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| 1 | Video capsule endoscopy vs double-balloon enteroscopy in the diagnosis of small bowel bleeding:A systematic review and metaanalysis显示文摘AIM To compare the diagnostic accuracy of video capsule endoscopy(VCE) and double-balloon enteroscopy(DBE) in cases of obscure gastrointestinal bleeding(OGIB) of vascular origin.METHODS MEDLINE(via PubMed), LILACS(via BVS) and Cochrane/CENTRAL virtual databases were searched for studies dated before 2017. We identified prospective and retrospective studies, including observational, cohort, single-blinded and multicenter studies, comparing VCE and DBE for the diagnosis of OGIB, and data of all the vascular sources of bleeding were collected. All patients were subjected to the same gold standard method. Relevant data were then extracted from each included study using a standardized extraction form. We calculated study variables(sensitivity, specificity, prevalence, positive and negative predictive values and accuracy) and performed a meta-analysis using Meta-Disc software.RESULTS In the per-patient analysis, 17 studies(1477 lesions) were included. We identified3150 exams(1722 VCE and 1428 DBE) in 2043 patients and identified 2248 sources of bleeding, 1467 of which were from vascular lesions. Of these lesions, 864(58.5%) were diagnosed by VCE, and 613(41.5%) were diagnosed by DBE. The pretest probability for bleeding of vascular origin was 54.34%. The sensitivity of DBE was 84%(95%CI: 0.82-0.86; heterogeneity: 78.00%), and the specificity was92%(95%CI: 0.89-0.94; heterogeneity: 92.0%). For DBE, the positive likelihood ratio was 11.29(95%CI: 4.83-26.40; heterogeneity: 91.6%), and the negative likelihood ratio was 0.20(95%CI: 0.15-0.27; heterogeneity: 67.3%). Performing DBE after CE increased the diagnostic yield of vascular lesion by 7%, from 83% to90%.CONCLUSION The diagnostic accuracy of detecting small bowel bleeding from a vascular source is increased with the use of an isolated video capsule endoscope compared with isolated DBE. However, concomitant use increases the detection rate of the bleeding source. | Hélcio Pedrosa Brito Igor Braga Ribeiro Diogo Turiani Hourneaux de Moura Wanderley Marques Bernardo Dalton Marques Chaves Rogério Kuga Ethan Dwane Maahs Robson Kiyoshi Ishida Eduardo Turiani Hourneaux de Moura Eduardo Guimaraes Hourneaux de Moura | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，12： | 10 |
| 2 | Imaging considerations in intraductal papillary mucinous neoplasms of the pancreas显示文摘With the widespread use of cross-sectional imaging,particularly computed tomography(CT) and magnetic resonance imaging(MRI),and the continuous improvement in the image quality of these techniques,the diagnosis of incidental pancreatic cysts has increased dramatically in the last decades.While the vast majority of these cysts are not clinically relevant,a small percentage of them will evolve into an invasive malignant tumor making their management challenging.Mucinous cystic neoplasms and intraductal papillary mucinous neoplasms(IPMN) are the most common pancreatic cystic lesions with malignant potential.Imaging findings on CT and MRI correlate tightly with the presence of malignant degeneration in these neoplasms.IPMN can be classified based on their distribution as main duct,branch duct or mixed type lesions.MRI is superior to CT in demonstrating the communication of a branch duct IPMN with the main pancreatic duct(MPD).Most branch duct lesions are benign whereas tumors involving the MPD are frequently associated with malignancy.The presence of solid nodules,thick enhancing walls and/or septae,a wide(> 1 cm) connection of a side-branch lesion with the MPD and the size of the tumor > 3 cm are indicative of malignancy in a branch and mixed type IPMN.A main pancreatic duct > 6 mm,a mural nodule > 3 mm and an abnormal attenuating area in the adjacent pancreatic parenchyma on CT correlates with malignant disease in main duct and mixed type IPMN.An accurate characterization of these neoplasms by imaging is thus crucial for selecting the best management options.In this article,we review the imaging findings of IPMN including imaging predictors of malignancy and surgical resectability.We also discuss follow-up strategies for patients with surgically resected IPMN and patients with incidental pancreatic cysts. | Ivan Pedrosa Dennis Boparai | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 4 |
