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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Transcystic Common Bile Duct Exploration in the Management of Patients With Choledocholithiasis显示文摘 | Sergio Rojas-Ortega Daniel Arizpe-Bravo Eduardo R Mar??n López Rachid Cesin-Sánchez Gerardo Reed-San Roman Crispina Gómez | 2003 | Journal of Gastrointestinal Surgery2003，，4： | 3 |
| 3 | Carbon nanotubes as reinforcement of styrene-butadiene rubber 显示文摘 | Alejandro D F Silvia G Gerardo H R | 2007 | Applied Surface Science2007，254，1： | 1 |
| 4 | Randomised trial of roxithromycin in non-Q-wave coronary syndromes: ROXIS pilot study显示文摘 | Enrique G Gerardo B Ana D | | The Lancet0，350，： | 1 |
| 5 | Pressurized Liquid Extraction of Capsaicinoids from Peppers显示文摘 | Gerardo F Barbero Miguel Palma Carmelo G | 2006 | Agfic Food Chen2006，54，： | 1 |
| 6 | Two alternative modeling approaches for the evaluation of wind farm active and reactive power performances显示文摘 | Gerardo G Tapia A Ostolaza J X | 2006 | IEEE Trans on Energy Conversion2006，21，4： | 1 |
| 7 | Transcystic common bile duct exploration in the management of patients with choledocholithiasis显示文摘 | Dr. Sergio Rojas-Ortega M.D. Daniel Arizpe-Bravo M.D. Eduardo R. Maryn López M.D. Rachid Cesin-Sánchez M.D. Gerardo Reed-San Roman M.D. Crispina Gómez | 2003 | Journal of Gastrointestinal Surgery2003，，4： | 1 |
| 8 | Synthesis and characterization of polyaniline and polyaniline-Carbon nanotubes nanostructures for electrochemical supercapacitors显示文摘 | Marcela A Gerardo G Teresita Kessler | 2014 | Journal of Power Sources2014，56，245： | 1 |
| 9 | Influence of tungsten on the carbon nanotubes growth by CVD process显示文摘 | MARIANO E GERARDO H R MORENO M S SILVIA G ROBERTO C | 2009 | Journal of Alloys and Compounds2009，479，12： | 1 |
| 10 | Effect of the number of parity on the main reproductive indicators of sows 显示文摘 | Gerardo 0 O Aureliano J A Antonio G V | 2014 | Revista Cientifica-Facultad De Ciencias Veterinarias2014，23，6： | 1 |
| 11 | Carbon nanotubes as reinforcement of styrene-butadiene rubber显示文摘 | Alejandro D F Silvia G Gerardo H R | 2007 | Applied Sur- face Science2007，254，1： | 1 |
| 12 | A new simpli- fied multilevel inverter topology for DC-AC conversion 显示文摘 | GERARDO C VICTOR G CARLOS S | 2006 | IEEE Transactions on power electronics2006，21，5： | 1 |
| 13 | Microbial enzymes involved in polyurethane biodegradation: a review显示文摘 | ARACELI L T GERARDO G S RAUL R H | 2012 | Journal of Polymers and the Environment2012，20，： | 1 |
| 14 | A Repetitive-based Controller for the Compens- ation of 6/:l Harmonic Components 显示文摘 | Gerardo Es Cobar Perla G Hernandez- Briones PanFilo R Martinez et a/ | 2008 | IEEE Transactions on Industrial Electronics2008，55，8： | 1 |
| 15 | The evolution of agriculture in insects显示文摘 | Mueller U G Gerardo N M Aanen D K | 2005 | Annual Review of Ecology and Systematics2005，36，： | 1 |
| 16 | Curcumin induces cell arrested and apoptosis in associated with the inhibition of constitively active NF-κ3 and STAT 3 pathways in Hodgkin's lymphoma cells 显示文摘 | Gerardo G Mackenzie Nina Queisser | 2008 | Int J Cancer2008，123，3： | 1 |
| 17 | Effect of the number of parity on the main reproductive indicators of sows显示文摘 | Gerardo O O Aureliano J A Antonio G V | 2014 | Revista Cientifica-Facultad De Ciencias Veterinarias2014，23，6： | 1 |
| 18 | Pressurized Liquid Extraction of Capsaicinoids from Peppers 显示文摘 | Gerardo F Barbem Miguel Palma Carmelo G al | 2006 | Agric Food Chen2006，54，： | 1 |
| 19 | Natural clinoptilolite as an exchanger of Ni 2+ and NH 4 + ions under hydrothermal conditions and high ammonia concentration显示文摘 | Inocente Rodr??guez-Iznaga Ariel Gómez Gerardo Rodr??guez-Fuentes Adelaida Ben??tez-Aguilar Juan Serrano-Ballan | 2002 | Microporous and Mesoporous Materials2002，，1： | 1 |
| 20 | 2型糖尿病患者强化血糖控制的利与弊显示文摘糖尿病是全球主要的健康问题,治疗花费高,有较高的发病率、致残率和死亡率,显著影响患者生活质量。绝大多数糖尿病患者属于2型糖尿病。从既往研究看,减少2型糖尿病并发症的主要策略是加强血糖控制。然而大量证据表明,除了降低非致死性心肌梗死的发生率外,强化(相对于适度)血糖控制对重要的微血管和大血管并发症预后没有显著获益。但是,严格的血糖控制却会增加严重低血糖的风险,并会增加药物种类、副作用和成本等额外负担。此外,来自心血管结局研究的数据表明,使用特定类别的降糖药可大大改善心血管、肾脏和死亡的结果,而这些效应在很大程度上不是由降糖作用带来的。因此,为2型糖尿病患者提供基于循证医学的、以患者为中心的诊疗,需要转变范式并脱离以血糖为中心的糖尿病管理观点。与其优先考虑加强血糖控制,不如将重点放在确保患者获得足够的糖尿病照护,使血糖目标和患者的目标与情况保持一致,最大程度地减少短期和长期并发症,减轻治疗负担以及改善生活质量上。 | Rene Rodriguez-Gutierrez Jose Gerardo Gonzalez-Gonzalez Jorge A Zuniga-Hernandez- Rozalina G McCoy 吴量(译) 潘洁敏(校) | 2020 | 英国医学杂志中文版2020，23，9： | 1 |
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