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| 1 | 选择性头部降温在新生儿脑病后全身轻度低温中应用的多中心随机试验 | Gluckman P.D. Wyatt J.S. Azzopardi D. A. J. Gunn 郭俊 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，8： | 4 |
| 2 | 选择性头部降温对胎羊缺血性脑损伤纹状体神经元凋亡和星形胶质细胞增殖的影响显示文摘目的研究选择性头部降温对缺血性脑损伤胎羊纹状体神经元凋亡和星形胶质细胞增殖的影响。方法胎羊于妊娠117~124d时通过双侧颈动脉阻塞30min造成双侧脑缺血损伤,损伤后将胎羊随机分为:损伤组(n=10)、2h低温组(损伤后2h开始亚低温治疗,n=7)和6h低温组(损伤后6h开始亚低温治疗,n=8),另设正常对照组(n=5)。通过冷循环水进行选择性头部降温,取脑组织用免疫组化法检测胎羊纹状体caspase-3(半胱天冬氨酸酶-3),GFAP(胶质纤维酸性蛋白)和PCNA(增殖细胞核抗原)的表达。结果①纹状体神经元凋亡:正常对照组中,caspase-3表达极少(11.00±13.77),损伤组caspase-3免疫阳性细胞为177.70±48.69,明显增加(P=0.000),损伤后2h治疗组(54.14±39.44,P=0.000)和损伤后6h治疗组(122.43±52.36,P=0.017)均能减少caspase-3免疫阳性细胞。②纹状体星形胶质细胞增殖:与正常对照组(163.40±21.98)相比,缺血性脑损伤组的GFAP免疫阳性细胞明显增多(433.25±66.69,P=0.000),损伤后2h开始亚低温治疗(219.50±35.31,P=0.000)和损伤后6h开始亚低温治疗(272.50±86.20,P=0.000)均能减少GFAP免疫阳性细胞。③纹状体PCNA阳性细胞的表达:在正常对照组中,PCNA免疫阳性细胞较少,为153.40±12.46,缺血性脑损伤组的PCNA免疫阳性细胞明显增多(353.70±45.60,P=0.000),损伤后2h开始亚低温治疗(187.14±26.26,P=0.000)和损伤后6h开始亚低温治疗(230.25±67.46,P=0.000)均能减少PCNA免疫阳性细胞。结论亚低温可以抑制纹状体神经元的凋亡和星形胶质细胞的增殖,该作用可能为选择性头部降温的脑保护作用机制之一。 | 骆菲 曹云 Guan J Gunn AJ Bennet L George S Gluckman PD 杨毅 陈莲 | 2007 | 复旦学报(医学版)2007，34，4： | 2 |
| 3 | Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilicalcord blood from an HLA- identical sihling显示文摘 | Gluckman E BroXllleyer HA Auerbach AD | 1989 | N Engl J Med1989，321，17： | 1 |
| 4 | Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibiling显示文摘 | Gluckman E Broxmeyer HA Auerbach AD | 1989 | N Engl J Med1989，321，17： | 1 |
| 5 | Selective head cooling with mild systemic hypothermia after neonatal encephalopathy:multicentre randomised trial显示文摘 | Gluckman PD Wyatt JS Azzopardi D | 2005 | Lancet2005，365，： | 1 |
| 6 | Bone marrow trans- plantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): a report of the EBMT SAA working party显示文摘 | Bacigalupo A Hows J Gluckman E | 1988 | Br J Haematol1988，70，2： | 1 |
| 7 | Relative importance of patient,procedural and anatomic risk factors for early vein graft thrombosis after coronary artery bypass graft surgery显示文摘 | McLean RC Nazarian SM Gluckman TJ | | 0，，： | 1 |
| 8 | The Ubiquitin Ligase Mul1 Induces Mitophagy in Skeletal Muscle in Response to Muscle-Wasting Stimuli显示文摘 | Sudarsanareddy Lokireddy Isuru W. Wijesoma Serena Teng Sabeera Bonala Peter D. Gluckman Craig McFarlane Mridula Sharma Ravi Kambadur | 2012 | Cell Metabolism2012，，5： | 1 |
| 9 | African-American and white head and neck carcinoma patients in a University Medical Center Setting:Are treatments provided and are outcomes similar or disparate?显示文摘 | Murdock JM Gluckman JK | 2001 | Cancer2001，91，1： | 1 |
