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| 1 | Crystal structure of the African swine fever virus structural protein p35 reveals its role for core shell assembly显示文摘Dear Editor,The African swine fever(ASF)is a highly contagious hemorrhagic and lethal disease in domestic pigs.The ASF outbreaks of in many Asia countries,including China,Vietnam,Mongolia,and South Korea,have posed a huge threat to the pig indusry.In the attempt to stop ASF from spreading further in China's Mainland,more than 10 million pigs have been culled since August 2018.The causative agent for ASF is a DNA virus,African swine fever virus(ASFV).Although this deadly disease has been reported in Kenya nearly one hundred years ago,there has been no vaccine for protection from ASFV infection or effective treatments to cure ASF until now. | Guobang Li Dan Fu Guangshun Zhang Dongming Zhao Mingyu Li Xue Geng Dongdong Sun Yuhui Wang Cheng Chen Peng Jiao Lin Cao Yu Guo Zihe Rao | 2020 | Protein & Cell2020，11，8： | 3 |
| 2 | Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding显示文摘Dear Editor, African swine fever (ASF) is a highly contagious disease of domestic pigs caused by African swine fever virus (ASFV),with mortality rates approaching 90%-100%.The first ASF case was described in 1921 in Kenya.Over the past decades, ASF has spread from Sub-Saharan Africa to Europe and Asia, and pose a huge threat to global food safety.Since the first ASF case reported in August 2018, more than 10 million pigs had been culled in China at an enormous economic loss.The risk of ASFV mutating to infect humans is extremely low.However, ASF not only threatens food security but also severely strikes the world economy in many fields, such as the global supply of the blood thinner heparin,most of which is produced from pigs.Hence, ASF is a strictly monitored infectious animal disease by OIE (World Organization for Animal Health), unfortunately, there is no approved drug or vaccine against this lethal viral disease. | Dan Fu Dongming Zhao Wei Zhang Guangshun Zhang Mingyu Li Zheng Zhang Yuhui Wang Dongdong Sun Peng Jiao Cheng Chen Yu Guo Zihe Rao | 2020 | Protein & Cell2020，11，8： | 3 |
| 3 | A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options显示文摘Signaling pathway alterations in COVID-19 of living humans as well as therapeutic targets of the host proteins are not clear.We analyzed 317 urine proteomes,including 86 COVID-19,55 pneumonia and 176 healthy controls,and identified specific RNA virus detector protein DDX58/RIG-I only in COVID-19 samples.Comparison of the COVID-19 urinary proteomes with controls revealed major pathway alterations in immunity,metabolism and protein localization.Biomarkers that may stratify severe symptoms from moderate ones suggested that macrophage induced inflammation and thrombolysis may play a critical role in worsening the disease.Hyper activation of the TCA cycle is evident and a macrophage enriched enzyme CLYBL is up regulated in COVID-19 patients.As CLYBL converts the immune modulatory TCA cycle metabolite itaconate through the citramalyl-CoA intermediate to acetyl-CoA,an increase in CLYBL may lead to the depletion of itaconate,limiting its anti-inflammatory function.These observations suggest that supplementation of itaconate and inhibition of CLYBL are possible therapeutic options for treating COVID-19,opening an avenue of modulating host defense as a means of combating SARS-CoV-2 viruses. | Yuntao Liu Lan Song Nairen Zheng Jinwen Shi Hongxing Wu Xing Yang Nianci Xue Xing Chen Yimin Li Changqing Sun Cha Chen Lijuan Tang Xiaotian Ni Yi Wang Yaling Shi Jianwen Guo Guangshun Wang Zhongde Zhang Jun Qin | 2022 | Science China(Life Sciences)2022，65，9： | 1 |
| 4 | Methylpredsnisolone inhibition of TNF-αexpression and NF-kB activation after spinal cord injury in rats 显示文摘 | Jan CU Guangshun Fan Shawei Chen | 1998 | Molecular Brain Research1998，59，： | 1 |
| 5 | The Preparation of Core-Shell CaCO3 Particles and Its Effect on Mechanical Property of PVC Composites显示文摘 | Xiong Ying Chen Guangshun Guo Shaoyun | 2006 | Journal of Applied Polymer Science2006，102，： | 1 |
| 6 | Solid mechanochemical preparation of core-shell SiO2 particles and their improvement on the mechanical properties of PVC composites显示文摘 | Xiong Ying Chen Guangshun Guo Shaoyun | 2008 | Journal of Polymer Science:part B: Polymer Physics2008，46，10： | 1 |
| 7 | Effect of ultrasonic oscillations on processing behavior and mechanical properties of metallocene-catalyzed linear low-density polyethylene/low-density polyethylene blends显示文摘 | Wu Hong Guo Shaoyun Chen Guangshun | 2004 | Journal of Applied Polymer Science2004，94，： | 1 |
