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| 1 | Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease显示文摘BACKGROUND In non-alcoholic fatty liver disease(NAFLD), a high-fat or high-fructose diet increases intestinal permeability and promotes derangement of the gut-liver axis.We hypothesize that, diet could be able to modulate intestinal permeability in patients with NAFLD.AIM To detect diet-induced modification of intestinal permeability in patients with NAFLD undergoing a Mediterranean diet or a low-fat diet.METHODS The current study was a dietary intervention for non-diabetic, patients with biopsy-verified NAFLD and increased transaminases. A crossover design was employed: participants underwent 16 weeks of Mediterranean diet, 16 wk of free wash-out, and 16 weeks of low-fat diet. Both diets were hypocaloric and no consumption of supplements was allowed. All patients were followed bimonthly by a dietitian. Evaluations of clinical and metabolic parameters were completed at baseline and at the end of each dietary period. Intestinal permeability was assessed by chromium-51 ethylene diamine tetraacetate excretion testing(51 CrEDTA).RESULTS Twenty Caucasian patients, 90% male, median age 43 years, body mass index(BMI) 30.9, with biopsy-verified NAFLD were enrolled. At the end of 16 weeks of a Mediterranean diet, a significant reduction in mean body weight(-5.3 ± 4.1 kg,P = 0.003), mean waist circumference(-7.9 ± 4.9 cm, P = 0.001), and mean transaminase levels [alanine aminotransferase(ALT)-28.3 ± 11.9 IU/L, P =0.0001; aspartate aminotransferase(AST)-6.4 ± 56.3 IU/L, P = 0.01] were observed. These benefits were maintained after 16 wk of wash-out and also after16 wk of low-fat diet, without further improvements. Fourteen of the 20 patients had intestinal permeability alteration at baseline(mean percentage retention of51 Cr-EDTA = 5.4%), but no significant changes in intestinal permeability were observed at the end of the 16 wk of the Mediterranean diet or 16 wk of the low-fat diet.CONCLUSION Mediterranean diet is an effective strategy for treating overweight, visceral obesity and serum transaminase in patients with NAFLD. If the Mediterranean diet can improve intestinal permeability in patients with NAFLD, it deserves further investigation. | Marco Biolato Fiorella Manca Giuseppe Marrone Consuelo Cefalo Simona Racco Giacinto A Miggiano Venanzio Valenza Antonio Gasbarrini Luca Miele Antonio Grieco | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 2 | High-Resolution Crystal Structure and Redox Properties of Chloroplastic Triosephosphate Isomerase from Chlamydomonas reinhardtii显示文摘Triosephosphate isomerase (TPI ) 催化 glyceraldehyde-3-phosphate 的互变现象到 dihydroxyacetone 磷酸盐。光合的有机体通常包含位于细胞质和叶绿体的 TPI 的二 isoforms。当细胞质的 TPI 涉及 glycolysis 时, chloroplastic isoform 参予 CalvinBenson 周期,为碳固定负责的一个关键光合的过程。与它的细胞质的对应物相比, chloroplastic TPI 的功能的特征糟糕被调查了,它的三维的结构没被解决。最近,几研究包括 dithiol/disulfide 交换, glutathionylation,和 nitrosylation 作为不同氧化还原作用修正的一个潜在的目标建议了 TPI。然而,在蛋白质活动的既不效果也不位于这些氧化还原作用修正下面的分子的机制被调查了。这里,我们 recombinantly 生产了并且从单细胞的绿水藻 Chlamydomonas reinhardtii (Cr ) 净化了 TPI。酶的生物化学的性质被描出,它的结晶的结构在 1.1 的一个决定是坚定的 ? 。CrTPI 是有包含典型(/)8 桶褶层的子单元的 homodimer。尽管为 TRX 规定的证据都没被获得, CrTPI 被发现由 nitrosoglutathione 由氧化谷胱甘肽和 trans-nitrosylation 经历 glutathionylation,证实它到多重氧化还原作用修正的敏感。 | Mirko Zaffagnini Laure Michelet Chiara Sciabolini Nastasia Di Giacinto Samuel Morisse Christophe H. Marchand Paolo Trost Simona Fermani Stephane D Lemaire | 2014 | Molecular Plant2014，7，1： | 4 |
| 3 | Diabetic retinopathy and age-related macular degeneration: a survey of pharmacoutilization and cost in Calabria, Italy显示文摘The aged population is constantly growing, thus fostering an increase in age-dependent diseases. Among these, diabetic retinopathy (DR) along with age-related macular degeneration entails progressive vision loss. Since such conditions are associated with the proliferation of novel vessels, their pharmacotherapeutic management consists of the intravitreal injection of anti-vascular endothelial growth factor drugs, able to hinder the driving of vascular proliferation prompted by vascular endothelial growth factor. The humanized anti-vascular endothelial growth factor monoclonal antibody ranibizumab provided evidence for efficacy in several trials, hence earning approval by the US Food and Drug Administration for therapeutic use in all the stages of DR. Due to the lack of epidemiologic and pharmacoeconomic evaluation in the local Calabria Region context, the present retrospective observational study focused on prevalence of DR and age-related macular degeneration, treatment and cost of therapy with ranibizumab in 870 patients arriving to clinical observation at the 'Mater Domini” University Hospital in Calabria, Italy from January 2014 to June 2017. Data were extracted from the database of ophthalmology ward and subjected to statistical analysis. The results suggest that the most frequent retinal diseases are age-related macular