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| 1 | Ultrafine Grained HSLA Steels for Cold Forming显示文摘The industrial level production of ultrafine grained(or ultrafine ferrite)ferrous alloys was investigated through three examples of steels that complied with the EN 10149-2 Euronorm and were produced by advanced controlled hot rolling techniques.The steel samples were tension tested and chemically analyzed,and the microstructure was evaluated through quantitative metallographic techniques to determine parameters such as yield stress,amount of microalloying elements,strain hardening coefficient,grain size,and grain size distribution.These steels were microalloyed with Ti,Nb,and Mn with ASTM grain sizes of approximately 13-15.The careful control of chemical composition and deformation during production,giving a specific attention to the deformation sequences,austenite non-recrystallization temperatures and allotropic transformations during cooling,are indispensable to obtain steels with an adequate strain hardening coefficient that allows cold working operations such as bending,stretching or drawing. | R González J O García M A Barbés M J Quintana L F Verdeja J I Verdeja | 2010 | Journal of Iron and Steel Research(International)2010，17，10： | 7 |
| 2 | Recurrence of inflammatory pseudotumor in the distal bile duct: Lessons learned from a single case and reported cases显示文摘煽动性的 myofibroblastic 肿瘤(IMT ) 或煽动性的假肿瘤(IP ) 广泛地在文学被讨论了。他们通常在肺和上面的呼吸道被发现。然而,包含 biliopancreatic 区域的案例报导在最近的年增加了。限制到胰腺的头或远侧的胆汁管的这些损害的 Immunohistochemical 学习似乎与那些在称为自体免疫的胰腺炎的一个新实体观察了兼容,但是通常强烈的纤维变性反应(带状配列) 支配生产一个团。当这个条件限于胰腺的头时,胆总管可能被煽动性的过程包含,黄疸可以经常发生类似于胰的腺癌。我们以前报导了从与是一个极其稀罕的实体的自体免疫的胰腺炎联系的胆汁管产生的 IMT 的一个案例。在 Kaush-Whipple 切除术以后的四年,平淡的后续上的放射学的检查揭示了一个肿瘤团,建议本地复发。指导超声的 FNA 证实了我们的可疑诊断。作为其它,这个现在的案例建议坚持的后续是必要的以便在这个特定的地点阻止不可逆的肝损坏。 | EM López-Tomassetti Fernández H Díaz Luis A Martín Malagón I Arteaga González A Carrillo Pallarés | 2006 | World Journal of Gastroenterology2006，12，24： | 7 |
| 3 | Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease显示文摘AIM: To determine serum vitamin D levels and colonic vitamin D receptor(VDR) expression in inflammatory bowel disease(IBD) and non-IBD patients and correlate these with histopathology.METHODS: Puerto Rican IBD(n = 10) and non-IBD(n = 10) patients ≥ 21 years old scheduled for colonoscopy were recruited. Each patient completed a questionnaire and provided a serum sample and a colonic biopsy of normal-appearing mucosa. For IBD patients, an additional biopsy was collected from visually diseased mucosa. Serum vitamin D levels were measured by ultra-performance liquid chromatography and mass spectrometry. Hematoxylin and eosin stained tissue sections from colonic biopsies were classified histologically as normal or colitis(active/inactive), and scored for the degree of inflammation present(0-3, inactive/absent to severe). Tissue sections from colonic biopsies were also stained by immunohistochemistry for VDR, for which representative diagnostic areas were photographed and scored for staining intensity using a 4-point scale.RESULTS: The IBD cohort was significantly younger(40.40 ± 5.27, P < 0.05) than the non-IBD cohort(56.70 ± 1.64) with a higher prevalence of vitamin D deficiency(40% vs 20%, respectively) and insufficiency(70% vs 50%, respectively). Histologic inflammation was significantly higher in visually diseased