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| 1 | Simultaneous intraductal papillary neoplasms of the bile duct and pancreas treated with chemoradiotherapy显示文摘Some authors have suggested that intraductal papillary mucinous neoplasms of the bile duct(IPMN-B) could be the the biliary counterpart of IPMN of the pancreas(IPMN-P) since they share several clinical-pathological features.These include prominent intraductal papil-lary proliferation pattern,a gastrointestinal phenotype,frequent mucin hyper-secretion and progression to mu-cinous carcinoma.To date there are just four reported cases of patients with synchronous IPMN-B and IPMN-P all of which were treated surgically.We hereby report the case of a 76-year-old woman who was incidentally diagnosed with both an asymptomatic 3 cm bulky uid lesion obstructing the bile duct lumen,diagnosed as a malignant IPMN-B,and synchronous multiple pancreatic cystic lesions(10-13 mm) communicating with an irreg-ular Wirsung,diagnosed as branch duct IPMN-P.Since surgery was ruled-out because of the patient's age and preferences,she underwent a conservative manage-ment regimen comprising both chemotherapy and radio-therapy.This was effective in decreasing the mass size and in resolving subsequent jaundice.This is also the f irst reported case of IPMN-B successfully treated with chemoradiotherapy.Clinicians should consider medical treatment as an option in this clinical scenario,in pa-tients who may be unf it for surgery. | Roberto Valente Gabriele Capurso Paola Pierantognetti Elsa Iannicelli Matteo Piciucchi Adriana Romiti Paolo Mercantini Alberto Larghi Giulia Francesca Federici Viola Barucca Maria Falchetto Osti Emilio Di Giulio Vincenzo Ziparo Gianfranco Delle Fave | 2012 | World Journal of Gastrointestinal Oncology2012，4，2： | 13 |
| 2 | Hepatitis B in patients with hematological diseases: An update显示文摘Hepatitis B virus(HBV) reactivation(HBVr) in patients undergoing immunosuppressive therapy is still a hot topic worldwide. Its prevention and management still represents a challenge for specialists dealing with immunosuppressed patients. Aim of this paper is to provide a critical review of the relevant information emerged in the recent literature regarding HBV reactivation following immunosuppressive treatments for oncohematological tumors. A computerized literature search in MEDLINE was performed using appropriate terms arrangement, including English-written literature only or additional relevant articles. Articles published only in abstract form and case reports not giving considerable news were excluded. Clinical manifestation of HBVr can be manifold, ranging from asymptomatic self-limiting anicteric hepatitis to life-threatening fulminant liver failure. In clusters of patients adverse outcomes are potentially predictable. Clinicians should be aware of the inherent risk of HBVr among the different virological categories(active carriers, occult HBV carriers and inactive carriers, the most intriguing category), and classes of immunosuppressive drugs. We recommend that patients undergoing immunosuppressive treatments for hematological malignancies should undergo HBV screening. In case of serological sign(s) of current or past infection with the virus, appropriate therapeutic or preventive strategies are suggested, according to both virological categories, risk of HBVr by immunosuppressive drugsand liver status. Either antiviral drug management and surveillance and pre-emptive approach are examined, commenting the current international recommendations about this debated issue. | Chiara Coluccio Paola Begini Alfredo Marzano Adriano Pellicelli Barbara Imperatrice Giulia Anania Gianfranco Delle Fave Massimo Marignani | 2017 | World Journal of Hepatology2017，9，25： | 5 |
| 3 | Static and rotational intensity modulated techniques for head-neck cancer radiotherapy: A planning comparison显示文摘 | Sara Broggi Lucia Perna Francesco Bonsignore Giuseppe Rinaldin Claudio Fiorino Anna Chiara Cristina Frigerio Ivana Butti Giulia Sangalli Italo Dell’Oca Nadia Di Muzio Giovanni Mauro Cattaneo Fausto Declich | 2014 | Physica Medica2014，，： | 1 |
| 4 | Augmentative repetitive Transcranial Magnetic Stimulation (rTMS) in the acute treatment of poor responder depressed patients: a comparison study between high and low frequency stimulation显示文摘 | Bernardo Dell’Osso Lucio Oldani Giulia Camuri Cristina Dobrea Laura Cremaschi Beatrice Benatti Chiara Arici Benedetta Grancini A. Carlo Altamura | 2014 | European Psychiatry2014，，： | 1 |
| 5 | Microalbuminuria and pulse pressure in hypertensive and atherosclerotic men显示文摘 | Roberto Pedrinelli Giulia Dell'Omo Giuseppe Penno | 2000 | Hypertension2000，35，： | 1 |
| 6 | Low-Grade Inflammation and Microalbuminuria in Hypertension显示文摘 | Roberto Pedrinelli Giulia Dell' Omo Vitantonio Di Bello | 2004 | Arteriosclerosis Thrombosis and Vascular Biolog2004，24，： | 1 |
| 7 | Early leftventricular mechanics abnormalities in prehypertension:A two-dimensionalstrain echocardiography study显示文摘 | Vitantonio Di Bello Enrica Talinil Giulia Dell’ Omo ei al | 2010 | Am J Hypertension2010，23，4： | 1 |
