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| 1 | sTREM-1 is a specific biomarker of TREM-1 pathway activation显示文摘TREM-1(triggering receptor expressed on myeloid cells-1)is a transmembrane receptor expressed by innate immune cells,including endothelial cells and platelets.TREM-1 is a crucial mediator of septic shock that acts by synergizing with Toll-like receptors(TLRs)to amplify the inflammatory responses to pathogens,thus promoting sepsis-induced immune dysregulation and organ dysfunction[1,2,3]. | Lucie Jolly Kévin Carrasco Margarita Salcedo-Magguilli Jean-Jacques Garaud Simon Lambden Tom van der Poll Alexandre Mebazaa Pierre-François Laterre Sebastien Gibot Amir Boufenzer Marc Derive | 2021 | Cellular & Molecular Immunology2021，18，8： | 8 |
| 2 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 3 | Adherence to combination therapy enhances sustained response in genotype-1–infected patients with chronic hepatitis C显示文摘 | John G. McHutchison Michael Manns Keyur Patel Thierry Poynard Karen L. Lindsay Christian Trepo Jules Dienstag William M. Lee Carmen Mak Jean–Jacques Garaud Janice K. Albrecht | 2002 | Gastroenterology2002，，4： | 2 |
| 4 | Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism显示文摘 | Zheng LM Ojcjus DM Garaud F | 1996 | J Exp Med1996，184，2： | 1 |
| 5 | IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation显示文摘 | Garaud S Le Dantec C Jousse-Joulin S | | 0，，09： | 1 |
| 6 | Autoreactive B Cells and Epigenetics显示文摘 | Renaudineau Y Garaud S Le Dantec C | | 0，，01： | 1 |
| 7 | Detection by immunogold labelling of P75 readthrough protein near an extremity of beet necrotic yellow vein virus particles显示文摘 | Anne-Marie Haeberlé Christiane Stussi-Garaud Corinne Schmitt J. -C. Garaud K. E. Richards H. Guilley G. Jonard | 1994 | Archives of Virology (-)1994，，1： | 1 |
| 8 | IL - 10 production by B cells expressing CD5 with the alternative exon 1B 显示文摘 | Garaud S Le Dantec C de Mendoza AR | 2009 | Ann N Y Aead Sei2009，1173，： | 1 |
| 9 | Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma显示文摘 | Garaud P Bardet E | 2004 | J Clin Oncol2004，22，： | 1 |
| 10 | Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation显示文摘 | TORCHINSKY M B GARAUDE J MARTIN A P | 2009 | Nature2009，458，： | 1 |
| 11 | CD4? follicular helper T cell infiltration predicts breast cancer survival显示文摘 | Gu-Trantien C Loi S Garaud S | 2013 | J Clin Invest2013，123，7： | 1 |
| 12 | Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oro- pharynx carcinoma显示文摘 | Denis F Garaud P Bardet E | 2004 | J Clin Oncol2004，22，1： | 1 |
| 13 | CD4^sup +^ follicular helper T cell infiltration predicts breast cancer survival显示文摘 | Gu-Trantien Chunyan Loi Sherene Garaud Soizic Equeter Carole Libin Myriam deWind Alexandre Ravoet Marie LeBuanec H?l?ne Sibille Catherine Manfouo-Foutsop Germain Veys Isabelle Haibe-Kains Benjamin Singhal Sandeep K Michiels Stefan Roth? Fra | 2013 | Journal of Clinical Investigation2013，，7： | 1 |
| 14 | Late toxicity results of the GORTEC 94-01 randomized trial comparing radiotherapy with concomitant radiochemotherapy for advanced-stage orophar',nx carcinoma:comparison of LENT/SOMA, RTOG/ EORTC, and NCI-CTC scoring systems 显示文摘 | Denis F Garaud P Bar let li | 2003 | lnt J Radiat Oncol Biol Phys2003，，： | 1 |
| 15 | PKCθIs Required for NK CellActivation and in vivo Control of Tumor Progression显示文摘 | AguilóJI Garaude J Pardo J | 2009 | J Immunol2009，182，4： | 1 |
| 16 | Innate immune recognition of infected apoptotic cells directs T(H) 17 cell differ- entiation 显示文摘 | Torehinsky MB Garaude J Martin AP | 2009 | Nature2009，458，7234： | 1 |
| 17 | Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism显示文摘 | Zheng LM Ojcjus DM Garaud F | 1996 | J Exp Med1996，184，2： | 1 |
| 18 | CD4 ( + ) follicular helper T cell infiltration predicts breast cancer survival显示文摘 | Gu-Trantien C Loi S Garaud S | 2013 | J Clin Invest2013，123，7： | 1 |
| 19 | Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific im- mune responses显示文摘 | Garaude J Kent A van Rooijen N | 2012 | Sci Transl Mcd2012，4，120： | 1 |
| 20 | Interlcukin-6 is responsible for aberrant B-cell receptor-mediated regulation of RAG expression in systemic lupus erythematosus显示文摘 | Hillion S Garaud S Devauehelle V | 2007 | Immunology2007，3，： | 1 |
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