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| 1 | Role of surgical resection for multiple hepatocellular carcinomas显示文摘AIM:To clarify the role of surgical resection for multiple hepatocellular carcinomas(HCCs)compared to transarterial chemoembolization(TACE)and liver transplantation(LT). METHODS:Among the HCC patients who were managed at Yonsei University Health System between January 2003 and December 2008,160 patients who met the following criteria were retrospectively enrolled:(1) two or three radiologically diagnosed HCCs;(2)no radiologic vascular invasion;(3)Child-Pugh class A;(4) main tumor smaller than 5 cm in diameter;and(5) platelet count greater than 50 000/mm3.Long-term outcomes were compared among the following three treatment modalities:surgical resection or combined radiofrequency ablation(RFA)(n=36),TACE(n=107), and LT(n=17).The survival curves were computed using the Kaplan-Meier method and compared with a log-rank test.To identify the patients who gained a survival benefit from surgical resection,we also investigated prognostic factors for survival following surgical resection.Multivariate analyses of the prognostic factors for survival were performed using the Cox proportional hazard model. RESULTS:The overall survival(OS)rate was significantly higher in the surgical resection group than in the TACE group(48.1%vs 28.9%at 5 years,P<0.005). LT had the best OS rate,which was better than that of the surgical resection group,although the difference was not statistically significant(80.2%vs 48.1%at 5 years,P=0.447).The disease-free survival rates were also significantly higher in the LT group than in the surgical resection group(88.2%vs 11.2%at 5 years, P<0.001).Liver cirrhosis was the only significant prognostic factor for poor OS after surgical resection. Clinical liver cirrhosis rates were 55.6%(20/36)in the resection group and 93.5%(100/107)in the TACE group.There were 19 major and 17 minor resections. En bloc resection was performed in 23 patients,multisite resection was performed in 5 patients,and combined resection with RFA was performed in 8 patients. In the TACE group,only 34 patients(31.8%)were recorded as having complete remission after primary TACE.Seventy-two patients(67.3%)were retreated with repeated TACE combined with other therapies. In patients who underwent surgical resection,the 16 patients who did not have cirrhosis had higher 5-year OS and disease-free survival rates than the 20 patients who had cirrhosis(80.8%vs 25.5%5-year OS rate, P=0.006;22.2%vs 0%5-year disease-free survival rate,P=0.048).Surgical resection in the 20 patients who had cirrhosis did not provide any survival benefit when compared with TACE(25.5%vs 24.7%5-year OS rate,P=0.225).Twenty-nine of the 36 patients who underwent surgical resection experienced recur-rence.Of the patients with cirrhosis,80%(16/20) were within the Milan criteria at the time of recurrence CONCLUSION:Among patients with two or three HCCs, no radiologic vascular invasion,and tumor diameters≤ 5 cm,surgical resection is recommended only in those without cirrhosis. | Sung Hoon Choi Gi Hong Choi Seung Up Kim Jun Yong Park Dong Jin Joo Man Ki Ju Myoung Soo Kim Jin Sub Choi Kwang Hyub Han Soon Il Kim | 2013 | World Journal of Gastroenterology2013，19，3： | 12 |
| 2 | Sequential transcatheter arterial chemoembolization and portal vein embolization before right hemihepatectomy in patients with hepatocellular carcinoma显示文摘Background:Recent studies showed that sequential selective transcatheter arterial chemoembolization(TACE)and portal vein embolization(PVE)provided better future liver remnant(FLR)regeneration rate and disease-free survival following surgery compared with PVE alone.The present study aimed to clarify whether preoperative sequential TACE and PVE before right hemihepatectomy can reduce postoperative hepatocellular carcinoma(HCC)recurrence and improve long-term disease-free and overall