mucosa from IBD patients(1.95 ± 0.25) than in normalappearing mucosa from control patients(0.25 ± 0.08, P < 0.01) and from IBD patients(0.65 ± 0.36, P < 0.05) and correlated inversely with VDR expression in visually diseased colonic tissue from IBD patients(r =-0.44, P < 0.05) and from IBD patients with Crohn's disease(r =-0.69, P < 0.05), but not in normal-appearing colonic tissue from control patients or IBD patients. Control and IBD patient serum vitamin D levels correlated positively with VDR expression in normal colon from control and IBD patients(r = 0.38, P < 0.05) and with patient age(r = 0.54, P < 0.01). CONCLUSION: Levels of serum vitamin D correlate positively with colonic VDR expression in visually normal mucosa whereas inflammation correlates negatively with colonic VDR expression in visually diseased mucosa in Puerto Rican patients. | Yamilka Abreu-Delgado Raymond A Isidro Esther A Torres Alexandra González Myrella L Cruz Angel A Isidro Carmen I González-Keelan Priscilla Medero Caroline B Appleyard | 2016 | World Journal of Gastroenterology2016，22，13： | 5 |
| 4 | FIT阳性结直肠癌筛查对象的结肠胶囊内窥镜检查与CT结肠成像检查对比:一项前瞻性随机试验--VICOCA研究显示文摘背景:结肠胶囊内窥镜检查(colon capsule endoscopy,CCE)和CT结肠成像(CT colonography,CTC)是用于结直肠癌(CRC)筛查的微创技术。我们的目的在于比较CCE和CTC在CRC筛查发现粪便免疫化学试验(faecal immunochemicaltest,FIT)阳性的受试者中识别结直肠肿瘤患者的效能。主要研究结果是CCE和CTC检出肿瘤性病变效能的比较。方法:VICOCA研究是一项于2014年3月至2016年5月进行的前瞻性、单中心随机试验。在进行结肠镜检查之前,共向662人提出检查建议,其中349人被随机分入CCE组或CTC组。内镜医师并未知晓CCE和CTC检查的结果。结果:共349人纳入分组,其中CCE组173人、CTC组176人。共290人同意参加该研究,其中CCE组147人、CTC组143人。在意向筛查分析中,CCE组检出结直肠肿瘤的敏感度、特异度、阳性预测值和阴性预测值分别为98.1%、76.6%、93.7%和92.0%,CTC组相应分别为64.9%、95.7%、96.8%和57.7%。在检出显见的肿瘤性病变方面,CCE组和CTC组的敏感度分别为96.1%和79.3%。CCE组对晚期结直肠肿瘤的检出率有相比CTC组更高的趋势(分别为100%和93.1%,RR=1.07,P=0.08)。CCE组和CTC组均识别出所有癌症患者。CCE组检出存在任一肿瘤性病变患者的比例高于CTC组(分别为98.6%和81.0%,RR=1.22,P=0.002)。结论:虽然两种技术在识别晚期结直肠肿瘤患者方面的效能相近,但CCE检出任一肿瘤性病变的敏感度更高。 | 佟伟华 GONZáLEZ-SUáREZ B PAGéS M ARAUJO I K | 2020 | 结直肠肛门外科2020，26，6： | 4 |
| 5 | Mapping aboveground biomass by integrating geospatial and forest inventory data through a k-nearest neighbor strategy in North Central Mexico显示文摘As climate change negotiations progress,monitoring biomass and carbon stocks is becoming an important part of the current forest research.Therefore,national governments are interested in developing forest-monitoring strategies using geospatial technology.Among statistical methods for mapping biomass,there is a nonparametric approach called k-nearest neighbor(kNN).We compared four variations of distance metrics of the kNN for the spatially-explicit estimation of aboveground biomass in a portion of the Mexican north border of the intertropical zone.Satellite derived,climatic,and topographic predictor variables were combined with the Mexican National Forest Inventory(NFI)data to accomplish the purpose.Performance of distance metrics applied into the kNN algorithm was evaluated using a cross validation leave-one-out technique.The results indicate that the Most Similar Neighbor(MSN)approach maximizes the correlation between predictor and response variables(r=0.9).Our results are in agreement with those reported in the literature.These findings confirm the predictive potential of the MSN approach for mapping forest variables at pixel level under the policy of Reducing Emission from Deforestation and Forest Degradation(REDD+). | Carlos A AGUIRRE-SALADO Eduardo J TREVIO-GARZA Oscar A AGUIRRE-CALDERóN Javier JIMNEZ-PREZ Marco A GONZLEZ-TAGLE José R VALDZ-LAZALDE Guillermo SNCHEZ-DíAZ Reija HAAPANEN Alejandro I AGUIRRE-SALADO Liliana MIRANDA-ARAGóN | 2014 | Journal of Arid Land2014，6，1： | 3 |
