| 1 | White Matter Deficits Underlying the Impaired Consciousness Level in Patients with Disorders of Consciousness显示文摘In this study, we aimed to(1) identify white matter(WM) deficits underlying the consciousness level in patients with disorders of consciousness(DOCs) using diffusion tensor imaging(DTI), and(2) evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest(ROIs), and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients. | Xuehai Wu Jiaying Zhang Zaixu Cui Weijun Tang Chunhong Shao Jin Hu Jianhong Zhu Yao Zhao Lu Lu Gang Chen Georg Northoff Gaolang Gong Ying Mao Yong He | 2018 | Neuroscience Bulletin2018，34，4： | 8 |
| 5 | The pattern of cortical thickness underlying disruptive behaviors in Alzheimer’s disease显示文摘Background Disruptive behaviors,including agitation,disinhibition,irritability,and aberrant motor behaviors,are commonly observed in patients with Alzheimer’s disease(AD).However,the neuroanatomical basis of these disruptive behaviors is not fully understood.Objective To confirm the differences in cortical thickness and surface area between AD patients and healthy controls and to further investigate the features of cortical thickness and surface area associated with disruptive behaviors in patients with AD.Methods One hundred seventy-four participants(125 AD patients and 49 healthy controls)were recruited frommemory clinics at the Peking University Institute of Sixth Hospital.Disruptive behaviors,including agitation/aggression,disinhibition,irritability/lability,and aberrant motor activity subdomain scores,were evaluated using the Neuropsychiatry Inventory.Both whole-brain vertex-based and region-of-interest-based cortical thickness and surface area analyses were automatically conducted with the CIVET pipeline based on structural magnetic resonance images.Both group-based statistical comparisons and brain-behavior association analyses were performed using general linear models,with age,sex,and education level as covariables.Results Compared with healthy controls,the AD patients exhibited widespread reduced cortical thickness,with the most significant thinning located in the medial and lateral temporal and parietal cortex,and smaller surface areas in the left fusiform and left inferior temporal gyrus.High total scores of disruptive behaviors were significantly associated with cortical thinning in several regions that are involved in sensorimotor processing,language,and expression functions.The total score of disruptive behaviors did not show significant associations with surface areas.ConclusionWe highlight that disruptive behaviors in patientswith AD are selectively associated with cortical thickness abnormalities in sensory,motor,and language regions,which provides insights into neuroanatomical substrates underlying disruptive behaviors.These findings could lead to sensory,motor,and communication interventions for alleviating disruptive behaviors in patients with AD. | Raymond M.Xiong Teng Xie Haifeng Zhang Tao Li Gaolang Gong Xin Yu Yong He | 2022 | Psychoradiology2022，2，3： | 0 |
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