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| 1 | Long-term results of subtotal colectomy with cecorectal anastomosis for isolated colonic inertia显示文摘AIM: To evaluate the results of sub total colectomy with cecorectal anastomosis (STC-CRA) for isolated colonic inertia (CI). METHODS: Fourteen patients (mean age 57.5 ± 16.5 year) underwent surgery for isolated CI between January 1986 and December 2002. The mean frequency of bowel motions with the aid of laxatives was 1.2 ± 0.6 per week. All subjects underwent colonoscopy, anorectal manometry, cinedefaecography and colonic transit time (CTT). CI was defined as diffuse markers delay on CTT without evidence of pelvic floor dysfunction. All patients underwent STC- CRA. Long-term follow-up was obtained prospectively by clinical visits between October 2005 and February 2006 at a mean of 10.5 ± 3.6 years (range 5-16 years) during which we considered the number of stool emissions, the presence of abdominal pain or digitations, the use of pain killers, laxatives and/or fibers. Patients were also asked if they were satisfied with the surgery. RESULTS: There was no postoperative mortality. Postoperative complications occurred in 21.4% (3/14). At the end of follow-up, bowel frequency was significantly (P < 0.05) increased to a mean of 4.8 ± 7.5 per day (range 1-30). One patient reported disabling diarrhea. Two patients used laxatives less than three times per month without complaining of what they called constipation. Overall, 78.5% of patients would have chosen surgery again if necessary. CONCLUSION: STC-CRA is feasible and safe in patientswith CI achieving 79% of success at a mean follow- up of 10.5 years. A prospective controlled evaluation is warranted to verify the advantages of this surgical approach in patients with CI. | Antonio Iannelli Thierry Piche Raffaella Dainese Pascal Fabiani Albert Tran Jean Mouiel Jean Gugenheim | 2007 | World Journal of Gastroenterology2007，13，18： | 14 |
| 2 | Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients显示文摘AIM: To assess pre-orthotopic liver transplantation (OLT) factors that could be evaluated pre-operatively or con- trolled post-operatively associated with hepatocellular carcinoma (HCC) recurrence and disease-free survival after liver transplantation (LT).METHODS: Four hundred and twelve patients trans- planted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to iden- tify independent predictors of recurrence. RESULTS: Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were: presence of cirrhosis (P = 0.001), etiology of liver disease (P = 0.03), α fetoprotein level (< 200, 200 to 2000, or > 2000; P < 0.0001), γ-GT activity (N, N to 2N or > 2N; P = 0.02), the number of nodules (1, 2-3 or ≥ 4; P = 0.02), maximal diameter of the largest nodule (< 3 cm, 3 to 5 cm or > 5 cm; P < 0.0001), the sum of the diameter of the nodules (< 3 cm, 3 to 5 cm, 5 to 10 cm or >10 cm; P < 0.0001), bi- lobar location (P = 0.01), preoperative portal thrombosis (P < 0.0001), peri-operative treatment of the tumor (P = 0.002) and chemoembolization (P = 0.03), tumor differentiation (P = 0.01), initial type of calcineurin inhibitor (P = 0.003), the use of antilymphocyte antibodies (P = 0.02), rejection episodes (P = 0.003) and period of LT (P < 0.0001). By multivariate analysis, 6 variables were independently associated with HCC recurrence: maximal diameter of the largest nodule (P < 0.0001), time of LT (P < 0.0001), tumor differentiation (P < 0.0001), use of anti-lymphocyte antibody (ATG) or anti-CD3 antibody (OKT3) (P = 0.005), preoperative portal thrombosis (P = 0.06) and the number of nodules (P = 0.06). CONCLUSION: This study identif ies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recurrence, and confi rms the prognostic value of tumor differentiation. | Thomas Decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole Meyer Jean Gugenheim Francois Durand Pierre-Henri Bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian Ducerf Georges Philippe Pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux | 2006 | World Journal of Gastroenterology2006，12，45： | 10 |
