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| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | A de novo paradigm for mental retardation显示文摘 | Vissers L E de Ligt J Gilissen C | 2010 | Nat Genet2010，42，12： | 1 |
| 3 | The origin and early development of wheat glutenin particles显示文摘 | T.W.J.M. van Herpen J.H.G. Cordewener H.J. Klok J. Freeman A.H.P. America D. Bosch M.J.M. Smulders L.J.W.J. Gilissen P.R. Shewry R.J. Hamer | 2008 | Journal of Cereal Science2008，，3： | 1 |
| 4 | Seven different genes encode a diverse mixture of isoforms of Bet v 1, the major birch pollen allergen 显示文摘 | Schenk MF Gilissen LJ Esselink GD | 2006 | BMC Genomies2006，6，4： | 1 |
| 5 | 6-Thioguanine-related hepatotoxicity in patients with inflammatory bowel disease: Dose or level dependent?显示文摘 | Luc J.J. Derijks Lennard P.L. Gilissen Nanne K.H. de Boer Chris J.J. Mulder | 2006 | Journal of Hepatology2006，，： | 1 |
| 6 | Next- generation genetic testing for retinitis pigmentosa显示文摘 | Neveling K Collin RW Gilissen C | 2012 | Hum Mutat2012，33，6： | 1 |
| 7 | A Post‐Hoc Comparison of the Utility of S anger Sequencing and Exome Sequencing for the Diagnosis of Heterogeneous Diseases显示文摘 | Kornelia Neveling Ilse Feenstra Christian Gilissen Lies H. Hoefsloot Erik‐Jan Kamsteeg Arjen R. Mensenkamp Richard J. T. Rodenburg Helger G. Yntema Liesbeth Spruijt Sascha Vermeer Tuula Rinne Koen L. Gassen Danielle Bodmer Dorien Lugtenberg Rick Reuver We | 2013 | Human Mutation2013，，12： | 1 |
| 8 | A post-hoe comparison of the utility of sanger sequencing and exome sequencing for the diagnosis of heterogeneous diseases显示文摘 | Neveling K Feenstra I Gilissen C | 2013 | Hum Mutat2013，34，12： | 1 |
| 9 | Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal recessive osteogenesis imperfecta显示文摘 | Becker J Semler O Gilissen C | | 0，，3： | 1 |
| 10 | Geleasting,a near net shape technique显示文摘 | GILISSEN R ERAUW J P SMOLDRES A | 2000 | Materials and Design2000，21，： | 1 |
| 11 | EffeCt of photodynamic therapy on the endothelium-dependent relaxation of isolated rat aortas 显示文摘 | Gilissen M J Vandemerbeldewit LEA Star WM | 1993 | Cancer Res1993，53，： | 1 |
| 12 | Nuclear receptors nur77and nurr1modulate mesenchymal stromal cell migration显示文摘 | Maijenburg MW Gilissen C Melief SM | 2011 | Stem Cells Dev2011，21，2： | 1 |
| 13 | Nuclear receptors Nur77 and Nurrl modulate mesenchymal stromal cell migration显示文摘 | Maijenburg MW Gilissen C Melief SM | 2012 | Stem Cells Dev2012，21，2： | 1 |
| 14 | Genome sequencing identifies major causes of severe intellectual disability 显示文摘 | Gilissen C Jayne Y Djie Tjwan Thungl | 2014 | Nature2014，511，7509： | 1 |
| 15 | De novo muta- tions of SETBP1 cause Schinzel-Giedion syndrome 显示文摘 | Hoischen A van Bon BWM Gilissen C | 2010 | Nature genetics2010，42，6： | 1 |
| 16 | Gelcasting,a near net shape technique显示文摘 | Gilissen R Erauw J P Smolders A | 2000 | Materials and Design2000，21，： | 1 |
| 17 | Gelcasting, a near shape technique 显示文摘 | Gilissen R Erauw J P Smoldres A | 2000 | Materials and Design2000，21，： | 1 |
| 18 | Gelcasting a near net shape technique显示文摘 | GILISSEN U R ERAUWL J P SMOLDERS A | 2000 | Materials and Design2000，21，4： | 1 |
| 19 | Gelcasting,a near net shape technique显示文摘 | GILISSEN R ERAUW J P SMOLDERS A | 2000 | Materialsand Design2000，21，4： | 1 |
| 20 | Nuclear receptors Nur77 and Nurrl modulate mesenchymal stromal cell migration显示文摘 | Maijenburg MW Gilissen C Melief SM | 2012 | Stem Cells Dev2012，21，2： | 1 |
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