|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | LOV to BLUF: Flavoprotein Contributions to the Optogenetic Toolkit显示文摘Optogenetics 是联合光、基因的途径 non-invasively 与优美空间与时间的控制防碍细胞的事件的一块新兴的地。尽管它从神经科学原来产生了, optogenetics 对许多不同生物系统的学习广泛地适用,从这种技术产生的应用程序的范围继续增加。而且,使用设计新 optogenetic 工具的光敏感的蛋白质的全部剧目很快正在膨胀。察觉到的光,氧,或电压和 Blue-Light-Utilizing 黄素腺嘌 dinucleotide (一度时髦的风尚)(BLUF )(LOV ) 领域代表新贡献者到 optogenetic 工具箱。这些小(100140-amino 酸) 黄素蛋白模块从对 UV-A/blue 光作出回应的植物和细菌的光敏电阻器被导出。在最近的年里,可观的进步在揭开被成为了 LOV 和 BLUF 领域的 photoactivation 机制。这知识在合成 photoswitches 的设计被使用了并且荧光灯有在房间生物学和生物工学的应用的记者。在这评论,我们总结 LOV 和 BLUF photosensors 的光化学的性质并且加亮一些这些黄素蛋白怎么正在被采用人工地调整并且想象的最近的进展许多生物过程。 | John M. Christie Jayde Gawthorne Gillian Young Niall J. Fraser^c and Andrew J. Roe | 2012 | Molecular Plant2012，5，3： | 2 |
| 3 | Posterior retroperitoneoscopic adrenalectomy is a safe and effective alternative to transabdominal laparoscopic adrenalectomy for pheochromocytoma显示文摘 | Paxton V D Gillian C A Elibabeth G G | 2011 | J Surg2011，150，： | 1 |
| 4 | Genetic variation in Taenia solium显示文摘 | Gillian C Hector HG Minoru N | 2006 | Parasitology International2006，55，1： | 1 |
| 5 | Two different Em-like genes are expressed in Arabidopsis thaliana seeds during maturation显示文摘 | Pascale Gaubier Monique Raynal Gillian Hull Gordon M. Huestis Fran?oise Grellet César Arenas Montserrat Pagès Michel Delseny | 1993 | MGG Molecular & General Genetics1993，，3： | 1 |
| 6 | Improving interrater agreement about brain microbleeds:Development of the brain observer microbleed scale(BOMBS)显示文摘 | Cordonnier C Gillian M Jackson CA | | 0，，： | 1 |
| 7 | Genetic diversity of the biofilm covering Montacuta ferruginosa(Mollusca, Bivalvia) as evaluated by denaturing gradient gel electrophoresis analysis and cloning of PCR amplified gene fragment coding for 16S rDNA显示文摘 | Gillian D C Speksnijder A G C L Zwart G | 1998 | Applied and Environmental Microbioloxy1998，64，9： | 1 |
| 8 | Yeast ecology of Kombuch a fermentation显示文摘 | AI L T GILLIAN H JULIA C | 2004 | International Journal of Food Microbiology2004，95，2： | 1 |
| 9 | Genetic diversity of the biofilm covering Montacuta ferruginosa ( Mollusca, Bivalvia ) as evaluated by denaturing gradient gel electrophoresis analysis and cloning of PCR amplified gene fragment coding for 16S rDNA显示文摘 | Gillian D Speksnijder A G C L Zwart G J M | 1998 | Applied and Environmental Microbiology1998，64，9： | 1 |
| 10 | Photography, public pedagogy and the politics of place-making in post-industrial areas显示文摘 | Maarten L Gillian C Stijn O | 2012 | Social and Cultural Geography2012，13，7： | 1 |
| 11 | Diabetes and the Risk of Lung Cancer 显示文摘 | Gillian C Hall C Michael Robert MD Magdy Boulis | 2005 | DiabetesCare2005，28，3： | 1 |
| 12 | Cytokines and systemic lupuserythematosus显示文摘 | Gillian SD Jonathan TP Esther C | 2000 | Ann Rheum Dis2000，59，4： | 1 |
| 13 | Cloning of a differentially expressed tropomyosin isoform from cultured rabbit aortic smooth muscle cells显示文摘 | Adeed A Girjes D K Gillian W C | 2002 | IJBCB2002，34，： | 1 |
| 14 | Rapid and sensi- tive liquid chromatography-tandem mass spectrometry for the quantitation of epirubicin and identification of metabo- lites in biological samples 显示文摘 | Rachel W Gillian MM John C | 2007 | Talanta2007，72，4： | 1 |
| 15 | Disrupting tumor blood vessels显示文摘 | GILLIAN M T CHRYSO K BRUCE C B | 2005 | Nature2005，5，6： | 1 |
| 16 | Psoriasis and Pustular Dermati tis Triggered by TNF-α Inhibitors in Patients With Rheumato logic Conditions 显示文摘 | Gillian C Mehran G Janet P | 2007 | Arch Dermatol2007，143，2： | 1 |
| 17 | Genetic diversity of the biofilm covering Montacuta ferruginosa (Mollusca,Bivalvia) as evaluated by denaturing gradient gel electrophoresis analysis and cloning of PCR amplified gene fragment coding for 16S rDNA显示文摘 | Gillian D C Speksnijder A G C L Zwart G | 1998 | Applied and Environmental Microbiology1998，64，9： | 1 |
| 18 | Genetic diversity of the biofilm covering Montacuta ferruginosa ( Mollusca , Bivalvia ) as evaluated by denaturing gradient gel eleetrophoresis analysis and cloning of PCR amplified gene fragment coding for 16S rDNA 显示文摘 | GILLIAN D SPEKSNIJDER A G C L ZWART G J M | 1998 | Appl Environm Mierobiol1998，64，9： | 1 |
| 19 | Comparison of study reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy显示文摘 | FRANK GROTHUES GILLIAN C SMITH BSC | 2006 | Am J Cardiol2006，，90： | 1 |
| 20 | Randomized trial on the influence of the length of two insulin pen needles on glycemic control and patient preference in obese patients with diabetes显示文摘 | Gillian Kreugel MS Joost C Keers C | 2011 | Diabetes Technology & Therapeutics2011，13，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员