| 10 | Effects of aspirin responsiveness and platelet reactivity on early vein graft thrombosis after coronary artery bypass graft surgery显示文摘 | Gluckman TJ McLean RC Schulman SP | | 0，，： | 1 |
| 11 | Is cryoglobulin detection of clinical significance in chronic glomerulonephritis not related to systemic disease显示文摘 | Agrafiotis A Gluckman JC Baumelou A | 1981 | Clin Nephrol1981，16，3： | 1 |
| 12 | 胰岛素样生长因子-1减少胎羊缺血性脑白质损伤后淀粉样前体蛋白表达(英文)显示文摘目的 淀粉样前体蛋白 (β APP)是脑白质损伤早期敏感的指标 ,并参与缺氧缺血性脑损伤机制。本研究观察胎羊缺血性脑白质损伤及胰岛素样生长因子 1(IGF 1)治疗对淀粉样前体蛋白 (β APP)表达的影响。方法 胎羊于胎龄 117 12 4天 (足月为 14 7天 )时通过双侧颈动脉阻塞 30min造成双侧脑缺血损伤 ,损伤后胎羊随机分为损伤组 (n =8)和重组人IGF 1(rhIGF 1)治疗组 (n =9) ;另设正常对照组 (n =5 ) ,为假手术动物。治疗组缺血后 90min经侧脑室注射 3μgrhIGF 1;损伤组经侧脑室注射等量人工脑脊液。缺血损伤后 96h结束实验 ,处死动物 ,取出胎羊 ,固定脑组织。免疫组化法检测脑白质胶质原纤维酸性蛋白 (GFAP)、β APP阳性细胞及白质内髓鞘碱性蛋白 (MBP)密度。应用免疫荧光双标记观察APP表达阳性细胞。结果 与正常对照组 (2 7.8± 4 .8)比较 ,缺血损伤组MBP密度 (4.7± 7.1,P <0 .0 0 1)明显减少。正常对照组未见 β APP阳性细胞 ,损伤后阳性细胞数明显增加 (49.6± 2 3.7,P <0 .0 0 1) ,rhIGF 1治疗可减少 β APP阳性细胞数 (17.9± 16 .5 ,P <0 .0 1)。免疫荧光双标记显示部分细胞为 β APP GFAP双标阳性细胞。 结论 胎羊缺血性脑白质损伤可导致星形胶质细胞表达β APP ,β APP表达增加可能与脑损伤有关? | 曹云 Alistair Jan GUAN Laura BENNET David WU Sherly GEORGE Peter GLUCKMAN Jian GUAN 邵肖梅 | 2004 | 中国当代儿科杂志2004，6，6： | 1 |
| 13 | Selective head cooling with mild systemic hypothermia after neonatal encephalopathy:multicentre randomised trial显示文摘 | Gluckman PD Wyatt JS Azzopardi D | 2005 | Lancet2005，365，9460： | 1 |
| 14 | The Developmental Origins of the Metabolic Syndrome显示文摘 | GLUCKMAN PD HANSON MA | 2004 | Trends Endocrinol Metab(S1043-2760)2004，15，4： | 1 |
| 15 | Selective head cooling with mind systemic hypothermia after neonatal encephalopathy: mul- ticentre randomized trial显示文摘 | Gluckman PD Wyatt JS Azzopardi D | 2005 | Lancet2005，365，9460： | 1 |
| 16 | Living with the past : evolution, de- velopment, and patterns of disease 显示文摘 | GLUCKMAN PD HANSON MA | 2004 | Science2004，305，5691： | 1 |
| 17 | Gossip and scandal显示文摘 | Gluckman M | 1963 | Current Anthropology1963，，4： | 1 |
| 18 | Recovery of fertility after chemotherapy, irradiation and bone marrow allo- graft: further evidence against massive oocyte regeneration by bone marrow-derived germline stem cells显示文摘 | VEITIA R A GLUCKMAN E FELLOUS M | 2007 | Stem Ceils2007，25，5： | 1 |
| 19 | A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury显示文摘 | Gluckman P D Klempt N D Guan J | 1992 | Biochem Biophys Res Commun1992，182，2： | 1 |
| 20 | Cord blood banking for hematopoietic stem cell transplantation: an international cord blood transplant registry显示文摘 | Gluckman E Wagner J Hows J | 1993 | Bone Marrow Tansplant1993，11，3： | 1 |
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