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| 1 | Impact of on-range choice feeding with black soldier fly larvae(Hermetia illucens)on flock performance,egg quality,and range use of free-range laying hens显示文摘Semi-intensive free-range farm systems are common in Australia, and these systems frequently practise on-range feeding. The objective of this study was to investigate the benefit of on-range choice feeding on flock performance, egg quality, and range use of free-range laying hens using black soldier fly larvae(Hermetia illucens, BSF). A total of 160 mature ISA brown laying hens, previously determined to range daily, were allocated to a control group(control) or a treatment group(BSF) with various replicates depending on the parameter investigated. All hens were fed ad libitum indoors with a wheat-soy based diet formulated according to breed requirements. Black soldier fly hens were offered dried BSF larvae ad libitum on the range. Body weight, feed intake, BSF intake, egg production, feed conversion ratio, internal and external egg quality parameters, and individual range use using radio-frequency identification(RFID)technology was evaluated. Black soldier fly hens consumed on average 15 ± 1.7 g BSF larvae/hen per day.There were no differences between BSF and control hens for any of the performance parameters obtained(P > 0.05). Egg weight, shell weight, and shell thickness of eggs from BSF hens were significantly lower(P = 0.003, P = 0.001, and P = 0.004, respectively) than those of eggs from control hens. Egg yolk colour was significantly paler in eggs from BSF hens(P < 0.001). No significant ranging differences between the BSF and control hens were observed(P > 0.05) except for BSF hens showing longer total maximum time for a single visit to the range(P = 0.011). In conclusion, the average intake of BSF larvae indicated a good level of acceptance. Feed formulation should be adjusted for the intake of the choice fed source. The impact of choice-feeding on range use was minor. | Isabelle Ruhnke Camille Normant Dana L.M.Campbell Zafar Iqbal Caroline Lee Geoff N.Hinch Julie Roberts | 2018 | Animal Nutrition2018，，4： | 12 |
| 2 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 3 | Role of the complement cascade in cerebral aneurysm formation,growth,and rupture显示文摘Rupture of intracranial aneurysms is the most common cause of nontraumatic subarachnoid hemorrhage,but the intricate neuroinflammatory processes which contribute to aneurysm pathophysiology are not well‑understood.Mounting evidence has implicated the complement cascade in the progression of aneurysms from their formation to rupture.In this article,we identify and review studies that have sought to determine the role of the complement system in the aneurysm pathogenesis.The studies were generally