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| 1 | MiR-9 reduces human acyl-coenzyme A:cholesterol acyltransferase-1 to decrease THP-1 macrophage-derived foam cell formation显示文摘MicroRNAs (miRNAs ) post-transcriptionally 由指向 mRNAs 调整基因表示并且控制大量生物函数。最近的研究显示了 miRNAs 能在哺乳动物调整类脂化合物和胆固醇新陈代谢。酰辅酶 A:cholesterol acyltransferase (ACAT ) 是在细胞的胆固醇新陈代谢的关键酶。积累的 cholesteryl 酉旨被 ACAT1 主要在泡沫房间的形成期间综合,早动脉粥样硬化患者损害的一个特点。这里,我们表明 miR-9 能指向人的 ACAT1 mRNA 的 3-untranslated 区域,明确地在不同人的房间线减少人的 ACAT1 或记者萤火虫酶(Fluc ) 蛋白质然而并非他们的 mRNAs,并且机能上地减少从 THP-1-derived 巨噬细胞的泡沫房间的形成。我们的调查结果建议 miR-9 可能是在细胞的胆固醇动态平衡和减少的一个重要管理者在由减少 ACAT1 蛋白质的 vivo 的泡沫房间的形成。 | Jiajia Xu Guangjing Hu Ming Lu Ying Xiong Qin Li Catherine C.Y. Chang Baoliang Song Tayuan Chang Boliang Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 17 |
| 2 | Rehabilitation and Sustainable Use Pattern of Rocky-desertified Land in Southwest China’s Poverty-stricken Karst Mountainous Areas——A Case Study in Benggu Township, Xichou County, Yunnan, China显示文摘The rocky desert in a karst area directly causes the lack of soil, water and forest, hence leading to the poverty there. In 1990, the villagers from the Muzhe Village in Benggu Township, Xichou County, Yunnan declared a war against rocky desert in an attempt to ask the fields for more yields. They invented a distinctive land rehabilitation and sustainable use pattern called “transforming heavenand earth” that had been practiced in Southwest China’s karst areas. The key mechanism of the pattern was to develop terraced fields with well conserved soil, water and fertility by exploding rocks in the fields, building stone walls, gathering more soil, and improving soil quality and productivity for the fields in combination with building of irrigation facilities and roads, as well as with forestation and agriculture structure adjustment. The purpose of the pattern was to alleviate poverty in the karst areas by improving soil productivity and promoting agriculturaldevelopment. A typical area was studied with the help of Participatory Rural Appraisal (PRA) and the pattern was carried out there for fifteen years, have produced excellent ecological benefits and good economic benefits. Its application in the area approved that it was a sustainable land use pattern for rocky desert areas. | YANG Zisheng LIU Yansui BAO Guangjing LI Zhiguo HE Yimei | 2006 | Journal of Mountain Science2006，3，3： | 10 |
| 3 | ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-a-processing alteration显示文摘 | Ming Zhu Xiaonan Zhao Jia Chen Jiajia Xu Guangjing Hu Dongqing Guo Qin Li Xiaowei Zhang Catherine C.Y. Chang Baoliang Song Ying Xiong Tayuan Chang Boliang Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 7 |
| 4 | The optional long 5'-untranslated region of human ACAT1 mRNAs impairs the production of ACAT1 protein by promoting its mRNA decay显示文摘我们以前报导了人的 ACAT1 mRNAs 用 AUG13971399 开始 codon 生产 50 kDa 蛋白质,并且另外一个未成年者用在上游的在里面框架 GGC12741276 开始 codon 的 56 kDa isoform。GGC12741276 codon 在可选的长 5-untranslated 区域被定位(5-UTR, nt 11396 ) mRNAs。相应于这 5-UTR 的 DNA 序列位于二个不同染色体, 7 和 1。在当前的工作,我们报导可选的长 5-UTR 显著地损害从 AUG13971399 codon 开始的人的 ACAT1 蛋白质的生产,主要由支持它的 mRNA 腐烂。西方的污点分析显示可选的长 5-UTR potently 损害了从 AUG13971399 codon 开始的不同蛋白质的生产,意味着这损害效果没被 3-UTR 或 ACAT1 mRNA 的编码顺序影响。反向的抄写量的聚合酶链反应的结果证明这 5-UTR 戏剧性地减少了它的连接 mRNAs 的内容。到 mRNA 比率的蛋白质的分析证明这 5-UTR 主要减少了它的 mRNA 稳定性而非改变它的翻译效率。我们下次执行了 plasmid transfection 实验并且使用了放线菌素 D 禁止抄写。结果证明这 5-UTR 支持了它的 mRNA 腐烂。用在 vitro 准备的 RNA 的另外的 transfection 和 nucleofection 实验说明了那,在细胞质和房间的原子核,没有连接,可选的长 5-UTR-linked mRNAs 比那些快腐烂了。总的来说,我们的学习在抄写以后的水平把新卓见带到人的 ACAT1 基因表示的规定。 | Xiaonan Zhao Jia Chen Lei Lei Guangjing Hu Ying Xiong Jiajia Xu Qin Li Xinying Yang Catherine C.Y. Chang Baoliang Song Tayuan Chang Boliang Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 6 |
| 5 | Can semipermeable membranes coating materials influence in vivo performance for paliperidone tri-layer ascending release osmotic pump tablet:In vitro evaluation and in vivo pharmacokinetics study显示文摘One purpose of this study was to develop a paliperidone(PAL)tri-layer ascending release pushepull osmotic pump(TA-PPOP)tablet which could meet the needs of clinical applications.And another purpose was to investigate whether different coating materials influenced in vivo performance of TA-PPOP.The ascending release mechanism of this trilayer delivery system on theory was elaborated.TA-PPOP was prepared by means of coating with cellulose acetate(CA)or ethyl cellulose(EC).Several important influence factors such as different core tablet compositions and different coating solution ingredients involved in the formulation procedure were