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| 1 | Genetic changes of p53,K-ras,and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary显示文摘AIM: To disclose geographic differences in genetic changes involved in gallbladder carcinogenesis between two distinct high-incidence areas of Japan and Hungary.METHODS: We examined 42 cases of gallbladder carcinoma: 22 Japanese and 20 Hungarian cases. p53 mutations at exons 5 to 8 and K-ras mutations at codon 12 were tested by direct sequencing. Microsatellite instability was determined from fluorescent dye-labeled PCR amplifications of five-microsatellite markers (BAT-25, BAT-26, D2S123, D5S346, and D17S250).RESULTS: Mutations of p53 were detected in 11 of 22 Japanese cases and 6 of 18 Hungarian cases (11/22 vs 6/18, P = 0.348). Transition at CpG sites was found in none of 11 Japanese cases and 2 of 6 Hungarian cases; the difference was marginally significant (0/11 vs 2/6, P = 0.110). K-ras mutations were detected in only one of the Hungarian cases. Eight of 19 (42.1%) Japanese cases were MSI-high (presence of novel peaks in more than one of the five loci analyzed), whereas only 1 of 15 (6.7%) Hungarian cases was MSI-high (P = 0.047).CONCLUSION: It appears that the p53 mutations and MSI differ in patients with gallbladder carcinoma between two distinct high-incidence areas. Geographic variation might exist in the process of gallbladder carcinogenesis. | Masayuki Nagahashi Yoichi Ajioka Istvan Lang Zoltan Szentirmay Miklos Kasler Hiroto Nakadaira Naoyuki Yokoyama Gen Watanabe Ken Nishikura Toshifumi Wakai Yoshio Shirai Katsuyoshi Hatakeyama Masaharu Yamamoto | 2008 | World Journal of Gastroenterology2008，14，1： | 9 |
| 2 | A genetic algorithm with mod- ified crossover operator and search area adaptation for the job- shop scheduling problem 显示文摘 | WATANABE M IDA K GEN M | 2005 | Computers and Industrial Engineering2005，48，4： | 1 |
| 3 | 仓鼠妊娠期瘦素分泌及其调节机制显示文摘对妊娠期瘦素的分泌及其调节机制进行探讨.将100只3月龄雌性金黄仓鼠分成16组,每组6-7只,每天采血样用于测定其妊娠期的瘦素分泌.实验结果表明,瘦素于妊娠第9天开始显著升高,于妊娠第12天达到高峰.为验证不同生殖阶段的血清是否对瘦素分泌有不同影响,将不同生殖阶段抽提与未抽提类固醇激素的血清加入培养液中进行培养,发现动情期及妊娠期的血清均可刺激体外培养的脂肪细胞瘦素分泌,动情期抽提与未抽提类固醇激素的血清对脂肪细胞瘦素分泌的刺激作用没有显著差异(P>0.05).与动情期血清相比,妊娠中后期未抽提类固醇激素的血清显著刺激脂肪细胞瘦素分泌(P<0.01).但妊娠中后期的血清在抽提类固醇激素后对瘦素分泌的刺激作用显著下降,与动情期的血清对瘦素分泌的刺激作用已没有显著差异(P>0.05).妊娠不同阶段未抽提类固醇激素的血清对瘦素分泌的刺激作用有很大差异,妊娠第15天的血清对瘦素分泌的刺激作用显著高于妊娠第8天(P<0.0001)和妊娠第12天(P<0.001)的血清.体外研究进一步表明,肾上腺皮质素、孕酮以及胰岛素均能刺激瘦素分泌,而雌激素却能抑制体外瘦素分泌.研究结果提示,妊娠期血液类固醇激素水平的上升是引起妊娠期瘦素峰出现的重要因素. | 王诚 杨利国 Gen Watanabe Kazuyoshi Taya | 2003 | 科学通报2003，48，8： | 1 |
