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| 1 | The role of KATP channels in cerebral ischemicstroke and diabetes显示文摘ATP 敏感的钾(K ATP ) 隧道无所不在地在多重机关在房间的血浆膜上被表示包括心,胰和大脑。K ATP 隧道在响应新陈代谢的状态控制并且调整细胞的功能起重要作用,它被 ATP 禁止并且由 Mg 自动数据处理激活,允许房间联合细胞的新陈代谢的状态(ATP/ADP 比率) 到房间膜的电的活动。K ATP 隧道调停在胰腺的小岛贝它房间的胰岛素分泌物,和控制脉管的音调。在 pathophysiological 条件下面, K ATP 隧道在局部缺血或组织缺氧期间在心脏的 myocytes 和神经原起 cytoprotective 作用。K ATP 隧道是 hetero-octameric 建筑群,由四形成毛孔的 Kir6.x 和四规章的 sulfonylurea 受体 SURx 组成子单元。这些子单元是在各种各样的房间类型表示的差别,因此决定房间的敏感到特定的隧道修饰词。antidiabetic 药的 Sulfonylurea 班堵住 K ATP 隧道,是在击的 neuroprotective,能是高度之一司烧为糖尿病的病人的风险因素。在这评论,我们讨论了 K ATP 隧道 blockers 当在与糖尿病患者和服的 ischemic 击有关的病理学的条件下面使用了时。 | Vivian SZETO Nai-hong CHEN Hong-shuo SUN Zhong-ping FENG | 2018 | Acta Pharmacologica Sinica2018，39，5： | 13 |
| 2 | Boceprevir,GC-376,and calpain inhibitors Ⅱ,Ⅻ inhibit SARS-CoV-2 viral replication by targeting the viral main protease显示文摘A new coronavirus SARS-CoV-2,also called novel coronavirus 2019(2019-nCoV),started to circulate among humans around December 2019,and it is now widespread as a global pandemic.The disease caused by SARS-CoV-2 virus is called COVID-19,which is highly contagious and has an overall mortality rate of 6.35%as of May 26,2020.There is no vaccine or antiviral available for SARS-CoV-2.In this study,we report our discovery of inhibitors targeting the SARS-CoV-2 main protease(Mpro).Using the FRET-based enzymatic assay,several inhibitors including boceprevir,GC-376,and calpain inhibitorsⅡ,andⅫwere identified to have potent activity with single-digit to submicromolar ICs0 values in the enzymatic assay.The mechanism of action of the hits was further characterized using enzyme kinetic studies,thermal shift binding assays,and native mass spectrometry.Significantly,four compounds(boceprevir,GC-376,calpain inhibitorsⅡandⅫ)inhibit SARS-CoV-2 viral replication in cell culture with EC50 values ranging from 0.49 to 3.37μM.Notably,boceprevir,calpain inhibitorsⅡandⅫrepresent novel chemotypes that are distinct from known substrate-based peptidomimetic Mpro inhibitors.A complex crystal structure of SARS-CoV-2 Mpro with GC-376,determined at 2.15(A)resolution with three protomers per asymmetric unit,revealed two unique binding configurations,shedding light on the molecular interactions and protein conformational flexibility underlying substrate and inhibitor binding by Mpro.Overall,the compounds identified herein provide promising starting points for the further development of SARS-CoV-2 therapeutics. | Chunlong Ma Michael Dominic Sacco Brett Hurst Julia Alma Townsend Yanmei Hu Tommy Szeto Xiujun Zhang Bart Tarbet Michael Thomas Marty Yu Chen Jun Wang | 2020 | Cell Research2020，30，8： | 13 |
| 3 | Pharmacological approaches promoting stem cell- based therapy following ischemic stroke insults显示文摘击能导致长期的神经病学的赤字。成年神经发生,在在整个生活的大脑的不同区域的新生的神经原的连续产生,被看作了 appoaches 之一恢复神经病学的功能追随者 ischemic 击。然而,导致局部缺血的自发的神经发生不是 suffcient,这样基于房间的治疗,包括的灌输的外长的干细胞或帮助受伤大脑的修理的刺激内长的干细胞,在众多的动物实验被学习了,一些驾驶临床的试用。当时神经病学的功能上的基于房间的治疗的效果在在使随机化的控制试用未经证实的恢复遗体期间,药理学代理人被管理了帮助基于房间的治疗。在这评论,我们总结了导致局部缺血的神经发生和干细胞的限制移植,以及可以提高基于房间的治疗的功效的药的潜在的 proneuroregenerative 效果。明确地,我们讨论了提高增长,移植,区别,幸存和新生的神经原的功能连接的药,它可以恢复 neurobehavioral 功能并且在击病人改进结果。 | Shu-zhen ZHU Vivian SZETO Mei-hua BAO Hong-shuo SUN Zhong-ping FENG | 2018 | Acta Pharmacologica Sinica2018，39，5： | 8 |
| 4 | Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes显示文摘Background:To test clinically relevant factors associated with quantitative artifact-free deep capillary plexus(DCP)metrics in patients with diabetes mellitus(DM).Methods:563 eligible eyes(221 with no diabetic retinopathy[DR],135 with mild DR,130 with moderate DR,and 77 with severe DR)from 334 subjects underwent optical coherence tomography-angiography(OCT-A)with a swept-source OCT(Triton DRI-OCT,Topcon,Inc.,Tokyo,Japan).Strict criteria were applied to exclude from analysis those DCP images with artifacts and of poor quality,including projection artifacts,motion artifacts,blurriness,signal loss,B-scan segmentation error,or low-quality score.A customized MATLAB program was then used to quantify DCP morphology