|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 2 | Nitro-Phenlactone, a Carlactone Analog with Pleiotropic Strigolactone Activities显示文摘 | Kun-Peng Jia Boubacar A. Kountche Muhammad Jamil Xiujie Guo Valentine O, Ntui Andreas REffenacht Soizic Rochange Salim AI-Babili | 2016 | Molecular Plant2016，9，9： | 1 |
| 3 | CD4^sup +^ follicular helper T cell infiltration predicts breast cancer survival显示文摘 | Gu-Trantien Chunyan Loi Sherene Garaud Soizic Equeter Carole Libin Myriam deWind Alexandre Ravoet Marie LeBuanec H?l?ne Sibille Catherine Manfouo-Foutsop Germain Veys Isabelle Haibe-Kains Benjamin Singhal Sandeep K Michiels Stefan Roth? Fra | 2013 | Journal of Clinical Investigation2013，，7： | 1 |
| 4 | One-step enantioselective synthesis of (4S) -isosclerone lhrough tfioh'anformalion of juglone by an endophy/ic fimgus 显示文摘 | Soizic Prado Didier Buisson ldrissa Ndoye Marine Vallet Bastien Nay | 2013 | Tetrahedron Letters2013，54，： | 1 |
| 5 | Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues显示文摘 | Soizic P Yves L J Brigitte S J | 2007 | Bioorganic&Medicinal Chemistry2007，15，： | 1 |
| 6 | Prognostic Value of 18F-FDG PET/CT Metabolic Parameters in Metastatic Differentiated Thyroid Cancers显示文摘 | Soizic Masson-Deshayes Claire Schvartz Cécile Dalban Sofiane Guendouzen Jean-Marie Pochart Audrey Dalac Sandrine Fieffe Claire Bruna-Muraille Tienhan Sandrine Dabakuyo-Yonli Dimitri Papathanassiou | 2015 | Clinical Nuclear Medicine2015，，6： | 1 |
| 7 | Female fertility preservation in cancer patients: an instrumental tool for the envisioning a postdisease life显示文摘 | Rachel Trè ves Micha? l Grynberg Soizic le Parco Astrid Finet Marine Poulain Renato Fanchin | 2014 | Future Oncol2014，，： | 1 |
| 8 | Platinum compounds sensitize ovarian carcinoma cells to ABT-737 by modulation of the Mcl-1/Noxa axis显示文摘 | Karin Simonin Monique N’Diaye Stéphanie Lheureux Claire Loussouarn Soizic Dutoit Mélanie Briand Florence Giffard Emilie Brotin Cécile Blanc-Fournier Laurent Poulain | 2013 | Apoptosis2013，，4： | 1 |
| 9 | 龙工作室显示文摘龙工作室是一个拉长的微变形的盒体它逐渐脱离地面,直刊开始凌驾在一排高柱之上将结构抬离地面,框视出北太西洋的海景,时有源于格陵兰冰川的冰山浮现。 | Attila Béres Ryan Jφrgensen Ken Beheim-Schwarzbach Nick Herder Rubén SáezLópez Soizic Bernard Colin Hertberger Christina Mayer Olivier Bourgeois PálStorsveen ZdenekDohnalek Bent René Synnevág | 2012 | 城市环境设计2012，，9： | 0 |
| 10 | 扁工作室显示文摘扁工作室是一个坐落在福戈岛东端的白色尖角形体,栖止在沿海岸线的岩石地带。工作室正门极富对比色彩,因其最南端高于地面6.1m(20英尺),工作室紧凑的梯影平面,因其东西两面的外墙的延展而加大,在南面形成了一个掩蔽的三角形入口平台,在北面则是俯瞰大洋的露台。 | Attila Béres Ryan Jφrgensen Ken Beheim-Schwarzbach Nick Herder Rubén SáezLópez Soizic Bernard Colin Hertberger Christina Mayer Olivier Bourgeois PálStorsveen ZdenekDohnalek Bent René Synnevág | 2012 | 城市环境设计2012，，9： | 0 |
| 11 | 桥工作室显示文摘从深湾宅(DeepBayHouse)通往桥工作室的路径,从地图上看来很短。但考虑到地形,海岸线上一路壮美的岩石祀花岗岩上长满的苔藓,现实就会是另外一种情形。桥工作室给人的第一印象是其抽象的特质。 | Attila Béres Ryan Jφrgensen Ken Beheim-Schwarzbach Nick Herder Rubén SáezLópez Soizic Bernard Colin Hertberger Christina Mayer Olivier Bourgeois PálStorsveen ZdenekDohnalek Bent René Synnevág | 2012 | 城市环境设计2012，，9： | 0 |
| 12 | 塔工作室显示文摘塔工作室显著地坐落在多岩石的绵长海岸线上。工作室雕塑般的剪影因其向上弯折而显得前凸后翘。这样一座无窗的黑塔,在每一个来岛的普通游客心中都不免引起困惑和疑问:“那是什么?” | Attila Béres Ryan Jφrgensen Ken Beheim-Schwarzbach Nick Herder Rubén SáezLópez Soizic Bernard Colin Hertberger Christina Mayer Olivier Bourgeois PálStorsveen ZdenekDohnalek Bent René Synnevág | 2012 | 城市环境设计2012，，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员