| 1 | Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy rats显示文摘Luteolin (3',4',5,7-tetrahydroxyflavone) has powerful anti-apoptotic and antioxidant properties. This study aimed to investigate the effects of luteolin on hyperglycemia-mediated apoptosis in the hippocampi of rats with streptozotocin-induced diabetic encephalopathy after injection into the tail veins, and the molecular mechanisms involved. Biochemistry and terminal deoxynucleotidyl transferase mediated dUTP nick end labelling detection results showed that luteolin treatment (given twice daily for 15 days) significantly inhibited hyperglycemia-mediated apoptosis, decreased malondialdehyde levels and increased glutathione levels in the hippocampi of streptozotocin-induced diabetic rats. Western blot analysis revealed that luteolin also inhibited the expression of apoptosis-related factors and cytochrome c release from mitochondria. Luteolin also improved the learning and memory abilities of rats with diabetic encephalopathy in a water maze test. Further western blot analysis revealed that luteolin treatment facilitated neuronal cell survival through activation of the phosphatidylinositol 3-kinase/Akt signaling pathway, an extracellular signal pathway involved in the suppression of cell apoptosis and promotion of cell survival. These experimental findings indicate that luteolin can inhibit apoptosis of hippocampal nerve cells in rats with diabetic encephalopathy, and that this effect is mediated by an indirect antioxidative effect, the inhibition of activation of apoptosis-related factors and the activation of phosphatidylinositol 3-kinase/Akt signal pathway. | Guiru Ren Jingjing Kong Ning Jia Xiuli Shang | 2013 | Neural Regeneration Research2013，8，12： | 1 |
| 2 | The crystallographic texture and dependent mechanical properties of the CrCoNi medium-entropy alloy by laser remelting strategy显示文摘Laser remelting(LR)has attracted widespread attention in recent years as an effective method to reduce internal defects and improve the surface quality of additively manufactured(AM)parts.In the present study,three different LR inter-layer scanning strategies(LR0,LR90 and LR45)and their effects on the porosity,microstructure,crystallographic texture and related mechanical properties of parts have been studied.Optical microscope,X-ray diffraction,and scanning electron microscope were used as characterization tools.In the LR90 sample,it shows obvious{111}<110>texture and strong<111>preferred orientation along the scanning direction(SD),while the 0°offset and the 45°rotation of LR scanning strategy form a finer microstructure and weak crystallographic texture.Meanwhile,the mechanical properties of the LR sample are improved compared with the sample only by laser metal deposition(LMD),and a combination of higher strength and optimal uniform elongation is obtained in the LR45 sample.The overall results show that a reasonable LR scanning strategy can reduce the anisotropy of AM parts and improve their mechanical properties. | Pengsheng Xue Lida Zhu Jinsheng Ning Peihua Xu Shuhao Wang Zhichao Yang Yuan Ren Guiru Meng | 2022 | Journal of Materials Science & Technology2022，，16： | 0 |
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