survival.Methods:Recurrence and survival outcomes were retrospectively evaluated in 205 patients with HCC who underwent right hemihepatectomy by a single surgeon from November 1993 to November 2017.Patients were divided into four groups according to the procedure performed before the surgery:sequential TACE and PVE(TACE-PVE),PVE-only,TACE-only,or na?ve control groups.The baseline patient and tumor characteristics,postoperative outcomes,recurrence-free survival and overall survival were analyzed.Results:Baseline patient and tumor characteristics upon diagnosis were similar in all four groups,while sequential TACE and PVE were well tolerated.The TACE-PVE group had a higher mean increase in percentage FLR volume compared with that of the PVE-only group(17.46%±6.63%vs.12.14%±5.93%;P=0.001).The TACE-PVE group had significantly better overall and disease-free survival rates compared with the other groups(both P<0.001).Conclusions:Sequential TACE and PVE prior to surgery can be an effective therapeutic strategy for patients with HCC scheduled for major hepatic resection.The active application of preoperative sequential TACE and PVE for HCC would allow more patients with marginal FLR volume to become candidates for major hepatic resection by promoting compensatory FLR hypertrophy without the deterioration of basal hepatic functional reserve or tumor progression. | Gil Chun Park Sung Gyu Lee Young In Yoon Kyu Bo Sung Gi Young Ko Dong Il Gwon Dong Hwan Jung Yong Kyu Jung | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，3： | 9 |
| 3 | Primary large cell neuroendocrine carcinoma in the common bile duct:First Asian case report显示文摘Large cell neuroendocrine carcinoma(LCNEC)in the biliary system is a poorly differentiated,high-grade neuroendocrine tumor.These tumors exhibit aggressive behavior and an increased tendency for early nodal and distant metastases.Herein,we report an unusual case of a pure primary LCNEC of the common bile duct(CBD).A 75-year-old female presented with nausea and jaundice.The patient underwent a CBD excision with lymph node dissection.Upon histological and immunohistochemical examination,the tumor exhibited pure large cell-type neuroendocrine features.Metastases were noted in two of the eight lymph nodes.The patient was administered adjuvant chemotherapy.The patient’s cancer recurred 7 mo after surgery,and the patient died from liver failure 5 mo after recurrence.The prognosis of LCNEC of CBD remains poor despitecurative resection and adjuvant chemotherapy.The role of additional therapies,such as multimodal treatment including radiation therapy,must be further studied to improve the prognoses of patients. | Sung Bae Park Suk Bae Moon Young Joon Ryu Jeana Hong Yang Hee Kim Gi Bong Chae Seong Kweon Hong | 2014 | World Journal of Gastroenterology2014，20，47： | 8 |
| 4 | Texture tailoring and bendability improvement of rolled AZ31 alloy using {10-12} twinning: The effect of precompression levels显示文摘In this study,the texture of a rolled Mg alloy is effectively modified through the application of precompression and subsequent annealing treatment,leading to a remarkable improvement in the bending formability of the alloy at room temperature.Precompression induces lattice reorientation through{10-12}twinning,and annealing treatment reduces the stored strain energy of the precompressed material,which results in the formation of a stable grain structure with two dominant texture components.With an increase in precompression,the tensile strain in the outer region of the bending samples is accommodated to a greater extent due to more pronounced{10-12}twinning and basal slip.As a result,the bending formability of the material at room temperature improves with greater precompression.The variation in microstructure,texture,and bending behavior in relation to the degree of precompression is discussed in detail. | Jong Un Lee Ye Jin Kim Sang-Hoon Kim Jeong Hun Lee Min-Seong Kim Shi-Hoon Choi Byoung Gi Moon Young Min Kim Sung Hyuk Park | 2019 | Journal of Magnesium and Alloys2019，7，4： | 5 |
