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| 1 | 肱骨干骨折后桡神经麻痹的系统评价显示文摘目的采用循证医学研究方法,系统评价肱骨干骨折后桡神经麻痹(radialnervepalsy,RNP)的不同处理方法,为临床治疗决策提供证据基础。方法采用PubMed、Datastar及CochraneDatabase等互联网公共搜索引擎作为检索工具,检索过去40年中发表的有关肱骨干骨折后桡神经麻痹的文献,再对入选文献的参考文献行手工检索,制定数据抽取问表,对入选文献进行数据抽取、汇总、归纳和荟萃分析。结果共检索到391篇原始文献,其中324篇得自电子检索,67篇得自手工检索。有35篇符合最终的入选标准,总计随访患者1045例。其中21篇文献共记录了发生于4517例肱骨干骨折中的532例桡神经麻痹,肱骨干骨折后桡神经麻痹的发生率为11.8%。肱骨干中1/5和中远1/5部位的桡神经麻痹发生率明显高于其他部位(P<0.05)。不同骨折类型中,横形和螺旋形骨折较斜形和粉碎性骨折更易于并发桡神经麻痹(P<0.0001)。肱骨干骨折后桡神经麻痹总的恢复率为88.1%,早期保守治疗的病例自发性恢复率为70.7%。观察等待组和早期手术探查组之间神经恢复的最终结果没有明显差别。结论对肱骨干骨折后桡神经麻痹采用早期保守治疗不会影响神经的最终恢复结果,可以避免许多不必要的手术。 | 邵云潮 Paul Harwood Martin RW Grotz Peter V Giannoudis 陈统一 张光健 | 2005 | 中华骨科杂志2005，25，10： | 19 |
| 2 | Optimizing outcomes for patients with gastric cancer peritoneal carcinomatosis显示文摘Peritoneal carcinomatosis (PC) from gastric cancer has traditionally been considered a terminal progression of the disease and is associated with poor survival out-comes. Positive peritoneal cytology similarly worsens the survival of patients with gastric cancer and treatment options for these patients have been limited. Recent ad-vances in multimodality treatment regimens have led to innovative ways to care for and treat patients with this disease burden. One of these advances has been to use neoadjuvant therapy to try and convert patients with positivecytologyorlow-volume PC to negative cytolo-gy with no evidence of active peritoneal disease.These strategies include the use of neoadjuvant systemic chemotherapy alone,using neoadjuvant laparoscopic heated intraper itoneal chemotherapy(NLHIPEC)after systemic chemotherapy,or using neoadjuvant intra-peritoneal and systemic chemother apy(NIPS)in a bi-dir ectional manner. For patients with higher volume PC,cytoreductive surgery (CRS) and hyperthermic intrape-ritoneal chemotherapy(HIPEC)have been mainstays of treatment. When used together, CRS and HIPEC can improve overall outcomes in properly selected patients,but overall survival outcomes remain unacceptably low.The extent of peritoneal disease, commonly measured by the peritoneal carcinomatosis index (PCI), and the com-pleteness of cytor eduction,has been shown to greatly impact outcomes in patients undergoing CRS and HIPEC.The uses of NLHIPEC and NLHIPEC plus NIPS have both been shown to decrease the PCI and thus increase the opportunity for complete cytoreduction. Newer therapies like pressurized intraperitoneal aerosol chemother apy and immunotherapy, such as catumaxomab, along with improved systemic chemotherapeutic regimens, are being explored with great interest.There is exciting progress being made in the management of PC from gastric can-cer and its’ treatment is no longer futile. | Jennifer L Leiting Travis E Grotz | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 4 |
| 3 | Small bowel perforation after duodenal stent migration:An interesting case of a rare complication显示文摘Duodenal stents are frequently used for palliating malignant gastric outlet obstruction.Successful stent placement relieves obstructive symptoms,is cost effective,and has a relatively low complication rate.However,enteral stents have the potential of migrating distally and rarely,even lead to bowel perforation.We present a rare case of a duodenal stent placed as a palliative measure for gastric outlet obstruction due to unresectable pancreatic cancer that migrated distally after a gastrojejunostomy resulting in small bowel perforation. | Peter HU Lee Robert Moore Akshay Raizada Richard Grotz | 2011 | World Journal of Radiology2011，3，6： | 3 |