degeneration and DR and that the use of ranibizumab has been decreasing over the 4-year study period together with the associated cost per patient which was similar for both disorders. Therefore, appropriateness of treatment with drugs other than ranibizumab needs to be assessed in this setting and deep monitoring of pharmacologic treatment for retinal diseases is necessary to prevent or delay visual acuity decrease and complete vision loss. Study procedures were performed in accordance with the 'Mater Domini” University Hospital ethical standards of the responsible committee on human experimentation. | Damiana Scuteri Ada Vero Mariacristina Zito Maria Diana Naturale Giacinto Bagetta Carlo Nucci Paolo Tonin Maria Tiziana Corasaniti | 2019 | Neural Regeneration Research2019，14，8： | 3 |
| 4 | Evaluation of C-Reactive Protein Measurement for Assessing the Risk and Prognosis in Ischemic Stroke: A Statement for Health Care Professionals From the CRP Pooling Project Members显示文摘 | Mario Di Napoli Markus Schwaninger Roberto Cappelli Elena Ceccarelli Giacinto Di Gianfilippo Cristina Donati Hedley C.A. Emsley Sandro Forconi Stephen J. Hopkins Luca Masotti Keith W. Muir Anna Paciucci Francesca Papa Sabina Roncacci Dirk Sander Kerstin S | 2005 | Stroke2005，，6： | 2 |
| 5 | Combination of neural and statisticalalgorithms for supervised classification of remote - sensing images显示文摘 | Giorgio Giacinto Fabio Rol i Lorenzo Bruzzone | 2000 | Pattern Recognition Letters2000，21，5： | 1 |
| 6 | A Two-Stage CMABased Receiver for Blind Joint Equalization and Multiuser Detection in High Data-Rate DS-CDMA Systems显示文摘 | Giacinto Gelli Luigi Paura Francesco Verde | 2004 | IEEE Trsnsaetions on Wireless Communications2004，3，4： | 1 |
| 7 | Alarm clustering for intrusion detection systems in computer networks显示文摘 | Roberto Perdisci Giorgio Giacinto Fabio Roli | 2006 | Engineering Applications of Artificial Intelligence2006，19，4： | 1 |
| 8 | Dynamic Classifier Selection Based on Multiple Classifier Behaviour显示文摘 | Giacinto G Roll F | 2001 | Pattern Recognition2001，34，9： | 1 |
| 9 | Dynamic classifier selection based on multiple classifier behavior显示文摘 | Giacinto G Roli F | 2001 | Pattern Recognition2001，34，9： | 1 |
| 10 | Shock detection and discontinuity tracking for unsteady flows显示文摘 | GIACINTO M D VALORANI M | 1989 | Computers & Fluids1989，17，1： | 1 |
| 11 | Fusion of multiple classifiers for intrusion detection in computer networks显示文摘 | Giacinto G Roli F Didaci L | | 0，，12： | 1 |
| 12 | Design of effective neural network ensembles for image classification purposes显示文摘 | Giacinto G Roli F | 2001 | Image and Vision Computing2001，19，910： | 1 |
| 13 | Fusion of multiple classifiers for intrusion detection in computer networks显示文摘 | Giacinto G Roli F Didaci L | 2003 | Pattern Recognition Letters2003，24，12： | 1 |
| 14 | Alarm clustering for intrusion detection systems in computer networks显示文摘 | Roberto Perdisci Giorgio Giacinto Fabio Roli | 2006 | Engineering Applications of Artificial Intelligence2006，，4： | 1 |
| 15 | Differential regional effects of monetary policy: A geographical SVAR approach显示文摘 | Di Giacinto Valter | 2003 | International Regional Science Review2003，26，： | 1 |
| 16 | Alarm clusteringfor intrusion detection systems in computer networks显示文摘 | Roberto Perdisci Giorgio Giacinto Fabio Roli | 2006 | Engineer-ing Applications of Artificial Intelligence2006，19，4： | 1 |
| 17 | An approach to the automatic design of multiple classifier system 显示文摘 | GIACINTO G FABIO R | 2001 | Pattern Recognition Letters2001，22，1： | 1 |
| 18 | HCV-positive status and hepatitis flares in patients with B-cell non-Hodgkin’s lymphoma treated with rituximab-containing regimens显示文摘 | Massimo Marignani Manuela Mangone M. Christina Cox Stefano Angeletti Barbara Veggia Antonella Ferrari Michela di Fonzo Paola Begini Elia Gigante Giacinto Laverde Antonietta Aloe-Spiriti Bruno Monarca Gianfranco Delle Fave | 2010 | Digestive and Liver Disease2010，，2： | 1 |
| 19 | Combined Descemet stripping automated endothelial keratoplasty and intravitreal dexamethasone implant for concomitant pseudophakic bullous keratopathy and cystoid macular edema显示文摘Dear Editor,Endothelial cell density decreases with age and in various ocular conditions,including corneal endotheliitis,uveitis,pseudoexfoliation syndrome,and birth injury(1)The reduction of endothelial cell density is exacerbated over time after intraocular surgery(1)Descemet stripping automated endothelial keratoplasty(DSAEK)is considered the primary procedure for patients with only endothelial dysfunction. | Gabriella Cirigliano Marco R Pastore Alberto A Perrotta Chiara De Giacinto Daniele Tognetto | 2019 | International Journal of Ophthalmology(English edition)2019，12，5： | 1 |
| 20 | Fusion of Multiple Classifiers for Intrusion Detection in Computer Networks显示文摘 | Giacinto G Roli F Didaci L | 2003 | Pattern Recognition Letters2003，24，12： | 1 |
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