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| 1 | Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke显示文摘Introduction: Increased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored. Methods: We retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (MRS) 30- 365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to MRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score. Results: 110 patients met the inclusion criteria. The likelihood of a 1-point rise in the MRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels. Conclusions: These results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV. | Adam de Havenon Alicia Bennett Gregory J Stoddard Gordon Smith Lee Chung Steve O’Donnell J Scott McNally David Tirschwell Jennifer J Majersik | 2017 | Stroke & Vascular Neurology2017，2，1： | 6 |
| 2 | Liver Environment and HCV Replication Affect Human T-Cell Phenotype and Expression of Inhibitory Receptors显示文摘 | Daniela C. Kroy Donatella Ciuffreda Jennifer H. Cooperrider Michelle Tomlinson Garrett D. Hauck Jasneet Aneja Christoph Berger David Wolski Mary Carrington E. John Wherry Raymond T. Chung Kenneth K. Tanabe Nahel Elias Gordon J. Freeman Rosemarie H. de Kru | 2014 | Gastroenterology2014，，2： | 2 |
| 3 | Using genetic algorithms for concept learning显示文摘 | DE JONG K A SPEARS W M GORDON F D | 1993 | Machine Learning1993，13，： | 1 |
| 4 | UVB light regulates expression ofantioxidants and inf]arl+rnatory mediators in human corneal epithelial cells显示文摘 | Black AT Gordon M K Heck DE el al | 2011 | Bioehem Pharmacol2011，81，： | 1 |
| 5 | A Phase I trial of a potent P-glycoprotein inhibitor, zosuquidar trihydrochloride ( LY335979 ) , administ-ered intravenously in combination with doxorubicin in patients with advanced malignancy 显示文摘 | Sandier A Gordon M De Alwis DP | 2004 | Clin Cancer Res2004，10，10： | 1 |
| 6 | UVB light regulates expression of antioxidants and inflammatory mediators in human corneal epithelial cells显示文摘 | Black AT Gordon MK Heck DE Gallo MA Laskin DL Laskin JD | | 0，，07： | 1 |
| 7 | Migration intentions and behavior:decision making in a rural philippine province显示文摘 | Gordon F De Jong Brenda Davis Root | 1985 | Population and environment1985，8，12： | 1 |
| 8 | Techniques and Training with GreenLight HPS 120-W Laser Therapy of the Prostate: Position Paper显示文摘 | Gordon Muir Fernando Gómez Sancha Alexander Bachmann Benjamin Choi Edward Collins Jean de la Rosette Oliver Reich Shahin Tabatabaei Henry Woo | 2007 | European Urology Supplements2007，，： | 1 |
| 9 | A Phase I trial of a po2tent P2glycop rotein inhibitor, zosuquidar trihydrochloride (LY335979), administered intravenously in combination with doxo mbicin in patientswith advanced malignancy 显示文摘 | Sandier A Gordon M De Alwis DP | 2004 | C/in Cancer Res2004，10，10： | 1 |
| 10 | Degradation of microcystin toxins in a falling film photocata- lytic reaction with immobilized titanium dioxide catalyst显示文摘 | Shephard Gordon S Stockkenstrom Sonja Villiers David de | 2002 | Water Research2002，36，1： | 1 |
| 11 | Imaging in cystic renal disease显示文摘 | de Bruyn R Gordon I | 2000 | Arch Dis Child2000，83，5： | 1 |
| 12 | Association of Novel Genetic Loci With Circulating Fibrinogen Levels: A Genome-Wide Association Study in 6 Population-Based Cohorts显示文摘 | Abbas Dehghan Qiong Yang Annette Peters Saonli Basu Joshua C. Bis Alicja R. Rudnicka Maryam Kavousi Ming-Huei Chen Jens Baumert Gordon D.O. Lowe Barbara McKnight Weihong Tang Moniek de Maat Martin G. Larson Susana Eyhermendy Wendy L. McArdle Thomas Lumley | 2009 | Circulation: Cardiovascular Genetics2009，，2： | 1 |
| 13 | A Phase I trial of a potent P-glycop rotein inhibitor, zosuquidar trihydrochloride (LY335979), administered intravenously in combination with doxoruhicin in patientswith advanced malignancy显示文摘 | SandlerA Gordon M De Alwis D P | 2004 | Clin Cancer Res2004，10，10： | 1 |
| 14 | UpweUing and river runoff as sources of dissolved nitrous oxide to the Alsea estuary, Oregon 显示文摘 | De Angelis M A Gordon L I | 1985 | Estuar Coast Shelf Sei1985，20，4： | 1 |
| 15 | Imaging in cystic renal disease显示文摘 | de Bruyn R Gordon Ⅰ | 2000 | Arch Dis Child2000，83，5： | 1 |
| 16 | Concerns of patients with inflammatory bowel disease: results from a clinical population显示文摘 | Elizabeth C de Rooy Brenda B Toner Robert G Maunder Gordon R Greenberg David Baron A.Hillary Steinhart Robin McLeod Zane Cohen | 2001 | The American Journal of Gastroenterology2001，，： | 1 |
| 17 | Differential cataractogenic potency of TGF-beta 1,beta 2,beta 3 and their expression in the postnatal rat eye显示文摘 | Gordon Thomson C De Jorgh RU Hales AM | 1998 | Invest Ophthalmol Vis Sci1998，39，8： | 1 |
| 18 | Dysphagia in Acute Stroke 显示文摘 | Ca Gordon Ri Langton hewer De T Wade | 1987 | British Medical Journal1987，295，15： | 1 |
| 19 | Comparative evaluation of no dye assistance,indocyanine green and triamcinolone acetonide for internal limiting membrane peeling during macular hole surgery显示文摘 | Tsipursky MS Heller MA De Souza SA Gordon A J Bryan JS Ziemianski MC | | 0，，06： | 1 |
| 20 | Toward Motivation- al Theory of Migration Decision Making显示文摘 | Ralph R Sell Gordon F De Jong | 1978 | Journal of Population1978，1，4： | 1 |
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