|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 2 | Investigating different bio-responses of the upper ocean to Typhoon Haitang using Argo and satellite data显示文摘The responses of the upper ocean to Typhoon Haitang in July 2005 are investigated using Argo float and multiplatform satellite data.The results show decreasing sea surface temperature(SST),a deepening of the mixed layer depth(MLD),and enhanced Chlorophyll-a(Chl-a)concentration.Two extreme cool regions are identified.While the magnitude of SST cooling in the two regions is similar,the biological response(Chla enhancement)differs.To facilitate comparisons,the region to the northeast of Taiwan is defined as region A and the region east of Taiwan as region B.Ekman pumping and the intrusion of the Kuroshio play an important role in the enhancement of Chl-a in region A.Cold eddies provide the material source for the formation of the cold center in region B,where mixing is dominant.Because of the relatively high translation speed(5 m/s)in region B,Ekman pumping has little influence on the cooling and Chl-a enhancement processes.Moreover,the MLD is shallower than the nutricline,which means that mixing does not result in a marked increase in nutrients in the euphotic layer(where the nutrient concentration is uniformly depleted).Sea temperatures,in contrast,gradually decrease with depth below the bottom of the mixed layer.In contrast to region A,region B showed no significant enhancement of Chl-a but strong SST cooling. | Haixia Shan Yuping Guan Jianping Huang | 2014 | Chinese Science Bulletin2014，59，8： | 6 |
| 3 | 2017 Chinese expert consensus on the clinical application ofserum marker for thyroid cancer显示文摘In recent years, the clinical incidence of thyroid cancer has been increasing year by year, and its risk assessment and clinical management methods have also been accordingly modified and constantly improved. There are great differences between the clinical diagnostic and therapeutic modes and disease management of thyroid cancer employed by various medical institutions in China, particularly with regard to the clinical application of serum marker of thyroid cancer. To this end, the China Anti-Cancer Association Thyroid Cancer Specialized Committee Chinese Association of Thyroid Oncology organized this compilation of ExpertConsensus on Clinical Application of Serum Marker of Thyroid Cancer to help and impel relevant clinical institutions and professionals to standardize clinical diagnosis, treatment, and long-term management of thyroid cancer, and to properly utilize the serum marker for scientific auxiliary clinical diagnosis and assessment of thyroid cancer before and after operation. | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Wei Cui Li Gao Zairong Gao Lin Guo Zhuming Guo Tao Huang Xiaoming Huang Yansong Lin Qinjiang Liu Xin Ni Jianwu Qin Li Ren Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Bin Zhang DaiweiZhao Ying Zheng Jingqiang Zhu Xiangqian Zheng 无 | 2018 | Cancer Biology & Medicine2018，15，4： | 3 |
| 4 | ZIC1 Is a Putative Tumor Suppressor in Thyroid Cancer by Modulating Major Signaling Pathways and Transcription Factor FOXO3a显示文摘 | Wei Qiang Yuan Zhao Qi Yang Wei Liu Haixia Guan Siqing Lv Meiju Ji Bingyin Shi Peng Hou | 2014 | The Journal of Clinical Endocrinology & Metabolism2014，，7： | 2 |
| 5 | Sulfated polymannuroguluronate, a novel anti-acquired immune deficiency syndrome (AIDS) drug candidate, targeting CD4 in lymphocytes显示文摘 | Benchun Miao Meiyu Geng Jing Li Fuchuan Li Haixia Chen Huashi Guan Jian Ding | 2004 | Biochemical Pharmacology2004，，4： | 1 |
| 6 | EGF enhances the migration of cancer cells by up-regulation of TRPM7显示文摘 | Haixia Gao Xingjuan Chen Xiaona Du Bingcai Guan Yani Liu Hailin Zhang | 2011 | Cell Calcium2011，，6： | 1 |
| 7 | EGF enhances the migration of cancer cells by up-regulation of TRPM7显示文摘 | Haixia Gao Xingjuan Chen Xiaona Du Bingcai Guan Yani Liu Hailin Zhang | 2011 | Cell Calcium2011，，6： | 1 |
