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3篇 您的检索式：作者名="Greg Nowak"

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		题名	作者	年代	出处	被引量
	1	Ethanol stimulates bile acid formation in primary human hepatocytes显示文摘	Lisa-Mari Nilsson Jan Sj?vall Stephen Strom Karl Bodin Greg Nowak Curt Einarsson Ewa Ellis	2007	Biochemical and Biophysical Research Communications2007，，4：	1
	2	Transplantation With Livers From Deceased Donors Older Than 75 Years显示文摘	Trygve Thorsen Einar Martin Aandahl William Bennet Michael Olausson Bo-G?ran Ericzon Greg Nowak Frans Duraj Helena Isoniemi Allan Rasmussen Tom H. Karlsen Aksel Foss	2015	Transplantation2015，，12：	1
	3	Morphological alterations and redox changes associated with hepatic warm ischemia-reperfusion injury显示文摘AIM To study the effects of warm ischemia-reperfusion(I/R) injury on hepatic morphology at the ultrastructural level and to analyze the expression of the thioredoxin(TRX)and glutaredoxin(GRX) systems.METHODS Eleven patients undergoing liver resection were subjected to portal triad clamping(PTC). Liver biopsies were collected at three time points; first prior to PTC(baseline), 20 min after PTC(post-ischemia) and 20 min after reperfusion(post-reperfusion). Electron microscopy and morphometry were used to study and quantify ultrastructural changes, respectively. Additionally, gene expression analysis of TRX and GRX isoforms was performed by quantitative PCR. For further validation of redox protein status, immunogold staining was performed for the isoforms GRX1 and TRX1.RESULTS Post-ischemia, a significant loss of the liver sinusoidal endothelial cell(LSEC) lining was observed(P = 0.0003) accompanied by a decrease of hepatocyte microvilli in the space of Disse. Hepatocellular morphology was well preserved apart from the appearance of crystalline mitochondrial inclusions in 7 out of 11 patients. Postreperfusion biopsies had similar features as post-ischemia with the exception of signs of a reactivation of the LSECs. No changes in the expression of redox-regulatory genes could be observed at mR NA level of the isoforms of the TRX family but immunoelectron microscopy indicated a redistribution of TRX1 within the cell.CONCLUSION At the ultrastructural level, the major impact of hepatic warm I/R injury after PTC was borne by the LSECs with detachment and reactivation at ischemia and reperfusion, respectively. Hepatocytes morphology were well preserved. Crystalline inclusions in mitochondria were observed in the hepatocyte after ischemia.	Rim Jawad Melroy D'souza Lisa Arodin Selenius Marita Wallenberg Lundgren Olof Danielsson Greg Nowak Mikael Bjornstedt Bengt Isaksson	2017	World Journal of Hepatology2017，9，34：	1

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