| 4 | 18 F-FDG uptake in primary gastric malignant lymphoma correlates with glucose transporter 1 expression and histologic malignant potential显示文摘 | Yuko Watanabe Hiroaki Suefuji Yasumitsu Hirose Hayato Kaida Gen Suzuki Jun Uozumi Etsuyo Ogo Mayumi Miura Konomi Takasu Kanoko Miyazaki Keita Nakahara Masatoshi Ishibashi Takashi Okamura Koichi Ohshima Naofumi Hayabuchi | 2013 | International Journal of Hematology2013，，1： | 1 |
| 5 | A genetic algorithm with modified crossover operator and search area adaptation for the job-shop scheduling problem显示文摘 | WATANABE M IDA K GEN M | 2005 | Computers & Industrial Engineering2005，48，4： | 1 |
| 6 | Well-differentiated adenocarcinoma mimicking complete-type intestinal metaplasia in the stomach显示文摘 | Yasushi Endoh Gen Tamura Teiichi Motoyama Yoichi Ajioka Hidenobu Watanabe | 1999 | Human Pathology1999，，7： | 1 |
| 7 | Nuclear factor-kappa B decoy suppresses nerve injury and improves mechanical allodynia and thermal hyperalgesia in a rat lumbar disc herniation model显示文摘 | Munetaka Suzuki Gen Inoue Takefumi Gemba Tomoko Watanabe Toshinori Ito Takana Koshi Kazuyo Yamauchi Masaomi Yamashita Sumihisa Orita Yawara Eguchi Nobuyasu Ochiai Shunji Kishida Masashi Takaso Yasuchika Aoki Kazuhisa Takahashi Seiji Ohtori | 2009 | European Spine Journal2009，，： | 1 |
| 8 | Generation of a Recombinant Akabane Virus Expressing Enhanced Green Fluorescent Protein显示文摘 | Takenaka-Uema A Murata Y Gen F Ishihara-Saeki Y Watanabe K Uchida K Kato K Murakami S Haga T Akashi H Horimoto T | 2015 | J Virol2015，89，18： | 1 |
| 9 | Immunolocalization of rqGF and its receptors trkA and p75 in the oviducts of golden hamsters during the estrous cycle显示文摘 | Weng Q Shi Z Q Gen Watanabe | 2009 | Exp Anim2009，58，5： | 1 |
| 10 | Adenoviral Oncolytic Suicide Gene Therapy for a Peritoneal Dissemination Model of Gastric Cancer in Mice显示文摘 | Yu Imamura Shinji Ishikawa Nobutaka Sato Ryuichi Karashima Kotaro Hirashima Yukiharu Hiyoshi Youhei Nagai Yoshikatsu Koga Naoko Hayashi Masayuki Watanabe Gen Yamada Hideo Baba | 2010 | Annals of Surgical Oncology2010，，2： | 1 |
| 11 | Small cell neuroendocrine carcinoma of the ampulla of Vater with foci of squamous differentiation: a case report显示文摘 | Gen Sugawara Akihiro Yamaguchi Masatoshi Isogai Yoshio Watanabe Yuji Kaneoka Masahiko Suzuki | 2004 | Journal of Hepato-Biliary-Pancreatic Surgery2004，，1： | 1 |
