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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Medical treatment for sphincter of oddi dysfunction:Can it replace endoscopic sphincterotomy?显示文摘AIM:To report the results of a medical management of sphincter of oddi dysfunction(SOD) after an intermediate follow-up period.METHODS:A total of 59 patients with SOD(2 men and 57 women,mean age 51 years old) were included in this prospective study.After medical treatment for one year,the patients were clinically re-evaluated after an average period of 30 mo.RESULTS:The distribution of the patients according to the Milwaukee's classification was the following:11 patients were type 1,34 were type 2 and 14 were type 3.Fourteen patients underwent an endoscopic sphincterotomy(ES) after one year of medical treatment.The median intermediate follow-up period was 29.8 ± 3 mo(3-72 mo).The initial effectiveness of the medical treatment was complete,partial and poor among 50.8%,13.5% and 35%,respectively,of the patients.At the end of the follow-up period,37 patients(62.7%) showed more than 50% improvement.The rate of improvement in patients who required ES was not significantly different compared with the patients treated conservatively(64.2% vs 62.2%,respectively).CONCLUSION:Our study confirms that conservative medical treatment could be an alternative to endoscopic sphincterotomy because,after an intermediate follow-up period,the two treatments show the same success rates. | Véronique Vitton Salah Ezzedine Jean-Michel Gonzalez Mohamed Gasmi Jean-Charles Grimaud Marc Barthet | 2012 | World Journal of Gastroenterology2012，18，14： | 9 |
| 3 | Maintenance of Remission Among Patients With Crohn’s Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped显示文摘 | Edouard Louis Jean–Yves Mary Gwenola Vernier–Massouille Jean–Charles Grimaud Yoram Bouhnik David Laharie Jean–Louis Dupas Hélène Pillant Laurence Picon Michel Veyrac Mathurin Flamant Guillaume Savoye Raymond Jian Martine DeVos Rapha?l Porcher Gilles Paint | 2012 | Gastroenterology2012，，1： | 4 |
| 4 | Large endoscopic mucosal resection for colorectal tumors exceeding 4 cm显示文摘AIM:To evaluate the feasibility and the outcome of endoscopic mucosal resection(EMR)for large colorectal tumors exceeding 4 cm(LCRT)undergoing piecemeal resection. METHODS:From January 2005 to April 2008,146 digestive tumors larger than 2 cm were removed with the EMR technique in our department.Of these,34 tumors were larger than 4 cm and piecemeal resection was carried out on 26 colorectal tumors.The mean age of the patients was 71 years.The mean follow-up duration was 12 mo. RESULTS:LCRTs were located in the rectum,left colon,transverse colon and right colon in 58%,15%, 4%and 23%of cases,respectively.All were sessile tumors larger than 4 cm with a mean size of 4.9 cm (4-10 cm).According to the Paris classification,34%of the tumors were typeⅠs,58%typeⅡa,4%typeⅡb and 4%typeⅡc.Pathological examination showed tubulous adenoma in 31%,tubulo-villous adenoma in 27%,villous adenoma in 42%,high-grade dysplasia in38%,in situ carcinoma in 19%of the cases and mucosal carcinoma(m2)in 8%of the cases.The two cases(7.7%)of procedural bleeding that occurred were managed endoscopically and one small perforation was treated with clips.During follow-up,recurrence of the tumor occurred in three patients(12%),three of whom received endoscopic treatment. CONCLUSION:EMR for tumors larger than 4 cm is a safe and effective procedure that could compete with endoscopic submucosal dissection,despite providing incomplete histological assessment. | Philippe Ah Soune Charles Ménard Ezzedine Salah Ariadne Desjeux Jean-Charles Grimaud Marc Barthet | 2010 | World Journal of Gastroenterology2010，16，5： | 4 |
| 5 | Serum calprotectin as a biomarker for Crohn’s disease显示文摘 | M.-A. Meuwis G. Vernier-Massouille J.C. Grimaud Y. Bouhnik D. Laharie E. Piver L. Seidel J.F. Colombel E. Louis | 2013 | Journal of Crohn’s and Colitis2013，，： | 2 |
| 6 | Complications of Endoscopic Sphincterotomy: Results From a Single Tertiary Referral Center显示文摘 | M. Barthet N. Lesavre A. Desjeux M. Gasmi P. Berthezene S. Berdah X. Viviand J. Grimaud | 2002 | Endoscopy2002，，12： | 2 |
| 7 | Miss rate for colorectal neoplastic polyps: a prospective multicenter study of back-to-back video colonoscopies显示文摘 | D. Heresbach T. Barrioz M. Lapalus D. Coumaros P. Bauret P. Potier D. Sautereau C. Boustière J. Grimaud C. Barthélémy J. Sée I. Serraj P. D’Halluin B. Branger T. Ponchon | 2008 | Endoscopy2008，，04： | 2 |
| 8 | Receptor activator of nuclear factor kappaB ligand (RANKL) /osteoprotegerin (OPG) ratio is increased in severe osteolysis显示文摘 | Grimaud E Soubigou L Couillaud S | 2003 | Am J Pathol2003，163，5： | 1 |
| 9 | Polluting Non-Renewable Resources, Innovation and Growth: Welfare and Environmental Policy显示文摘 | Grimaud A Rouge L | 2005 | Re- sources and Energy Economics2005，27，： | 1 |
| 10 | Tapia, syndrome following shoulder surgery显示文摘 | Boisseau N Rabarijaona H Grimaud D | 2002 | Br J Anaesth2002，88，6： | 1 |
| 11 | Comparison of plasma-sprayed alumina coatings by RF and DC plasma spraying 显示文摘 | L Bianchi A Grimaud F Blein | 1995 | Journal of Thermal Spray Technology1995，4，： | 1 |
| 12 | Definition and character-ization of an inhibitor for interleukin-31显示文摘 | Venereau E Diveu C Grimaud L | 2010 | J Biol Chem2010，285，14： | 1 |
| 13 | Product market competition and optimal debt contracts : the limited liability effect revisited 显示文摘 | Faure - Grimaud A | 2000 | European Economic Review2000，，44： | 1 |
| 14 | Risk of cancer from azathioprine therapy in multiple sclerosis:a case-control study显示文摘 | Confavreux C Saddier P Grimaud J | 1996 | Neurology1996，46，6： | 1 |
| 15 | Influence of Substrate Roughness and Temperature on the Adhesion/Cohesion of Alumina Coatings显示文摘 | Mellali M Fauchais P Grimaud A | 1996 | Surf Coat Technol1996，81，： | 1 |
| 16 | Environment, Directed Technical Change and Economic Policy显示文摘 | André Grimaud Luc Rouge | 2008 | Environmental and Resource Economics2008，，4： | 1 |
| 17 | Proteome and phosphoproteome analysis of starch granule-associated proteins from normal maize and mutants affected in starch biosynthesis显示文摘 | Grimaud F Rogniaus H James M G | 2008 | Journal of Experimental Botany2008，59，12： | 1 |
| 18 | Non-renewable resources and growth with vertical innovations:Optimum,equilibrium and economic policies显示文摘 | Grimaud A Rouge L | 2003 | Journal of Environmental Economics and Management2003，45，： | 1 |
| 19 | Comparison of plasma sprayed alumina coating by RF and DC plasma spraying显示文摘 | Ianchi B L Grimaud A Lein B F | 1995 | Thermal Spray Technology1995，4，1： | 1 |
| 20 | Long-term investigation of microbial fuel cells treating primary sludge or digested sludge 显示文摘 | Ge Z Zhang F Grimaud J | 2013 | Bioresouree Technology2013，136，： | 1 |
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