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| 1 | Pancreatic fistula after pancreatectomy:Evolving definitions,preventive strategies and modern management显示文摘Pancreatic resection is the treatment of choice for pancreatic malignancy and certain benign pancreatic disorders. However, pancreatic resection is technically a demanding procedure and whereas mortality after a pancreaticoduodenectomy is currently < 3%-5% in experienced high-volume centers, post-operative morbidity is considerable, about 30%-50%. At present, the single most significant cause of morbidity and mortality after pancreatectomy is the development of pancreatic leakage and fistula (PF). The occurrence of a PF increases the length of hospital stay and the cost of treatment, requires additional investigations and procedures, and can result in life-threatening complications. There is no universally accepted definition of PF that would allow standardized reporting and proper comparison of outcomes between different centers. However, early recognition of a PF and prompt institution of appropriate treatment is critical to the prevention of potentially devastating consequences. The present article, reviews the evolution of post resection pancreatic fistula as a concept, and discusses evolving definitions, the current preventive strategies and the management of this problem. | Shailesh V Shrikhande Melroy A D'Souza | 2008 | World Journal of Gastroenterology2008，14，38： | 26 |
| 2 | A comparison of computer aided surgery registration methods for endoscopic sinus surgery显示文摘 | HARDY S M MELROY C WHITE D R | 2006 | Am J Rhinol2006，20，： | 1 |
| 3 | TIP,an integral membrane protein of the soybean seed protein storage vacuole, undergoes developmentally regulated membrane insertion and removal显示文摘 | MELROY D L HERMANE M | 1991 | Planta1991，184，： | 1 |
| 4 | A soybean vacuolar protein(P34) related to thiol proteases which is synthesized as a glycoprotein precursor during seed maturation 显示文摘 | Kalinski A J Melroy D L Dwivedi R S | 1992 | Journal of Biological Chemistry1992，267，12： | 1 |
| 5 | A soybean vacuolar protein(P34)related to thiol proteases which is synthesized as a glycoprotein precursor during seed maturation显示文摘 | KALINSKIA J MELROY D L DWIVEDIR S | 1992 | Journal of Biological Chemistry1992，267，12： | 1 |
| 6 | 查看详情显示文摘 | Toney M F Howard J N Richer J Borges G L Gordon J G Melroy O R Wiseler D G Yee D Sorensen L B | | 0，，： | 1 |
| 7 | A soybean vacuolar protein(P34) related to thiol proteases which is synthesized as a glycoprotein precursor during seed maturation 显示文摘 | Kalinski A J Melroy D L Dwivedi R S | 1992 | Journal of Biological Chemistry1992，，12： | 1 |
| 8 | Morphological alterations and redox changes associated with hepatic warm ischemia-reperfusion injury显示文摘AIM To study the effects of warm ischemia-reperfusion(I/R) injury on hepatic morphology at the ultrastructural level and to analyze the expression of the thioredoxin(TRX)and glutaredoxin(GRX) systems.METHODS Eleven patients undergoing liver resection were subjected to portal triad clamping(PTC). Liver biopsies were collected at three time points; first prior to PTC(baseline), 20 min after PTC(post-ischemia) and 20 min after reperfusion(post-reperfusion). Electron microscopy and morphometry were used to study and quantify ultrastructural changes, respectively. Additionally, gene expression analysis of TRX and GRX isoforms was performed by quantitative PCR. For further validation of redox protein status, immunogold staining was performed for the isoforms GRX1 and TRX1.RESULTS Post-ischemia, a significant loss of the liver sinusoidal endothelial cell(LSEC) lining was observed(P = 0.0003) accompanied by a decrease of hepatocyte microvilli in the space of Disse. Hepatocellular morphology was well preserved apart from the appearance of crystalline mitochondrial inclusions in 7 out of 11 patients. Postreperfusion biopsies had similar features as post-ischemia with the exception of signs of a reactivation of the LSECs. No changes in the expression of redox-regulatory genes could be observed at mR NA level of the isoforms of the TRX family but immunoelectron microscopy indicated a redistribution of TRX1 within the cell.CONCLUSION At the ultrastructural level, the major impact of hepatic warm I/R injury after PTC was borne by the LSECs with detachment and reactivation at ischemia and reperfusion, respectively. Hepatocytes morphology were well preserved. Crystalline inclusions in mitochondria were observed in the hepatocyte after ischemia. | Rim Jawad Melroy D'souza Lisa Arodin Selenius Marita Wallenberg Lundgren Olof Danielsson Greg Nowak Mikael Bjornstedt Bengt Isaksson | 2017 | World Journal of Hepatology2017，9，34： | 1 |
| 9 | A comparison of computer-aided surgery registration methods for endoscopic sinus surgery显示文摘 | HARDY S M MELROY C WHITE D R | 2006 | Am J Rhinol2006，20，： | 1 |
| 10 | Listening to users in a manufacturing organization:a context-based approach to the development of a computer-supported collaborative work system显示文摘 | D'Souza Melroy E Greenstein Joel S | 2003 | International Journal of Industrial Ergonomics2003，32，4： | 1 |
| 11 | A soybean vacuolar protein (P34) related to thiol proteases is synthesized as a glycoprotein precursor during seed maturation显示文摘 | Kalinski A Melroy D L Dwivedi R S | 1992 | The Journal of Biological Chemistry1992，267，12： | 1 |
| 12 | A soybean vacuolar protein(P34) related to thiol proteases which is synthesized as aglycoprotein precursor during seed maturation 显示文摘 | Kalinski A J Melroy D L Dwivedi R S | 1992 | Journal of Biological Chemistry1992，267，12： | 1 |
| 13 | Borderline resectable pancreatic tumors:Is there a need for further refinement of this stage?显示文摘BACKGROUND:The ideal treatment of patients with 'borderline resectable pancreatic tumors (BRTs)' needs to be established.Current protocols advise neoadjuvant chemo(radio)therapy,although some patients may appear to have BRT on preoperative imaging and a complete resection may be achieved without the need for vascular resection.The aim of the present study was to identify specific findings on preoperative imaging that could help predict in which patients with BRT a complete resection,with or without vascular resection (VR),could be achieved.METHODS:Twelve patients with BRTs were identified.Tumor location,maximum degree of circumferential contact (CC),length of contact of the tumor with major vessels (LC),and luminal narrowing of vessels at the point of contact with the tumor (venous deformity,VD) were graded on preoperatively acquired multidetector computed tomography (MDCT) images and then compared with the intraoperative findings and need for VR.RESULTS:A complete resection (R0) was achieved in 10 patients with 2 having microscopic positive margins (R1) on histopathology at the uncinate margin.Four of the 10 patients required VR (40%).In 3 of the 4 patients whose tumors required VRs,CC was ≥grade III and VD was grade 2.LC did not influence the need for VR.CONCLUSIONS:It is possible to achieve a complete resection at the first instance in patients found to have BRTs on preoperative imaging.Preoperative MDCT-based grading systems and our proposed criteria may help identify such patients,thus avoiding any delay in curative resections in such patients. | Shailesh V Shrikhande Supreeta Arya Savio George Barreto Sachin Ingle Melroy A D'Souza Rohini Hawaldar Parul J Shukla | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 0 |
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