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| 1 | Serum osmolality and ions,and gill Na^(+)/K^(+)-ATPase of spottedtail goby Synechogobius ommaturus(R.)in response to acute salinity changes显示文摘This study was carried out to determine the effects of abrupt salinity change on osmoregulatory ability of the spottedtail goby Synechogobius ommaturus.720 juvenile fish(65.3±11.8 g)were transferred to 200 L tanks(with 40 juveniles in each tank),in which salinities were abruptly changed from 10 to 20,30,40,50 and freshwater.Survival rate,serum osmolality,electrolytes(Na^(+),Cl^(-),and K^(+))and gill Na^(+)/K^(+)-ATPase(NKA)activity were assessed successively in 528 h.Results showed serum osmolality,ion concentrations and gill Na^(+)/K^(+)-ATPase activity increased significantly when fish were transferred to salinity 40 and 50 and all fish in these groups died by the end of the experiment.Serum osmolality,Na^(+),Cl^(-)and K^(+)in fish transferred to a salinity of 20,30 and freshwater were not affected and no mortality was detected.Compared with the control group,a significantly decrease of NKA activity happened in the freshwater group,but the activity in 20 and 30 groups was not affected significantly.The results indicated that S.ommaturus could adapt rapidly and maintain homeostasis in a wide range of salinities(from freshwater to salinity 30)and this species may be suitable for aquaculture in estuarine and coastal areas where rapid salinity fluctuations commonly occur. | Chun Shui Yonghai Shi Xueming Hua Zhonghua Zhang Haiming Zhang Genhai Lu Yongde Xie | 2018 | Aquaculture and Fisheries2018，3，2： | 4 |
| 2 | Phytoplankton and chlorophyll a relationships with ENSO in Prydz Bay, East Antarctica显示文摘The historical data of phytoplankton and chlorophyll a(Chl a)(1990–2002)obtained during the Chinese National Antarctic Research Expedition(CHINARE)in the Prydz Bay have been integrated.The results showed that the temperature,salinity,nutrients,and oxygen of seawater changed when El Nino/La Nina occurred.The variation of biological communities reflected the response of ecosystem to environmental changes.During El Ni?o period,Chl a concentration and phytoplankton community structure changed significantly,and the relative proportion of diatoms increased while dinoflagellates decreased.During La Ni?a period,the proportion of diatoms decreased,but the golden-brown algae and blue-green algae increased significantly.The variation of phytoplankton population directly affected the biodiversity of the bay,which were also quite sensitive to the marine environment changes.Meanwhile,the satellite remote sensing data of 2002–2011(December–March)have been used to study the temporal connection change of Chl a and phytoplankton in the Prydz Bay.We found that there were significant differences in the monthly variation characteristics of satellite remote sensing Chl a and sea surface temperature(SST),which had some links with sea ice melting and El Ni?o/La Ni?a events.We found that the start time of bloom advanced,lagged or synchronized with the changes of the SST,and we also found the occurrence time of phytoplankton bloom corresponded with the sea ice melting inner bay.To some extent,this study will help us understand the relationships between ENSO events and the phytoplankton bloom in the Southern Ocean. | ZHANG HaiSheng HAN ZhengBing ZHAO Jun YU PeiSong HU ChuanYu SUN WeiPing Yang Dan ZHU GenHai LU Bing Hans-UIrich PETER Walter VETTER | 2014 | Science China Earth Sciences2014，57，12： | 1 |
| 3 | Absent in melanoma 2 attenuates proliferation and migration and promotes apoptosis of human colorectal cancer cells by activating P38MAPK signaling pathway显示文摘Colorectal cancer(CRC)stands among the top prevalent cancers worldwide and holds a prominent position as a major contributor to cancer-related mortality globally.Absent in melanoma 2(AIM2),a constituent of the interferoninducible hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats protein family,contributes to both cancer progression and inflammasome activation.Despite this understanding,the precise biological functions and molecular mechanisms governed by AIM2 in CRC remain elusive.Consequently,this study endeavors to assess AIM2’s expression levels,explore its potential antitumor effects,elucidate associated cancer-related processes,and decipher the underlying signaling pathways in CRC.Our findings showed a reduced AIM2 expression in most CRC cell lines.Elevation of AIM2 levels suppressed CRC cell proliferation and migration,altered cell cycle by inhibiting G1/S transition,and induced cell apoptosis.Further research uncovered the participation of P38 mitogen-activated protein kinase(P38MAPK)in AIM2-mediated modulation of CRC cell apoptosis and proliferation.Altogether,our achievements distinctly underscored AIM2’s antitumor role in CRC.AIM2 overexpression inhibited proliferation and migration and induced apoptosis of CRC cells via activating P38MAPK signaling pathway,indicating AIM2 as a prospective and novel therapeutic target for CRC. | ZHI ZHANG XIAOSONG LI YING ZHANG HAO ZHU ZHENGUO QIAO YANG LU XIUWEI MI HUIHUA CAO GENHAI SHEN SONGBING HE | 2024 | Oncology Research2024，32，2： | 0 |
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