| 8 | Effect of high-energy vibromilling on interfacial interaction and mechanical properties of PVC/nano-CaCO3 composites显示文摘 | TIAN Manhong CHEN Guangshun GUO Shaoyun | 2005 | Macromol Mater Eng2005，290，9： | 1 |
| 9 | Ultrasonic Improvement of Rheological and Processing Behaviour of LLDPE During Extrusion显示文摘 | Shaoyun Guo Yuntao Li Guangshun Chen | 2003 | Polymer International2003，52，1： | 1 |
| 10 | Ultrasonic Improvement of the Compatibility and Rheological Behavior of High-density Polyethylene/polystyrene Blends显示文摘 | Guangshun Chen Shaoyun Guo | 2002 | Journal of Applied Polymer Science2002，86，1： | 1 |
| 11 | Modi- fication of a theoretical modal for the prediction of thermal expansion behavior of particulate composites: application to poly ( vinyl chloride)/talc composites 显示文摘 | Guangshun Chen Deng Zhiwei Xiong Lei | 2013 | Journal of Macro- molecular Science Part B: Physics2013，52，9： | 1 |
| 12 | Ultrasonic improvement of rheologieal behavior of polystyrene 显示文摘 | Guangshun Chen Shaoyun Guo | 2002 | J Appl Polym Sci2002，，84： | 1 |
| 13 | Ultrasonic improvement of rheological and processing behaviour of LLDPE during extrusion显示文摘 | Shaoyun Guo Yuntao Li Guangshun Chen | 2003 | Polym Int2003，52，： | 1 |
| 14 | Diffusion coefficients, kinematic viscosities, and refractive indices for heptane + thylnaphalene, sulfolane + 1-methylnaphalene, water + N, N-dimethylformamide, water + methanol, water + N-formylmorpholine, and water+N-methylpyrrolidone显示文摘 | Chen Guangshun Hou Y Knapp H | 1995 | J Chem Eng Data1995，40，4： | 1 |
| 15 | Effect of ultrasonic oscillations on the rheological behavior and morphology of Illite-filled high-density polyethylene composites显示文摘 | Chen Guangshun Guo Shaoyun | 2005 | Applied Polymer Science2005，96，： | 1 |
| 16 | Leucine-rich glioma-inactivated protein 1 antibody-mediated autoimmune encephalitis in a 4-year-old girl:a case report显示文摘Background:Leucine-rich glioma-inactivated protein 1(LGI1)antibody-mediated encephalitis is a rare subtype of autoimmune encephalopathy,which is associated with autoimmunity against the neuronal plasma membrane proteins.The characteristic symptoms of this disease are memory dysfunction,seizures,faciobrachial dystonic seizures,cognitive deficits,neuropsychiatric disturbances,and intractable hyponatremia.The diagnosis of this disease mainly depends on the presence of anti-LGI1 antibody in serum or cerebrospinal fluid of patients.LGI1 antibody encephalitis has been reported mostly in adults,with rare occurrences in children.Case presentation:In this report,we described a 4-year-old girl with typical seizures.Seizure types included focal seizures and generalized tonic-clonic seizures.The electroencephalogram findings showed focal discharges.Brain magnetic resonance imaging(MRI)showed normal.The cerebrospinal fluid(CSF)levels of cells,glucose,and chloride were within the normal range,and the culture did not reveal growth of any pathogen.Test of serum LGI1-Ab was positive,while the tests for autoimmune encephalitis antibody series in CSF were negative.The seizures of the patient were completely controlled after the therapy of immunoglobulin,methylprednisolone and antiepileptic drugs(AEDs),and the mental state almost returned to normal.Conclusion:To our knowledge,the patient described here may be the youngest case of LGI1 antibody encephalitis reported to date.Children with the LGI1 antibody-associated encephalitis may present only with single symptoms such as epileptic seizures and have good response to the therapy of immunoglobulin,methylprednisolone and antiepileptic drugs.Our case report will provide hints for pediatricians in the diagnosis and treatment of LGI1-antibody encephalitis. | Junxia Luo Jianguo Shi Yehong Chen Wandong Hu Yujie Guo Guangshun Hou Zaifen Gao | 2021 | Acta Epileptologica2021，3，1： | 1 |
| 17 | Synthesis, Characterization, and Biological Application of Size-Controlled Nanocrystalline NaYF4:Yb, Er Infrared-to-Visible Up-Conversion Phosphors显示文摘 | Guangshun Yi Huachang Lu Shuying Zhao Yue Ge Wenjun Yang Depu Chen and Lianghong Guo | 2004 | Journal of Nann Letters2004，4，11： | 1 |
| 18 | Effect of High - Energy Vibromilling on Interfacial Interaction and Mechanical Properties of PVC/Nano - CaCO3 Composites 显示文摘 | Manhong Tian Guangshun Chen Shaoyun Guo | 2005 | Macromol Mater Eng2005，，290： | 1 |
| 19 | The Preparation of PVC core- shell CaCO3 Particle and Its Effect On Mechanical Property of PVC Composite显示文摘 | Xiong Ying Guangshun Chen Shaoyun Guo | 2006 | Journal of Applied Polymer Science2006，，102： | 1 |
| 20 | A study on the morphology mechanical properties of PVC/nano-SiO2composites显示文摘 | Chen Guangshun Tian Manhong Guo Shaoyun | 2006 | J Macromolecular Science Part B:Physics2006，45，5： | 1 |
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