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| 1 | Gut-microbiome-brain axis:the crosstalk between the vagus nerve,alpha-synuclein and the brain in Parkinson's disease显示文摘This critical review of the literature shows that there is a close link between the microbiome,the gut,and the brain in Parkinson's disease.The vagus nerve,the main component of the parasympathetic nervous system,is involved in the regulation of immune response,digestion,heart rate,and control of mood.It can detect microbiota metabolites through its afferents,transferring this gut information to the central nervous system.Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression,as well as treatment responses.These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's disease.More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit. | Júlio César Claudino dos Santos Leandro Freitas Oliveira Felipe Micelli Noleto Camilla Teixeira Pinheiro Gusmão Gerly Anne de Castro Brito Glauce Socorro de Barros Viana | 2023 | Neural Regeneration Research2023，18，12： | 2 |
| 2 | Piplartine, an amide alkaloid from Piper tuberculatum , presents anxiolytic and antidepressant effects in mice显示文摘 | F. Cícero Bezerra Felipe Jucélio Trajano Sousa Filho Louise Emanuele de Oliveira Souza Jefferson Alexandre Silveira Daniel Esdras de Andrade Uchoa Edilberto Rocha Silveira Otília Deusdênia Loiola Pessoa Glauce S. de Barros Viana | 2006 | Phytomedicine2006，，： | 1 |
| 3 | Oxidative stress in the hippocampus after pilocarpine‐induced status epilepticus in Wistar rats显示文摘 | Rivelilson M.Freitas Silvania M. M.Vasconcelos Francisca C. F.Souza Glauce S. B.Viana Marta M. F.Fonteles | 2005 | FEBS Journal2005，，6： | 1 |
| 4 | Time-dependent analysis of nociception and anxiety-like behavior in rats submitted to persistent inflammation of the temporomandibular joint显示文摘 | Glauce Crivelaro do Nascimento Christie Ramos Andrade Leite-Panissi | 2014 | Physiology & Behavior2014，，： | 1 |
| 5 | Changes in the proteomic profile during differentiation and maturation of human monocyte-derived dendritic cells stimulated with granulocyte macrophage colony stimulating factor/interleukin-4 and lipopolysaccharide显示文摘 | Sandra RP Vitor MF Glauce GG | 2005 | Proteomics2005，5，： | 1 |
| 6 | High-throughput phenotyping of two plant-size traits of Eucalyptus species using neural networks显示文摘In forest modeling to estimate the volume of wood,artificial intelligence has been shown to be quite effi-cient,especially using artificial neural networks(ANNs).Here we tested whether diameter at breast height(DBH)and the total plant height(Ht)of eucalyptus can be pre-dicted at the stand level using spectral bands measured by an unmanned aerial vehicle(UAV)multispectral sensor and vegetation indices.To do so,using the data obtained by the UAV as input variables,we tested different configurations(number of hidden layers and number of neurons in each layer)of ANNs for predicting DBH and Ht at stand level for different Eucalyptus species.The experimental design was randomized blocks with four replicates,with 20 trees in each experimental plot.The treatments comprised five Eucalyptus species(E.camaldulensis,E.uroplylla,E.saligna,E.gran-dis,and E.urograndis)and Corymbria citriodora.DBH and Ht for each plot at the stand level were measured seven times in separate overflights by the UAV,so that the multispectral sensor could obtain spectral bands to calculate vegetation indices(VIs).ANNs were then constructed using spectral bands and VIs as input layers,in addition to the categorical variable (species), to predict DBH and Ht at the stand level simultaneously. This report represents one of the first appli-cations of high-throughput phenotyping for plant size traits in Eucalyptus species. In general, ANNs containing three hidden layers gave better statistical performance (higher esti-mated r, lower estimated root mean squared error-RMSE) due to their greater capacity for self-learning. Among these ANNs, the best contained eight neurons in the first layer, seven in the second, and five in the third (8 − 7 − 5). The results reported here reveal the potential of using the gener-ated models to perform accurate forest inventories based on spectral bands and VIs obtained with a UAV multispectral sensor and ANNs, reducing labor and time. | Marcus Vinicius Vieira Borges Janielle de Oliveira Garcia Tays Silva Batista Alexsandra Nogueira Martins Silva Fabio Henrique Rojo Baio Carlos Antônio da Silva Junior Gileno Brito de Azevedo Glauce Taís de Oliveira Sousa Azevedo Larissa Pereira Ribeiro Teodoro Paulo Eduardo Teodoro | 2022 | Journal of Forestry Research2022，33，2： | 1 |
