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| 1 | A simple Tenax? extraction method to determine the availability of sediment‐sorbed organic compounds显示文摘 | GerardCornelissen HenkRigterink Dorien E. M.ten Hulscher Bea A.Vrind Paul C. M.van Noort | 2009 | Environmental Toxicology and Chemistry2009，，4： | 2 |
| 2 | Fatigue in children and adolescents with inflammatory bowel disease显示文摘AIM To identify factors other than active disease and anemia that contribute to fatigue in pediatric inflammatory bowel disease(IBD).METHODS We performed an electronic search in Medline and EMBASE from their inception to May 2017 using the search term 'fatigue' or the related keywords 'physical impairment' and 'inflammatory bowel disease' with the filter 'child'(age 0-18 years). Cross-sectional and case-control studies were included. We restricted our search to studies published in English. We used the PRISMA checklist and flow diagram. Duplicate articles were manually deleted in End Note. To identify further relevant studies, we checked the reference lists of the selected articles.RESULTS We identified 149 papers, of which 19 were retrieved for full text review. Eleven studies were subsequently excluded because fatigue was not evaluated as an outcome measure. Eight papers focused on the desired topic and were discussed in the final analysis. A lack of uniformity of outcome measures made the pooling of data impossible. In all but one study, questionnaires were used to evaluate fatigue. In the remaining study, an accelerometer was used to measure daily activities, sleeping time and their relationships with fatigue in a more quantifiable manner. Adolescents with IBD are significantly more fatigued than healthy controls. In addition to active disease, increased anxiety or depression and disturbed family relationships were frequently reported predictors of fatigue. Quantitative measurement of physical activity in patients with Crohn's disease showed a reduction in the number of steps per day, and patients with ulcerative colitis had a shorter duration of physical activity during the day.CONCLUSION Fatigue in pediatric IBD is related to a combination of biological, functional and behavioral factors, which should all be taken into account when managing fatigue. | Els Van de Vijver Ann Van Gils Laura Beckers Yannick Van Driessche Nicolette Dorien Moes Patrick Ferry van Rheenen | 2019 | World Journal of Gastroenterology2019，25，5： | 2 |
| 3 | Lead phytotoxicity in soils and nutrient solutions is related to lead induced phosphorus deficiency显示文摘 | Karlien Cheyns Sofie Peeters Dorien Delcourt Erik Smolders | 2012 | Environmental Pollution2012，，： | 1 |
| 4 | Physical Activity and Endometrial Cancer Risk, a Systematic Review of Current Evidence 显示文摘 | Dorien Voskuil Evelyn M Monninkhof Sjoerd G | 2007 | Cancer Epidemiol Biomarkers Prey2007，16，4： | 1 |
| 5 | Altered bile composition after liver transplantation is associated with the development of nonanastomotic biliary strictures显示文摘 | Carlijn I. Buis Erwin Geuken Dorien S. Visser Folkert Kuipers Elizabeth B. Haagsma Henkjan J. Verkade Robert J. Porte | 2008 | Journal of Hepatology2008，，1： | 1 |
| 6 | A Post‐Hoc Comparison of the Utility of S anger Sequencing and Exome Sequencing for the Diagnosis of Heterogeneous Diseases显示文摘 | Kornelia Neveling Ilse Feenstra Christian Gilissen Lies H. Hoefsloot Erik‐Jan Kamsteeg Arjen R. Mensenkamp Richard J. T. Rodenburg Helger G. Yntema Liesbeth Spruijt Sascha Vermeer Tuula Rinne Koen L. Gassen Danielle Bodmer Dorien Lugtenberg Rick Reuver We | 2013 | Human Mutation2013，，12： | 1 |
| 7 | Proteome profiling of mouse embryonic stem cells to define markers for cell differentiation and embryotoxicity 显示文摘 | Ahmed M Osman Dorien AM van Dartel Edwin Zwarta | 2010 | Reproductive Toxicology2010，30，2： | 1 |
| 8 | Inhibition of denitrification and N2O emission by urine-derived benzoic and hippuric acid 显示文摘 | van Groenigen Jan Willem Palermo Vanessa Kool Dorien M | 2006 | Soil Biology and Biochemistry2006，38，8： | 1 |
