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| 1 | Safety of the long-term use of proton pump inhibitors显示文摘The proton pump inhibitors (PPIs) as a class are remarkably safe and effective for persons with peptic ulcer disorders. Serious adverse events are extremely rare for PPIs, with case reports of interstitial nephritis with omeprazole, hepatitis with omeprazole and lansoprazole, and disputed visual disturbances with pantoprazole and omeprazole. PPI use is associated with the development of fundic gland polyps (FGP); stopping PPIs is associated with regression of FGP. In the absence of Helicobacter pylori infection, the long-term use of PPIs has not been convincingly proven to cause or be associated with the progression of pre-existing chronic gastritis or gastric atrophy or intestinal metaplasia. Mild/modest hypergastrinemia is a physiological response to the reduction in gastric acid secretion due to any cause. The long-term use of PPIs has not been convincingly proven to cause enterochromaff in-like cell hyperplasia or carcinoid tumors. PPIs increase the risk of community acquired pneumonia, but not of hospital acquired (nosocomial) pneumonia. There is no data to support particular care in prescribing PPI therapy due to concerns about risk of hip fracture with the long-termuse of PPIs. Long-term use of PPIs does not lead to vitamin B12 def iciencies, except possibly in the elderly, or in persons with Zollinger-Ellison Syndrome who are on high doses of PPI for prolonged periods of time. There is no convincingly proven data that PPIs increase the risk of Clostridium difficile-associated diarrhea in persons in the community. The discontinuation of PPIs may result in rebound symptoms requiring further and even continuous PPI use for suppression of symptoms. As with all medications, the key is to use PPIs only when clearly indicated, and to reassess continued use so that long-term therapy is used judiciously. Thus, in summary, the PPIs are a safe class of medications to use longterm in persons in whom there is a clear need for the maintenance of extensive acid inhibition. | Alan BR Thomson Michel D Sauve Narmin Kassam Holly Kamitakahara | 2010 | World Journal of Gastroenterology2010，16，19： | 20 |
| 2 | 法国行政法官对规范性行政行为的合法性审查显示文摘按照对行政、司法机关分离的理解,法国的行政行为合法性审查由行政法官完成。这是司法法院、行政法院双轨制的结果。法院双轨制是法国法律制度的基石,这与中国的法院体制截然不同。在中国,存在单一的法院体系,在每一个法院内部设立不同的审判庭,分别承担着不同性质的司法审判职能。 | 让-马克·索维(Jean-Marc SAUVE) 张莉(译) | 2011 | 比较法研究2011，25，2： | 12 |
| 3 | Retinorecipient areas in the diurnal murine rodent Arvicanthis niloticus : A disproportionally large superior colliculus显示文摘 | Frédéric Gaillard Harvey J. Karten Yves Sauvé | 2013 | J Comp Neurol2013，，8： | 2 |
| 4 | Hormonal control of androgen receptor function through Sirtl 显示文摘 | Fu M Liu M Sauve AA | 2006 | Mol Cell Biol2006，26，21： | 1 |
| 5 | Two-dimensional echocardiography estimation of right ventricular ejection fraction by wall motion score index显示文摘 | Lebeau R Di Lorenzo M Sauve C | 2004 | Can J Cardiol2004，20，2： | 1 |
| 6 | Modeling of Cd and Pb speciation in soil solutions by WinHumicV and NICA-Donnan model显示文摘 | Ge Y MacDonald D Sauvé S | 2005 | Environmental Modeling and Software2005，20，： | 1 |
| 7 | Outcomes from an inter- provincial program of newborn open heart surgery 显示文摘 | Robertson CM Joffe AR Sauve RS | 2004 | J Pediatr2004，144，： | 1 |
| 8 | A multicenter study on the clinical out-come of chorioamnionitis in preterm infants显示文摘 | Soraisham AS Singhal N McMillan DD Sauve Rs Lee SK Ca-nadian Neonatal Network | 2009 | Am J Obstet Gy-necol2009，200，4： | 1 |
| 9 | Solid-solution Partitioning of metals in contaminated soils: dependence on pH,total metal burden,and organic matter 显示文摘 | Sauve S Hendershot W Allen H E | 2000 | Environmental Science & Technology2000，34，： | 1 |
| 10 | Multiresidue method for the determination o f residues of 251 pesticide in fruits and vegetables by gas chromatography/mass spec-trometry and liquid chromatograph y wit h fluorescence detection 显示文摘 | FILLION J SAUVE F SELWYN J | 2000 | Journal of AOAC International2000，83，3： | 1 |
| 11 | The biochemistry of sirtuine显示文摘 | SAUVE AA WOLBERGER C SCHRAMM VL | 2006 | Annu Rev Biochem2006，75，4： | 1 |
| 12 | CIA,a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant显示文摘 | Sauvé F McBroom LD Gallant J | | 0，，1： | 1 |
| 13 | Cognitive impairments in chronic heart failure: a case controlled study 显示文摘 | Sauve MJ Lewis WR Blankenbiller M | 2009 | Journal of Cardiac Failure2009，15，1： | 1 |
| 14 | Congenital cytomegalovirus infection显示文摘 | Leung AK Sauve RS Davies HD | 2003 | J Natl Med Assoc2003，95，3： | 1 |
| 15 | Soil solution speciation of Pb^2+:effects of organic matter and pH显示文摘 | Sauvé S McBride M B Hendershot W H | 1998 | Soil Science Society of American Journal1998，62，3： | 1 |
| 16 | A high percentage yield of tyrosine hydroxylase-positive cells from rat E14 mesencephalic cell culture显示文摘 | Shimoda K Sauve Y Marini A | | 0，，02： | 1 |
| 17 | Postoperative Complications Following Colectomy for Ulcerative Colitis in Children显示文摘 | Ing Shian Soon Iwona Wrobel Jennifer C.C. deBruyn Reg Sauve David L. Sigalet Belle S. Kaplan Marie-Claude Proulx Gilaad G. Kaplan | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，6： | 1 |
| 18 | Muhiresidue method for the determination of residues of 251 pesticide in fruits and vegetables by gas chromatography/mass spectrometry and liquid chromatography with hfluores-cence detection 显示文摘 | FILLION J SAUVE F SELWYN J | 2000 | Journal of AOAC International2000，83，3： | 1 |
| 19 | Dye sensitization of nanocrystalline titanium dioxide with osmium and ruthenium polypyridyl complexes显示文摘 | SAUV EG CASS M E COIA G | 2000 | J Phys Chem B2000，104，29： | 1 |
| 20 | SIRTR1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1显示文摘 | Bouras T Fu M Sauve A A | 2005 | J Biol Chem2005，280，10： | 1 |
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