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| 1 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 2 | Additive Benefits of Twice Forest Bathing Trips in Elderly Patients with Chronic Heart Failure显示文摘长期的心失败(CHF ) ,源于各种各样的心血管的疾病(CVD ) 的后果的临床的症候群,逐渐地正在成为病态和死亡的一个全球原因。我们更早证明了洗旅行的一个 4 天的森林能在病人上向附属治疗学的影响提供 CHF。为了进一步调查影响和森林洗澡的最佳的频率的持续时间,与 CHF 在病人摔倒,我们招募了经历了在 4 个星期以后再洗旅行的第一个森林并且也就是,随机把他们分成了二个组的那些对象城市的控制组(城市)和洗组(森林)的森林。在洗旅行的第二个 4 天的森林以后,我们象氧化应力一样在大脑 natriuretic 肽层次,心失败的 biomarker,和稀释煽动性的回答观察了稳定的衰落。因此,这探索研究表明了添加剂好处两次,森林洗澡与 CHF 在老病人摔倒,它能进一步为在 CVD 分析如此的干预的效果铺平道路。 | MAO Gen Xiang CAO Yong Bao YANG Yan CHEN Zhuo Mei DONG Jian Hua CHEN Sha Sha WU Qing LYU Xiao Ling JIA Bing Bing YAN Jing WANG Guo Fu | 2018 | Biomedical and Environmental Sciences2018，31，2： | 18 |
| 3 | Parkinson’s disease in China:a forty-year growing track of bedside work显示文摘The number and health burden of Parkinson’s disease increase rapidly in China.It is estimated that China will have nearly half of the Parkinson’s disease population in the world in 2030.In this review,we present an overview of epidemiology and health economics status of Parkinson’s disease across China and discuss the risk factors of Parkinson’s disease and related complications.From the view of clinical research,we also discuss the current status of clinical trials,diagnostic biomarkers,treatment of Parkinson’s disease,tertiary network and post-occupation education in Chinese Parkinson’s disease clinics. | Gen Li Jianfang Ma Shishuang Cui Yixi He Qin Xiao Jun Liu Shengdi Chen | 2019 | Translational Neurodegeneration2019，8，1： | 16 |
| 4 | Health Effect of Forest Bathing Trip on Elderly Patients with Chronic Obstructive Pulmonary Disease显示文摘Forest bathing trip is a short,leisurely visit to forest.In this study we determined the health effects of forest bathing trip on elderly patients with chronic obstructive pulmonary disease(COPD).The patients were randomly divided into two groups.One group was sent to forest,and the other was sent to an urban area as control. | JIA Bing Bing YANG Zhou Xin MAO Gen Xiang LYU Yuan Dong WEN Xiao Lin XU Wei Hong LYU XIAO Ling CAO Yong Bao WANG Guo Fu | 2016 | Biomedical and Environmental Sciences2016，29，3： | 15 |
| 5 | Optimization of the Assembly Efficiency for Lidamycin Chromophore Bound to its Apoprotein:A Case Study using Orthogonal Array显示文摘Objective Lidamycin (LDM) can be dissociated to an apoprotein (LDP) and an active enediyne chromophore (AE).The detached AE can reassemble with its LDP‐containing fusion protein to endow the latter with potent antitumor activity.However,the reassembly of AE with LDP is affected by several factors.Our aim was to optimize the assembly efficiency of the AE with a LDP‐containing fusion protein and investigate the influence of several factors on the assembly efficacy.Methods A method based on RP‐HPLC was developed to analyze the assembly rate,and an orthogonal experimental design L9 (3 4 ) was used to investigate the effects of temperature,assembly time,pH and molecular ratio of LDP‐containing fusion protein to AE on the assembly rate.Furthermore,the determined optimum conditions for the assembly rate of the LDP‐containing fusion protein with AE were applied and evaluated.Results A calibration curve based on the LDM micromolar concentration against the peak‐area of AE by HPLC was obtained.The order in which individual factors in the orthogonal experiment affected the assembly rate were temperature>time>pH>molar ratio of AE to protein and all were statistically significant (P<0.01).The optimal assembly conditions were temperature at 10°C,time of 12 h,pH 7.0,and the molar ratio of AE: protein of 5:1.The assembly rate of AE with a LDP‐containing fusion protein was improved by 23% after condition optimization.Conclusion The assembly rate of chromophore of lidamycin with its LDP‐containing fusion protein was improved after condition optimization by orthogonal design,and the optimal conditions described herein should prove useful for the development of this type of LDP‐containing fusion protein. | ZHONG Gen Shen GUO Xiao Fang ZHANG Sheng Hua ZHEN Yong Su | 2011 | Biomedical and Environmental Sciences2011，24，6： | 9 |
