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| 1 | Budesonide induces complete remission in autoimmune hepatitis显示文摘瞄准:泼尼松和 azathioprine 为自体免疫的肝炎(AIH ) 代表标准疗法。然而,仅仅, 65% 病人进入完全的组织学的宽恕。最近, budesonide (芽) 被报导是一种有希望的选择。在这研究,我们在 AIH 估计了芽的功效和安全。方法:十八个病人(12 个女人, 6 个男人;吝啬的年龄 45.4+/-21 年) 与芽(Budenofalk ) 与 AIH 被对待在上面三次每日、跟随的 3 mg 为至少 24 wk.Seven,病人们也有主要胆汁性肝硬变(n=5 ) 或主要致硬化的胆管炎(n=2 ) 的特征。先进的肝纤维变性或肝硬化在 6 个病人是在场的。结果:十五(83%) 病人们有完全的临床、生物化学的宽恕。十个病人,与尖锐肝炎包括五,作为首要的治疗被给芽,哪个七进入宽恕。三个病人,二与肝肝硬化,没改善。有第二线的治疗的所有病人经历了长期的宽恕。组织学的宽恕也在三个病人被看见。临床上相关的导致芽的副作用与肝肝硬化(n=4 ) 仅仅在病人被记录。结论:芽在在我们有 AIH.Side 效果的病人的多数的宽恕正式就职是有效的,治疗失败主要与肝肝硬化在病人被观察。 | Antal Csepregi Christoph R(o|¨)cken Gerhard Treiber Peter Malfertheiner | 2006 | World Journal of Gastroenterology2006，12，9： | 14 |
| 2 | Breath and string test: A diagnostic package for the identification of treatment failure and antibiotic resistance of Helicobacter pylori without the necessity of upper gastrointestinal endoscopy显示文摘AIM: Helicobacter pylori ( H pylofi) resistance after failed eradication has a major impact on the outcome of a further treatment regimen. The aim of this study was to assess the validity of a non-invasive strategy using the 13C-urea breath test (UBT) and the gastric string test in identifying post-treatment resistance of Hpylori.METHODS: The UBT was routinely performed 4 to 6 wk after H pylorieradication therapy. Forty-two patients (24 females, 18 males, mean age 48 years) with a positive UBT were included in the study. A gastric string test using a capsule containing a 90 cm-long nylon fiber was performed.Before the capsule was swallowed, the free end of the string was taped to the cheek. After one hour in the stomach, the string was withdrawn. The distal 20 cm of the string was inoculated onto an agar plate and processed under microaerophilic conditions. Following the string test, upper gastrointestinal endoscopy was performed to obtain gastric biopsies for conventional culture.RESULTS: H pyloriwas successfully cultured from the gastric string in 34 patients (81%), but not in 5 patients due to contamination with oropharyngeal flora. Hpyloriwas cultured from the gastric biopsies obtained at endoscopy in 39 patients (93%).CONCLUSION: The UBT followed by the gastric string test in the case of treatment failure is a valid diagnostic strategy with the aim of determining the post-therapeutic antibiotic resistance of Hpyloriwith little inconvenience to the patient.Upper GI-endoscopy can be avoided in several cases by applying consequently this diagnostic package. | Andreas Leodolter Kathlen Wolle Ulrike von Arnim Stefan Kahl Gerhard Treiber Matthias P.Ebert Ulrich Peitz Peter Malfertheiner | 2005 | World Journal of Gastroenterology2005，11，4： | 10 |
| 3 | Acute exacerbation of autoimmune hepatitis induced by Twinrix显示文摘We report on a 26-year-old man who presented with severe jaundice and elevated serum liver enzyme activities after having received a dose of Twinrix(○R). In his past medical history, jaundice or abnormal liver function tests were never recorded. Following admission, an elevated immunoglobulin G level and antinuclear antibodies at a titer of 320 with a homogenous pattern were found. Histology of a liver biopsy showed marked bridging liver fibrosis