| 4 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 5 | Is There a Role for Endoscopic Therapy as a Definitive Treatment for Post-Laparoscopic Bile Duct Injuries?显示文摘 | Javairiah Fatima Joshua G. Barton Travis E. Grotz Zhimin Geng William S. Harmsen Marianne Huebner Todd H. Baron Michael L. Kendrick John H. Donohue Florencia G. Que David M. Nagorney Michael B. Farnell | 2010 | Journal of the American College of Surgeons2010，，4： | 2 |
| 6 | Surveilance strategies for gastrointestinal stromal tumors显示文摘 | Grotz TE Donohue JH | | 0，，： | 1 |
| 7 | Treatment results of patients with multiple trauma:an analysis of 3406 cases treated between 1972 and 1991 at a German level I trauma center 显示文摘 | Regel G Lobenhoffer P Grotz M et el | 1995 | J Trauma1995，38，1： | 1 |
| 8 | Effect of ibandronate on bone loss and renal function after kidney transplantation显示文摘 | Grotz W Nagel C Poeschel D | 2001 | J Am Soc Nephrol2001，12，7： | 1 |
| 9 | Hypocomplementemic urticarial vasculitis syndrome:an interdisciplinary challenge显示文摘 | Grotz W Babe HA Becker JU | 2009 | Dtsch Arztebl Int2009，106，46： | 1 |
| 10 | Intestinal cytokine response after gut isehemia:role of gut barrier failure显示文摘 | Grotz MR Deitch EA Ding J | 1999 | Ann Surg1999，229，4： | 1 |
| 11 | Low-dose aspirin therapy is associated with improved allograft function and prolonged allograft survival after kidney transplantation显示文摘 | Grotz W Siebig S Olschewski M | 2004 | Transplantation2004，77，12： | 1 |
| 12 | Erectile dysfunction after fracture of the pelvis显示文摘 | Harwoad PJ Grotz M Eardley I | 2005 | J Bone Joint Surg(Br)2005，87，3： | 1 |
| 13 | Molecular aspects of Cu,Fe and Zn homeostasis in plants显示文摘 | GROTZ N GUERINOT M L | 2006 | Biochim Biophys Acta2006，1763，： | 1 |
| 14 | Effect of ibandronate on bone loss and renal function after kidney transplantation显示文摘 | GROTZ W NAGEL C POESCHEL D | 2001 | J Am Soc Nephrol2001，12，7： | 1 |
| 15 | Glycine reduces the inflammatory response and organ damage in a two-hit sepsis model in rats显示文摘 | Grotz MR Pape HC Van Griensven M | 2001 | Shock2001，16，2： | 1 |
| 16 | Pattern of organ failure following severe trauma显示文摘 | Regel G Grotz M Weltner T | 1996 | World J Surg1996，20，4： | 1 |
| 17 | IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth显示文摘 | Vert G Grotz N Dedaldechamp F | 2002 | Plant Cell2002，14，： | 1 |
| 18 | Early cellular alterations in bone after radiation therapy and its reation to osteoradionecrosis 显示文摘 | Al-Nawas B Duschner H Grotz KA | 2004 | J Oral Maxillofac Surg2004，62，8： | 1 |
| 19 | Networks,Milieux and Individual Firm Strategies:Empirical Evidence of an Innovative SME Environment显示文摘 | Reinhold Grotz Boris Braun | 1993 | Geografiska Annaler1993，，75： | 1 |
| 20 | Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency 显示文摘 | Grotz N Fox T Connolly E | 1998 | Proc Natl Acad Sci USA1998，95，12： | 1 |
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