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| 1 | Survival outcome of patients with spontaneously ruptured hepatocellular carcinoma treated surgically or by transarterial embolization显示文摘AIM: To evaluate clinical outcomes of patients that underwent surgery, transarterial embolization (TAE), or supportive care for spontaneously ruptured hepatocellular carcinoma (HCC). METHODS: A consecutive 54 patients who diagnosed as spontaneously ruptured HCC at our institution between 2003 and 2012 were retrospectively enrolled. HCC was diagnosed based on the diagnostic guidelines issued by the 2005 American Association for the Study of Liver Diseases. HCC rupture was defined as disruption of the peritumoral liver capsule with enhanced fluid collection in the perihepatic area adjacent to the HCC by dynamic liver computed tomography, and when abdominal paracentesis showed an ascitic red blood cell count of > 50000 mm 3 /mL in bloody fluid. RESULTS: Of the 54 patients, 6 (11.1%) underwent surgery, 25 (46.3%) TAE, and 23 (42.6%) supportive care. The 2-, 4and 6-mo cumulative survival rates at 2, 4 and 6 mo were significantly higher in the surgery (60%, 60% and 60%) or TAE (36%, 20% and 20%) groups than in the supportive care group (8.7%, 0% and 0%), respectively (each, P < 0.01), and tended to be higher in the surgical group than in the TAE group. Multivariate analysis showed that serum bilirubin (HR = 1.09, P < 0.01), creatinine (HR = 1.46, P = 0.04), and vasopressor requirement (HR = 2.37, P = 0.02) were significantly associated with post-treatment mortality, whereas surgery (HR = 0.41, P < 0.01), and TAE (HR = 0.13, P = 0.01) were inversely associated with posttreatment mortality. CONCLUSION: Post-treatment survival after surgery or TAE was found to be better than after supportive care, and surgery tended to provide better survival benefit than TAE. | Young-Joo Jin Jin-Woo Lee Seoung-Wook Park Jung Il Lee Don Haeng Lee Young Soo Kim Soon Gu Cho Yong Sun Jeon Kun Young Lee Seung-Ik Ahn | 2013 | World Journal of Gastroenterology2013，19，28： | 23 |
| 2 | Safety and efficacy of tenofovir in chronic hepatitis B-related decompensated cirrhosis显示文摘AIM To evaluate the safety and efficacy of tenofovir disoproxil fumarate(TDF) as a first-line therapy in decompensated liver disease. METHODS We enrolled 174 chronic hepatitis B-related liver cirrhosis patients treated with 300 mg/d TDF at six Korean centers. Of the 174 cirrhosis patients, 57 were assigned to the decompensated cirrhosis group and 117 were assigned to the compensated cirrhosis group. We followed the patients for 12 mo and evaluated clinical outcomes, including biochemical, virological, and serological responses. We also evaluated changes in hepatic and renal function and compared the decompensated and compensated cirrhosis groups. RESULTS The 1-year complete virological response(CVR) and Hepatitis B e antigen(HBe Ag) seroconversion were seen in 70.2% and 14.2% in the decompensated cirrhosis group, respectively. The rates of HBe Ag seroconversion/loss and ALT normalization at month 12 were similar in both groups. TDF treatment was also effective for decreasing the level of hepatitis B virus(HBV) DNA in both groups, but CVR was higher in the compensated group(88.9% vs 70.2%, P = 0.005). Tenofovir treatment for 12 mo resulted in improved Child-Turcotte-Pugh(CTP) and model for end-stage liver disease(MELD) scores in decompensated group(P < 0.001). Of the 57 decompensated patients, 39(68.4%) achieved CTP class A and 27(49.1%) showed improvement in the CTP score of 2 points after 12 mo of TDF. The observed rate of confirmed 0.5 mg/d L increases in serum levels of creatinine in the decompensated and compensated cirrhosis group were 7.0% and 2.5%, respectively(P < 1.000).CONCLUSION TDF therapy in decompensated cirrhosis patients was effective for decreasing HBV DNA levels and improving hepatic function with relatively lower CVR than in compensated cirrhosis. Thus, physicians should carefully monitor not only renal function but also treatment responses when using TDF in decompensated cirrhosis patients. | Soon Kyu Lee Myeong Jun Song Seok Hyun Kim Byung Seok Lee Tae Hee Lee Young Woo Kang Suk Bae Kim Il Han Song Hee Bok Chae Soon Young Ko Jae Dong Lee | 2017 | World Journal of Gastroenterology2017，23，13： | 14 |