| 8 | Prognostic value of human papillomavirus in anal squamous cell carcinoma显示文摘 | Paola Simona Ravenda Elena Magni Edoardo Botteri Michela Manzotti Massimo Barberis Davide Vacirca Cristina Maria Trovato Veronica Dell’Acqua Maria Cristina Leonardi Mario Sideri Nicola Fazio Maria Giulia Zampino | 2014 | Cancer Chemotherapy and Pharmacology2014，，5： | 1 |
| 9 | Microalbuminuria and Pulse Pressure in Hypertensive and Atherosclerotlc Men 显示文摘 | Roberto Pedrinelli Giulia Dell Giuseppe Penno | 2000 | Hypertension2000，35，1： | 1 |
| 10 | Determination of Plutonium Isotopes in Radioactive Waste Contaminated with Uranium and Thorium显示文摘Nucleco is the Sogin Group’s Italian leading company in the sector of radiological services,radioactive waste management,decontamination and reclamation of industrial sites and nuclear power plants.Nucleco is 60%owned by Sogin and 40%by ENEA-National Agency for New Technologies.The waste characterization carried out by Nucleco SpA includes a large variety of radionuclides belonging to the gamma,beta and alpha emitter families.The determination of Uranium and Plutonium isotopes plays a key role in the waste characterization.Nucleco SpA has distinguished itself in characterizations of radioactive waste in complex and nuclear plant matrices.These matrices have large amounts of alpha emitters,in particular isotopes of Uranium,Thorium and Plutonium.A significant presence of U238 results in such a large amount of Th234(and daughters)that interferes with the determination of Pu241.Hence,there is the need of finding a pre-treatment,extraction and subsequent purification technique that would allow Th234 to be detached and thus Pu241 to be determined in complex high-activity matrices.The above elements are extracted using chromatography columns.An isotope of the element to be analyzed,with known activity,is added at the beginning of the process to determine the extraction yield.Before being eluted into the column,the sample undergoes a series of treatments in order to be purified of any interferents.The method developed by Nucleco involves the oxidation of Pu at valence+6 and the subsequent precipitation,in fluorides form,of the elements with valence+4 and+3(i.e.Th234).Pu241 is then measured by LSC(Liquid Scintillation Counting),while the other isotopes are measured by alpha spectrometry after electrodeposition on a metal plate. | Raguso Damiano Dell’Omo Emiliano Colavolpe Giulia Gentile Fabiana | 2023 | Journal of Environmental Science and Engineering(B)2023，12，3： | 0 |
| 11 | Liver biopsy:analysis of results of two specialist teams显示文摘AIM:To analyze the safety and the adequacy of a sample of liver biopsies(LB)obtained by gastroenterologist(G)and interventional radiologist(IR)teams.METHODS:Medical records of consecutive patients evaluated at our GI unit from 01/01/2004 to31/12/2010 for whom LB was considered necessary to diagnose and/or stage liver disease,both in the setting of day hospital and regular admission(RA) care,were retrieved and the data entered in a database.Patients were divided into two groups:one undergoing an ultrasonography(US)-assisted procedure by the G team and one undergoing US-guided biopsy by the IR team.For the first group,an intercostal approach(US-assisted) and a Menghini modified type needle 16 G(length 90 mm) were used.The IR team used a subcostal approach(US-guided) and a semiautomatic modified Menghini type needle 18 G(length 150 mm).All the biopsies were evaluated for appropriateness according to the current guidelines.The number of portal tracts present in each biopsy was assessed by a revision performed by a single pathologist unaware of the previous pathology report.Clinical,laboratory and demographic patient characteristics,the adverse events rate and the diagnostic adequacy of LB were analyzed.RESULTS:During the study period,226 patients,126 males(56%) and 100 females(44%),underwent LB:167(74%) were carried out by the G team,whereas 59(26%) by the IR team.LB was mostly performed in a day hospital setting by the G team,while IR completed more procedures on inpatients(P < 0.0001).The groups did not differ in median age,body mass index(BMI),presence of comorbidities and coagulation parameters.Complications occurred in 26 patients(16 G team vs 10 IR team,P = 0.15).Most gross samples obtained were considered suitable for basal histological evaluation,with no difference among the two teams(96.4% G team vs 91.5% IR,P = 0.16).However,the samples obtained by the G team had a higher mean number of portal tracts(G team 9.5 ± 4.8; range 1-29 vs IR team 7.8 ± 4.1; range 1-20)(P = 0.0192) and a longer mean length(G team 22 mm ± 8.8 vs IR team 15 ± 6.5 mm)(P = 0.0001).CONCLUSION:LB can be performed with similar outcomes both by G and IR.Use of larger dimension needles allows obtaining better samples,with a similar rate of adverse events. | Giulia Anania Elia Gigante Matteo Piciucchi Emanuela Pilozzi Eugenio Pucci Adriano Maria Pellicelli Carlo Capotondi Michele Rossi Flavia Baccini Giulio Antonelli Paola Begini Gianfranco Delle Fave Massimo Marignani | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，2： | 0 |
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