| 6 | Alkaloids from Isatis indigotica显示文摘Isaindigotone 1 and 3-(2’-hydroxyphenyl)-4(3H)-quinazolinone 2 were isolated from the roots of Isatis indigotica. Compound 1 was elucidated as a new alkaloid.Compound 2 was discovered for the first time from a natural | Ke Min DENG Xiao Yun WU Gen Jin YANG and Guo Wei QIN (Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Shanghai 200031) (School of Pharmacy, Second Military Medical University, Shanghai 200433) ( Visiting scholar from Dept. of Chemistr | 1997 | Chinese Chemical Letters1997，8，3： | 9 |
| 7 | Protective effect of YHI and HHI-I against experimental acute pancreatitis in rabbits显示文摘ProtectiveefectofYHIandHHIIagainstexperimentalacutepancreatitisinrabbitsZHAOLianGen,WUXiaoXian,HANEnKun,CHENYuLing,CHENC... | ZHAO Lian Gen, WU Xiao Xian, HAN En Kun, CHEN Yu Ling, CHEN Chi and XU Dong Qin | 1998 | World Journal of Gastroenterology1998，4，3： | 6 |
| 8 | Selective conversion of syngas to propane over ZnCrO_x-SSZ-39 OX-ZEO catalysts显示文摘Oxide-Zeolite(OX-ZEO) bifunctional catalyst design concept has been exemplified in several processes to direct conversion syngas to value-added chemicals and fuels such as mixed light olefins, ethylene, aromatics and gasoline.Herein we demonstrate that the product can be steered toward liquefied petroleum gas(LPG) with a selectivity up to 89% in hydrocarbons especially propane selectivity reaching 80% at CO conversion of 63% using ZnCrOx-H-SSZ-39 catalyst.Interestingly, the quantity of the acid sites of SSZ-39 does not influence obviously the hydrocarbon distribution but the strength is crucial for selective formation of propane.This finding provides an alternative route of LPG synthesis from a variety of carbon resources via syngas. | Gen Li Feng Jiao Dengyun Miao Yong Wang Xiulian Pan Toshiyuki Yokoi Xiangju Meng Feng-Shou Xiao Andrei-Nicolae Parvulescu Ulrich Müller Xinhe Bao | 2019 | Journal of Energy Chemistry2019，28，9： | 6 |
| 9 | Negishi Coupling for Highly Selective Syntheses of Allenes via Ligand Effect and Mechanistic Study via SAESI-MS/MS显示文摘β-H elimination is an intrinsic problem in transition metal-catalyzed reactions.We describe herein an interesting ligand effect for Et2Zn acting as either ethyl provider or H provider,respectively:by applying SPhos or Gorlos-Phos as the ligand,β-H elimination has been successfully controlled in the corresponding Negishi coupling reaction affording different poly-substituted allenes in good yields and excellent selectivities.SAESI-MS (Solvent Assisted Electrospray Ionization Mass Spectrometry) has been applied to successfully capture the highly reactive organometallic intermediates,which show the different coordination behaviors of Pd with SPhos or Gorlos-Phos as the ligand in the catalytic cycle.In addition,the different reactivities of Int 1 and Int 2 towards the formation of the final allene products have been demonstrated via SAESI-MS/MS experiments.These MS studies visualized the whole catalytic cycle for the Negishi coupling reaction while nicely explain the observed reactivity and selectivity. | Yangguangyan Zheng Bukeyan Miao Anni Qin Junzhe Xiao Qi Liu Gen Li Li Zhang Fang Zhang Yinlong Guo Shengming Ma | 2019 | Chinese Journal of Chemistry2019，37，10： | 5 |
| 10 | Attractor for Lattice System of Dissipative Zakharov Equation显示文摘我们认为一个无限的格子的解决方案的 asymptotic 行为是消散的 Zakharov 方程的动态系统。由介绍在空格和建立的制服的内部产品和标准在“解决方案的尾巴结束”估计的新重量,我们克服 Sobolev 协议在无限的格子系统下面嵌入的缺乏引起的一些困难,并且证明全球引起注意的人的存在;然后由在有限维的空间使用元素分解和一个多面体的盖住的性质,我们为全球引起注意的人的 Kolmogorov ɛ-entropy 获得上面的界限;最后,我们在场全球引起注意的人的上面的半连续性。 | Fu Qi YIN Sheng Fan ZHOU Zi Gen OUYANG Cui Hui XIAO | 2009 | Acta Mathematica Sinica,English Series2009，25，2： | 4 |