| 3 | Role of surgical resection for multiple hepatocellular carcinomas显示文摘AIM:To clarify the role of surgical resection for multiple hepatocellular carcinomas(HCCs)compared to transarterial chemoembolization(TACE)and liver transplantation(LT). METHODS:Among the HCC patients who were managed at Yonsei University Health System between January 2003 and December 2008,160 patients who met the following criteria were retrospectively enrolled:(1) two or three radiologically diagnosed HCCs;(2)no radiologic vascular invasion;(3)Child-Pugh class A;(4) main tumor smaller than 5 cm in diameter;and(5) platelet count greater than 50 000/mm3.Long-term outcomes were compared among the following three treatment modalities:surgical resection or combined radiofrequency ablation(RFA)(n=36),TACE(n=107), and LT(n=17).The survival curves were computed using the Kaplan-Meier method and compared with a log-rank test.To identify the patients who gained a survival benefit from surgical resection,we also investigated prognostic factors for survival following surgical resection.Multivariate analyses of the prognostic factors for survival were performed using the Cox proportional hazard model. RESULTS:The overall survival(OS)rate was significantly higher in the surgical resection group than in the TACE group(48.1%vs 28.9%at 5 years,P<0.005). LT had the best OS rate,which was better than that of the surgical resection group,although the difference was not statistically significant(80.2%vs 48.1%at 5 years,P=0.447).The disease-free survival rates were also significantly higher in the LT group than in the surgical resection group(88.2%vs 11.2%at 5 years, P<0.001).Liver cirrhosis was the only significant prognostic factor for poor OS after surgical resection. Clinical liver cirrhosis rates were 55.6%(20/36)in the resection group and 93.5%(100/107)in the TACE group.There were 19 major and 17 minor resections. En bloc resection was performed in 23 patients,multisite resection was performed in 5 patients,and combined resection with RFA was performed in 8 patients. In the TACE group,only 34 patients(31.8%)were recorded as having complete remission after primary TACE.Seventy-two patients(67.3%)were retreated with repeated TACE combined with other therapies. In patients who underwent surgical resection,the 16 patients who did not have cirrhosis had higher 5-year OS and disease-free survival rates than the 20 patients who had cirrhosis(80.8%vs 25.5%5-year OS rate, P=0.006;22.2%vs 0%5-year disease-free survival rate,P=0.048).Surgical resection in the 20 patients who had cirrhosis did not provide any survival benefit when compared with TACE(25.5%vs 24.7%5-year OS rate,P=0.225).Twenty-nine of the 36 patients who underwent surgical resection experienced recur-rence.Of the patients with cirrhosis,80%(16/20) were within the Milan criteria at the time of recurrence CONCLUSION:Among patients with two or three HCCs, no radiologic vascular invasion,and tumor diameters≤ 5 cm,surgical resection is recommended only in those without cirrhosis. | Sung Hoon Choi Gi Hong Choi Seung Up Kim Jun Yong Park Dong Jin Joo Man Ki Ju Myoung Soo Kim Jin Sub Choi Kwang Hyub Han Soon Il Kim | 2013 | World Journal of Gastroenterology2013，19，3： | 12 |
