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| 1 | Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis显示文摘恶意的阴囊的细菌房间肿瘤(TGCT ) 与 70% 增加的发生最后是在白种人男性(20-40 年) 的最经常的癌症 20 年,可能由于联合行动(epi ) 基因并且(微) 环境因素。TGCT 作为他们的普通先锋在 situ (CIS ) 有癌,这被期望,从在它的成熟过程堵住的一个胚胎的细菌房间发源。然而, TGCT 的全面痊愈率是超过 90% 人幸存 TGCT 能介绍全身的癌症治疗的长期的副作用。相反,没有这些长期的副作用,为 CIS 诊断并且对待的人仅仅继续生活。因此, CIS 的早察觉有大健康好处,它将要求一个增进知识的屏蔽方法。这评论描述了病原学和早察觉的 TGCT 和为 TGCT 在风险屏蔽人的未来潜力的早致病。为屏蔽,明确的风险侧面基于基因、环境的风险因素被需要。自从 2009 ,宽协会学习的几个染色体( GWAS )被出版了,在有重要协会在或在基因 KITLG , SPRY4 , BAK1 , DMRT1 , TERT , ATF7IP , HPGDS , MAD1L1 , RFWD3 , TEX14 ,和 PPM1E 附近的单个核苷酸的多型性( SNP )上报导,可能与 TGCT 开发有关。出生前, perinatal,和出生后的环境因素也影响 CIS 的发作。noninvasive 为 CIS 的早察觉方法将在一个临床的背景,在精液的特定的 miRNA 察觉为似乎很有希望是高度有益的。进一步的研究被需要发展基于基因环境相互作用,明确的 TGCT 风险侧面为 CIS 与 noninvasive 察觉方法结合了。 | Jenny E Elzinga-Tinke Gert R Dohle Leendert HJ Looijenga | 2015 | Asian Journal of Andrology2015，17，3： | 4 |
| 2 | Serrated polyps of the colon: how reproducible is their classification?显示文摘 | Arzu Ensari Banu Bilezik?i Fatima Carneiro Gülen Bülbül Do?usoy Ann Driessen Ay?e Dursun Jean-Fran?ois Flejou Karel Geboes Gert de Hertogh Anne Jouret-Mourin Cord Langner Ir?s D. Nagtegaal Johan Offerhaus Janina Orlowska Ari Ristim?ki Julian Sanz-Ortega B | 2012 | Virchows Archiv2012，，5： | 1 |
| 3 | Liquid crystalline perylene-3, 4-dicarboximide derivatives with high thermal and photochemical stability显示文摘 | CHRISTIAN M VOLKER E | 1998 | Materials Science1998，81，1： | 1 |
| 4 | Management-based risk prediction in community-acquired pneumonia by scores and biomarkers 显示文摘 | Martin K Santiago E Gert H | 2013 | Eur Respir J2013，41，4： | 1 |
| 5 | Characterization of bovine collagens using capillary electrophoresis - an alternative to slab gel electrophoresis 显示文摘 | Paul C A Son K A Gert E B | 2000 | Journal of Pharmaceutical and Biomedical Analysis2000，22，： | 1 |
| 6 | Narcolepsy:Clinical features,new pathophysiologic insights,and future perspectives显示文摘 | OVEREEM S MIGNOT E GERT VAN DIJK J | 2001 | J Clin Neuroghysiol2001，18，： | 1 |
| 7 | Surgical outcome in an elderly population with intracranial meningioma显示文摘 | Umansky F Ashkenazi E Gerte M | 1992 | J Neurol Neurosurg Psychiatry1992，55，： | 1 |
| 8 | Constraint-induced movement therapy after stroke显示文摘 | Gert Kwakkel Janne M Veerbeek Erwin E H van Wegen Steven L Wolf | 2015 | Lancet Neurology2015，，2： | 1 |
| 9 | Interdependence between Eastern and Western European stock markets: Evidence from intraday data 显示文摘 | e gert B Ko ? enda E | 2007 | Economic Systems2007，，2： | 1 |
| 10 | Tert-butoxy- carbonylation of amino acids and their derivatives:N- tert-butoxycarbonyl-l-phenylalanine 显示文摘 | Oskar K Waiter E K Gert V L | 1985 | Org Synth1985，1，63： | 1 |
| 11 | Capacity of Lemna gibba L (Duck-weed) for uranium and arsenic phytoremediation in mine tailing waters 显示文摘 | Martin M Barbara T Gert D E | 2004 | International Journal of Phytore mediation2004，6，4： | 1 |
| 12 | Serrated polyps of the colon: how reproducible is their classification?显示文摘 | Arzu Ensari Banu Bilezik?i Fatima Carneiro Gülen Bülbül Do?usoy Ann Driessen Ay?e Dursun Jean-Fran?ois Flejou Karel Geboes Gert de Hertogh Anne Jouret-Mourin Cord Langner Ir?s D. Nagtegaal Johan Offerhaus Janina Orlowska Ari Ristim?ki Julian Sanz-Ortega B | 2012 | Virchows Archiv2012，，5： | 1 |
| 13 | Narcolepsy:clinical features,new pathophysiologic insights,and future perspectives显示文摘 | Overeem S Mignot E Gert van Dijk J | 2001 | J Clin Neurphysiol2001，18，1： | 1 |
| 14 | High-dose daunorubicin in older patients with acute myeloid leukemia显示文摘 | BOB L GERT J OSSENKOPPEL E | 2009 | N Engl J Med2009，361，： | 1 |