| 11 | A New Method for Blood NT-proBNP Determination Based on a Near-infrared Point of Care Testing Device with High Sensitivity and Wide Scope显示文摘Objective To develop a rapid, highly sensitive, and quantitative method for the detection of NT-proBNP levels based on a near-infrared point-of-care diagnostic(POCT) device with wide scope. Methods The lateral flow assay(LFA) strip of NT-proBNP was first prepared to achieve rapid detection. Then, the antibody pairs for NT-proBNP were screened and labeled with the near-infrared fluorescent dye Dylight-800. The capture antibody was fixed on a nitrocellulose membrane by a scribing device. Serial dilutions of serum samples were prepared using NT-proBNP-free serum series. The prepared test strips, combined with a near-infrared POCT device, were validated by known concentrations of clinical samples. The POCT device gave the output of the ratio of the intensity of the fluorescence signal of the detection line to that of the quality control line. The relationship between the ratio value and the concentration of the specimen was plotted as a work curve. The results of 62 clinical specimens obtained from our method were compared in parallel with those obtained from the Roche E411 kit. Results Based on the log-log plot, the new method demonstrated that there was a good linear relationship between the ratio value and NT-proBNP concentrations ranging from 20 pg/mL to 10 ng/mL. The results of the 62 clinical specimens measured by our method showed a good linear correlation with those measured by the Roche E411 kit. Conclusion The new LFA detection method of NT-proBNP levels based on the near-infrared POCT device was rapid and highly sensitive with wide scope and was thus suitable for rapid and early clinical diagnosis of cardiac impairment. | ZHANG Xiao Guang SHU Yao Gen GAO Ju WANG Xuan LIU Li Peng WANG Meng CAO Yu Xi ZENG Yi | 2017 | Biomedical and Environmental Sciences2017，30，6： | 4 |
| 12 | Effect of Different Bacterial-Feeding Nematode Species on Soil Bacterial Numbers,Activity,and Community Composition显示文摘The effects of bacterial-feeding nematodes on bacterial number,activity,and community composition were studied through a microcosm experiment using sterilized soil inoculated with soil bacteria(soil suspension)and with bacteria and three species of bacterial-feeding nematodes(Cephalobus persegnis,Protorhabditis filiformis,and Caenorhabditis elegans).Catalyzed reporter deposition-fluorescence in situ hybridization,CO_2 evolution,and denaturing gradient gel electrophoresis(DGGE)of PCR.amplified 16S rRNA gene fragments were used to investigate bacterial numbers,activity,and community composition,respectively.Our results showed that bacterial numbers and activity significantly increased in the presence of bacterial-feeding nematodes,which indicated that bacterial-feeding nematodes had a significant positive effect on soil bacteria.The different nematode species had different effects on bacterial numbers and activity.C.persegnis and P.filiformis,isolated from native soil,increased the bacterial number and activity more than C.elegans.The DGGE analysis results showed that dominant bacterial species significantly differed among the treatments,which suggested that bacterial-feeding nematode species modified the bacterial community composition in soil.Further gene sequence analysis results showed that the dominant bacterial species in this study were gram-negative bacteria.Given the completely same conditions except nematode species,the varied selective feeding behavior of different nematode species was the most likely reason for the altered bacterial community composition.Overall,the alteration of bacterial numbers,activity and community composition resulting from the bacterial-feeding nematodes may ultimately affect soil ecological functioning and processes. | XIAO Hai-Feng LI Gen LI Da-Ming HU Feng LI Hui-Xin | 2014 | Pedosphere2014，24，1： | 4 |
