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| 1 | 室外风环境视角下的高层住宅项目规划指标研究(英文)显示文摘目的:确定建筑容积率、建筑密度和建筑层数之间的关系,并将其作为主要的规划指标,研究其对室外风环境的影响。创新点:在以高层、高密度为特点的城市建设中,一个地块的用地规划指标可直接影响居住区的室外物理环境质量。一个高层建筑群的规划设计不应该只关注建筑物,还应考虑室外物理环境的品质。本研究从室外风环境角度出发,对13种"容积率-建筑密度-建筑层数"指标组合形成的高层建筑群布局进行对比,从而得到可直接服务于城市建设项目的规划策略。方法:1.通过确定建筑容积率、建筑密度和建筑层数之间的关系,建立三维高层建筑群布局模型,列出19种可能的指标组合(图2);2.通过日照模拟分析工具Tarch和建筑消防间距计算筛选出13种符合当前规划要求的指标组合;3.运用风环境模拟软件Phoenics,对13种指标组合形成的高层建筑群布局进行风环境模拟运算;利用图形分析软件Photoshop CS,计算出舒适风面积比值,并进行相互对比(图3和4);4.根据土建造价对不同建筑群布局的总造价进行对比(图6)。结论:在规划设计中,通常认为较低的容积率和较低的建筑高度意味着建筑体量较小,室外物理环境会更好。但是,本研究发现建筑层数越多、建筑高度越高,行人高度的室外舒适风区面积越大。不过,建筑层数从25层升到30层,舒适风区面积增加有限。加之考虑层数越高导致造价越高的因素,当面对容积率为2.0~4.0的高层地块时,不能简单地认为建筑层数最高的规划方案就是最好的方案。 | Xiao-yu YING Grace DING Xiao-jun HU Yin-qi ZHANG | 2016 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2016，17，5： | 5 |
| 2 | Targeted hepatitis C screening among ex‐injection drug users in the community显示文摘 | Vincent Wai‐Sun Wong Grace Lai‐Hung Wong Angel Mei‐Ling Chim Tsz‐Fai Cheng Shirley Wing‐Yan Cheung Carol Man‐Sze Lai Kylie Joan‐Yi Szeto Sharon Tsang Stephen Ho‐Chun Wu Kenneth Kar‐Lung Yan Alex Yui Hui Desmond Chi‐Him Yiu Brian Bing‐Ying Wu David Cheung | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 3 | Customer Confusion: The Mobile Phone Market 显示文摘 | Turnbull Peter W Sheena Leek Grace Ying | 2000 | Journal of Marketing Management2000，16，14： | 1 |
| 4 | Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds显示文摘The serum and glucocorticoid-regulated kinase (SGK) family has been implicated in the regulation of many cellular processes downstream of the PI3K pathway. It plays a crucial role in PI3K-mediated tumorigenesis, making it a potential therapeutic target for cancer. SGK family consists of three isoforms (SGK1, SGK2, and SGK3), which have high sequence homology in the kinase domain and similar substrate speci?city with the AKT family. In order to identify novel compounds capable of inhibiting SGK3 activity, a high-throughput screening campaign against 50,400 small molecules was conducted using a fuorescence-based kinase assay that has a Z' factor above 0.5. It identiifed 15 hits (including nitrogen-containing aromatic, favone, hydrazone, and naphthalene derivatives) with IC50 values in the low micromolar to sub-micromolar range. Four compounds with a similar scaffold (i.e., a hydrazone core) were selected for structural modi?cation and 18 derivatives were synthesized. Molecular modeling was then used to investigate the structure-activity relationship (SAR) and potential protein–ligand interactions. As a result, a series of SGK inhibitors that are active against both SGK1 and SGK3 were developed and important functional groups that control their inhibitory activity identified. | Grace Qun Gong Ke Wang Xin-Chuan Dai Yan Zhou Rajesh Basnet Yi Chen De-Hua Yang Woo-Jeong Lee Christina Maree Buchanan Jack Urquhart Flanagan Peter Robin Shepherd Ying Chen Ming-Wei Wang | 2018 | Acta Pharmacologica Sinica2018，39，12： | 1 |
| 5 | 神经胶质细胞炎症反应的RNA调控及其作为中枢神经系统疾病治疗靶点的潜力显示文摘神经炎症的一个主要标志是小胶质细胞和星形胶质细胞的激活以及炎症介质(如IL-1β、TNF-α、iNOS和IL-6)的诱导。神经炎症会导致从急性中枢神经系统创伤到慢性神经退行性疾病等多种神经系统疾病的进展。mRNA稳定性的转录后调控途径和翻译效率是这些炎症介质表达的主要驱动因素。这一调节水平的一个共同元素以富含腺嘌呤和尿苷的元素(ARE)为中心,该元素存在于编码这些炎症介质的mRNA的3’非翻译区(UTR)中。(ARE)-结合蛋白(AUBPs)——如人类抗原R(HuR)、三四脯氨酸(TTP)和KH型剪接调节蛋白(KSRP)——是指导这些转录后通路的关键节点,可以促进(HuR)或抑制(TTP和KSRP)胶质细胞产生炎症介质。本综述将讨论ARE介导的RNA调节的基本概念及其对胶质细胞驱动的神经炎症性疾病的影响。还将讨论针对这种新的基因调控水平以达到治疗效果的策略,并对其治疗神经系统疾病潜力的初步研究进行回顾性分析。 | Abhishek Guha Mohammed Amir Husain Ying Si L Burt Nabors Natalia Filippova Grace Promer Reed Smith Peter H King 杜一星(编译) | 2023 | 神经损伤与功能重建2023，18，2： | 0 |
| 6 | Dispersion of Titanium(Ⅳ) Oxide Nanoparticles in Mixed Matrix Membrane Using Octaisobutyl Polyhedral Oligomeric Silsesquioxane for Enhanced CO2/CH4 Separation Performance显示文摘Titanium(IV) oxide (TiO2) nanoparticles have been incorporated into mixed matrix membranes (MMMs) to improve gas separation performance. However, TiO2 nanoparticles tend to agglomerate due to high surface energy and van der Waals forces. This leads to precipitation which causes the formation of non-homogeneous MMM morphology. In this study, the effect of octaisobutyl polyhedral oligomeric silsesquioxane (POSS) addition on TiO2/polysulfone MMM was investigated. The aims are to enhance gas separation performance whilst preventing agglomeration of TiO2 nanoparticles. The results demonstrated that inclusion of POSS as dispersant increases MMMs’ CO2/CH4 selectivity and permeance, possibly due to less void formation and more evenly distributed pore structure. For example, synergistic addition of 5 wt% TiO2 and 5 wt% POSS increased the CO2/CH4 selectivity up to 390% compared to MMM without POSS. This is supported by elemental mapping of titanium which revealed that POSS successfully dispersed TiO2 nanoparticles and prevented aggregation. TiO2-POSS/PSf MMMs also retained their favorable thermal stability. | Grace Ying En Tan Pei Ching Oh Kok Keong Lau Siew Chun Low | 2019 | Chinese Journal of Polymer Science2019，37，7： | 0 |
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