| 15 | A multimetrie maeroinver- tebrate index for assessing the water quality of the Cau river basin in Vietnam 显示文摘 | Hong H N Gert E Wim G | 2014 | Limnologiea2014，45，： | 1 |
| 16 | Are Social Value Orientations Expressed Automatically Deci- sion Making in the Dictator Game 显示文摘 | GERT CORNELISSEN DEWITI'E S WARLOP L | 2011 | Personality and Social Psychology Bulletin2011，37，8： | 1 |
| 17 | In situ gelling hydrogels for pharmaceutical and biomedical applications 显示文摘 | van Tomme S R Storm Gert Hennink W E | 2008 | Int JPharm2008，355，12： | 1 |
| 18 | Reinnervation of avulsed and reimplantedventral rootlets in the cervical spinal cord of the cat显示文摘 | Hoffmann CF Marani E Gert van DJ | 1996 | J Neurosurg1996，84，： | 1 |
| 19 | A robust minimax approach to classification显示文摘 | Gert R G L Laurent E G Chiranjib Bhattacharyya | 2002 | Journal of Machine Learning Research2002，，3： | 1 |
| 20 | Intra-arterial thrombolytics during endovascular thrombectomy for acute ischaemic stroke in the MR CLEAN Registry显示文摘Introduction The efficacy and safety of local intra-arterial(IA)thrombolytics during endovascular thrombectomy(EVT)for large-vessel occlusions is uncertain.We analysed how often IA thrombolytics were administered in the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands(MR CLEAN)Registry,whether it was associated with improved functional outcome and assessed technical and safety outcomes compared with EVT without IA thrombolytics.Methods In this observational study,we included patients undergoing EVT for an acute ischaemic stroke in the anterior circulation from the MR CLEAN Registry(March 2014-November 2017).The primary endpoint was favourable functional outcome,defined as an modified Rankin Scale score≤2 at 90 days.Secondary endpoints were reperfusion status,early neurological recovery and symptomatic intracranial haemorrhage(sICH).Subgroup analyses for IA thrombolytics as primary versus adjuvant revascularisation attempt were performed.Results Of the 2263 included patients,95(4.2%)received IA thrombolytics during EVT.The IA thrombolytics administered were urokinase(median dose,250000 IU(IQR,193750-250000))or alteplase(median dose,20 mg(IQR,12-20)).No association was found between IA thrombolytics and favourable functional outcome(adjusted OR(aOR),1.16;95%CI 0.71 to 1.90).Successful reperfusion was less often observed in those patients treated with IA thrombolytics(aOR,0.57;95%CI 0.36 to 0.90).The odds of sICH(aOR,0.82;95%CI 0.32 to 2.10)and early neurological recovery were comparable between patients treated with and without IA thrombolytics.For primary and adjuvant revascularisation attempts,IA thrombolytics were more often administered for proximal than for distal occlusions.Functional outcomes were comparable for patients receiving IA thrombolytics as a primary versus adjuvant revascularisation attempt.Conclusion Local IA thrombolytics were rarely used in the MR CLEAN Registry.In the relatively small study sample,no statistical difference was observed between groups in the rate of favourable functional outcome or sICH.Patients whom required and underwent IA thrombolytics were patients less likely to achieve successful reperfusion,probably due to selection bias. | Sabine L Collette Reinoud P H Bokkers Aryan Mazuri Geert J LycklamaàNijeholt Robert J van Oostenbrugge Natalie E LeCouffe Faysal Benali Charles B L M Majoie Jan Cees de Groot Gert Jan R Luijckx Maarten Uyttenboogaart 无 | 2023 | Stroke & Vascular Neurology2023，8，1： | 0 |
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