conducted by immunhistological analyses on aneurysm tissue collected intraoperatively,and multiple components of the complement cascade and its modulators were identified in specific regions of the aneurysm wall.The results of the studies suggest that the complement cascade is locally upregulated and disinhibited in the perianeurysmal environment,and that it contributes to chronic as well as acute immunological damage to the aneurysm wall.In the future,understanding the mechanisms at work in complement‑mediated damage is necessary to leading the development of novel therapies. | Blake E.S.Taylor Geoff Appelboom Robert Zilinyi Ariana Goodman David Chapel Melissa LoPresti Edward Sander Connolly Jr. | 2015 | Neuroimmunology and Neuroinflammation2015，2，1： | 2 |
| 4 | Defining the toxic mode of action of ester sulphonates using the joint toxicity of mixtures显示文摘 | Hodges Geoff Roberts David W Marshall Stuart J | 2006 | Chemosphere2006，64，1： | 1 |
| 5 | Legitimizing Fluvial Ecosystems as Users of Water: An Overview显示文摘 | ROBERT J. NAIMAN STUART E. BUNN CHRISTER NILSSON GEOFF E. PETTS GILLES PINAY LISA C. THOMPSON | 2002 | Environmental Management2002，，4： | 1 |
| 6 | Rapid detection and simultaneous subtype differentiation of influenza A viruses by real time PCR显示文摘 | Belinda Stone Julie Burrows Sonia Schepetiuk Geoff Higgins Alan Hampson Robert Shaw TuckWeng Kok | 2004 | Journal of Virological Methods2004，，2： | 1 |
| 7 | Human thrombin and FXa mediate porcine endothelial cell activation;modulation by expression of TFPI-CD4 and hirudin-CD4 fusion proteins 显示文摘 | Riesbeck K McVey J H Geoff K C Edward G D T Robert I L Anthony D | 2001 | Xenotransplantation2001，8，4： | 1 |
| 8 | Thruster fault diagnosis and accommodation for open-frame underwater vehicles 显示文摘 | Edin Omerdic Geoff Roberts | 2004 | Control Engineering Practice2004，，12： | 1 |
| 9 | Thruster fault diagnosis and accommodation for open-frame underwater vehicles 显示文摘 | Edin Omerdic Geoff Roberts | 2004 | Control Engineering Practice2004，，12： | 1 |
| 10 | Harmonization of Animal Clinical Pathology Testingin Toxicity and Safety Studies Fundamental and Applied Toxicology显示文摘 | Kurt Weingand Geoff Brown Robert Hall | 1996 | Fundamental and applied toxicology1996，29，： | 1 |
| 11 | Experimental comparison of B-PPM and NRZ coding for- mats in a 1550nm trans-atmospheric optical communication link under deep fading conditions 显示文摘 | PEACH Robert BURDGE Geoff WYATT Jeff | 2008 | Free-Space Laser Communications VIII2008，7091，70： | 1 |
| 12 | The Princeton III Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease显示文摘 | Ajay Nehra Graham Jackson Martin Miner Kevin L. Billups Arthur L. Burnett Jacques Buvat Culley C. Carson Glenn R. Cunningham Peter Ganz Irwin Goldstein Andre T. Guay Geoff Hackett Robert A. Kloner John Kostis Piero Montorsi Melinda Ramsey Raymond Rosen Ri | 2012 | Mayo Clinic Proceedings2012，，8： | 1 |