| 12 | Role of cardiac sympathetic nerves in preventing orthostatic hypotension in Parkinson’s disease显示文摘 | Tomohiko Nakamura Masaaki Hirayama Takashi Hara Yasuaki Mizutani Junichiro Suzuki Hirohisa Watanabe Gen Sobue | 2014 | Parkinsonism and Related Disorders2014，，： | 1 |
| 13 | Small cell neuroendocrine carcinoma of the ampulla of Vater with foci of squamous differentiation: a case report显示文摘 | Gen Sugawara Akihiro Yamaguchi Masatoshi Isogai Yoshio Watanabe Yuji Kaneoka Masahiko Suzuki | 2004 | Journal of Hepato - Biliary - Pancreatic Surgery2004，，1： | 1 |
| 14 | Effect of transverse compressive stress on internal reinforced Nb 3 Sn superconducting wires and coils显示文摘 | Gen Nishijima Kazuo Watanabe Tadahiro Araya Kazumune Katagiri Koichi Kasaba Kazutomi Miyoshi | 2005 | Cryogenics2005，，10： | 1 |
| 15 | 仓鼠妊娠期间瘦素分泌及其与部分妊娠相关激素的关系显示文摘目的 :探讨妊娠期间影响瘦素分泌活动的因素及其相互关系。方法 :将 10 0只金黄色仓鼠配种后分成 16组 (每组 6只~ 7只 ) ,让其妊娠、分娩 ,同时于每天 11∶0 0h采血 ,用RIA测定其中瘦素、GH、FSH、LH、孕酮、雌激素和抑制素水平 ,同时分析妊娠期间瘦素与摄食、母体体重变化等的关系。结果 :金黄色仓鼠于妊娠12天有一瘦素峰。妊娠期瘦素与性腺激素之间有显著相关 ,但与垂体激素之间无显著相关性。妊娠期瘦素水平与摄食及母体和孕体的总重量之间无显著相关性 ,但与去除孕体后的母体体重之间呈显著相关。结论 :瘦素与性激素之间的显著相关 ,表明这些激素对妊娠瘦素峰的形成有重要作用 ;妊娠期瘦素与摄食之间的非相关性 ,提示妊娠期间具有强烈的瘦素抵抗 ;去除孕体后的体重结果提示 ,妊娠期间瘦素仍然是机体中枢的体重信号。 | 王诚 杨利国 Gen Watanabe Kazuyoshi Taya | 2003 | 放射免疫学杂志2003，16，1： | 1 |
| 16 | 性腺激素对仓鼠妊娠期瘦素分泌活动的调节显示文摘目的 :验证性腺激素对瘦素分泌的影响 ,寻找妊娠期瘦素峰出现的原因。方法 :用 3月龄的金黄仓鼠作为实验动物。制备雌激素及孕激素硅胶埋植管、检验其释放剂量以用于提供后续实验中持续性的高水平雌激素及孕酮 ;制备雌激素以及抑制素的抗血清、检验其生物活性 ,用于后续实验中消减体内这两种激素的生物学作用 ,观察这两种激素缺失对于瘦素分泌活动的影响 ;通过妊娠期间卵巢切除来观察该期间内性腺对于瘦素分泌活动的影响。通过对于切除性腺的动物激素埋植的方法来观察不同激素对在体时瘦素分泌的作用。结果 :金黄仓鼠于妊娠第 11天去除卵巢后瘦素水平显著下降 ,妊娠第 12天的瘦素峰消失 ;妊娠第 11天注射雌激素及抑制素抗血清对瘦素的分泌没有产生显著影响 ;与正常对照相比 ,未孕的金黄仓鼠切除卵巢后瘦素水平显著下降 (p <0 0 5 ) ,切除卵巢后单独埋植雌激素、孕酮不能阻止瘦素水平的下降 ,但是当埋植孕酮和雌激素复合物时瘦素的水平得到恢复。这些结果说明性腺激素对于瘦素的分泌有重要的调节作用。单独的雌激素或孕激素对瘦素分泌没有影响 ,但雌激素与孕激素复合物却对于瘦素的分泌有重要的调节作用。结论 :妊娠后期高水平的雌激素、孕激素等性腺激素的综合作用可能促成了该期瘦素水平的上升。 | 王诚 杨利国 Gen Watanabe Kazuyoshi Taya | 2003 | 放射免疫学杂志2003，16，1： | 1 |
| 17 | Active solution space and search on job-shop scheduling problem显示文摘 | Watanabe M Ida K Gen M | 2006 | Electrical Engineering in Japan2006，154，4： | 1 |
| 18 | Short-Segment Fixation Without Fusion for Thoracolumbar Burst Fractures With Neurological Deficit Can Preserve Thoracolumbar Motion Without Resulting in Post-traumatic Disc Degeneration: A 10-Year Follow-up Study显示文摘 | Tomoaki Toyone Tomoyuki Ozawa Kunimasa Inada Toshiyuki Shirahata Ryutaro Shiboi Atsuya Watanabe Keisuke Matsuki Fumio Hasue Takayuki Fujiyoshi Yasuchika Aoki Gen Inoue Sumihisa Orita Seiji Ohtori Yuichi Wada Tadashi Tanaka Kazuhisa Takahashi | 2013 | Spine2013，，17： | 1 |
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