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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | Network-based ap- proach to modeling uncertainty in a supply chain显示文摘 | BLACKHURST J WU T GRADY P | 2004 | Interna- tional Journal of Production Research2004，42，8： | 1 |
| 3 | A statistical analysis of the effect of electric vehicle battery charging on distribution system harmonic voltages显示文摘 | Staats P T Grady W M Arapostathis A | 1998 | IEEE Trans on Power Delivery1998，13，2： | 1 |
| 4 | Reviews:Hormone replace ment the rapy and endometrial cancer risk:A meta-analysis显示文摘 | Grady D Gebretsadik T Kerlikowske K | 1995 | Obstet Gyneclo1995，85，2： | 1 |
| 5 | Hormone replacement therapy and endometrial cancer risk:a meta- analysis显示文摘 | Grady D Gebretsadik T Kerlikowske K | 1995 | Obstet Gynecol1995，85，： | 1 |
| 6 | Random walks for interactive organ segmentation in two and three dimensions:Implementation and validation显示文摘 | Grady L Schiwietz T Aharon S | | 0，，2： | 1 |
| 7 | Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis 显示文摘 | Grady T Liang P Ernst SA | 1997 | Gastroenterology1997，113，6： | 1 |
| 8 | Aspects of the phylogeny of the Trematoda Rudolphi, 1808 ( Platyhelminthes : Cercomeria) 显示文摘 | Brooks D R Bandoni S M Grady R T | 1989 | Can J Zool1989，67，： | 1 |
| 9 | Hormone replacement therapy and endometrial cancer risk:a meta-analysis显示文摘 | GRADY D GEBRETSADIK T KERLIKOWSKE K | 1995 | Obstetrics&Gynecology1995，85，2： | 1 |
| 10 | Network based approach to modeling uncertainty in a supply chain显示文摘 | Blackhurst J Wu T O'Grady P | 2004 | International Journal of Production Research2004，42，8： | 1 |
| 11 | Partnership economics nursing's challenge in a quantum age显示文摘 | Malloch K Porter O Grady T | 1999 | Nurs Econ1999，17，6： | 1 |
| 12 | Effects of pH on the rates of aerobic metabolism of phospho- rus-accumulating and glycogen-accumulating organ- isms显示文摘 | FILIPE C D M DAIGGER G T GRADY C P L | 2001 | Water Environment Research2001，73，： | 1 |
| 13 | Development andpreliminary validation of a real-time RT-PCR based method targetingtmRNA for the rapid and specific detection of Salmonella显示文摘 | McGUINNESS S BARRY T O GRADY J | 2012 | FoodResearch International2012，45，2： | 1 |
| 14 | Stoichiometry and kinetics of acetate uptake under anaerobic conditions by an enriched culture of phosphorus-accumulating organisms at different pHs显示文摘 | FILIPE C D M DAIGGER G T GRADY C P L | 2001 | Biotechnology Bioengineering2001，76，1： | 1 |
| 15 | Rmadonftzed trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women显示文摘 | HULLEY S GRADY D BUSH T | 1998 | JAMA1998，280，： | 1 |
| 16 | Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis显示文摘 | GRADY T LIANG P ERNST SA | 1997 | Gastroenterology1997，113，6： | 1 |
| 17 | Aripiprazole显示文摘 | GRADY M A GASPERONI T L KIRKPATRICK P | 2003 | Nat Rev Drug Discov2003，2，6： | 1 |
| 18 | Heart and Estro?gen/ progestin Replacement Study ( HERS): design, meth?ods, and baseline characteristics显示文摘 | Grady D Applegate W Bush T | 1998 | Control Clin Trials1998，19，4： | 1 |
| 19 | Viral upper respiratory tract infection and otitis media complication in young childred显示文摘 | Chonmaitree T Revai K Grady JJ | 2008 | Clin Infect Dis2008，46，6： | 1 |
| 20 | A statistical method for predicting the net harmonic currents generated by a concentration of electric vehicle battery chargers显示文摘 | Staats P T Grady W M Arapostathis A | 1997 | IEEE Trans on Power Delivery1997，12，3： | 1 |
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