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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors 显示文摘 | Gideon M Blumenthal Joell J | 2014 | Oncotarget2014，5，18： | 1 |
| 3 | Gene expression profiling in lung tissues from mice exposed to cigarette smoke, lipopolysaccharide, or smoke plus lipopolysaccharide by inhalation显示文摘 | Meng Q R Gideon K M Harbo S J | 2006 | Inhal Toxicol2006，18，： | 1 |
| 4 | The Effects of Low-Dose Simvastatin and Ezetimibe Compared to High-Dose Simvastatin Alone on Post-Fat Load Endothelial Function in Patients With Metabolic Syndrome: A Randomized Double-Blind Crossover Trial显示文摘 | Jobien K Olijhoek Gideon R Hajer Yolanda van der Graaf Geesje M Dallinga-Thie Frank L J Visseren | 2008 | Journal of Cardiovascular Pharmacology2008，，2： | 1 |
| 5 | Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity显示文摘 | Gideon P John J Frech M | 1992 | Mol Cell Biol1992，12，5： | 1 |
| 6 | A Program for Design in Structural DNA Nanotechnology显示文摘 | J J Birac W B Sherman J Kopatsch P E Constantinou N C Seeman GIDEON | 2006 | J Mol Graphics & Modeling2006，25，： | 1 |
| 7 | Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti- inflammatory cytokines is associated with sterilization 显示文摘 | Gideon HP Phuah J Myers AJ | 2015 | PLnS Pathog2015，11，10： | 1 |
| 8 | Characterization and three-dimensional structures of two dis?tinct bacterial xyloglucanases from families GH5 and GH12显示文摘 | TRACEY M G FARID M I KATHERINE M JENS M E SHIRLEY R JOHAN P T MADS E B PER L J STEFFEN D KATJA S J TORBEN V B KEITH S W HARRY B GIDEON J D | 2007 | Journal of Biological Chemistry2007，282，19： | 1 |
| 9 | A multicenter, long-term study on arrhythmias in children with Ebstein anomaly 显示文摘 | Tammo D Gideon J Marry ER | 2010 | Pedi- atr Cardiol2010，31，2： | 1 |
| 10 | Whole-genome sequencing reveals principles of brain retrotransposition in neurodevelopmental disorders显示文摘神经祖先房间经历体的 retrotransposition 事件,主要包含 L1 元素,它能是潜在地有害的。这里,我们分析 20 件大脑样品和 80 件非大脑样品的整个染色体,并且描绘了许多 neurodevelopmental 混乱包括 Rett 症候群,有块茎的硬化,混乱毛细管扩张和孤独性影响的病人的 retrotransposition 风景。我们比在病理学对正常的大脑在非大脑样品并且甚至更高观察了的报导在大脑纸巾的 retrotranspositions 的数字高。体的大脑 retrotransposons 的多数把重复元素集成到先存在,优先地, A/T 富有的 L1 定序,导致嵌套的插入。我们的调查结果文件在 L1 大脑插入事件的多数的编码 endonuclease 独立人士机制的指纹。插入是非古典的因为他们在两结束被截断,当主人元素,和他们的目标序列与大多数另外的 retrotranspositions 的古典 endonuclease 主题相对照与一个 CCATT 主题被充实,在一样的取向集成。我们显示出元素优先地集成到与神经功能和疾病联系的基因的那 L1Hs。当保卫免于有害事件时,我们为新奇插入作为闪电杆建议那先存在的 retrotransposons 行为,它可以给基因表示的好调整。压倒性地不受管束的 retrotransposition 可以突破这保护措施机制并且在 neurodevelopmental 混乱增加有害 mutagenesis 的风险。 | Jasmine Jacob-Hirsch Eran Eyal Binyamin A Knisbacher Jonathan Roth Karen Cesarkas Chen Dor Sarit Farage-Barhom Vered Kunik Amos J Simon Moran Gal Michal Yalon Sharon Moshitch-Moshkovitz Rick Tearle Shlomi Constantini Erez Y Levanon Ninette Amariglio Gideon Rechavi | 2018 | Cell Research2018，28，2： | 1 |
| 11 | Prospective randomized compar- ison of pneumatic dilatation technique in patients with idiopathic achalasia 显示文摘 | Gideon RM Castell DO Yarze J | 1999 | Dig Dis Sci1999，44，： | 1 |
| 12 | Structure and function of endoglucanase V显示文摘 | GIDEON J DAVIES G GUY DODSON | 1993 | Nature1993，，365： | 1 |
| 13 | In vivo antibody response and in vitro CTL activation induced by selected measles vaccine candidates, prepared with purified Quil A components显示文摘 | Koert J Stittelaar Jolande Boes Gideon F.A Kersten Arjen Spiekstra Paul G.H Mulder Petra de Vries Paul J.M Roholl Kristian Dalsgaard Germie van den Dobbelsteen Loek van Alphen Albert D.M.E Osterhaus | 2000 | Vaccine2000，，23： | 1 |
| 14 | Changes in neural network homeostasis trigger neuropsychiatric symptoms显示文摘 | Winkelmann Aline Maggio Nicola Eller Joanna Caliskan G?rsel Semtner Marcus H?ussler Ute J?ttner Ren? Dugladze Tamar Smolinsky Birthe Kowalczyk Sarah Chronowska Ewa Schwarz G?nter Rathjen Fritz G Rechavi Gideon Haas Carola A Kulik Akos Glov | 2014 | Journal of Clinical Investigation2014，，2： | 1 |
| 15 | Basel III and the net stable funding ratio 显示文摘 | GIDEON F PETERSEN M A PETERSEN M J HLATSH- WAYO L N P | 2013 | ISRN Applied Mathematics2013，，8： | 1 |
| 16 | Gene expression profiling in lung tissues from miee exposed to cigarette smoke, lipopolysac- charide, or smoke plus lipopolysaccharide by inhalation 显示文摘 | Meng QR Gideon KM Harbo S J | 2006 | Inhal Toxicol2006，18，8： | 1 |
| 17 | The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection 显示文摘 | Lin PL Dietrich J Tan E Abalos RM Burgos J Bigbce C Bigbee M Milk L Gideon HP Rodgers M Cochran C Guinn KM Sherman DR Klein E Janssen C Flynn JL Andersen P | 2012 | J Clin Invest2012，122，1： | 1 |
| 18 | Recombinant human PTH 1-34 (For- teo): an anabolic drug for osteoporosis 显示文摘 | DEAL C GIDEON J | 2003 | Cleve Clin J Med2003，70，7： | 1 |
| 19 | Complete atrioventricular canal associated with tetralogy of Fallot显示文摘 | Francisco J Puga MD | 1984 | The Journal of Thoracic and Cardiovascular Surgery1984，87，： | 1 |
| 20 | Management of residual penile curvature after penile prosthesis placement显示文摘Residual penile curvature is a common situation following the implantation of a penile prosthesis in patients with Peyronie’s disease.Currently,there is a variety of options for the correction of residual curvature,including penile modeling,plication techniques,as well as tunical incision/excision with or without grafting.A literature search of PubMed and Medline databases was conducted from 1964 until 2020,using search terms for all articles in the English language.In this article,we provide a review of the techniques and the outcomes,according to the published literature. | Denis V Krakhotkin David J Ralph Gideon A Blecher Volodymyr A Chernylovskyi Francesco Greco Evgeny E Bakurov Ruslan A Bugaev | 2021 | Asian Journal of Andrology2021，23，2： | 0 |
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