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| 1 | MiR-29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6显示文摘Osteosarcoma 是骨头的最普通的主要肉瘤,并且它是在青少年和年轻成年人之中的癌症死亡的一个领先的原因。然而,糟糕位于 osteosarcoma carcinogenesis 遗体下面的分子的机制理解。最近, cyclin 依赖的 kinase (CDK6 ) 6 作为重要 oncogene 被识别。我们发现了那 CDK6 蛋白质水平,而非 CDK6 mRNA 水平,比的在 osteosarcoma 纸巾是高得多的在正常邻近的纸巾,它显示在 osteosarcoma 涉及 CDK6 规定的 post-transcriptional 机制。MiRNAs 是镇压的小非编码的 RNA 在 post-transcriptional 水平的基因表示并且广泛地被显示了在许多人的癌症起重要作用。在这研究,我们用生物信息学方法作为 CDK6 的一个新奇管理者调查了 miR-29b 的角色。我们证明 CDK6 能是由经由到在 osteosarcoma 房间的 3-UTR 区域的绑定的 miR-29b 的 downregulated。而且,我们在 osteosarcoma 纸巾识别了在 miR-29b 和 CDK6 蛋白质层次之间的反的关联。最后,我们在 osteosarcoma 房间检验了 CDK6 表示的 miR-29b-driven 压抑的功能。结果表明 miR-29b 由在增长和移植进程指向 CDK6 充当 osteosarcoma 的肿瘤 suppressor。一起拿,我们的结果在 osteosarcoma 在 CDK6 的规定为 miR-29b 加亮一个重要角色并且可以为未来 osteosarcoma 治疗打开新大街。 | Kegan Zhu Lei Liu Junliang Zhang Yanbo Wang Hongwei Liang Gentao Fan Zhenhuan Jiang Chen-Yu Zhang Xi Chen Guangxin Zhou | 2016 | Protein & Cell2016，7，6： | 18 |
| 2 | Preparation and SO2 Adsorption Behavior of Coconut Shell-Based Activated Carbon via Microwave-Assisted Oxidant Activation显示文摘A series of oxidants supported on coconut shell-based activated carbon(CAC) through microwave irradiation were prepared and characterized using scanning electron microscopy(SEM), N_2 adsorption/desorption analysis, and X-ray photoelectron spectroscopy(XPS). The SO_2 adsorption capacities and rates were evaluated by adsorption tests performed in a fixed bed reactor with a simulated flue gas, and the adsorption isotherm models were validated against the experimental results. The findings revealed that the SO_2 adsorption capacity decreased in the following order: MW-K_2Cr_2O_7-CAC > MWKMnO_4-CAC > MW-H_2O_2-CAC > MW-CAC. The SO_2 adsorption capacities and adsorption rates of the samples increased with an increasing oxidizability of the oxidants owing to the increment of mean pore size and oxygen-containing functional groups. In addition, a high initial SO_2 concentration and a low bed temperature could positively affect the SO2 adsorption. Finally, the Langmuir model validated that SO_2 was mainly adsorbed through chemical adsorption on the sample surfaces. | Jia Fengrui Li Zhou Wang Engang He Jicheng Dong Hui Liu Guangxin Jian Weiwei | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，1： | 3 |
| 3 | Biotin–streptavidin enzyme-linked immunosorbent assay for detecting Tetrabromobisphenol A in electronic waste显示文摘 | Dan Bu Huisheng Zhuang Xinchu Zhou Guangxin Yang | 2014 | Talanta2014，，： | 1 |
| 4 | Modification of colloidal silica on the mechanical properties of acrylic based polyurethane/silica composites 显示文摘 | Chen Guodong Zhou Shuxue Gu Guangxin | 2007 | Colloids and Surfaces A: Physicochem Eng Aspects2007，，296： | 1 |
| 5 | Preparation and properties of transparent PMMA/ZrO2 nanocomposites using 2-hydroxyethyl methacrylate as a coupling agent显示文摘 | Hu Yiqing Gu Guangxin Zhou Shuxue | 2011 | Polymer2011，52，1： | 1 |
| 6 | Acrylic -Based Polyurethane/Silica Hybrids Prepared by Acid-Catalyzed Sol Gel Process: Structure andMechanical Properties 显示文摘 | Chen Guodong Zhou Shuxue GU Guangxin | 2005 | Macromol Chem Phys2005，206，： | 1 |
| 7 | Effects of surface properties of colloidal silica particles on redlspersibility and properties of acrylic-based poly-urethane/silica composites显示文摘 | Chen Guodong Zhou Shuxue Gu Guangxin | 2005 | J Colloid Interface Sci2005，281，： | 1 |
| 8 | Numerical simulation of the developing course of piping 显示文摘 | ZHOU Xiaojie JIE Yuxin LI Guangxin | 2012 | Computers and Geotechnics2012，44，： | 1 |
| 9 | Modification of colloidal silica on the mechanical properties of acrylic based polyurethane/silica composites显示文摘 | Guodong Chen Shuxue Zhou Guangxin Gu Limin Wu | 2006 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2006，，1： | 1 |
| 10 | Study on the morphology and tribological properties of acrylic based polyurethane/fumed silica composite coatings显示文摘 | Shuxue Zhou Limin Wu Weidian Shen Guangxin Gu | 2004 | Journal of Materials Science2004，，5： | 1 |
| 11 | Effect of the particle size of nanosilica on the performance of epoxy/silica composite coatings显示文摘 | Junjie Yuan Shuxue Zhou Guangxin Gu | 2005 | Journal of Materials Science2005，，40： | 1 |
| 12 | Effects of surface properties of colloidal silica particles on redispersibility and properties of acrylic-based polyurethane/silica composites显示文摘 | GUODONG CHEN SHUXUE ZHOU GUANGXIN GU | | 0，，02： | 1 |
| 13 | Effects of surface properties of colloidal silica particles on redispersibility and properties of acrylic based polyurethane/silica composites 显示文摘 | Chen Guodong Zhou Shuxue Gu Guangxin | 2005 | Journal of Colloid and Interface Science2005，281，12： | 1 |
| 14 | Modification and Dispersion of Nanosilica显示文摘 | Chen Hui Zhou Shuxue Gu Guangxin | 2004 | Journal of Dispersion Science and Technology2004，25，6： | 1 |
| 15 | Microstructure and properties of polyester-based polyurethane/titania hybrid films prepared by sol-gel process 显示文摘 | Yongchun Chen Shuxue Zhou Guangxin Gu | 2006 | Polymer2006，，47： | 1 |