| 8 | Preparation of temperature sensitive molecularly imprinted polymer for solid-phase microextraction coatings on stainless steel fiber to measure ofloxacin显示文摘 | Tong Zhao Xiujuan Guan Wanjin Tang Ying Ma Haixia Zhang | 2014 | Analytica Chimica Acta2014，，： | 1 |
| 9 | HighThyroglobulin Antibody Levels Increase the Risk ofDifferentiated Thyroid Carcinoma 显示文摘 | Qin Jing Yu Zhenqian Guan Haixia | 2015 | Disease markers2015，8，15： | 1 |
| 10 | Preparation and characterization of L-Leucine-modified amphiprotic bifunetional mesoporous SBA-15 molecular sieve as a drug carrier for ribavirin 显示文摘 | Xu Zhigang Ji Yongsheng Guan Min Huang Huayu Zhao Chuande Zhang Haixia | 2010 | Applied Surface Science2010，256，10： | 1 |
| 11 | Prevalence of Hyperuricemia and Gout in Mainland China from 2000 to 2014: A Systematic Review and Meta-Analysis显示文摘 | Rui Liu Cheng Han Di Wu Xinghai Xia Jianqiu Gu Haixia Guan Zhongyan Shan Weiping Teng Lorenzo Cavagna | 2015 | BioMed Research International2015，，： | 1 |
| 12 | Spectroscopic investigation of interaction between mangiferin and bovine serum albumin显示文摘 | Hui Lin Jingfeng Lan Min Guan Fenling Sheng Haixia Zhang | 2009 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2009，，5： | 1 |
| 13 | Variant rs8400 enhances ALKBH5 expression through disrupting miR-186 binding and promotes neuroblastoma progression显示文摘Objective:AlkB homolog 5(ALKBH5)has been proven to be closely related to tumors.However,the role and molecular mechanism of ALKBH5 in neuroblastomas have rarely been reported.Methods:The potential functional single-nucleotide polymorphisms(SNPs)in ALKBH5 were identified by National Center for Biotechnology Information(NCBI)dbSNP screening and SNPinfo software.TaqMan probes were used for genotyping.A multiple logistic regression model was used to evaluate the effects of different SNP loci on the risk of neuroblastoma.The expression of ALKBH5 in neuroblastoma was evaluated by Western blotting and immunohistochemistry(IHC).Cell counting kit-8(CCK-8),plate colony formation and 5-ethynyl-2'-deoxyuridine(EdU)incorporation assays were used to evaluate cell proliferation.Wound healing and Transwell assays were used to compare cell migration and invasion.Thermodynamic modelling was performed to predict the ability of miRNAs to bind to ALKBH5 with the rs8400 G/A polymorphism.RNA sequencing,N6-methyladenosine(mA)sequencing,mA methylated RNA immunoprecipitation(MeRIP)and a luciferase assay were used to identify the targeting effect of ALKBH5 on SPP1.Results:ALKBH5 was highly expressed in neuroblastoma.Knocking down ALKBH5 inhibited the proliferation,migration and invasion of cancer cells.miR-186-3p negatively regulates the expression of ALKBH5,and this ability is affected by the rs8400 polymorphism.When the G nucleotide was mutated to A,the ability of miR-186-3p to bind to the 3'-UTR of ALKBH5 decreased,resulting in upregulation of ALKBH5.SPPI is the downstream target gene of the ALKBH5 oncogene.Knocking down SPP1 partially restored the inhibitory effect of ALKBH5 downregulation on neuroblastoma.Downregulation of ALKBH5 can improve the therapeutic efficacy of carboplatin and etoposide in neuroblastoma.Conclusions:We first found that the rs8400 G>A polymorphism in the m6A demethylase-encoding gene ALKBH5 increases neuroblastoma susceptibility and determines the related mechanisms.The aberrant regulation of ALKBH5 by miR-186-3p caused by this genetic variation in ALKBH5 promotes the occurrence and development of neuroblastoma through the ALKBH5-SPP1 axis. | Qian Guan Huiran Lin Wenfeng Hua Lei Lin Jiabin Liu Linqing Deng Jiao Zhang Jiwen Cheng Zhonghua Yang Yong Li Jun Bian Haixia Zhou Suhong Li Li Li Lei Miao Huimin Xia Jing He Zhenjian Zhuo | 2023 | Chinese Journal of Cancer Research2023，35，2： | 0 |