| 3 | Clinical relevance of aberrant polypoid nodule scar after endoscopic submucosal dissection显示文摘AIM To describe a series of patients with aberrant polypoid nodule scar developed after gastric endoscopic submucosal dissection(ESD), and to discuss its pathogenesis and clinical management. METHODS We reviewed retrospectively the endoscopic database of two academic institutions located in Brazil and Japan and searched for all patients that underwent ESD to manage gastric neoplasms from 2003 to 2015. The criteria for admission in the study were:(1) successful en bloc ESD procedure with R0 and curative resection confirmed histologically;(2) postoperative endoscopic examination with identification of a polypoid nodule scar(PNS) at ESD scar;(3) biopsies of the PNS with hyperplastic or regenerative tissue, reviewed by two independent experienced gastrointestinal pathologists, one from each Institution. Data were examined for patient demographics, Helicobacter pylori status, precise neoplastic lesion location in the stomach, tumor size, histopathological assessment of the ESD specimen, and postoperative information including medical management, endoscopic and histological findings, and clinical outcome.RESULTS A total of 14 patients(10 men/4 women) fulfilled the inclusion criteria and were enrolled in this study. One center contributed with 8 cases out of 60 patients(13.3%) from 2008 to 2015. The second center contributed with 6 cases(1.7%) out of 343 patients from 2003 to 2015. Postoperative endoscopic follow-up revealed similar findings in all patients: A protruded polypoid appearing nodule situated in the center of the ESD scar surrounded by convergence of folds. Biopsies samples were taken from PNS, and histological assessment revealed in all cases regenerative and hyperplastic tissue, without recurrent tumor or dysplasia. Primary neoplastic lesions were located in the antrum in 13 patients and in the angle in one patient. PNS did not develop in any patient after ESD undertaken for tumors located in the corpus, fundus or cardia. All patients have been followed systematically on an annual basis and no malignant recurrence in the ESD scar has been identified(mean follow-up period: 45 mo).CONCLUSION PNS may occur after ESD for antral lesions and endoscopically look concerning, especially for the patient or the family doctor. However, as long as curative R0 resection was successfully achieved and histology demonstrates only regenerative and hyperplastic tissue, PNS should be viewed as a benign alteration that does not require any type of intervention, other than endoscopic surveillance. | Vitor Arantes Noriya Uedo Moises Salgado Pedrosa Yasuhiko Tomita | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 4 |
| 4 | Colonic duplication in an adult mimicking a tumor of pancreas显示文摘Duplications of the alimentary tract are uncommon congenital malformations that can present diagnostic difficulties. We report a rare case of a cystic colonic duplication in a female adult. Preoperative investigations were suggestive of pancreatic tumor. The diagnosis was established based on the histopathological examination of the resected specimen. We concluded that, though uncommon, intestinal duplication should be considered in differential diagnosis of abdominal mass. | Fabiana Pirani Carneiro Maria de Nazareth Sobreira Ana Emília B de Azevedo Andréa Pedrosa Ribeiro Alves Karina Martins Campos | 2008 | World Journal of Gastroenterology2008，14，6： | 3 |