| 5 | Intrauterine midgut volvulus without malrotation:Diagnosis from the 'coffee bean sign'显示文摘Fetal midgut volvulus is quite rare, and most cases are associated with abnormalities of intestinal rotation or fixation. We report a case of midgut volvulus without malrotation, associated with a meconium pellet, during the gestation period. This 2.79 kg, 33-wk infant was born via a spontaneous vaginal delivery caused by preterm labor. Prenatal ultrasound showed dilated bowel loops with the appearance of a 'coffee bean sign'. This patient had an unusual presentation with a distended abdomen showing skin discoloration. An emergency laparotomy revealed a midgut volvulus and a twisted small bowel, caused by complicated meconium ileus. Such nonspecific prenatal radiological signs and a low index of suspicion of a volvulus during gestation might delay appropriate surgical management and result in ischemic necrosis of the bowel. Preterm labor, specific prenatal sonographic findings (for example, the coffee bean sign) and bluish discoloration of the abdominal wall could suggest intrauterine midgut volvulus requiring prompt surgical intervention. | Jun Seok Park Seong Jae Cha Beom Gyu Kim Yong Seok Kim Yoo Shin Choi In Taik Chang Gwang Jun Kim Woo Seok Lee Gi Hyeon Kim | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 6 | Subacute electroacupuncture at Baihui (GV 20) and Dazhui (GV 14) promotes post-stroke functional recovery via neurogenesis and astrogliosis in a photothrombotic stroke mouse model显示文摘OBJECTIVE:To investigate the optimal timing and underlying mechanism of electroacupuncture(EA)at Baihui(GV 20)and Dazhui(GV 14)for improved long-term functional recovery after focal cerebral ischemia in a photothrombotic stroke mouse model.METHODS:Totally 50 adult male C57 BL/6 J mice were assigned into 5 groups:(a)the control group,sham-operated mice(n=10);(b)the vehicle group,focal cerebral ischemia induction without EA(n=10);(c)the acute EA group,mice received EA immediately post-ischemia,followed by once-daily treatments for 7 consecutive days(n=10);(d)the subacute EA group,mice received EA 4 days post-ischemia,followed by once-daily treatments for 7 consecutive days(n=10);(e)the delayed EA group.EA stimulation(2 Hz,2 V for 20 min)was applied to acupuncture points(acupoints),Baihui(GV 20)and Dazhui(GV 14),once a day for 7 consecutive days beginning immediately(acute treatment),4 d(subacute treatment)and 10 d(delayed treatment)after focal cerebral ischemia in C57 BL/6 J mice.Behavioral assessments were conducted 21 and 28 d post-ischemia and histopathological analyses were performed 28 days post-ischemia.RESULTS:The subacute EA treatment at Baihui(GV20)and Dazhui(GV 14)significantly improved functional recovery compared to the vehicle group 28 d after ischemic brain injury,although brain atrophy was not reduced.The number of Neu N+and Neu N+/Brd U+cells as well as GFAP intensity in the ipsilateral cortex were significantly increased in the subacute group compared to the vehicle group 28 d post-ischemia.We concluded that EA stimulation 4 d post-ischemia(subacute treatment)enhanced neurogenesis and astrogliosis,likely contributing to long-term functional recovery following focal cerebral ischemia.CONCLUSION:Our findings suggest that the timing of the EA therapy at Baihui(GV 20)and Dazhui(GV 14)determines the therapeutic effects in mice with focal cerebral ischemia induced by photothrombotic occlusion. | Young-Wook Park Gi Yoon Heo Min Jae Kim Seo-Yeon Lee Byung Tae Choi Hwa Kyoung Shin | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 4 |