| 14 | Analysis of Predictability of Local Rainstorm in Qinghai during August 19-20,2019显示文摘Based on conventional meteorological observation data,ECMWF model data,etc.,the causes of rainstorm in the northeast of Qinghai from the afternoon to the night of August 19,2019 were analyzed,and the causes and predictability of major forecast errors were discussed.The results show that there was high temperature,high humidity and high energy in the middle and low layers in the early period of rainstorm.As the subtropical high retreated eastwards,the high-altitude trough of the westerly belt and the vertical shear line of the plateau moved eastwards to make ground cold air move eastwards,and local short-term heavy precipitation appeared under the influence of this weather system.At the same time,the high-level dry and cold air moved into convective unstable areas.The wind speed at 700 hPa strengthened,and the low-level jet stream appeared to aggravate the instability of atmospheric stratification,which was more conducive to the generation of convection.The forecast results of precipitation based on various numerical models were significantly smaller,and the predicted western cold air was obviously weaker,which was also one of the reasons why the weak transportation of the western water vapor resulted in a small value of predicted precipitation.In the adjustment of model forecast,the proportion and amount of convective precipitation should be adjusted to be large,which has a certain indicating significance for the forecast of convective precipitation.In short-term nowcasting,the deviation of major weather systems predicted based on the model should be corrected in real time,and attention should be paid to the location of ground specific humidity and the convergence line.The falling area of heavy precipitation can be judged according to the high-value area of specific humidity,and the maximum of specific humidity appeared 1-2 h earlier than short-term heavy rainfall. | Qingping LI Liang XU Qin GUAN Yao HU Chenghong MEI Jinhai LI Chengzhen SHI Haixia QI | 2020 | Meteorological and Environmental Research2020，11，5： | 0 |
| 15 | Multi-omics for COVID-19:driving development of therapeutics and vaccines显示文摘The ongoing COVID-19 pandemic caused by SARS-CoV-2 has raised global concern for public health and economy.The development of therapeutics and vaccines to combat this virus is continuously progressing.Multi-omics approaches,including genomics,transcriptomics,proteomics,metabolomics,epigenomics and metallomics,have helped understand the structural and molecular features of the virus,thereby assisting in the design of potential therapeutics and accelerating vaccine development for COVID-19.Here,we provide an up-to-date overview of the latest applications of multi-omics technologies in strategies addressing COVID-19,in order to provide suggestions towards the development of highly effective knowledge-based therapeutics and vaccines. | Mengyu Guo Muya Xiong Jinying Peng Tong Guan Haixia Su Yanyi Huang Cai-Guang Yang Yang Li Diana Boraschi Thanigaimalai Pillaiyar Guanbo Wang Chengqi Yi Yechun Xu Chunying Chen | 2023 | National Science Review2023，10，9： | 0 |
| 16 | CYP2S1 is a synthetic lethal target in BRAFV600E-driven thyroid cancers显示文摘BRAF^(V600E)is the most common genetic alteration and has become a major therapeutic target in thyroid cancers;however,intrinsic feedback mechanism limited clinical use of BRAF^(V600E)specific inhibitors.Synthetic lethal is a kind of interaction between two genes,where only simultaneously perturbing both of the genes can lead to lethality.Here,we identified CYP2S1 as a synthetic lethal partner of BRAF^(V600E)in thyroid cancers.First,we found that CYP2S1 was highly expressed in papillary thyroid cancers(PTCs)compared to normal thyroid tissues,particularly in conventional PTCs(CPTCs)and tall-cell PTCs(TCPTCs),and its expression was positively associated with BRAFV600E mutation.CYP2S1 knockdown selectively inhibited cell proliferation,migration,invasion and tumorigenic potential in nude mice,and