| 9 | Gene set assembly for quantitative predietion of developmental toxicity in the embryonie stem cell test 显示文摘 | Jeroen LA Penningsa Dorien AM | 2011 | Toxicology2011，284，13： | 1 |
| 10 | Increased hippuric acid content of urine can reduce soil N2O fluxes 显示文摘 | Kool Dorien M Hoffland Ellis Hummelink Eduard W J | 2006 | Soil Biology and Biochemistry2006，38，5： | 1 |
| 11 | The Insulin-like Growth Factor System in Cancer Prevention:Potential of Dietary Intervention Strategies显示文摘 | Dorien W V Alina V Laura J V | 2005 | Cancer Epidemiol Biomarkers2005，14，1： | 1 |
| 12 | What artificial urine composition is adequate for simulating soil N2O fluxes and mineral N dynamics 显示文摘 | Kool Dorien M Hoffland Ellis Abrahamse Sander (P A) | 2006 | Soil Biology and Biochemistry2006，38，7： | 1 |
| 13 | Autosomal dominant polycystic kidney disease: evidence for the existence of a third locus in a Portuguese family显示文摘 | Salomé Almeida Edgar Almeida Dorien Peters José Reim?o Pinto Isabel Távora Jo?o Lavinha Martjn Breuning Mateus Martins Prata | 1995 | Human Genetics1995，，1： | 1 |
| 14 | Co-constructing identities in speeches:How the construction of an“other”identity is defining for the“self”identity and vice versa显示文摘 | Van De Mieroop Dorien | 2008 | Pragmatics2008，，4： | 1 |
| 15 | Characterization of the KNOX class homeobox genes Oskn2 and Oskn3 identified in a collection of cDNA libraries covering the early stages of rice embryogenesis显示文摘 | A. Dorien Postma-Haarsma Ira I.G.S. Verwoert Oscar P. Stronk Jan Koster Gerda E.M. Lamers J. Harry C. Hoge Annemarie H. Meijer | 1999 | Plant Molecular Biology1999，，2： | 1 |
| 16 | Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test显示文摘 | Dorien AM van Dartel Pennings JA | 2011 | Toxicology Letters2011，201，： | 1 |
| 17 | Body Mass Index Modulates Aromatic DNA Adduct Levels and Their Persistence in Smokers显示文摘 | Roger WL Godschalk Dorien E M Feldker Paul J A Borm | 2002 | Cancer Epidemiology Biomarkers & Prevention2002，11，8： | 1 |
| 18 | Rapid increase of bile salt secretion is associated with bile duct injury after human liver transplantation显示文摘 | Erwin Geuken Dorien Visser Folkert Kuipers Hans Blokzijl Henri G.D. Leuvenink Koert P. de Jong Paul M.J.G. Peeters Peter L.M. Jansen Maarten J.H. Slooff Annette S.H. Gouw Robert J. Porte | 2004 | Journal of Hepatology2004，，6： | 1 |
| 19 | Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer survivors and women at high familial breast cancer risk显示文摘 | Dorien W Johannes MG Hester SA | 2008 | Nutrition and Cancer2008，60，3： | 1 |
| 20 | In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease显示文摘Polycystic kidney disease(PKD)is a prevalent genetic disorder,characterized by the formation of kidney cysts that progressively lead to kidney failure.The currently available drug tolvaptan is not well tolerated by all patients and there remains a strong need for alternative treatments.The signalling rewiring in PKD that drives cyst formation is highly complex and not fully understood.As a consequence,the effects of drugs are sometimes difficult to predict.We previously established a high-throughput microscopy phenotypic screening method for quantitative assessment of renal cyst growth.Here,we applied this 3D cyst growth phenotypic assay and screened 2320 small drug-like molecules,including approved drugs.We identified 81 active molecules that inhibit cyst growth.Multi-parametric phenotypic profiling of the effects on 3D cultured cysts discriminated molecules that showed preferred pharmacological effects above genuine toxicological properties.Celastrol,a triterpenoid from Tripterygium wilfordii,was identified as a potent inhibitor of cyst growth in vitro.In an in vivo iKspCre-Pkd1^lox,lox mouse model for PKD,celastrol inhibited the growth of renal cysts and maintained kidney function. | Tijmen H.Booij Wouter N.Leonhard Hester Bange Kuan Yan Michiel Fokkelman Anna J.Plugge Kimberley A.M.Veraar Johannes G.Dauwerse Gerard J.P.van Westen Bob van de Water Leo S.Price Dorien j.M.Peters | 2020 | Journal of Molecular Cell Biology2020，12，8： | 1 |
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