| 13 | Salidroside Reduces PDE2A Expression by Down-regulating p53 in Human Embryonic Lung Fibroblasts显示文摘Salidroside(SAL) is a glucoside of tyrosol and a key constituent of Rhodiola rosea L. The diverse pharmacological activities of SAL include anti-inflammatory, cardioprotective, and neuroprotective effects(1)Our previous investigation showed that the anti-aging effects of SAL involve reductions of the levels of advanced glycation end products in a D-galactose induced mouse model(2)Additionally. | XING Wen Min CHEN Sha Sha WANG San Ying GAO Wen Yan WAN Xiao Qing SU Hui Li YANG Yi ZHANG Jing YAN Jing MAO Gen Xiang | 2019 | Biomedical and Environmental Sciences2019，32，2： | 3 |
| 14 | A new triterpenoid saponin from Clematis ganpiniana显示文摘A new triterpenoid saponin,named clematiganoside A(1),was isolated from the whole plant of Clematis ganpiniana.Its structure was elucidated on the basis of 1D,2D NMR,TOF-MS and ESI-MS techniques,and physicochemical properties. | Feng Sun Qing He Pei Gen Xiao Yi Yu Cheng | 2007 | Chinese Chemical Letters2007，18，9： | 3 |
| 15 | Two new phenethanol glycosides from Ligustrum robustum显示文摘二新 phenethanol glycosides,命名 ligurobustoside P (1 ) , ligurobustoside Q (2 ) 从 Ligustrum robustum 的叶子被孤立,和已知的复合 angoroside,是的 A (3 ) 第一从这种孤立。二新 phenethanol glycosides (12 ) 的结构被高分辨率的电子电离质量的联合阐明 spectrometry (HR-ESI-MS ) , 1H NMR, 13C NMR, HMQC,和 HMBC 系列第一次。 | Li Li Yong Peng Yong Liu Li Jia Xu Na Guo Ren Bing Shi Pei Gen Xiao | 2011 | Chinese Chemical Letters2011，22，3： | 3 |
| 16 | Alkaloids from Stems of Ervatamia yunnanensis (Ⅱ)显示文摘Six indole alkaloids were isolated from the stems of Ervatamia yunnanensis. Among them, 10-hydroxy-19, 20-dihydroisositsirikine (I) is new. The other five are known alkaloids, namely: matrine (II), 19, 20-dihydroisositsirikine (III), 19-s-voacangarine (IV), 11′-methoxyl-19s- heyneanine (V), conodurine (VI). The structural elucidation of the alkaloids was based on spectral means. | Shuang LIANG Xin Gen LUO Hai Sheng CHEN Xiao Dong ZHANG Mao HUANG Wen Yong LIU | 2006 | Chinese Chemical Letters2006，17，6： | 2 |
| 17 | Cypripediquinone A, a new phenanthraquinone from Cypripedium macranthum (Orchidaceae)显示文摘A new phenanthraquinone, cypripediquinone A, was isolated from the rhizome of Cypripedium macranthum (Orchidaceae ) and its structure was established as 2,4,7-trimethoxy-9. l0- phenanthraquinone mainly by spectroscopic analysis. | Jian Hua JU Jun Shan YANG Jin LI Pei Gen XIAO (Institute of Medicinal Plant Development. Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094) | 2000 | Chinese Chemical Letters2000，11，1： | 2 |
| 18 | Inverted S-shaped model for nonlinear fatigue damage of rock 显示文摘 | XIAO Jian-qing DING De-xin XU Gen JIANG Fu-liang | 2009 | International Journal of Rock Mechanics and Mining Sciences2009，46，3： | 1 |
| 19 | Synthesis and Characterization of the Tetrazole Analogues of α-Amino Acids显示文摘The tetrazole analogues have been synthesized from fluorenylmethoxycarbonyl (Fmoc)- protected amino acids by three steps. The structures of the analogues were characterized by HPLC-MS, 1H NMR and 13C NMR. | Yah Min HUO Gen Hu LEI Yin Mao WEI Xiao Hui ZHENG | 2006 | Chinese Chemical Letters2006，17，12： | 1 |
| 20 | A magnetic field strategy to porous Pt-Ni nanoparticles with predominant (111) facets for enhanced electrocatalytic oxygen reduction显示文摘For the first time, we developed porous Pt-Ni alloying nanoparticles with predominant(111) facets under intense magnetic fields. Electrochemical analysis revealed that the Pt-Ni alloying nanoparticles obtained at 2 Tesla exhibited a superior catalytic activity and durability for oxygen reduction reaction. This work demonstrated that the imposition of intense magnetic field could be considered as a new approach for developing efficient alloying electrocatalysts with preferential facets. | Xiao Lyu Weina Zhang Shuang Liu Xiaoyang Wang Gen Li Bowen Shi Kai Wang Xin Wang Qiang Wang Yi Jia | 2021 | Journal of Energy Chemistry2021，30，2： | 1 |
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