| 4 | Acute idiopathic pancreatitis in pregnancy:A case study显示文摘Acute pancreatitis during pregnancy is a rare event,and can be associated with high maternal mortality and fetal loss.Gallstone disease is thought to be the most common causative factor of acute pancreatitis,but,in many cases,the cause remains unclear.We report a case of a 36-year-old woman at 35 wk of gestation,who presented with severe pain confined to the upper abdomen and radiating to the back.The patient was diagnosed with acute idiopathic pancreatitis,which was managed conservatively;she recovered within several days and then delivered a healthy baby.Therefore it is important to consider acute pancreatitis when a pregnant woman presents with upper abdominal pain,nausea and vomiting in order to improve fetal and maternal outcomes for patients with acute pancreatitis. | Ji Yeon Kim Sung Hoon Jung Hyung Wook Choi Dong Jin Song Cheol Yoon Jeong Dong Hyun Lee Il Soon Whang | 2014 | World Journal of Gastroenterology2014，20，43： | 4 |
| 5 | Antioxidant effects of fermented sea tangle ( Laminaria japonica ) by Lactobacillus brevis BJ20 in individuals with high level of γ-GT: A randomized, double-blind, and placebo-controlled clinical study显示文摘 | Young Mi Kang Bae-Jin Lee Jung Il Kim Byung-Hyouk Nam Jae-Young Cha Young-Mog Kim Chang-Bum Ahn Jae-Suk Choi In Soon Choi Jae-Young Je | 2011 | Food and Chemical Toxicology (-)2011，，3： | 2 |
| 6 | Adding adefovir vs. switching to entecavir for lamivudine‐resistant chronic hepatitis B ( ACE study): a 2‐year follow‐up randomized controlled trial显示文摘 | Hyung Joon Yim Yeon Seok Seo Eileen L. Yoon Chang Wook Kim Chang Don Lee Sang Hoon Park Myung Seok Lee Choong Kee Park Hee Bok Chae Moon Young Kim Soon Koo Baik Yun Soo Kim Ju Hyun Kim Jung Il Lee Jin Woo Lee Sun Pyo Hong Soon Ho Um | 2013 | Liver Int2013，，2： | 2 |
| 7 | Weekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell carcinoma显示文摘AIM: To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate(FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma(SCC).METHODS: A multi-center, open-label, prospective phase Ⅱ study was designed.Thirty-three esophageal SCC patients with documented progression after fluoropyrimidine/platinum-based first-line chemotherapy were enrolled and treated with docetaxel 35 mg/m2 and gemcitabine 1000 mg/m2 iv at a FDR(10 mg/m2 per minute) on days 1 and 8.Treatment was repeatedevery twenty-one days until disease progression, unacceptable toxicity, or consent withdrawal.The primary endpoint was response rate(RR), and secondary endpoints were safety, progression-free survival(PFS) and overall survival(OS).RESULTS: Combination of weekly docetaxel and FDR gemcitabine was well tolerated: the most common treatment-related adverse events were anemia(97%), fatigue(64%) and neutropenia(55%).One patient with multiple lung and lymph node metastases died of respiratory failure after receiving four cycles of chemotherapy, and the possibility of drug-induced pneumonitis could not be completely excluded.Disease control(objective response plus stable disease) in the ITT population was achieved in 88% of patients, and the overall RR was 30%(95%CI: 15%-46%).The median PFS and OS were 4.0(95%CI: 3.4-4.6) and 8.8 mo(95%CI: 7.8-9.8 mo), respectively.CONCLUSION: A combination of weekly docetaxel and FDR gemcitabine showed promising antitumor activity and tolerability in previously treated, metastatic esophageal SCC. | Min-Young Lee Ki Sun Jung Hae Su Kim Ji Yun Lee Sung Hee Lim Moonjin Kim Hyun Ae Jung Sung Min Kim Jong Mu Sun Myung-Ju Ahn Jeeyun Lee Se Hoon Park Seong Yoon Yi In Gyu Hwang Sang-Cheol Lee Hee Kyung Ahn Do Hyoung Lim Soon Il Lee Keon Woo Park | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 8 | Adefovir and Lamivudine Combination Therapy in Patients with Entecavir-Resistant Chronic Hepatitis B: Antiviral Responses and Evolution of Mutations显示文摘 | Yim Hyung Joon Lee Hyun Jung Suh Sang Jun Seo Yeon Seok Kim Chang Wook Lee Chang Don Park Sang Hoon Lee Myung Seok Park Choong Kee Chae Hee Bok Kim Moon Young Baik Soon Koo Kim Yun Soo Kim Ju Hyun Lee Jung Il Lee Jin Woo Hong Sun Pyo Um | 2014 | Intervirology2014，，5： | 1 |