promoted cell apoptosis in BRAFV600E mutated thyroid cancer cells,but not in BRAF wildtype ones.Mechanistically,BRAF^(V600E)-mediated MAPK/ERK cascade upregulated CYP2S1 expression by an AHR-dependent pathway,while CYP2S1 in turn enhanced transcriptional activity of AHR through its metabolites.This AHR/CYP2S1 feedback loop strongly amplified oncogenic role of BRAF^(V600E)in thyroid cancer cells,thereby causing synthetic lethal interaction between CYP2S1 and BRA^(FV600E).Finally,we demonstrated CYP2S1 as a potential therapeutic target in both BRAF^(V600E)-drived xenograft and transgenic mouse models by targetedly delivering CYP2S1-specific siRNA.Altogether,our data demonstrate CYP2S1 as a synthetic lethal partner of BRAFV600E in thyroid cancers,and indicate that targeting CYP2S1 will provide a new therapeutic strategy for BRAFV600E mutated thyroid cancers. | Yiqi Li Xi Su Chao Feng Siyu Liu Haixia Guan Yue Sun Nongyue He Meiju Ji Peng Hou | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 17 | Comparative study of the effects of Tartary buckwheat seed and sprout consumption on the physiological indices and gut microbiota of C57BL/6J mice显示文摘Tartary buckwheat(Fagopyrum tataricum)is a well-known pseudocereal for its health and economic value.However,abundant antinutritional factors(ANFs)reduces its health benefits.As reported,germination can improve the nutritional profile of grains.In this study,we systematically evaluate the safety of Tartary buckwheat seeds(TB)and Tartary buckwheat sprouts(TBS)used as high active ingredients.After evaluating nutrition levels,bioactive compounds and ANFs in TBS during germinating,5^(th)-day TBS were selected as the raw material.C57BL/6J mice were gavaged daily with distilled water,TB,or TBS for 6 weeks.The physiological indices related to ANFs were determined.Results showed that the TB intake tends to generate negative effects on the gut microbiota,and organs.Additionally,upon TB intake,the Fe^(3+)content in serum,trypsin activity in pancreas and jejunum decreased,while the cytokine,IgE,and histamine levels in serum,water content in faeces,cytokine levels in liver and jejunum increased.Conversely,TBS did not induce any obvious negative effects on the above relevant indices and showed better lipid-lowering effect.Altogether,TBS are safer and more effective as a raw material to produce the functional food for long-term consumption with the intention of preventing and treating hyperlipidaemia. | Guohui Nan Haixia Zhao Qiong Wu Lisong Liu Zichao Guan Chenglei Li Huala Wu Dabing Xiang Qi Wu | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
| 18 | CACA guidelines for holistic integrative management of thyroid cancer显示文摘Purpose:In recent years,thyroid cancer is a common clinical problem.Since guidelines for the diagnosis and treatment of thyroid nodules and diferentiated thyroid cancer were revised in 2012,signifcant scientifc advances have occurred in the feld.The aim of this guidelines is to inform clinicians,researchers,patients and health policy makers on published evidence and expert consensus relating to the diagnosis and management of thyroid malignancy.Methods:In order to better promote the clinical management of thyroid cancer in China,Chinese Association of Thyroid Oncology(CATO)organized relevant experts to write these guidelines based on latest relevant literatures and clinical experience of multiple centers.The specifc clinical issues and topics addressed in these guidelines were based on published evidence,prior versions of the Chinese guidelines and expert consensus.Results and conclusion:The guidelines provide recommendations for the management of diferent types of thyroid carcinoma,including papillary,follicular,medullary,and anaplastic carcinomas. | Minghua Ge Ming Gao Ruochuan Cheng Xiaohong Chen Haixia Guan Yansong Lin Shaoyan Liu Yu Wang Chuanming Zheng Xiangqian Zheng | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员