| 13 | Thruster fault diagnosis and accommodation for open-frame underwater vehicles 显示文摘 | Edin Omerdic Geoff Roberts | 2004 | Control Engineering Practice2004，12，2： | 1 |
| 14 | Thruster fault diagnosis and accommodation for open-frame underwater vehicles 显示文摘 | Edin Omerdic Geoff Roberts | 2004 | Control Engineering Practice(S0967-0661)2004，12，12： | 1 |
| 15 | A rapid and simple method of detection of Blephaisma japonicum using PCR and immobilisation on FTA paper显示文摘 | Geoff H Jacqueline MH Robert M | 2003 | BMC Ecology2003，3，： | 1 |
| 16 | The aquatic toxicity ofanionic surfactants to Daphnia magna-A comparative QSARstudy of linear alkylhenzene sulphonates and ester sulphonates 显示文摘 | Geoff H d W Roberts S J Marshall | 2006 | Chemosphere2006，63，： | 1 |
| 17 | 美国2001年9月11日世贸中心被攻击后的环境研究显示文摘本文主要介绍了2001年9月11日世界贸易中心(WTC)被攻击之后在各学科领域的环境特征研究结果。文中提交的信息被世界贸易中心应急小组在2001年9月18日(热点信息)和2001年9月27日(制图和组成成分结果研究)使用。实验数据由喷气推进实验室/美国航空航天局(JPL/NASA)于2001年9月16、18、22、23日在世界贸易中心(WTC)通过机载可见光/红外成像光谱仪(AVIRIS)的高光谱遥感仪器获得。2001年9月17日和18日晚上,由两人组成的美国地质勘探局小组在世界贸易中心方圆1km之内收集了超过35个位置点的粉尘和空降碎片样品,其中为了避免受9月14日的暴雨影响选择了两个室内样本收集点,另外还收集到了两个有钢梁涂层的世贸残骸样品。美国地质勘探局地面工作人员在白天进行了实地反射光谱测量,用于现场校准AVIRIS遥感数据。AVIRIS数据的辐射定标和校正工作在喷气推进实验室/美国航空航天局(JPL/NASA)完成;表面反射率校准、光谱测图和解译工作在位于丹佛市的美国地质调查局成像光谱实验室完成;灰尘/碎屑和钢梁涂层样品的各种矿物学和化学参数的分析工作,在位于科罗拉多州丹佛市的美国地质调查局实验室完成,分析中使用了反射光谱法(RS)、扫描电子显微镜检查法(SEM)以及X射线衍射法(XRD)等。通过分析研究得出以下几个重要结论:(1)世贸中心大楼倒塌释放的粉尘主要有:玻璃纤维、石膏、混凝土、纸张以及其他建筑施工中常用的混合材料。(2)在实验室用RS、SEM和XRD方法分析发现,在三分之二以上的灰尘和空降碎片样本中只检测到微量的温石棉(小于总重量的1%),而到目前为止在所有粉尘样品中还没有检测到角闪石类石棉矿物。(3)对钢梁涂层样品分析发现,在世贸中心碎片中检测到的温石棉(蛇纹石矿物)占涂层材料总体积的比例高达20%,同样在这些钢梁涂层样品中也没有检测到角闪石类石棉矿物。(4)在地面仪器低百分比检测的限制下,AVIRIS矿物图主要是用来检测可能存在的石棉状矿物,图中并没有显示温石棉或闪石类石棉的大范围分布。从图中的孤立像素点或像素群(像素大小约2m×2m)可以看出,世贸中心周围地区的石棉状矿物含量变化范围大,从百分之几到百分之几十都有可能。由于AVIRIS数据中的某些光谱吸收强度和温石棉钢梁涂层的光谱相似,因此吸收特征图只显示出了蛇纹石矿物的存在,而不能说明蛇纹石是石棉状的,因为非石棉状蛇纹石矿物在建筑材料中也是非常常见的。AVIRIS矿物图可以显示含石棉量较高的区域和小范围非石棉状矿物的区域,但需要通过现场采样和实验分析来验证石棉的存在。另外,AVIRIS矿物图只能检测地表矿物,而不能检测地下掩埋的矿物。(5)AVIRIS矿物图中角闪石类矿物是几个孤立像素点,而不是像温石棉那样的像素群。少数几个世贸中心地区的角闪石像素点和整个城市的角闪石像素统计噪声水平相似。AVIRIS吸收特征图只显示了角闪石矿物的存在,而这些在非石棉状建筑材料中也是非常常见的,所以需要进行现场采样来确认石棉的存在。野外样品的实验室分析结果与矿物图上的蛇纹石温石棉和角闪石矿物是一致的。(6)实验分析和AVIRIS矿物图结果表明,无论是小尺度的个别样品,还是世贸中心一定方向和距离范围的大空间尺度,粉尘的成分都是多变的。通过对同一样品多次重复进行矿物学和化学物质分析发现,多变性可能是因为粉尘是由不同材料的不均匀混合造成的,这种空间差异是在几十米的大尺度到厘米甚至更小尺度范围下观测到的。AVIRIS矿物图还显示了位于东南偏南的2号大楼倒塌中心的物质铁含量较高,温石棉的分布主要(但并不唯一)呈向西和北方向不连续的放射状,也可能分布在超过世贸大厦遗址四分之三公里的东方向。(7)迄今为止,在粉尘和空降样品中只检测到微量的温石棉,但在有钢梁涂层的世贸中心碎片中温石棉含量达到总体积的20%之多,而且AVIRIS矿物图中温石棉可能存在的区域也表明在局部点可能发现石棉。(8)2001年9月16日收集到的AVIRIS数据显示,世贸中心大楼倒塌区域有若干热点存在,在核心区就有超过36个不同大小和温度的热点。分析数据发现,这些热点的温度都高于800°F,有些甚至超过了1300°F。截止到9月23日,从飞机上观察到的火灾点大部分已经消除或者减弱。(9)我们通过实验发现的灰尘样品有微量石棉的结论与美国环保署(www.epa.gov)进行的其他研究结果一致。我们的研究结果也进一步说明:①高含量石棉可能存在于钢梁涂层和AVIRIS矿物图中显示的局部区域;②粉尘和钢梁涂层中的石棉只含有温石棉,而不含有角闪石类石棉。