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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | Effects of temperature on aggregate local structure in a zinc-neutralized carboxylate ionomer 显示文摘 | FARRELL K V GRADY B P | 2000 | Macromolecules2000，33，19： | 1 |
| 3 | Isolation and characterization of genes encoding two chitinase enzymes from Serratia marcescens显示文摘 | Jones J D G Grady K L Suslow T V | 1986 | the EMBO Journal1986，5，： | 1 |
| 4 | Effect of a brown seaweed (Laminaria digitata)extract containing laminarin and fucoidan on the quality and shelf-life of fresh and cooked minced pork patties 显示文摘 | Moroney N C O'Grady M N O'Doherty J V | 2013 | Meat Science2013，94，3： | 1 |
| 5 | Key lessons learned in achie- ving widespread inspection use 显示文摘 | GRADY R B SLACK T V | 1994 | IEEE Software1994，7，： | 1 |
| 6 | Evaluation of the effects of selected phytochemicals on quality indices and sensorial properties of raw and cooked pork stored in different packaging systems 显示文摘 | Hayes J E Stepanyan V O'Grady M N | 2010 | Meat Science2010，85，2： | 1 |
| 7 | Heat transfer in high volume fraction CNT nano- composites:Effects of inter-nanotuhe thermal resist- ance 显示文摘 | BUI K GRADY B P PAPAVASSILIOU D V | 2011 | Chem Phys Lett2011，508，： | 1 |
| 8 | Assessment of recent process analytical technology (PAT) trends: a multiauthor review显示文摘 | Simon L L Pataki H Marosi G Meemken F Hungerbiihler K Baiker A Tummala S Glennon B Kuentz M Steele G Kramer H J M Rydzak J W Chen Z Morris J Kjell F Singh R Gani R Gernaey K V Louhi-Kultanen M O'Reilly J Sandler N Antikainen 0 Yliruusi J Frohberg P Ulrich J Braatz R D Leyssens T von Stosch M Oliveira R Tan R B H Wu H Khan M O'Grady D Pandey A Westra R Delle-Case E Pape D Angelosante D Maret Y Steiger 0 Lenner M Abbou-Oucherif'K Nagy Z K Litster J D Kamaraju V K Chiu M-S | 2015 | Organic Process Research & Development2015，19，1： | 1 |
| 9 | A customizable commercial miniaturized 320 N 256 indium gallium ar- senide short wave infrared camera显示文摘 | S Huang M O'Grady J V Groppe | 2004 | Infrared Sys- tems and Photoelectronic Technology2004，5563，2： | 1 |
| 10 | Environmen- tal Change, Extinction and Human Activity= Evidence from Caves in NW Madagascar显示文摘 | Burney D A James H F Grady F V | 1997 | Journal of Biogeogra- phy1997，24，6： | 1 |
| 11 | Removal of 17α-ethinylestradiol by Rhodococcus species显示文摘 | O'Grady aqueous D Evangelista S Yargeau V | 2009 | Environmental Engineering Science2009，26，9： | 1 |
| 12 | Eukaryotic initia- tion factor 4 GII ( eIF4GII ),but not eIF4GI,cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection显示文摘 | SVITKIN Y V GRADI A IMATAKA H | 1999 | J Virol1999，73，4： | 1 |
| 13 | Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes 显示文摘 | Rao S V O'Grady K Pieper K S | 2005 | Ant J Cardiol2005，96，9： | 1 |
| 14 | Epigenetics and colorectal cancer 显示文摘 | Lao V V Grady W M | 2011 | Nat Rev Gastroenterol Hepatol2011，8，： | 1 |
| 15 | Prospective study of psychosocial distress among patients undergoing radiotherapy for head and neck cancer显示文摘 | Chen AM Jennelle RL Grady V | 2009 | Int Radiat Oncol Biol Phys2009，73，1： | 1 |
| 16 | Unique thermal conduetivity behavior of single- walled carbon nanotube polystyrene composites 显示文摘 | Peters J E Papavassiliou D V Grady B P | 2008 | Macromolecule2008，41，20： | 1 |
| 17 | Oophorectomy vs ovarian conservation with hysterectomy:cardiovascular disease,hip fracture,and Cancer in the Women's Health Initiative Observational Study显示文摘 | Jacoby V L Grady D Wactawski Wende J | | 0，，8： | 1 |
| 18 | A shipboard method for arsenic speciation using semi - automated hydride generation atomic fluorescence spectroscopy 显示文摘 | FEATHERSTONE A M BOULT P R GRADY B V | 2000 | Analytica Chimica Acta2000，409，： | 1 |
| 19 | Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes显示文摘 | Rao S V O'Grady K Pieper K S Granger C B Newby L K Van de Werf F | 2005 | Am J Cardiol2005，96，： | 1 |
| 20 | Removal of aqueous 17ct- ethinylestradiol by Rhodocoecus species 显示文摘 | O'Grady D Evangelista S Yargeau V | 2009 | EnvironmentalEngineering Science2009，26，9： | 1 |
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