| 7 | Contrast-enhanced ultrasonography for the evaluation of liver fibrosis after biliary obstruction显示文摘AIM:To investigate perfusion change in contrastenhanced ultrasonography(CEUS) to evaluate liver fibrosis based on biliary obstruction using an animal model.METHODS:New Zealand white rabbits(3-4 kg) underwent bile duct ligation to form a biliary obstruction model.We performed liver CEUS and laboratory tests on the day before the operation(day 0) and every 7 postoperative days until the rabbits were sacrificed.After CEUS,signal intensity of liver parenchyma with a time-intensity curve was analyzed.Perfusion parameters were automatically calculated from regionof-interests,including peak signal intensity,mean transit time,area under the curve and time to peak.Histological grades of liver fibrosis were assessed according to the Metavir score system immediately after sacrifice.Generalized estimating equations were used to analyze the association between liver fibrosis grades and perfusion parameters for statistical analysis.The perfusion parameters were measured on the last day and the difference between day 0 and the last day were evaluated.RESULTS:From the nine rabbits,histological grades of liver fibrosis were grade 1 in one rabbit,grade 2 and 3 in three rabbits each,and grade 4 in two rabbits.Among the four CEUS parameters,only the peak signal intensity measured on the last day demonstrated a significant association with liver fibrosis grades(OR =1.392,95%CI:1.114-1.741,P =0.004).The difference in peak signal intensity between day 0 and the last dayalso demonstrated an association with liver fibrosis(OR =1.191,95%CI:0.999-1.419,P =0.051).The other parameters tested,including mean transit time,area under the curve,and time to peak,showed no significant correlation with liver fibrosis grades.CONCLUSION:This animal study demonstrates that CEUS can be used to evaluate liver fibrosis from biliary obstruction using peak signal intensity as a parameter. | Hyun Joo Shin Eun Young Chang Hye Sun Lee Jung Hwa Hong Gyuri Park Hyun Gi Kim Myung-Joon Kim Mi-Jung Lee | 2015 | World Journal of Gastroenterology2015，21，9： | 4 |
| 8 | A case of Clostridium difficile infection complicated by acute respiratory distress syndrome treated with fecal microbiota transplantation显示文摘Acute respiratory distress syndrome is a life-threatening disorder caused mainly by pneumonia.Clostridium difficile infection(CDI)is a common nosocomial diarrheal disease.Disruption of normal intestinal flora by antibiotics is the main risk factor for CDI.The use of broadspectrum antibiotics for serious medical conditions can make it difficult to treat CDI complicated by acute respiratory distress syndrome.Fecal microbiota transplantation is a highly effective treatment in patients with refractory CDI.Here we report on a patient with refractory CDI and acute respiratory distress syndrome caused by pneumonia who was treated with fecal microbiota transplantation. | Ji Eun Kim Tae-Geun Gweon Chang Dong Yeo Young-Seok Cho Gi Jun Kim Jae Young Kim Jong Wook Kim Hyunho Kim Hye Won Lee Taeseok Lim Hyoju Ham Hyun Jin Oh Yeongbok Lee Jaeho Byeon Sung Soo Park | 2014 | World Journal of Gastroenterology2014，20，35： | 3 |
| 9 | A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs显示文摘 | Mihaela Crisan Solomon Yap Louis Casteilla Chien-Wen Chen Mirko Corselli Tea Soon Park Gabriella Andriolo Bin Sun Bo Zheng Li Zhang Cyrille Norotte Pang-Ning Teng Jeremy Traas Rebecca Schugar Bridget M. Deasy Stephen Badylak Hans-J?rg B?hring Jean-Paul Gi | 2008 | Cell Stem Cell2008，，3： | 3 |
| 10 | Rational design and synthesis of hierarchically structured SnO2 microspheres assembled from hollow porous nanoplates as superior anode materials for lithium-ion batteries显示文摘 | Gi Dae Park Yun Chan Kang | 2018 | Nano Research2018，11，3： | 3 |
| 11 | Effect of esterification reaction of citric acid and ethylene glycol on the formation of multi-shelled cobalt oxide powders with superior electrochemical properties显示文摘第一次,在这研究,聚合先锋用弄干过程的一朵大规模水花在蛋黄壳粉末的准备被使用了。在柠檬性的酸的 carboxyl 组和在微滴内的乙烯乙二醇的氢氧根组之间的酯化作用反应在微滴的弄干的过程期间生产了器官的聚合物。在弄干过程的水花期间,聚合先锋与优异电气化学的性质启用了多壳钴氧化物蛋黄壳粉末的形成。在在 300, 400,和 500 PLD 的蛋黄壳粉末 treated 以后的粒子的壳的最大的数字(30 或 40 ? mg/m < 啜 class= “ a-plus-plus ” > 2 一次每 4 ? 星期) 。PLD 被开始 2 ? 在 temsirolimus 的开始以后的星期。FDG-PET/CT 在 bas 被执行吗?? | Gi Dae Park Jong-Heun Lee Jung-Kul Lee Yun Chan Kang | 2014 | Nano Research2014，7，12： | 2 |