investigated.The optimization of formulation and process was conducted by comparing different in vitro release behaviors of PAL.In vitro dissolution studies indicated that both the two formulations of different coating materials were able to deliver PAL at an ascending release rate during the whole 24 h test.The in vivo pharmacokinetics study showed that both self-made PPOP tablets with different coating had a good in vitro-in vivo correlation(IVIVC)and were bioequivalent with the brand product,which demonstrated no significant influence of the coating materials on the in vivo release acceleration of TA-PPOP. | Guangjing Li Yongjun Wang Hongming Chen Donglei Leng Panqin Ma Yanjie Dong Lifang Gao Zhonggui He | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，2： | 4 |
| 6 | Development and validation of a rapid and sensitive UHPLCeMS/MS method for the determination of paliperidone in beagle dog plasma显示文摘In order to evaluate the pharmacokinetic profile of paliperidone extended-release tablets in vivo,a simple and rapid ultra-high performance liquid chromatographyetandem mass spectrometry(UHPLCeMS/MS)method was developed and validated for the determination of paliperidone in beagle dog plasma.Paliperidone and diazepam(internal standard)were extracted from plasma samples with diethyl ether,and then separated on a C_(18) column(2.1×50 mm,2.6 mm)under gradient elution with methanol-0.1%formic acid at a flow rate of 0.3 ml/min.The compounds were detected using a triple-quadrupole mass spectrometer equipped with an electrospray ionization(ESI)source.The validated method was linear over the concentration range of 1.00-1000.00 ng/ml and the lower limit of quantitation was 1.00 ng/ml.The intra-day and inter-day precision values were not more than 15%(relative standard deviation<20%at low levels),while the accuracy was within±10%of nominal values.The validated UHPLC-MS/MS method was successfully applied to an oral pharmacokinetic study of paliperidone extended-release tablets in a beagle dog. | Hongming Chen Longshan Zhao Guangjing Li Donglei Leng Panqin Ma Lijin Tong Tianhong Zhang | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，5： | 3 |
| 7 | Low-level expression of human ACA T2 gene in monocytic cells is regulated by the C/EBP transcription factors显示文摘 | Dongqing Guo Ming Lu Xihan Hu Jiaiia Xu Guangjing Hu Ming Zhu Xiaowei Zhang Qin Li Catherine C. Y. Chang Tayuan Chang Baoliang Song Ying Xiong Boliang Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 3 |
| 8 | The physical and chemical effects of long-term sulfuric acid exposure on hybrid modified cement mortar 显示文摘 | Gengying Li Guangjing Xiong | 2009 | Cement and Concrete Composites2009，31，： | 1 |
| 9 | High level of preoperative serum fibrinogen is a predictor of poor prognosis in patients with esophageal squamous cell carcinoma显示文摘Objective This study aimed to elucidate the association between the level of preoperative serum fibrinogen(PSF)and the prognosis of patients with esophageal squamous cell carcinoma(ESCC).Methods From January 2010 to December 2016,all patients diagnosed with ESCC who underwent surgery in Qingdao Municipal Hospital were analyzed retrospectively.Moreover,the fibrinogen levels of all patients were assessed before surgery,and hyperfibrinogenemia was diagnosed when the fibrinogen level was≥4.0 g/L.The impact of PSF on disease-free survival(DFS)and overall survival(OS)was analyzed using the log-rank method and Cox proportional hazards regression model.P value less than 0.05 was considered statistically significant.Results A total of 336 patients were finally analyzed,and approximately 102 patients(30.36%)were diagnosed with hyperfibrinogenemia before surgery.Hyperfibrinogenemia was associated with older age(≥70 years)(P=0.012),advanced pathological T stage(P=0.003),and lymph node involvement(P=0.024).Univariate analysis showed that patients with hyperfibrinogenemia had shorter DFS(1.96 years vs.3.64 years,P=0.001)and OS(2.27 years vs.4.15 years,P<0.001)than patients without hyperfibrinogenemia.Multivariate analysis confirmed that PSF was an independent factor affecting DFS(risk ratio[RR]:1.35,95%confidence interval[CI]:1.02-1.79,P=0.038)and OS(RR:1.37,95%CI:1.03-1.83,P=0.034)in patients with ESCC.Conclusion For patients with operable ESCC,hyperfibrinogenemia had poor prognosis.Moreover,PSF is an independent prognostic factor for operable ESCC. | Chengcheng Shi Xiaofeng Xu Yuan Zhang Zhanfa Sun Guangjing Wang | 2020 | Oncology and Translational Medicine2020，6，5： | 1 |
| 10 | Sulphuric acid resistance of soluble soda glass-polyvinyl acetate latexmodified cement mortar 显示文摘 | Xiong Guangjing Chen Xiaohu | 2001 | Cem Concr Res2001，31，1： | 1 |