根据毒理学专家、流行病学专家和矿物学专家近20年分析研究的主要成果表明,闪石类石棉矿物比温石棉更易致癌(Ross,1999;Skinner等,1988;Van Oss等,1999:McDonald,2001)。但是,这一结论还没有被科学界普遍接受。Nolan等(2001)的文献中对这些问题有最新的深入探讨。(10)利用矿物学特性研究AVIRIS矿物图得出以下结论:温石棉占世贸中心残骸中有钢梁涂层材料总体积的20%之多,这些温石棉可能是在清理过程中作为灰尘无意释放到空气中的;AVIRIS矿物图显示石棉可能出现在粉尘的局部小范围集中区。这些为美国环保署和纽约公共卫生局清理粉尘和世贸中心残骸的工作提供了有用的建议,即在清理时应该采取合适的呼吸保护和防尘措施。 | Roger N.Clark Robert O.Green Gregg A.Swayze Greg Meeker Steve Sutley Todd M.Hoefen K.Eric Livo Geoff Plumlee Betina Pavri Chuck Sarture Steve Wilson Phil Hageman Paul Lamothe J.Sam Vance Joe Boardman Isabelle Brownfield Carol Gent Laurie C.Morath Joseph Taggart Peter M.Theodorakos Monique Adams 李强 | 2013 | 地壳构造与地壳应力2013，，2： | 0 |
| 18 | Profiling proteomic responses to hexokinase-II depletion in terpene-producing Saccharomyces cerevisiae显示文摘Hexokinase II(Hxk2)is a master protein in glucose-mediated transcriptional repression signaling pathway.De-grading Hxk2 through an auxin-inducible protein degradation previously doubled sesquiterpene(nerolidol)pro-duction at gram-per-liter levels in Saccharomyces cerevisiae.Global transcriptomics/proteomics profiles in Hxk2-deficient background are important to understanding genetic and molecular mechanisms for improved nerolidol production and guiding further strain optimization.Here,proteomic responses to Hxk2 depletion are investi-gated in the yeast strains harboring a GAL promoters-controlled nerolidol synthetic pathway,at the exponential and ethanol growth phases and in GAL80-wildtype and gal80Δbackgrounds.Carbon metabolic pathways and amino acid metabolic pathways show diversified responses to Hxk2 depletion and growth on ethanol,including upregulation of alternative carbon catabolism and respiration as well as downregulation of amino acid synthesis.De-repression of GAL genes may contribute to improved nerolidol production in Hxk2-depleted strains.Seven-teen transcription factors associated with upregulated genes are enriched.Validating Ash1-mediated repression on the RIM4 promoter shows the variation on the regulatory effects of different Ash1-binding sites and the syner-gistic effect of Ash1 and Hxk2-mediated repression.Further validation of individual promoters shows that HXT1 promoter activities are glucose-dependent in hxk2Δbackground,but much weaker than those in HXK2-wildtype background.In summary,inactivating HXK2 may relieve glucose repression on respiration and GAL promoters for improved bioproduction under aerobic conditions in S.cerevisiae.The proteomics profiles provide a better genetics overview for a better metabolic engineering design in Hxk2-deficient backgrounds. | Zeyu Lu Qianyi Shen Lian Liu Gert Talbo Robert Speight Matt Trau Geoff Dumsday Christopher B.Howard Claudia E.Vickers Bingyin Peng | 2023 | Engineering Microbiology2023，3，3： | 0 |
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