| 12 | Magnetic resonance imaging of the pancreas in streptozotocin-induced diabetic rats: Gadofluorine P and Gd-DOTA显示文摘AIM: To investigate the performance of Gadofluorine P-enhanced magnetic resonance imaging(MRI) on the diagnosis of diabetes in a streptozotocin(STZ)-induced diabetic rat model.METHODS: Fischer 344 rats were treated with STZ.Rats not treated with STZ served as controls. T1-weighted MRI was performed using a 3T scanner before and after the injection of Gd-DOTA or Gadofluorine P(6 diabetic rats, 5 controls). The normalized signal intensity(SI) and the enhancement ratio(ER) of the pancreas were measured at each time point, and the values were compared between the normal and diabetic rats using the Mann-Whitney test. In addition,the values were correlated with the mean islet number.Optimal cut-off values were calculated using a positive test based on receiver operating characteristics.Intrapancreatic Gd concentration after the injection of each contrast media was measured using laser ablation-inductively coupled plasma-mass spectrometry in a separate set of rats(4 diabetic rats, 4 controls for Gadofluorine P; 2, 2 for Gd-DOTA).RESULTS: The normalized SI and ER of the pancreas using Gd-DOTA were not significantly different between diabetic rats and controls. With Gadofluorine P, the values were significantly higher in the diabetic rats than in the control rats 30 min after injection(P < 0.05). The area under the receiver operating characteristic curve that differentiated diabetic rats from the control group was greater for Gadofluorine P than for Gd-DOTA(0.967 vs 0.667, P = 0.085). An increase in normalized SI 30 min after Gadofluorine P was correlated with a decrease in the mean number of islets(r 2 = 0.510, P = 0.014). Intra-pancreatic Gd was higher in rats with Gadofluorine P injection than Gd-DOTA injection(Gadofluorine P vs Gd-DOTA, 7.37 vs 0.00, P < 0.01). A significant difference in the concentration of intrapancreatic Gd was observed between the control and diabetic animals that were sacrificed 30 min after Gadofluorine P injection(control vs diabetic, 3.25 ng/g vs 10.55 ng/g, P < 0.05)CONCLUSION: In this STZ-induced diabetes rat model,Gadofluorine P-enhanced MRI of the pancreas showed high accuracy in the diagnosis of diabetes. | Hye Rim Cho Youkyung Lee Philip Doble David Bishop Dominic Hare Young-Jae Kim Kwang Gi Kim Hye Seung Jung Kyong Soo Park Seung Hong Choi Woo Kyung Moon | 2015 | World Journal of Gastroenterology2015，21，19： | 2 |
| 13 | Outcome after curative resection for a huge (≥10 cm) hepatocellular carcinoma and prognostic significance of gross tumor classification显示文摘 | Gi Hong Choi Dai Hoon Han Dong Hyun Kim Sae Byeol Choi Chang Moo Kang Kyung Sik Kim Jin Sub Choi Young Nyun Park Jun Yong Park Do Young Kim Kwang-Hyub Han Chae Yoon Chon Woo Jung Lee | 2009 | The American Journal of Surgery2009，，5： | 2 |
| 14 | Trigonelline attenuates the adipocyte differentiation and lipid accumulation in 3T3-L1 cells显示文摘 | Soundharrajan Ilavenil Mariadhas Valan Arasu Jeong-Chae Lee Da Hye Kim Sang Gun Roh Hyung Su Park Gi Jun Choi Vijayakumar Mayakrishnan Ki Choon Choi | 2013 | Phytomedicine2013，，： | 2 |