| 11 | An Improved Stator Flux Observation Method of Permanent Magnet Synchronous Motor显示文摘The stator flux and electromagnetic torque observation is the basis of direct torque controlled permanent magnet synchronous motor( PMSM) drive system. However,the traditional stator flux observer based on voltage model is affected by integral initial values and integral drift,that based on current model is affected by the parameters of PMSM,so a new stator flux observation method is proposed based on an improved secondorder generalized integrator( SOGI). Compared to the stator flux observation method based on the conventional SOGI,the proposed method can not only overcome the influence of integral initial values and integral drift,but also completely eliminate the DC offset's influence. Therefore,the observation accuracy of stator flux is further improved. The simulation and experimental results both show that the proposed method has a higher stator flux and electromagnetic torque observation precision. | Guangjing Su Hongmei Li Ying Dai Zheng Li | 2016 | Journal of Harbin Institute of Technology(New Series)2016，23，6： | 1 |
| 12 | A CDIO curriculum development in a civil en- gineering programme显示文摘 | Xiong Guangjing Lu Xiaohua | 2007 | World Transactions on Engineering and Technology Educa- tion2007，6，2： | 1 |
| 13 | Transition zone studies of new-to-old concrete with different binders显示文摘 | LI Gengying XIE Huicai XIONG Guangjing | 2001 | Cement and Con- crete Composites2001，23，： | 1 |
| 14 | A way for improving transition zone between concrete substrate and repair materials显示文摘 | Jinwei Liu Huicai Xie | 2002 | Cement and Concrete Research2002，32，12： | 1 |
| 15 | Sulphuric acid resistance of soluble soda glass-polyvinyl acetate latex-modified cement mortar显示文摘 | Guangjing X | 2001 | Cement and Concrete Research2001，31，： | 1 |
| 16 | Partial nitrification adjusted by hydroxylamine in aerobic granules under high DO and ambient temperature and subsequent Anammox for low C/N wastewater treatment显示文摘 | Guangjing Xu Xiaochen Xu Fenglin Yang Sitong Liu Yang Gao | 2012 | Chemical Engineering Journal2012，，： | 1 |
| 17 | The construction management system and practice of Three Gorges Project显示文摘Three Gorges Project (TGP),the largest water resources and hydropower project in the world with huge scale and complex techniques,has great comprehensive benefits mainly in flood control,power generation and navigation improvement.Through 17-year construction and practice,the project has been successfully completed.Some valuable experience from the successful construction of TGP has been gained for the management system and mechanism of hydropower project construction in China.Its construction management mode produces important influences on the management system of domestic capital construction.With combination of the construction management practice of TGP,the characteristics of management system and mechanism are summarized,and the suggestions on current hydropower development system and construction management mode are put forward. | Cao Guangjing | 2011 | Engineering Sciences2011，9，3： | 1 |
| 18 | No-cooperative games for multiple emergency locations in resource scheduling显示文摘When an emergency happens, the scheduling of relief resources to multiple emergency locations is a realistic and intricate problem, especially when the available resources are limited. A non-cooperative games model and an algorithm for scheduling of relief resources are presented. In the model, the players correspond to the multiple emergency locations, strategies correspond to all resources scheduling and the payoff of each emergency location corresponds to the reciprocal of its scheduling cost. Thus, the optimal results are determined by the Nash equilibrium point of this game. Then the iterative algorithm is introduced to seek the Nash equilibrium point. Simulation and analysis are given to demonstrate the feasibility and availability of the model. | Yang, Jijun Xu, Weisheng Wu, Qidi Wang, Guangjing | 2008 | Journal of Southeast University(English Edition)2008，24，S1： | 1 |
| 19 | A CDIO curriculum development in a civil engineering programme显示文摘 | Xiong Guangjing Lu Xiaohua | 2007 | World Transact ions on Engineering and Technology Education2007，6，2： | 1 |
| 20 | AdhesiveFailure of Grooved Tool in Milling of 3Cr-lMo-1/ 4V Steel显示文摘 | Tan Guangyu Liu Guangj un Li Guanghui | 2011 | International Journal of Materials Product Technology2011，42，34： | 1 |
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