and a chronic inflammation, compatible with autoimmune hepatitis. Treatment was started with budesonide and ursodeoxycholic acid,and led to complete normalization of the pathological liver function tests. We believe that Twinrix(○R) led to an acute exacerbation of an unrecognized autoimmune hepatitis in our patient. The pathogenesis remains to be clarified. It is tempting to speculate that inactivated hepatitis A virus and/or recombinant surface antigen of the hepatitis B virus -as seen in patients with chronic hepatitis C and unrecognized autoimmune hepatitis who were treated with interferon alpha-might have been responsible for disease exacerbation. | Antal Csepregi Gerhard Treiber Christoph R(o|¨)cken Peter Malfertheiner | 2005 | World Journal of Gastroenterology2005，11，26： | 2 |
| 4 | Eosinophilic gastroenteritis显示文摘 | Gerhard G Treiber Simone Weidner | 2007 | Clinical Gastroenterology and Hepatology2007，5，： | 1 |
| 5 | 幽门螺杆菌下调人胃黏膜分泌性白细胞蛋白酶抑制因子的表达显示文摘目的通过低剂量阿斯匹林的处理作为炎性模型,研究分析人胃和十二指肠黏膜分泌性白细胞蛋白酶抑制因子(SLPI)表达下调是否与幽门螺杆菌(Helicobacter prlori,Hp)定居或感染有关.方法选择20例健康志愿者分成Hp+和Hp-组,其中Hp+组成功进行了根除治疗.每组10人,每人口服阿司匹林100 mg/d.通过活检提取受试者不同部位胃黏膜的总RNA和蛋白,采用RT/realtime PCR检测SLPI的mRNA表达水平和单抗ELISA定量测定SLPI蛋白,统计分析SLPI基因表达的相关数据.结果与Hp-组比较,Hp+组胃窦黏膜SLPI表达水平显著降低,但Hp+组经抗生素根除治疗后其SLPI水平恢复至与Hp-组相当的水平.在低剂量阿司匹林处理下,所有受试者表现组织学观察到的活动性或慢性炎性征.各组在药物处理的不同时间虽有一定的差异,但与药物处理对照组(第0天)比较,SLPI的表达差异没有统计学意义[第1天:(77±880)pg/10?g蛋白;第3天:(941±149)pg/10?g蛋白;第7天:(763±363)pg/10?g蛋白].阿司匹林处理的1周内以胃窦为主的胃炎持续存在(活动性:1.5~1.7;慢性:1.2~2.1),但与Hp-和Hpe(根除组)比较,Hp+组的胃窦黏膜SLPI蛋白表达仍显著降低.结论低剂量阿司匹林处理所致炎性反应对人胃黏膜SLPI的表达没有影响,胃窦黏膜SLPI基因表达的下调与Hp感染有关. | 叶嗣颖 Thomas Wex Gerhard Treiber Michael Vieth Peter Malfertheiner | 2005 | 中华微生物学和免疫学杂志2005，25，10： | 0 |
| 6 | Impact of endoscopy-based research on quality of life in healthy volunteers显示文摘AIM:To study the impact of an endoscopy-based long-term study on the quality of life in healthy volunteers(HV).METHODS:Ten HV were included into a long-term prospective endoscopy-based placebo-controlled trial with 15 endoscopic examinations per person in 5 different drug phases.Participants completed short form-36(SF-36) and visual analog scale-based questionnaires(VAS) for different abdominal symptoms at days 0,7 and 14 of each drug phase.Analyses wereperformed according to short-and long-term changes and compared to the control group.RESULTS:All HV completed the study with duration of more than 6 mo.Initial quality of life score was comparable to a general population.Analyses of the SF-36 questionnaires showed no significant changes in physical,mental and total scores,either in a short-term perspective due to different medications,or to potentially endoscopic procedure-associated long-term cumulative changes.Analogous to SF-36,VAS revealed no significant changes in total scores for pathological abdominal symptoms and remained unchanged over the time course and when compared to the control population.CONCLUSION:This study demonstrates that quality of life in HV is not significantly affected by a longterm endoscopy-based study with multiple endoscopic procedures. | Alexander Link Gerhard Treiber Brigitte Peters Thomas Wex Peter Malfertheiner | 2010 | World Journal of Gastroenterology2010，16，4： | 0 |
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