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| 1 | The δ^(18)O variation of a stalagmite from Qixing Cave,Guizhou Province and indi-cated climate change during the Holocene显示文摘A stalagmite from Qixing Cave, Guizhou Province was dated with the TIMS U-series method and its oxygen isotope composition was analyzed. On the basis of the ages and the variations of the δ18O of the stalagmite, the climate change of the last 7.7 ka has been reconstructed in this area: 7.7-5.8 ka, summer monsoon maximum period; 5.8-3.8 ka summer monsoon weakening period; 3.8-0.15 ka, weakened summer monsoon and high amplitude climate fluctuations period. We put forward that the increasing trend of δ18O of the stalagmite reflected not only the weakening of the summer monsoon, which was caused by the decreasing of solar radiation in the Northern Hemisphere, but also the possibly decreasing contribution of the southwest monsoon to the rainfall of this area. These results are consistent with the output of the numerical climate-model modeling. The high amplitude fluctuation of the δ18O may imply the quick shift of the contributions of different moisture sources to the precipitation in this area. | CAI Yanjun, ZHANG Meiliang, PENG Zicheng, LIN Yushi, AN Zhisheng, ZHANG Zhaofeng & CAO YunningState Key Laboratory of Loess and Quaternary Geology, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710054, China Karst Dynamics Laboratory, Ministry of Land and Resources, Guilin 541003, China Department of Earth and Space Science, University of Science & Technology of China, Hefei 230023, China | 2001 | Chinese Science Bulletin2001，46，22： | 18 |
| 2 | LSECtin on tumor-associated macrophages enhances breast cancer sternness via interaction with its receptor BTN3A3显示文摘Macrophages have bee n suggested to con tribute to con structing a cancer stem cell(CSC)niche.However,whether and how macrophages regulate the activity of CSCs through juxtacrine signaling are poorly understood.Here we report LSECtin,a transmembrane protein highly expressed on tumor-associated macrophages(TAMs),enhances sternness of breast cancer cells(BCCs).We identified BTN3A3,a B7 family member with previously unknown functions as the receptor for LSECtin on BCCs responsible for stemness-promoting effect of LSECtin.In mice bearing human tumor xenografts,either macrophage-specific ablation of LSECtin or silencing of BTN3A3 in BCCs decreased CSC frequency and tumor growth.Admixture of LSECtin-positive macrophages increased the tumorigenic activity of BCCs dependent on BTN3A3.Disruption of the LSECtin-BTN3A3 axis with BTN3A3-Fc or anti-BTN3A3 mAb has a therapeutic effect on breast cancer.These findings define a juxtacrine signaling mechanism by which TAMs promote cancer stemness.Targeting this axis in the CSC niche may provide potential therapies to breast cancer. | Di Liu Qian Lu Xing Wang Jun Wang Ning Lu Zefei Jiang Xiaopeng Hao Jianbin Li Jing Liu Pengbo Cao Guilin Peng Yuandong Tao Dianyuan Zhao Fuchu He Li Tang | 2019 | Cell Research2019，29，5： | 8 |
| 3 | Nonintubated thoracoscopic lobectomy plus lymph node dissection following segmentectomy for central type pulmonary masses显示文摘IntroductionLung cancer is the most common cancer worldwide.In the United States,it causes more cancer-related deaths than the next four causes(breast cancer,prostate cancer,colon cancer,and pancreatic cancer)of cancer-related mortality combined(1).About 30% of people have already | Wenlong Shao Wei Wang Weiqiang Yin Zhihua Guo Guilin Peng Ying Chen Jianxing He | 2013 | Chinese Journal of Cancer Research2013，25，1： | 7 |
| 4 | Fine mapping a major QTL for flag leaf size and yield-related traits in rice显示文摘 | Peng Wang Guilin Zhou Huihui Yu Sibin Yu | 2011 | Theoretical and Applied Genetics2011，，8： | 1 |
| 5 | Puerarin blocks the signaling transmission mediated by P2X 3 in SG and DRG to relieve myocardial ischemic damage显示文摘 | Shuangmei Liu Chunping Zhang Qingming Shi Guilin Li Miaomiao Song Yun Gao Changshui Xu Hong Xu Bo Fan Shicheng Yu Chaoran Zheng Qicheng Zhu Bing Wu Lichao Peng Huangui Xiong Qin Wu Shangdong Liang | 2014 | Brain Research Bulletin2014，，： | 1 |
| 6 | Effect of heat stress on the porcine small intestine: A morphological and gene expression study显示文摘 | Jin Yu Peng Yin Fenghua Liu Guilin Cheng Kaijun Guo An Lu Xiaoyu Zhu Weili Luan Jianqin Xu | 2010 | Comparative Biochemistry and Physiology, Part A2010，，1： | 1 |
