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| 1 | Laparoscopy for rectal cancer reduces short-term mortality and morbidity: results of a systematic review and meta-analysis显示文摘 | Alberto Arezzo Roberto Passera Gitana Scozzari Mauro Verra Mario Morino | 2013 | Surgical Endoscopy2013，，5： | 4 |
| 2 | Esophagogastric cancer after bariatric surgery: systematic review of the literature显示文摘 | Gitana Scozzari Renza Trapani Mauro Toppino Mario Morino | 2012 | Surgery for Obesity and Related Diseases2012，，： | 1 |
| 3 | Alterations of MEN1 and E-cadherin/β-catenin complex in sporadic pulmonarycarcinoids显示文摘 | Serena Veschi Rossano Lattanzio Gitana Aceto Maria Curia Salvatore Magnasco Domenico Angelucci Alessandro Cama Mauro Piantelli Pasquale Battista | 2012 | International Journal of Oncology2012，，： | 1 |
| 4 | Is single-incision laparoscopic cholecystectomy safe? Results of a systematic review and meta-analysis显示文摘 | Alberto Arezzo Gitana Scozzari Federico Famiglietti Roberto Passera Mario Morino | 2013 | Surgical Endoscopy2013，，7： | 1 |
| 5 | Nonmodulation as the Mechanism for Salt Sensitivity of Blood Pressure in Individuals with Hypertension and Type 2 Diabetes Mellitus显示文摘 | Patricia C. Underwood Bindu Chamarthi Jonathan S. Williams Anand Vaidya Rajesh Garg Gail K. Adler Marissa P. Grotzke Gitana Staskus Devendra Wadwekar Paul N. Hopkins Claudio Ferri Anthony McCall Donald McClain Gordon H. Williams | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，10： | 1 |
| 6 | MUTYH:Not just polyposis显示文摘MUTYH is a base excision repair enzyme,it plays a crucial role in the correction of DNA errors from guanine oxidation and may be considered a cell protective factor.In humans it is an adenine DNA glycosylase that removes adenine misincorporated in 7,8-dihydro-8-oxoguanine(8-oxoG)pairs,inducing G:C to T:A transversions.MUTYH functionally cooperates with OGG1 that eliminates 8-oxodG derived from excessive reactive oxygen species production.MUTYH mutations have been linked to MUTYH associated polyposis syndrome(MAP),an autosomal recessive disorder characterized by multiple colorectal adenomas.MAP patients show a greatly increased lifetime risk for gastrointestinal cancers.The cancer risk in mono-allelic carriers associated with one MUTYH mutant allele is controversial and it remains to be clarified whether the altered functions of this protein may have a pathophysiological involvement in other diseases besides familial gastrointestinal diseases.This review evaluates the role of MUTYH,focusing on current studies of human neoplastic and non-neoplastic diseases different to colon polyposis and colorectal cancer.This will provide novel insights into the understanding of the molecular basis underlying MUTYH-related pathogenesis.Furthermore,we describe the association between MUTYH single nucleotide polymorphisms(SNPs)and different cancer and non-cancer diseases.We address the utility to increase our knowledge regarding MUTYH in the light of recent advances in the literature with the aim of a better understanding of the potential for identifying new therapeutic targets.Considering the multiple functions and interactions of MUTYH protein,its involvement in pathologies based on oxidative stress damage could be hypothesized.Although the development of extraintestinal cancer in MUTYH heterozygotes is not completely defined,the risk for malignancies of the duodenum,ovary,and bladder is also increased as well as the onset of benign and malignant endocrine tumors.The presence of MUTYH pathogenic variants is an independent predictor of poor prognosis in sporadic gastric cancer and in salivary gland secretory carcinoma,while its inhibition has been shown to reduce the survival of pancreatic ductal adenocarcinoma cells.Furthermore,some MUTYH SNPs have been associated with lung,hepatocellular and cervical cancer risk.An additional role of MUTYH seems to contribute to the prevention of numerous other disorders with an inflammatory/degenerative basis,including neurological and ocular diseases.Finally,it is interesting to note that MUTYH could be a new therapeutic target and future studies will shed light on its specific functions in the prevention of diseases and in the improvement of the chemo-sensitivity of cancer cells. | Maria Cristina Curia Teresa Catalano Gitana Maria Aceto | 2020 | World Journal of Clinical Oncology2020，11，7： | 1 |
| 7 | Bariatric Surgery Improves Urinary Incontinence but Not Anorectal Function in Obese Women显示文摘 | Gitana Scozzari Fabrizio Rebecchi Claudio Giaccone Paolo Chiaro Massimiliano Mistrangelo Mario Morino | 2013 | Obesity Surgery2013，，7： | 1 |
| 8 | Wingless/It/β-catenin signaling in liver metastasis from colorectal cancer:A focus on biological mechanisms and therapeutic opportunities显示文摘The liver is the most common site of metastases in patients with colorectal cancer.Colorectal liver metastases(CRLMs)are the result of molecular mechanisms that involve different cells of the liver microenvironment.The aberrant activation of Wingless/It(Wnt)/β-catenin signals downstream of Wnt ligands initially drives the oncogenic transformation of the colon epithelium,but also the progression of metastatization through the epithelial-mesenchymal transition/mesenchymalepithelial transition interactions.In liver microenvironment,metastatic cells can also survive and adapt through dormancy,which makes them less susceptible to pro-apoptotic signals and therapies.Treatment of CRLMs is challenging due to its variability and heterogeneity.Advances in surgery and oncology have been made in the last decade and a pivotal role for Wnt/β-catenin pathway has been recognized in chemoresistance.At the state of art,there is a lack of clear understanding of why and how this occurs and thus where exactly the opportunities for developing anti-CRLMs therapies may lie.In this review,current knowledge on the involvement of Wnt signaling in the development of CRLMs was considered.In addition,an overview of useful biomarkers with a revision of surgical and non-surgical therapies currently accepted in the clinical practice for colorectal liver metastasis patients were provided. | Federico Selvaggi Teresa Catalano Rossano Lattanzio Roberto Cotellese Gitana Maria Aceto | 2023 | World Journal of Gastroenterology2023，29，18： | 0 |
| 9 | 以海为疆咖啡航路迎接先驱者--第十三届雅克一瓦布尔穿越大西洋帆船赛显示文摘出发,吉塔纳队
对于吉塔纳队(Gitana Team)的两位船长塞巴斯蒂安·约瑟(Sebastien Josse)和托马斯·卢克塞尔(Thomas Rouxel)而言,从法国洛里昂(“埃德蒙德-罗斯柴尔德”号在法国洛里昂注册)到法国北部城市勒阿弗尔的航程需要极大的耐心。 | 肖素英 Gitana SA | 2018 | 游艇2018，0，1： | 0 |
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