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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Maintenance of Remission Among Patients With Crohn’s Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped显示文摘 | Edouard Louis Jean–Yves Mary Gwenola Vernier–Massouille Jean–Charles Grimaud Yoram Bouhnik David Laharie Jean–Louis Dupas Hélène Pillant Laurence Picon Michel Veyrac Mathurin Flamant Guillaume Savoye Raymond Jian Martine DeVos Rapha?l Porcher Gilles Paint | 2012 | Gastroenterology2012，，1： | 4 |
| 3 | MRI of fetal GI tract abnormalities显示文摘 | Veyrac C Couture A Saguintaah M | 2004 | Abdom Imaging2004，29，： | 1 |
| 4 | MRI of fetal GI tract abnormalities显示文摘 | Veyrac C Couture A Saguintaah M | | 0，，： | 1 |
| 5 | Evaluation of abdominal pain in Henoch-Schonlein syndrome by high frequency ultrasound显示文摘 | Couture A Veyrac C Baud C | 1992 | Pediatr Radiol1992，22，： | 1 |
| 6 | MRI of fetal GI tract abnormalities显示文摘 | Veyrac C Couture A Saguintaah M | 2004 | Abdom Imaging2004，29，4： | 1 |
| 7 | MRI of the fetal gastrointestinal tract显示文摘 | Saguintaah M Couture A Veyrac C | 2002 | Pediatr Radiol2002，32，6： | 1 |
| 8 | Anti-tumour necrosis factor alpha therapy and increased risk of de novo psoriasis: is it really a paradoxical side effect? 显示文摘 | Joyau C Veyrac G Dixneuf V | 2012 | Clin Exp Rheumatol2012，30，5： | 1 |
| 9 | A statement on cefazolinimmediate hypersensitivity: data from a large database, andfocus on the cross-reactivities 显示文摘 | Pipet A Veyrac G Wessel F | 2011 | Clin Exp Allergy2011，41，11： | 1 |
| 10 | Ultrasonography of the spermatic cord in children with testicular torsion : impact on the surgical strategy 显示文摘 | Kalfa N Veyrac C Baud C | 2004 | J Urol2004，172，42： | 1 |
| 11 | Brain ultrasonography in the premature infant显示文摘 | Veyrac C Couture A Saguintaah M | | 0，，07： | 1 |
| 12 | Interaction between melilot and acenocoumarol:Melilotruscus aculeatus显示文摘 | CHIFFOLEAU A HUGUENIN H VEYRAC G | 2001 | Therapie2001，56，： | 1 |
| 13 | Abdominal imaging in child abuse显示文摘 | Raissaki M Veyrac C Blondiaux E | 2011 | Pediatric Radiology2011，41，1： | 1 |
| 14 | MRI of fetal GI tractabnormalities显示文摘 | Veyrac C Couture A Saguintash M | 2004 | Abdom Imaging2004，29，： | 1 |
| 15 | Multicenter assessment of ultrasound of the spermatic cord in children with acute scrotum显示文摘 | Kalfa N Veyrac C Lopez M | | 0，，01： | 1 |
| 16 | Urticaire medicamenteuse et imputabiliue显示文摘 | Veyrac G Jolllet P | 2006 | Revue francalse dallergologie et dlmmunologie clinique2006，46，： | 1 |
| 17 | Uhrasonography of the spermatic cord in children with testicular torsion: impact on the surgical strategy 显示文摘 | Kalfa N Veyrac C Baud C | 2004 | J Urol2004，172，4： | 1 |
| 18 | Multicenter assessment of ultrasound of the spermativ-cord in children with acute scrotum 显示文摘 | Kalfa N Veyrac C Lopez M | 2007 | The journal of urology2007，177，1： | 1 |
| 19 | Multicenter as- sessment of ultrasound of the spermatic cord in children with acute scrotum显示文摘 | Kalfa N Veyrac C Lopez M | | J Urol0，177，1： | 1 |
| 20 | A statement on cefazo- lin immediate hypersensitivity: data from a large data- base, and focus on the cross-reactivities显示文摘 | Pipet A Veyrac G Wessel F | 2011 | Clin Exp Aller- gy2011，41，11： | 1 |
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