| 9 | Clinical Outcomes of Patients with Liver Cirrhosis Who Underwent Curative Surgery for Gastric Cancer: A Retrospective Multi-center Study显示文摘 | Hyun Joo Jang Jung Han Kim Hun Ho Song Kyung Hee Woo Mi Kim Sea Hyub Kae Jin Lee Ji Wong Cho Jung Hun Kang Soon Il Lee Soo Jung Gong Jung Ae Lee Dae Young Zang | 2008 | Digestive Diseases and Sciences2008，，2： | 1 |
| 10 | Development of an in situ Raman spectroscopic system for surface oxide films on metals and alloys in high temperature water 显示文摘 | Ji Hyun Kim Il Soon Hwang | 2005 | Nuclear Engineering and Design2005，235，： | 1 |
| 11 | Recurrence of hepatitis B is associated with cumulative corticosteroid dose and chemotherapy against hepatocellular carcinoma recurrence after liver transplantation显示文摘 | Nam‐Joon Yi Kyung‐Suk Suh Jai Young Cho Choon Hyuck Kwon Kwang‐Woong Lee Jae Won Joh Suk‐Koo Lee Soon Il Kim Kuhn Uk Lee | 2007 | Liver Transpl2007，，3： | 1 |
| 12 | Pharmacological mechanism responsible for the Atractylodes japonica -induced distal colonic contraction in rats显示文摘 | Keun Han Choi Seung Il Jeong Jun Ho Lee Byung Soon Hwang Sang Jun Kim Seoul Lee Bong Kyu Choi Kyu Yong Jung | 2010 | Phytomedicine2010，，5： | 1 |
| 13 | Phase II study of radiotherapy with three-dimensional conformal boost concurrent with paclitaxel and cisplatin for Stage IIIB non–small-cell lung cancer显示文摘 | Young Seok Kim Sang Min Yoon Eun Kyung Choi Byong Yong Yi Jong Hoon Kim Seung Do Ahn Sang-wook Lee Seong Soo Shin Jung Shin Lee Cheolwon Suh Sang-We Kim Dong Soon Kim Woo Sung Kim Heon Joo Park Charn Il Park | 2005 | International Journal of Radiation Oncology, Biology, Physics2005，，1： | 1 |
| 14 | Antioxidant effects of fermented sea tangle ( Laminaria japonica ) by Lactobacillus brevis BJ20 in individuals with high level of γ-GT: A randomized, double-blind, and placebo-controlled clinical study显示文摘 | Young Mi Kang Bae-Jin Lee Jung Il Kim Byung-Hyouk Nam Jae-Young Cha Young-Mog Kim Chang-Bum Ahn Jae-Suk Choi In Soon Choi Jae-Young Je | 2011 | 2011 (3-4)2011，，3： | 1 |
| 15 | Critical Heat Flux under Flow Oscillation of Water at Low- Pressure, Low-Flow Conditions 显示文摘 | Yun Il Kim Won-Pil Baek Soon Heung Chang | 1999 | Nuclear Engineering and Design 19991999，，： | 1 |
| 16 | Spontaneous regressionof a large heapto ellular carcinoma with skull metastasis显示文摘 | Soon Woo Nam Joon-Yeol Han Jin IL Kim | 2005 | Journal of Gastroen-terology And Hepatology2005，20，3： | 1 |
| 17 | WKYMVm‐Induced Activation of Formyl Peptide Receptor 2 Stimulates Ischemic Neovasculogenesis by Promoting Homing of Endothelial Colony‐Forming Cells显示文摘 | Soon Chul Heo Yang Woo Kwon Il Ho Jang Geun Ok Jeong Jung Won Yoon Chi Dae Kim Sang Mo Kwon Yoe‐Sik Bae Jae Ho Kim | 2014 | Stem Cells2014，，3： | 1 |
| 18 | A Ds-insertion mutant of OSH6 (Oryza sativa Homeobox 6) exhibits outgrowth of vestigial leaf-like structures, bracts, in rice显示文摘 | Sung Han Park Chul Min Kim Byoung Il Je Su Hyun Park Soon Ju Park Hai Long Piao Yuan-hu Xuan Mi Sook Choe Kouji Satoh Shoshi Kikuchi Kon Ho Lee Young Soon Cha Byung Ohg Ahn Hyeon So Ji Doh Won Yun Myung Chul Lee Seok-cheol Suh Moo Young Eun Chang-deok Han | 2007 | Planta2007，，1： | 1 |
| 19 | Gel characterisation and in vivo evaluation of minocycline-loaded wound dressing with enhanced wound healing using polyvinyl alcohol and chitosan显示文摘 | Jung Hoon Sung Ma-Ro Hwang Jong Oh Kim Jeong Hoon Lee Yong Il Kim Jeong Hoon Kim Sun Woo Chang Sung Giu Jin Jung Ae Kim Won Seok Lyoo Sung Soo Han Sae Kwang Ku Chul Soon Yong Han-Gon Choi | 2010 | International Journal of Pharmaceutics2010，，1： | 1 |
| 20 | Development of an in situ Raman spectroscopic system for surface oxide films on metals and alloys in high temperature water显示文摘 | Ji Hyun Kim Il Soon Hwang | 2005 | Nuclear Engineering and design2005，235，： | 1 |
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