| 6 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 7 | Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. | Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 8 | Proximal migration of a Double J catheter:case report and review of the literature显示文摘 | Garrido Abad P Fernandez Arjona M Fernández González I | 2008 | Arch Esp Urol2008，61，3： | 1 |
| 9 | Frequencies of virus-specific CD4 + and CD8 + T lymphocytes secreting gamma interferon after acute natural rotavirus infection in children and adults显示文摘 | Jaimes MC Rojas OL González AM Cajiao I Charpilienne A Pothier P | 2002 | J Virol2002，76，10： | 1 |
| 10 | On-line determination of fatty acid composition in intramuscular fat of Iberian pork loin by NIRS with a remote reflectance fibre optic probe显示文摘 | González-Martín I González-Pérez C Alvarez-García N | 2005 | Meat Science2005，69，2： | 1 |
| 11 | Inflammation, complement, ischemia and amoebic survival in acute experimental amoebic liver abscesses in hamsters显示文摘 | A Olivos-Garc??a M Nequiz-Avenda?o E Tello R.D Mart??nez A González-Canto R López-Vancell M.C Garc??a de León I Montfort R Pérez-Tamayo | 2004 | Experimental and Molecular Pathology2004，，1： | 1 |
| 12 | The role of white matter damage in late onset bipolar disorder显示文摘 | Besga A Martinez M Gonz I | 2011 | Maturitas2011，70，2： | 1 |
| 13 | Near infrared reflectance spectroscopy (NIRS) technology for determination of tocopherols in animal feeds显示文摘 | González-Martín I González-Cabrera J M BustamanteRangel M | 2006 | Analytica Chimica Acta2006，558，12： | 1 |
| 14 | Clinical response to ertapenem in severe community-acquired pneumonia:a retrospective series in an elderly population显示文摘 | Murcia J M Gonz(a)lez-Comeche J Mar(i)n A | | 0，，11： | 1 |
| 15 | Evaluation of H-type zeolites in the destructive oxidation of chlorinated volatile organic compounds显示文摘 | González-Velasco J R pez-Fonseca R L Aramzabal A I | 2000 | Applied Catalysis B:Environmental2000，24，34： | 1 |
| 16 | New mixed-ligand copper (Ⅱ) complex as a model for the met-al-binding role of 2-aminomethylbenzimidazole,a chelating anchor group used in ion-exchanger polymers:Synthesis,molecular and crystal structure and properties of (2-amin-omethylbenzimidazole) (imi显示文摘 | CUEVA I S SICILIA A G GONZáLEZ J M | | 0，，： | 1 |
| 17 | Origins of product heterogeneity in the spheripol high impact polypropylene process显示文摘 | URDAMPILLETA I GONZáLEZ A IRUIN J J | 2006 | Ind Eng Chem Res2006，45，12： | 1 |
| 18 | Rapid detection of cows' milk in sheeps' and goats' milk by a species-specific polymerase chain reac- tion technique显示文摘 | LOPEZ-CALI EJA I GONZ~LEZ 1 FAJARDO V | 2004 | J Dairy Sci2004，87，9： | 1 |
| 19 | Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanopartieles ( SLN ) : high pressure homogenization versus uhrasound显示文摘 | Silva AC Gonz a lez-Mira E Garc i a ML | 2011 | Colloids Surf B : Biointerfaces2011，86，： | 1 |
| 20 | A review of current PCR-based methodologies for the authentication of meats from game animal species显示文摘 | FAJARDO V GONZ(A)LEZ I ROJAS M | 2010 | Trends in Food Science & Technology2010，21，： | 1 |
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