| 7 | Extraction Process and Quality Standard of Danshen Jianxin Capsules显示文摘[Objectives]This study was conducted to establish the quality standard of Danshen Jianxin Capsules.[Methods]Orthogonal design was adopted to optimize the water extraction process by taking the amount of water added,extraction time and extraction times as factors,and the content of tanshinone I as the index.Salviae Miltiorrhizae,Notoginseng Radix Et Rhizoma and Radix Astragali in the capsules were qualitatively identified by TLC,and the content of tanshinone I in the capsules was determined by HPLC.[Results]The best water extraction process included the steps of adding 12 times of water each time,extracting the materials twice,for 1 h each time.In TLC identification,the test samples showed spots of the same color at the positions corresponding to tanshinone II A,ginsenoside Rg1,notoginsenoside R1 and astragaloside IV reference samples.[Conclusions]Danshen Jianxin Capsules was prepared by the water extraction method,which is characterized by high efficiency and being suitable for mass production.The quality control method is reliable,fast and accurate,which can effectively control the quality of the product. | Chengtong LIU Xinying MO Silu HE Donglian CHEN Guilin YANG Hongsheng TAN Peng LIANG Haisheng ZENG | 2023 | Medicinal Plant2023，14，1： | 1 |
| 8 | Effect of heat stress on the porcine small intestine: A morphological and gene expression study显示文摘 | Jin Yu Peng Yin Fenghua Liu Guilin Cheng Kaijun Guo An Lu Xiaoyu Zhu Weili Luan Jianqin Xu | 2010 | Comparative Biochemistry and Physiology Part A2010，，1： | 1 |
| 9 | Video-assisted thoracic surgery for ambiguous lung or mediastinal masses in response assessments for hematological malignancies显示文摘To the Editor:The morbidity of thoracic lesions is very high during the treatment of malignant hematological diseases,and tumor recurrence or invasion is common,in addition to infections.Percutaneous lung biopsy or bronchoscopy could result in severe hemoptysis,pneumothorax,or infection because of low platelets and hypo-immunity,and treatment is often ineffective due to the ambiguous diagnosis.Even when a patient is diagnosed with a fungal disease,it is difficult to eliminate the lesion with only antifungal medicine. | Runhui Zheng Guilin Peng Xin Xu Xiaodan Luo Chunyan Wang | 2022 | Chinese Medical Journal2022，，8： | 1 |
| 10 | The Formation Mechanism of Hydrogeochemical Features in a Karst System During Storm Events as Revealed by Principal Component Analysis显示文摘The hydrogeochemical parameters of Jiangjia Spring,the outlet of Qingrnuguan underground river system(QURS) in Chongqing,were found responding rapidly to storm events in late April,2008.A total of 20 kinds of hydrogeochemical parameters,including discharge,specific conductance,pH,water tempera- | Pingheng Yang Daoxian Yuan Kuang Yinglun,Wenhao Yuan,Peng Jia,Qiufang He 1.School of Geographical Sciences,Southwest University,Chongqing 400715,China. 2.Laboratory of Geochemistry and Isotope,Southwest University,Chongqing 400715,China 3.The Karst Dynamics Laboratory,Ministry of Land and Resources,Institute of Karst Geology,Chinese Academy of Geological Sciences,Guilin 541004,China | 2009 | 地学前缘2009，16，S1： | 0 |
| 11 | Numerical Study of the Biomechanical Behavior of a 3D Printed Polymer Esophageal Stent in the Esophagus by BP Neural Network Algorithm显示文摘Esophageal disease is a common disorder of the digestive system that can severely affect the quality of life andprognosis of patients. Esophageal stenting is an effective treatment that has been widely used in clinical practice.However, esophageal stents of different types and parameters have varying adaptability and effectiveness forpatients, and they need to be individually selected according to the patient’s specific situation. The purposeof this study was to provide a reference for clinical doctors to choose suitable esophageal stents. We used 3Dprinting technology to fabricate esophageal stents with different ratios of thermoplastic polyurethane (TPU)/(Poly-ε-caprolactone) PCL polymer, and established an artificial neural network model that could predict the radial forceof esophageal stents based on the content of TPU, PCL and print parameter. We selected three optimal ratios formechanical performance tests and evaluated the biomechanical effects of different ratios of stents on esophagealimplantation, swallowing, and stent migration processes through finite element numerical simulation and in vitrosimulation tests. The results showed that different ratios of polymer stents had different mechanical properties,affecting the effectiveness of stent expansion treatment and the possibility of postoperative complications of stentimplantation. | Guilin Wu Shenghua Huang Tingting Liu Zhuoni Yang Yuesong Wu Guihong Wei Peng Yu Qilin Zhang Jun Feng Bo Zeng | 2024 | Computer Modeling in Engineering & Sciences2024，138，3： | 0 |
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