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| 1 | Neoadjuvant chemotherapy for gastric cancer. Is it a must or a fake?显示文摘AIM To investigate the neoadjuvant chemotherapy(NAC) effect on the survival of patients with proper stomach cancer submitted to D2 gastrectomy.METHODS We proceeded to a review of the literature with Pub Med, Embase, ASCO and ESMO meeting abstracts as well as computerized use of the Cochrane Library for randomized controlled trials(RCTs) comparing NAC followed by surgery(NAC + S) with surgery alone(SA) for gastric cancer(GC). The primary outcome was the overall survival rate. Secondary outcomes were the site of the primary tumor, extension of node dissection according to Japanese Gastric Cancer Association(JGCA) performed in both arms, disease-specific(DSS) and disease-free survival(DFS) rates, clinical and pathological response rates and resectability rates after perioperative treatment. RESULTS We identified a total of 16 randomized controlled trials comparing NAC + S(n = 1089) with SA(n = 973) published in the period from January 1993-March 2017. Only 6 of these studies were well-designed, structured trials in which the type of lymph node(LN) dissection performed or at least suggested in the trial protocol was reported. Two out of three of the RCTs with D2 lymphadenectomy performed in almost all cases failed to show survival benefit in the NAC arm. Inthe third RCT, the survival rate was not even reported, and the primary end points were the clinical outcomes of surgery with and without NAC. In the remaining three RCTs, D2 lymph node dissection was performed in less than 50% of cases or only recommended in the 'Study Treatment' protocol without any description in the results of the procedure really perfomed. In one of the two studies, the benefit of NAC was evident only for esophagogastric junction(EGJ) cancers. In the second study, there was no overall survival benefit of NAC. In the last trial, which documented a survival benefit for the NAC arm, the chemotherapy effect was mostly evident for EGJ cancer, and more than one-fourth of patients did not have a proper stomach cancer. Additionally, several patients did not receive resectional surgery. Furthermore, the survival rates of international reference centers that provide adequate surgery for homogeneous stomach cancer patients' populations are even higher than the survival rates reported after NAC followed by incomplete surgery.CONCLUSION NAC for GC has been rapidly introduced in international western guidelines without an evidence-based medicinerelated demonstration of its efficacy for a homogeneous population of patients with only stomach tumors submitted to adequate surgery following JGCA guidelines with extended(D2) LN dissection. Additional larger sample-size multicentre RCTs comparing the newer NAC regimens including molecular therapies followed by adequate extended surgery with surgery alone are needed. | Rossella Reddavid Silvia Sofia Paolo Chiaro Fabio Colli Renza Trapani Laura Esposito Mario Solej Maurizio Degiuli | 2018 | World Journal of Gastroenterology2018，24，2： | 25 |
| 2 | Esophagogastric cancer after bariatric surgery: systematic review of the literature显示文摘 | Gitana Scozzari Renza Trapani Mauro Toppino Mario Morino | 2012 | Surgery for Obesity and Related Diseases2012，，： | 1 |
| 3 | The influence of exercise intensity on the power spectrum of heart rate variability显示文摘 | Renza Perini Claudio Orizio Giuseppe Baselli Sergio Cerutti Arsenio Veicsteinas | 1990 | European Journal of Applied Physiology and Occupational Physiology (-)1990，，1： | 1 |
| 4 | In vitro effects of dexamethasone on hypoxia -induced hyperpermeability and expression of vascular endothelial growth factor 显示文摘 | S Fischer D Renza W Schaperb | 2001 | Eur J Pharmacol2001，411，3： | 1 |
| 5 | Aerobic Training and Cardiovascular Responses at Rest and during Exercise in Older Men and Women显示文摘 | Renza Perini Nafine Fisher Arsenio Veiesteinas | 2002 | Med Sci Sports Exerc2002，34，4： | 1 |
| 6 | Pathways targeting solvent - free PUR coatings 显示文摘 | RENZA H BRUCYMANN B | 2001 | Progress in Organic Coatings2001，43，2： | 1 |
| 7 | The influence of exercise intensity on the power spectrum of heart rate variability显示文摘 | Renza Perini Claudio Orizio Giuseppe Baselli Sergio Cerutti Arsenio Veicsteinas | 1990 | European Journal of Applied Physiology and Occupational Physiology (-)1990，，1： | 1 |
| 8 | Surface proteomic analysis of differentiated versus stem‐like osteosarcoma human cells显示文摘 | Marica Gemei Claudia Corbo Francesca D'Alessio Rosa Di Noto Renza Vento Luigi Del Vecchio | 2013 | Proteomics2013，，22： | 1 |
| 9 | Interfacial and Chemical Properties of Pt TiO2 Pd TiO2 and Pt GaN Catalytic Nanodiodes Influencing Hot Electron Flow显示文摘 | Park JY Renzas J R Bryan B | 2007 | J Phys Chem C2007，111，15： | 1 |
| 10 | Data mining models for student careers显示文摘 | Renza Campagni Donatella Medini Renzo Sprugnoli | 2015 | Expert Systems with Applications2015，42，13： | 1 |
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