|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An atlas of CNV maps in cattle, goat and sheep显示文摘Copy number variation(CNV)is the most prevalent type of genetic structural variation that has been recognized as an important source of phenotypic variation in humans,animals and plants.However,the mechanisms underlying the evolution of CNVs and their function in natural or artificial selection remain unknown.Here,we generated CNV region(CNVR)datasets which were diverged or shared among cattle,goat,and sheep,including 886 individuals from 171 diverse populations.Using 9 environmental factors for genome-wide association study(GWAS),we identified a series of candidate CNVRs,including genes relating to immunity,tick resistance,multi-drug resistance,and muscle development.The number of CNVRs shared between species is significantly higher than expected(P<0.00001),and these CNVRs may be more persist than the single nucleotide polymorphisms(SNPs)shared between species.We also identified genomic regions under long-term balancing selection and uncovered the potential diversity of the selected CNVRs close to the important functional genes.This study provides the evidence that balancing selection might be more common in mammals than previously considered,and might play an important role in the daily activities of these ruminant species. | Yongzhen Huang Yunjia Li Xihong Wang Jiantao Yu Yudong Cai Zhuqing Zheng Ran Li Shunjin Zhang Ningbo Chen Hojjat Asadollahpour Nanaei Quratulain Hanif Qiuming Chen Weiwei Fu Chao Li Xiukai Cao Guangxian Zhou Shudong Liu Sangang He Wenrong Li Yulin Chen Hong Chen Chuzhao Lei Mingjun Liu Yu Jiang | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 2 | Investigation of aggregation in solvent extraction of lanthanides by acidic extractants (organophosphorus and naphthenic acid)显示文摘 | Naifu Zhou Jinguang Wu Zhijian Yu R. D. Neuman Dujin Wang Guangxian Xu | 1997 | Science in China Series B: Chemistry1997，，1： | 1 |
| 3 | Progress in the study on the composition and formation mechanism of gallstone显示文摘 | Ying Sun Zhanlan Yang Guorong Shen Yong Zhou Xiaosi Zhou Jinguang Wu Guangxian Xu | 2001 | Science in China Series B: Chemistry2001，，5： | 1 |
| 4 | Limb Ischemic Preconditioning Reduces Heart and Lung Injury After an Open Heart Operation in Infants显示文摘 | Zhou Wenwu Zeng Debing Chen Renwei Liu Jian Yang Guangxian Liu Pingbo Zhou Xinmin | 2010 | Pediatric Cardiology2010，，： | 1 |
| 5 | Limb Ischemic Preconditioning Reduces Heart and Lung Injury After an Open Heart Operation in Infants显示文摘 | Zhou Wenwu Zeng Debing Chen Renwei Liu Jian Yang Guangxian Liu Pingbo Zhou Xinmin | 2010 | Pediatric Cardiology2010，，1： | 1 |
| 6 | TEM study on extractive organic phase containing lanthanide ions显示文摘 | Li Yan Liao Hua Peng Qing Zhou Weijin Fu Honglan Wu Jinguang Xu Guangxian | 1994 | Journal of Alloys and Compounds1994，216，： | 1 |
| 7 | Paternally imprinted LATE-FLOWERING2 transcription factor contributes to paternal-excess interploidy hybridization barriers in wheat∞显示文摘Interploidy hybridization between hexaploid and tetraploid genotypes occurred repeatedly during genomic introgression events throughout wheat evolution,and is commonly employed in wheat breeding programs.Hexaploid wheat usually serves as maternal parent because the reciprocal cross generates progeny with severe defects and poor seed germination,but the underlying mechanism is poorly understood.Here,we performed detailed analysis of phenotypic variation in endosperm between two interploidy reciprocal crosses arising from tetraploid(Triticum durum,AABB)and hexaploid wheat(Triticum aestivum,AABBDD).In the paternal‐versus the maternal‐excess cross,the timing of endosperm cellularization was delayed and starch granule accumulation in the endosperm was repressed,causing reduced germination percentage.The expression profiles of genes involved in nutrient metabolism differed strongly between these endosperm types.Furthermore,expression patterns of parental alleles were dramatically disturbed in interploidy versus intraploidy crosses,leading to increased number of imprinted genes.The endosperm‐specific TaLFL2 showed a paternally imprinted expression pattern in interploidy crosses partially due to allele‐specific DNA methylation.Paternal TaLFL2 binds to and represses a nutrient accumulation regulator TaNAC019,leading to reduced storage protein and starch accumulation during endosperm development in paternal‐excess cross,as confirmed by interploidy crosses between tetraploid wild‐type and clustered regularly interspaced palindromic repeats(CRISPR)–CRISPR‐associated protein 9 generated hexaploid mutants.These findings reveal a contribution of genomic imprinting to paternal‐excess interploidy hybridization barriers during wheat evolution history and explains why experienced breeders preferentially exploit maternal‐excess interploidy crosses in wheat breeding programs. | Guanghui Yang Man Feng Kuohai Yu Guangxian Cui Yan Zhou Lv Sun Lulu Gao Yumei Zhang Huiru Peng Yingyin Yao Zhaorong Hu Vincenzo Rossi Ive De Smet Zhongfu Ni Qixin Sun Mingming Xin | 2023 | Journal of Integrative Plant Biology2023，65，12： | 0 |
| 8 | Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme显示文摘Dear Editor,Histone deacetylases(HDACs)are evolutionally conserved enzymes that remove acetyl modifications from histones and play a central role in epigenetic gene silencing.1 Class I HDACs are promising targets for epigenetic therapies for a range of diseases such as cancers,inflammations,infections,and neurological diseases.2 Yeast Rpd3 is the founding member of class I HDACs,which forms two distinct complexes:the∼1.2 MDa Rpd3L deacetylating histones at promoter regions,and the∼0.6 MDa Rpd3S targeting transcribed regions to suppress intragenic transcription initiation.3,4 Rpd3S consists of three core proteins:Rpd3,Sin3,and Ume15 along with two dedicated chromatin binding subunits:Eaf3 and Rco1.6 The structures of the yeast Rpd3S complex and its human homolog Sin3B complex have been recently reported.7,8 Here,we report the cryo-electron microscopy(cryo-EM)structure of the Rpd3S holoenzyme binding a nucleosome at 3.7Åresolution(Supplementary information,Table S1). | Yueyue Zhang Mengxue Xu Po Wang Jiahui Zhou Guangxian Wang Shuailong Han Gang Cai Xuejuan Wang | 2023 | Cell Research2023，33，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员