from the artifact-free DCP images by calculating three metrics:foveal avascular zone(FAZ),vessel density(VD),and fractal dimension(FD).Results:166(29.5%)eyes were excluded after quality control,leaving in the analysis 397 eyes(170 with no DR,101 with mild DR,90 with moderate DR,36 with severe DR)from 250 subjects.In the multiple regression models,larger FAZ area was associated with more severe DR(β=0.687;p=0.037),shorter axial length(AL)(β=−0.171;p=0.003),thinner subfoveal choroid thickness(β=−0.122;p=0.031),and lower body mass index(BMI)(β=−0.090;p=0.047).Lower VD was associated with more severe DR(β=−0.842;p=0.001),shorter AL(β=0.107;p=0.039),and poorer visual acuity(VA)(β=−0.133;p=0.021).Lower FD was associated with more severe DR(β=−0.891;p<0.001)and with older age(β=−0.142;p=0.004).Conclusions:Quantitative artifact-free DCP metrics are associated with VA,DR severity,AL,subfoveal choroidal thickness,age,and BMI in diabetic patients.The effects of ocular and systemic factors should be considered for meaningful interpretations of DCP changes in DM patients. | Fang Yao Tang Erica O.Chan Zihan Sun Raymond Wong Jerry Lok Simon Szeto Jason C.Chan Alexander Lam Clement C.Tham Danny S.Ng Carol Y.Cheung | 2020 | Eye and Vision2020，7，1： | 7 |
| 5 | Minimally Invasive Approach Provides at Least Equivalent Results for Surgical Correction of Mitral Regurgitation: A Propensity Matched Comparison显示文摘 | Andrew B. Goldstone Pavan Atluri Wilson Y. Szeto Alen Trubelja Jessica L. Howard John W. MacArthur Craig Newcomb Joseph P. Donnelly Dale M. Kobrin Mary A. Sheridan Christiana Powers Robert C. Gorman Joseph H. Gorman Alberto Pochettino Joseph E. Bavaria Mi | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，： | 2 |
| 6 | Metabolic acidosis and malnutrition in dialysis patients.显示文摘 | Szeto CC Chow KM | | 0，，： | 2 |
| 7 | Advance in the clinical laboratory assessment of urinary sediment显示文摘 | Chan RW Szeto CC | 2004 | Clin Chim Acta2004，340，12： | 1 |
| 8 | Levamisole induces interleukin-18 and shifts type 1/type 2 cytokine balance显示文摘 | Szeto C Gillespie KM Mathieson PW | 2000 | Immunology2000，100，： | 1 |
| 9 | Transportation network improvement and tolling strategies: the issue of intergeneration equity 显示文摘 | Szeto W Y Lo H K | 2006 | Transportation Research Part A2006，40，3： | 1 |
| 10 | Hypokalemia in Chinese peritoneal diaysis patients:prevalence and prognostic implication 显示文摘 | Szeto C C Show K M Kwan B C | 2005 | Am J Kidney Dis2005，46，1： | 1 |
| 11 | Oral sodium bicarbonate for the treatment of metabolic acidosis in peritoneal dialysis patients: a randomized placebo-control trial 显示文摘 | Szeto CC Wong TY Chow KM | 2003 | J Am Soc Nephrol2003，14，8： | 1 |
| 12 | Advances in the clinical laboratory asvsess-ment of urinary sediment显示文摘 | Chan RW Szeto CC | 2004 | Clin Chim Acta2004，340，1： | 1 |
| 13 | Plant structured textile fabrics 显示文摘 | SARKAR M FAN J T SZETO Y C | 2007 | Materials Letters2007，61，： | 1 |
| 14 | International Society for Peritoneal D:Peritoneal dialysis-related infections recommendations:2010 update显示文摘 | Li PK Szeto CC Piraino B | 2010 | Perit Dial Int2010，30，4： | 1 |
| 15 | Normal kinematics of the neck :the in- terplay between the cervical and thoracic spines显示文摘 | Tsang SM Szeto GP Lee RY | 2013 | Man Ther2013，18，5： | 1 |
| 16 | Introducing a music programme to reduce preoperative anxiety 显示文摘 | | 1999 | Br J Theatre Nurs1999，9，10： | 1 |
| 17 | The mesoscale dy namics of freezing rain storms over eastern Canada显示文摘 | Szeto K K Tremblay A Guan H | 1999 | J At mos Sci1999，56，10： | 1 |
| 18 | Liquid-based cytology and conventional cervical smears:a comparison study in an Asian screening population显示文摘 | Cheung AN Szeto EF Leung BS | 2003 | Cancer2003，99，33： | 1 |
| 19 | A risk analysis ofcontinuous ambulatory peritoneal dialysis-related peritonitis显示文摘 | Chow KM Szeto CC Leung CB | 2005 | Perit Dial Int2005，25，4： | 1 |
| 20 | Importance of dialysis ad- equacy in mortality and morbidity of chinese CAPD patients 显示文摘 | Szeto CC Wong TY Leung CB | 2000 | Kidney Int2000，58，1： | 1 |
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