| 15 | Variation in dynamic deformation behavior and resultant yield asymmetry of AZ80 alloy with extrusion temperature显示文摘In this work,variation in the dynamic recrystallization(DRX)and dynamic precipitation behavior of AZ80 alloy during extrusion due to changes in extrusion temperature was investigated,and the resultant microstructure and yield asymmetry were analyzed.As the extrusion temperature increases from 250℃to 350℃,the primary DRX mechanism changes from twin-induced DRX to discontinuous DRX,resulting in an increase in the DRX area fraction and un DRXed grain size.In addition,as the extrusion temperature rises,Mg17Al12 precipitation during extrusion decreases sharply throughout the extruded material.The reduction in the compressive yield strength(CYS)with increasing extrusion temperature is more pronounced than it is for the tensile yield strength(TYS),which ultimately increases the yield asymmetry of the extruded material.The higher extrusion temperature has less of an influence on the TYS due to the promotion of certain hardening effects.On the other hand,the greater reduction in the CYS is attributed to the increased fraction and size of regions in which{1012}twins predominantly form and the lower amount of precipitates,which effectively facilitates{1012}twinning. | Sang-Hoon Kim Sang Won Lee Byoung Gi Moon Ha Sik Kim Sung Hyuk Park | 2020 | Journal of Materials Science & Technology2020，42，11： | 2 |
| 16 | 3D-printed gelatin methacrylate (GelMA)/ silanated silica scaffold assisted by two-stage cooling system for hard tissue regeneration显示文摘Among many biomaterials,gelatin methacrylate(GelMA),a photocurable protein,has been widely used in 3D bioprinting process owing to its excellent cellular responses,biocompatibility and biodegradability.However,GelMA still shows a low processability due to the severe temperature dependence of viscosity.To overcome this obstacle,we propose a two-stage temperature control system to effectively control the viscosity of GelMA.To optimize the process conditions,we evaluated the temperature of the cooling system(jacket and stage).Using the established system,three GelMA scaffolds were fabricated in which different concentrations(0,3 and 10 wt%)of silanated silica particles were embedded.To evaluate the performances of the prepared scaffolds suitable for hard tissue regeneration,we analyzed the physical(viscoelasticity,surface roughness,compressive modulus and wettability)and biological(human mesenchymal stem cells growth,western blotting and osteogenic differentiation)properties.Consequently,the composite scaffold with greater silica contents(10 wt%)showed enhanced physical and biological performances including mechanical strength,cell initial attachment,cell proliferation and osteogenic differentiation compared with those of the controls.Our results indicate that the GelMA/silanated silica composite scaffold can be potentially used for hard tissue regeneration. | Eunjeong Choi Dongyun Kim Donggu Kang Gi Hoon Yang Bongsu Jung MyungGu Yeo Min-Jeong Park SangHyun An KyoungHo Lee Jun Sik Kim Jong Chul Kim Woonhyeok Jeong Hye Hyun Yoo Hojun Jeon | 2021 | Regenerative Biomaterials2021，8，2： | 2 |
| 17 | DJ-1 mediates paraquat-induced dopaminergic neuronal cell death显示文摘 | Hyun Joo Kwon Jun Young Heo Jung Hee Shim Ji Hoon Park Kang Sik Seo Min Jeong Ryu Jeong Su Han Minho Shong Jin H. Son Gi Ryang Kweon | 2011 | Toxicology Letters2011，，： | 2 |
| 18 | EMR for early gastric cancer in Korea: a multicenter retrospective study显示文摘 | Jae J. Kim Jun Haeng Lee Hwoon-Yong Jung Gin Hyug Lee Joo Yong Cho Chang Beom Ryu Hoon Jai Chun Jong Jae Park Wan Sik Lee Hyun Soo Kim Moon Gi Chung Jeong Seop Moon Seok Reyol Choi Geun Am Song Hyun Yong Jeong Sam Ryong Jee Sang Yong Seol Yong Bum Yoon | 2007 | Gastrointestinal Endoscopy2007，，4： | 2 |
| 19 | Reappraisal of serum alpha‐foetoprotein as a surveillance test for hepatocellular carcinoma during entecavir treatment显示文摘 | Gi‐Ae Kim Chang Hyeon Seock Jang Won Park Jihyun An Kwang‐Sun Lee Jee Eun Yang Young‐Suk Lim Kang Mo Kim Ju Hyun Shim Danbi Lee Han Chu Lee | 2015 | Liver Int2015，，1： | 2 |
| 20 | Human hepatocellular carcinomas with “Stemness”‐related marker expression: keratin 19 expression and a poor prognosis显示文摘 | Haeryoung Kim Gi Hong Choi Deuk Chae Na Ei Young Ahn Gwang Il Kim Jae Eun Lee Jai Young Cho Jeong Eun Yoo Jin Sub Choi Young Nyun Park | 2011 | Hepatology2011，，5： | 2 |
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