| 3 | Laparoscopic sleeve gastrectomy for morbid obesity显示文摘The incidence of obesity is steadily rising, and it has been estimated that 40% of the US population will be obese by the year 2025 if the current trend continues. In recent years there has been renewed interest in the surgical treatment of morbid obesity in concomitance with the epidemic of obesity. Bariatric surgery proved effective in providing weight loss of large magnitude, correction of comorbidities and excellent short-term and long-term outcomes, decreasing overall mortality and providing a marked survival advantage. The Laparoscopic Sleeve Gastrectomy (LSG) has increased in popularity and is currently very 'trendy' among laparoscopic surgeons involved in bariatric surgery. As LSG proved to be effective in achieving considerable weight loss in the short-term, it has been proposed by some as a sole bariatric procedure. This editorial focuses on the particular advantages of LSG in the treatment of morbid obesity. | Antonio Iannelli Raffaella Dainese Thierry Piche Enrico Facchiano Jean Gugenheim | 2008 | World Journal of Gastroenterology2008，14，6： | 5 |
| 4 | Ischemia-Reperfusion Injury and Ischemic-Type Biliary Lesions following Liver Transplantation显示文摘 | Raffaele Cursio Jean Gugenheim Maciej Kosieradzki | 2012 | Journal of Transplantation2012，，： | 3 |
| 5 | Autophagy and Liver Ischemia-Reperfusion Injury显示文摘 | Raffaele Cursio Pascal Colosetti Jean Gugenheim Han-Ming Shen | 2015 | BioMed Research International2015，，： | 2 |
| 6 | Effect of Polyethylene Glycol in Pig Intestinal Allotransplantation Without Immunosuppression显示文摘 | Thierry Yandza Michel Tauc Danielle Canioni Claire Rogel-Gaillard Ghislaine Bernard Alain Bernard Jean Gugenheim | 2012 | Journal of Surgical Research2012，，2： | 2 |
| 7 | Compared Efficacy of Preservation Solutions in Liver Transplantation: A Long‐Term Graft Outcome Study From the European Liver Transplant Registry显示文摘 | R. Adam V. Delvart V. Karam C. Ducerf F. Navarro C. Letoublon J. Belghiti D. Pezet D. Castaing Y. P. Le Treut J. Gugenheim P. Bachellier J. Pirenne P. Muiesan | 2015 | American Journal of Transplantation2015，，2： | 2 |
| 8 | Laparoscop ie man- agement of benign solid and cystic lesions of the liver显示文摘 | Katkhouda N HurwitzM Gugenheim J | 1999 | Ann surg1999，4，： | 1 |
| 9 | Laparoscopic management of benign solid and cystic lesions of the liver显示文摘 | Katkhouda N Hurwitz M Gugenheim J | 1999 | Ann Surg1999，229，： | 1 |
| 10 | Autophagy and liver ischemi- a-reperfusion injury显示文摘 | Cursio R Colosetti P Gugenheim J | 2015 | Biomed Res Int2015，，41： | 1 |
| 11 | Intermittent ischemia reduces warm hypoxia-reoxygenation-induced JNK(1)/ SAPK(1) activation and apoptosis in rat hepatocytes 显示文摘 | Crenesse D Laurens M Gugenheim J | 2001 | Hepatology2001，34，： | 1 |
| 12 | Cetuximab Shows Activity in Colorectal Cancer Patients With Tumors for Which FISH Analysis Does Not Detect an Increase in EGFR Gene Copy Number显示文摘 | Antoine Italiano MD Philippe Follana MD Fran?ois-Xavier Caroli MD Jean-Luc Badetti MD Daniel Benchimol MD Georges Garnier MD Jean Gugenheim MD Juliette Haudebourg MD Frédérique Keslair MS Gérard Lesbats MD Gérard Lledo MD Jean-Francois Roussel MD Florence | 2008 | Annals of Surgical Oncology2008，，2： | 1 |
| 13 | Laporoscop management of benign solid and cystic lesions of the live显示文摘 | Katkhouda N Hurwitz M Gugenheim J | 1999 | Ann Surg1999，229，1： | 1 |
| 14 | Internal hernia after laparoseopic Roux-en-Y gastric bypass for morbid obesity 显示文摘 | Iannelli A Facchiano E Gugenheim J | 2006 | Obes Surg2006，16，10： | 1 |
| 15 | Caspase inhibition protects from liver injury following ischemia and reprofusion in rats 显示文摘 | Cursio R Gugenheim J Ricci JE | 2000 | Transpl Int2000，131，： | 1 |
| 16 | Laparoscopic management of benign solid and cystic lesions of the liver 显示文摘 | Katkhouda N Hurwitz M Gugenheim J | 1999 | Ann Surg1999，229，4： | 1 |
| 17 | Internal hernia after laparoscopic Roux-en-Y gastric bypass for morbid obesity显示文摘 | Iannelli A Facchiano E Gugenheim J | | 0，，： | 1 |
| 18 | Effects of sleeve gastrectomy in high fat diet-induced obese mice: respective role of reduced caloric intake, white adipose tissue inflammation and changes in adipose tissue and ectopic fat depots显示文摘 | Anne-Sophie Schneck Antonio Iannelli Stéphanie Patouraux Déborah Rousseau Stéphanie Bonnafous Beatrice Bailly-Maitre Ophélia Thuc Carole Rovere Patricia Panaia-Ferrari Rodolphe Anty Albert Tran Philippe Gual Jean Gugenheim | 2014 | Surgical Endoscopy2014，，2： | 1 |
| 19 | The effects of femoral shaft malrotation on lower extremity anatomy 显示文摘 | Gugenheim JJ Probe RA BrinkerMR | 2004 | J Orthop Trauma2004，18，10： | 1 |
| 20 | Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients显示文摘 | Adeline Bertola Thomas Ciucci Déborah Rousseau Virginie Bourlier Carine Duffaut Stéphanie Bonnafous Claudine Blin-Wakkach Rodolphe Anty Antonio Iannelli Jean Gugenheim Albert Tran Anne Bouloumié Philippe Gual Abdelilah Wakkach | 2012 | Diabetes2012，，9： | 1 |
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