunov Functional for Multiple Delay General Lur'e Control Systems with Multiple Nonlinearities 显示文摘 | Gan Z X Ge W G | 2001 | Journal of Mathematics Analysis and Applications2001，259，2： | 1 |
| 16 | Lyapunov functional for multiple delay general Lurie systems with multiple non-linearities 显示文摘 | Gan Z X Ge W G | 2001 | Journal of Mathematical Analysis and Applications2001，259，2： | 1 |
| 17 | Requirement of the NFkappaB pathway for induction of Wnt-5A by interleukin-1beta in condylar chondrocytes of the temporomandibular joint:functional crosstalk between the Wnt-5A and NF-kappaB signaling pathways显示文摘 | Ge XP Gan YH Zhang CG | 2011 | Osteoarthritis Cartilage2011，19，1： | 1 |
| 18 | Time-course analysis of counts and degranulation of mast cells during early intestinal ischemia-reperfu- s!on injury in mice显示文摘 | Ge M Gan X Liu D | 2013 | Mol Med Rep2013，8，2： | 1 |
| 19 | Amyloid beta deposition related retinal pigment epithelium cell impairment and subretinal microglia activation in aged APPswePS1 transgenic mice显示文摘AIM:To identify the pathological role of amyloid beta(Aβ) deposition in retinal degeneration,and explore Aβ deposition on the retinal pigment epithelium cells(RPE) layer and the associated structural and functional changes in Alzheimer's disease transgenic mice.METHODS:RPE changes in the eyes of APPswe/PS1 transgenic and none transgenic(NTG) mice over 20 months old were examined.Histological changes were investigated via hematoxylin and eosin(H&E) staining and transmission electron microscopy(TEM) examination,whereas the expression of amyloid precursor protein(APP),Aβ,Zonula occludens-1(ZO-1) and Ionized calcium binding adaptor molecule-1(IBA-1) were investigated using immunohistochemistry and immunofluorescence techniques.All of the obtained results were quantitatively and statistically analyzed.RESULTS:In aged transgenic mice,an APP-positive immunoreaction and Aβ deposition were detected on the RPE layer but were undetectable in NTG mice.The RPE demonstrated some vacuole changes,shortened basal infoldings and basal deposition in histopathological examination and TEM tests,wherein irregular shapes were indicated by ZO-1 disorganization through fluorescence.Furthermore,IBA-1 positive cells were observed to have accumulated and infiltrated into the RPE layer and localized beneath the RPE/Bruch's membrane(Br M) complex,which was accompanied by an increase in BrM thickness in aged transgenic mice in comparison to NTG mice.The IBA-1 positive cells were found to be co-stained with Aβ deposition on the RPE flat mounts.CONCLUSION:The observed Aβ deposition in the RPE layer may cause RPE dysfunction,which is associated with microglia cells infiltration into the retina of aged transgenic mice,suggesting that Aβ deposition probably plays a significant role in RPE-related degenerative disease. | Zhi-Zhang Dong Juan Li Yi-Feng Gan Xue-Rong Sun Yun-Xia Leng Jian Ge | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 1 |
| 20 | Vacuum pyrolysis of waste print circuit board显示文摘 | Gan Ge Chen Lieqiang Peng Shaohong | 2005 | Journal of Coal Science & Engineering2005，11，1： | 1 |
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