| 5 | Automatic Detection of COVID-19 Infection Using Chest X-Ray Images Through Transfer Learning显示文摘The new coronavirus(COVID-19),declared by the World Health Organization as a pandemic,has infected more than 1 million people and killed more than 50 thousand.An infection caused by COVID-19 can develop into pneumonia,which can be detected by a chest X-ray exam and should be treated appropriately.In this work,we propose an automatic detection method for COVID-19 infection based on chest X-ray images.The datasets constructed for this study are composed of194 X-ray images of patients diagnosed with coronavirus and 194 X-ray images of healthy patients.Since few images of patients with COVID-19 are publicly available,we apply the concept of transfer learning for this task.We use different architectures of convolutional neural networks(CNNs)trained on Image Net,and adapt them to behave as feature extractors for the X-ray images.Then,the CNNs are combined with consolidated machine learning methods,such as k-Nearest Neighbor,Bayes,Random Forest,multilayer perceptron(MLP),and support vector machine(SVM).The results show that,for one of the datasets,the extractor-classifier pair with the best performance is the Mobile Net architecture with the SVM classifier using a linear kernel,which achieves an accuracy and an F1-score of 98.5%.For the other dataset,the best pair is Dense Net201 with MLP,achieving an accuracy and an F1-score of 95.6%.Thus,the proposed approach demonstrates efficiency in detecting COVID-19 in X-ray images. | Elene Firmeza Ohata Gabriel Maia Bezerra João Victor Souza das Chagas Aloísio Vieira Lira Neto Adriano Bessa Albuquerque Victor Hugo Cde Albuquerque Pedro Pedrosa Rebouças Filho | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，1： | 3 |
| 6 | 霉菌毒素的实际作用并不按数学公式来表现显示文摘单个霉菌毒素的影响在文献中已有了很好的捕述,但各种不同霉菌毒素的复合物又会产生怎样的作用呢?通常,会引发群体生产性能低下和/或疾病的单个霉菌毒素,其在在商业性养殖场中所表现出的作用常常低于所报道的在可控试验研究中所见到的毒性作用。 | 陈琳 Katia Pedrosa | 2012 | 国外畜牧学(猪与禽)2012，，2： | 3 |
| 7 | GI endoscopes显示文摘 | Shyam Varadarajulu Subhas Banerjee Bradley A. Barth David J. Desilets Vivek Kaul Sripathi R. Kethu Marcos C. Pedrosa Patrick R. Pfau Jeffrey L. Tokar Amy Wang Louis-Michel Wong Kee Song Sarah A. Rodriguez | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
| 8 | Endocytoscopy显示文摘 | Richard S. Kwon Louis-Michel Wong Kee Song Douglas G. Adler Jason D. Conway David L. Diehl Francis A. Farraye Sergey V. Kantsevoy Vivek Kaul Sripathi R. Kethu Petar Mamula Marcos C. Pedrosa Sarah A. Rodriguez William M. Tierney | 2009 | Gastrointestinal Endoscopy2009，，4： | 2 |
| 9 | Therapeutic potential of Lovastatin in mulliple sclerosis显示文摘 | Sena A pedrosa R Grace Morais M | 2005 | J Neurol2005，250，6： | 1 |
| 10 | A structured product development perspective for service operations显示文摘 | BITRAN G PEDROSA L | 1998 | European Management Journal1998，16，2： | 1 |
| 11 | Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity : a randomized double - blind controlled trial 显示文摘 | MOREIRA -PFRIMER L D PEDROSA M A TEIXEIRA L | 2009 | Ann Natr Metab2009，54，4： | 1 |
| 12 | Central- to- peripheral fat ratio, but not peripheral body fat, is related to insulin resistance and androgen markers in polycystic ovary syndrome显示文摘 | Godoy- Matos AF Vaisman F Pedrosa AP | 2009 | Gynecol Endocrinol2009，25，12： | 1 |
| 13 | Biventricular pacing improve clinical behavior and reduces prevalence of ventricular arrythymia in patients with heart failure显示文摘 | Martinelli FM Pedrosa AA Cosa R | 2002 | Arq Bras Cardiol2002，78，1： | 1 |
| 14 | Gialpha3 pro- tein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular ceils is a PLC-PKC-mediated event 显示文摘 | PEDROSA R GOMES P HOPFER U | 2004 | Am J Physiol Renal Physiol2004，287，5： | 1 |
| 15 | Pressure Transient Response in Stress-Sen- sitive Formations显示文摘 | Pedrosa O A Jr | 1986 | Paper SPE 151151986，，： | 1 |
| 16 | Copy number variation in chemokine super family: The complex scene of CCL3L-CCL4L genes in health and disease 显示文摘 | Colobran R Pedrosa E Carretero-lglesia L | 2010 | Clin Exp lmmunol2010，162，1： | 1 |
| 17 | Obstructive sleep apnea:the most common secondary cause of hypertension associated with resistant hypertension显示文摘 | Pedrosa R P Drager L F Gonzaga C C | | 0，，05： | 1 |
| 18 | MR classification of renal masses with pathologic correlation显示文摘 | Ivan Pedrosa Mary T. Chou Long Ngo Ronaldo H. Baroni Elizabeth M. Genega Laura Galaburda William C. DeWolf Neil M. Rofsky | 2008 | European Radiology2008，，： | 1 |
| 19 | Myocardial effects of ETB receptor stimulation 显示文摘 | Leite-Moreira AF Bras-Silva C Pedrosa C | 2002 | Rev Port Cardiol2002，21，9： | 1 |
| 20 | Master Planning in Brazilian Higher Education: Expanding the 3-Year Public College System in the State of Sao Paulo显示文摘 | PEDROSA R H L | 2010 | Research & Occasional Paper Series: CSHE2010，，10： | 1 |
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