| 16 | 采用中国道个新辅助化疗方案治疗四肢成骨肉瘤的回顾性分析(英文)显示文摘Objective: The aim of this study was to determine stand protocol for patients with extremity osteosarcoma by case following up after neoadjuvant chemotherapy and limb salvage operation. Methods: Between January 2000 and January 2007, 121 patients with extremity osteosarcoma were eligible for this analysis. After being graded according to Ennek- ing classification, all patients were preoperative chemotherapy (methotrexate, cisplatin, doxorubicin, and ifosfamide. Some patients with IIB tumors received extra interventional embolism). And postoperatively, the same protocols were employed, but poor responders (tumor necrosis < 95%) received more treatment cycles than good responders and took some new medicine in place of the former one. Most of patients underwent limb salvage operation (99/121), and the Musculoskeletal Tumor Society Score (MSTS) was used to evaluate the recovery of their limb functions. Results: The followed up last for average 37.3 months (range: 16–101 months). Most patients (76/121) survived, and the overall survival (OS) was 62.8%. Forty-seven of the 121 patients underwent osteoarticular allografts, among which 12 cases of disunion between the host bone and graft bone, 4 cases of allograft absorption and 3 local recurrences appeared. The mean MSTS score was 22.6 ± 4.13, with an excellent limb function in 17 patients, good in 19 patients, fair in 6 patients and poor in 7 patients. The overall excellent and good function outcome was obtained in 76.6% of the patients. Fifty-two of 121 patients underwent custom-made or modular tumor endoprosthesis replacememt, among which 1 case of aseptic loosening, 1 case of peri-prosthesis infection and 4 local recurrences appeared. The mean MSTS was 24.32 ± 3.85, with an excellent limb function in 28 patients, good in 16 patients, fair in 5 patients and poor in 3 patients. The overall excellent and good function outcome was obtained in 84.6% of the patients. Conclusion: Neoadjuvant chemotherapy and limb salvage surgery are effective methods to treat osteosarcoma at present, although some patients still dying from postoperative metastases. Therefore, early diagnosis individualized treatment and exploring for new and effective therapeutic strategy should be the key to an ideal treatment for osteosarcoma. | Sujia Wu Xin Shi Guangxin Zhou Meng Lu Chengjun Li Weiwen Wang Jianning Zhao | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，11： | 0 |
| 17 | Different dietary starch patterns in lowprotein diets:effect on nitrogen efficiency,nutrient metabolism,and intestinal flora in growing pigs显示文摘Background:Protein releases amino acids faster than starch releases glucose in digestive tract of pigs fed lowprotein(LP)diets.Poor synchronization of dietary glucose and amino acids supply leads to compromised nitrogen efficiency.Dietary starch patterns modulation may improve this situation.Methods:Growing barrows(29.7±2.0 kg)were randomly allotted into 5 dietary treatments with LP diets consisting of different purified starches.Treatments included:waxy corn starch(W LP),corn starch+waxy corn starch(C+W LP),corn starch(C LP),pea starch+waxy corn starch(P+W LP)and pea starch(P LP).In the experiment,growth performance,protein deposition,nutrient metabolism,and fecal microbial community of pigs were investigated.In vitro starch digestion was used for predicting the in vivo glucose response.Results:Dietary starch in vitro glucose release profile was determined by starch source and the ratio of amylopectin and amylose.C+W LP treatment showed decreased total nitrogen excretion and plasma citrulline concentration and improved plasma leptin concentration among treatments(P<0.05).Besides,the highest nitrogen apparent biological value,whole-body protein deposition and growth performance and lowest urinary nitrogen excretion were also observed in C+W LP treatment.Compared with the other groups,C+W LP and C LP showed increased plasma pyruvate,IGF-1,and lipase concentrations(P<0.05).The W LP group presented dramatically increased plasma alanine and urea nitrogen concentration and decreased aldolase and leptin concentrations(P<0.05).Dietary starch patterns did not make an impact on bacterial richness and diversity,but changed the taxonomic and functional structures of the microbial communities.Microbial protein fermentation product(isobutyrate and isovalerate)presented increased in P LP treatments compared with the other treatments(P<0.05).Conclusions:Dietary starch patterns modulation can regulate dietary glucose release profile,nutrient metabolism,protein turnover,and fecal microbial fermentation in pigs.The optimal dietary glucose release profile effectively strengthened whole-body protein deposition and improve nitrogen efficiency and growth performance in growing pigs fed LP diets. | Junyan Zhou Lu Wang Lijie Yang Guangxin Yang Xiangfang Zeng Shiyan Qiao | 2022 | Journal of Animal Science and Biotechnology2022，13，5： | 0 |
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