| 7 | Doxycycline induces bone repair and changes in Wnt signalling显示文摘Doxycycline(DOX) exhibits anti-inflammatory and MMP inhibitory properties. The objectives of this study were to evaluate the effects of DOX on alveolar bone repair. Controls(CTL) and DOX-treated(10 and 25 mg. kg^(-1)) molars were extracted, and rats were killed 7 or 14 days later. The maxillae were processed and subjected to histological and immunohistochemical assays.Hematoxylin-eosin staining(7th day) revealed inflammation in the CTL group that was partly reversed after DOX treatment. On the 14th day, the CTL group exhibited bone neoformation, conjunctive tissue, re-epithelization and the absence of inflammatory infiltrate. DOX-treated groups exhibited complete re-epithelization, tissue remodelling and almost no inflammation. Picrosirius red staining in the DOX10 group(7th and 14th days) revealed an increased percentage of type I and III collagen fibres compared with the CTL and DOX25 groups. The DOX10 and DOX25 groups exhibited increases in osteoblasts on the 7th and14th days. However, there were fewer osteoclasts in the DOX10 and DOX25 groups on the 7th and 14th days. Wnt-10 bimmunopositive cells increased by 130% and 150% on the 7th and 14th days, respectively, in DOX-treated groups compared with the CTL group. On the 7th day, Dickkopf(Dkk)-1 immunostaining was decreased by 63% and 46% in the DOX10 and DOX25 groups, respectively. On the 14th day, 69% and 42% decreases in immunopositive cells were observed in the DOX10 and DOX25 groups, respectively, compared with the CTL group. By increasing osteoblasts, decreasing osteoclasts, activating Wnt10b and neutralising Dkk, DOX is a potential candidate for bone repair in periodontal diseases. | kátia do nascimento gomes ana paula negreiros nunes alves paula góes pinheiro dutra glauce socorro de barros viana | 2017 | International Journal of Oral Science2017，9，3： | 1 |
| 8 | 营养不良:一场无声的大流行 健康饮食是一项人权,并且是公平、弹性社会的基础显示文摘2020年,公共卫生成为近年来最突出的问题,但早在新型冠状病毒肺炎(COVID-19)暴发之前,世界就已经目睹了一场更为安静的大流行:营养不良。受到营养不良影响的人数是惊人的。全球约1.49亿儿童发育迟缓(慢性营养不良),5000万儿童严重营养不足(消瘦)1,且营养不良作为直接或根本死因占所有儿童死亡的45%2。此外,有4000万5岁以下儿童超重,6.78亿成年人肥胖1。 | Henry E Mark Glauce Dias da Costa Claudia Pagliari Stefan A Unger 刘宇(译) | 2021 | 英国医学杂志中文版2021，24，3： | 0 |
| 9 | Behavioral study with Erythrina velutina fractions显示文摘Objective:To study the behavioral effects of semi purified fraction prepared from the stem bark of Erythrina velutina on mice.Methods:Three chloroformic fractions(CA) at 50 or 100 mg/kg(CA1,CA2 and CA3) were tested in two behavioral tests;plus maze and open field.Results:In the plus maze test,it was observed a decrease in the number of entries in the closed arms(NECA) CA2 at both doses as compared to the control group.In the open field test,CA2 and CA3 fractions decreased the number of squares crossed and the time of permanence on the bar,increased the number of falls at both doses in the rota rod test.The CA2 fraction decreased the NECA,but this data did not characterize an anxiolytic effect.It was the consequence from decrease of locomotor activity(LA) observed in the open field test,that the decrease of LA and rearing,the number of falls and the decrease in time of permanence on the bar in rota rod test were observed after treatment with CA2 and CA3 at both doses,suggesting sedative effect.Conclusion:The present work demonstrated that CA2 and CA3 fractions have impairing effect on LA and motor coordination. | Silvania Maria Mendes Vasconcelos Natalia Martins Lima Lucas Siqueira de Lucena Alexandre Cesar Praxedes Rodrigues Edilberto Rocha Silveira Carlos Clayton Torres Aguiar Paula Matias Soares Francisca Clea Florenco de Sousa Glauce Socorro de Barros Viana | 2009 | Asian Pacific Journal of Tropical Medicine2009，2，5： | 0 |
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