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| 1 | Pulse changes in patients with cervical spondylosis before and after acupuncture treatment显示文摘OBJECTIVE: To study changes in pulse diagram parameters(PDP) in patients with cervical spondylosis(CS) before and after acupuncture treatment, explore the characteristics of PDP and the relationship between PDP changes and therapeutic effectiveness, and provide evidence for outcome prediction and objective evaluation of CS treatment before and after acupuncture treatment.METHODS: Patients with CS were treated with acupuncture and measured with a pulse acquisition device based on image(PADBI) before the first and after the tenth acupuncture sessions. Changes in PDP from before until after the acupuncture sessions and patient impressions were analyzed to judge the effect of acupuncture treatment for.RESULTS: The PDP values in effective patients were closer to normal values. This indicated that Qi stagnation and blood stasis of the patients was improved. The PDP changes from before to after the first acupuncture treatment were more obvious than those from before to after the tenth acupuncture treatment. This result indicates that the speed of symptom improvement decreased significantly after several acupuncture courses. Analysis of correlation between efficacy and PDP showed that the changes in PDP in five patients was abnormal,which mainly manifested as values of h1, u, p, Pp,and t1, and no significant changes or differences were increased with standard values. This indicated that the symptoms of CS were not improved in these patients.CONCLUSION: PADBI can provide evidence for outcome prediction of acupuncture treatment in patients with CS. PADBI can provide evidence for objective evaluation of acupuncture treatment of CS. | Zhang Huiyu Guo Minfang Lu Xiaozuo | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 34 |
| 2 | Zircon U–Pb dating of Pubei granite and strontium isotope from sphalerite of the Xinhua Pb–Zn–(Ag) deposit,Yunkai Area of Guangxi Province,South China显示文摘The Yunkai Area is located at the southern South China Block and is part of the Qinzhou Bay-Hangzhou Bay Metallogenic Belt, which is a famous polymetallic mineralization belt. The Xinhua Pb–Zn–(Ag)deposit is located in the western part of Yunkai Area, with an abundance of Pubei batholiths. Zircon U–Pb geochronology of Pubei batholiths shows that crystallization age ranges from 251.9 ± 2.2 to 244.3 ± 1.8 Ma, thus belonging to Indosinian orogeny. Geochemistry and Sr isotopic compositions of the Pubei batholiths show that it is derived from the partial melting of large scale crustal melting during the stage of exhumation and uplifting of the lower-middle crust. In addition, strontium isotope of sphalerite from the Xinhua Pb–Zn–(Ag) deposit, has limited ranges in ^(87)Rb/^(86)Sr and ^(87)Sr/^(86)Sr, ranging from 0.4077 to 1.0449, and 0.718720 to 0.725245, respectively. The initial ^(87)Sr/^(86)Sr ratios of sphalerite ranges between 0.718720 and 0.725245, which is higher than that of upper continental crust and lower than that of the Pubei batholiths, illustrating the fluid might be derived from the mixing of Pubei pluton and upper continental crust. | Minfang Wang Xubo Zhang Daohui Pi Xiaonan Guo | 2016 | Acta Geochimica2016，35，2： | 2 |
| 3 | UV irradiation induced conductivity improvement in poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) film显示文摘We describe a simple method to increase the conductivity of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)film by exposure to ultraviolet(UV)light in vacuum.Up to four order of conductivity improvement(from 10 3to 50 S/cm)is achieved by irradiating PEDOT:PSS film with 254 nm ultraviolet(UV)light.Increased conductivity in UV treated PEDOT:PSS film is stable under ambient exposure.The mechanism for conductivity improvement is investigated by current-voltage measurement,atomic force microscopy,and absorption spectrum.Photo-cross-linking of PSS chains is determined as the reason for conductivity improvement.Our result demonstrates that UV treatment is capable of modifying the conductivity of PEDOT:PSS film independent of the process of film formation. | XING YingJie QIAN MinFang WANG GuiWei ZHANG GengMin GUO DengZhu WU JinLei | 2014 | Science China(Technological Sciences)2014，57，1： | 1 |
| 4 | Triptolide protects astrocytes from hypoxia/reoxygenation injury显示文摘Astrocytes in an in vitro murine astrocyte model of oxygen and glucose deprivation/hypoxia and reoxygenation were treated with different concentrations of triptolide (250, 500, 1 000 ng/mL) in a broader attempt to elucidate the protection and mechanism underlying triptolide treatment on astrocytes exposed to hypoxia/reoxygenation injury. The results showed that the matrix metalloproteinase-9, interleukin-1β, tumor necrosis factor α and interleukin-6 expressions were significantly decreased after triptolide treatment in the astrocytes exposed to hypoxia/ reoxygenation injury, while interleukin-10 expression was upregulated. In addition, the vitality of the injured astrocytes was enhanced, the triptolide's effect was apparent at 500 ng/mL. These experimental findings indicate that triptolide treatment could protect astrocytes against hypoxia/ reoxygenation injury through the inhibition of inflammatory response and the reduction of matrix metalloproteinase-9 expression. | Minfang Guo Hongcui Fan Jiezhong Yu Ning Ji Yongsheng Sun Liyun Liang Baoguo Xiao Cungen Ma | 2011 | Neural Regeneration Research2011，6，21： | 1 |
| 5 | Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis显示文摘Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous system.Macrophage polarization plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis,a traditional experimental model of multiple sclerosis.This study investigated the effect of Fasudil on macrophages and examined the therapeutic potential of Fasudil-modified macrophages in experimental autoimmune encephalomyelitis.We found that Fasudil induced the conversion of macrophages from the pro-inflammatory M1 type to the anti-inflammatory M2 type,as shown by reduced expression of inducible nitric oxide synthase/nitric oxide,interleukin-12,and CD16/32 and increased expression of arginase-1,interleukin-10,CD14,and CD206,which was linked to inhibition of Rho kinase activity,decreased expression of toll-like receptors,nuclear factor-κB,and components of the mitogen-activated protein kinase signaling pathway,and generation of the pro-inflammatory cytokines tumor necrosis factor-α,interleukin-1β,and interleukin-6.Crucially,Fasudil-modified macrophages effectively decreased the impact of experimental autoimmune encephalomyelitis,resulting in later onset of disease,lower symptom scores,less weight loss,and reduced demyelination compared with unmodified macrophages.In addition,Fasudil-modified macrophages decreased interleukin-17 expression on CD4^(+)T cells and CD16/32,inducible nitric oxide synthase,and interleukin-12 expression on F4/80^(+)macrophages,as well as increasing interleukin-10 expression on CD4^(+)T cells and arginase-1,CD206,and interleukin-10 expression on F4/80^(+)macrophages,which improved immune regulation and reduced inflammation.These findings suggest that Fasudil-modified macrophages may help treat experimental autoimmune encephalomyelitis by inducing M2 macrophage polarization and inhibiting the inflammatory response,thereby providing new insight into cell immunotherapy for multiple sclerosis. | Chunyun Liu Shangde Guo Rong Liu Minfang Guo Qing Wang Zhi Chai Baoguo Xiao Cungen Ma | 2024 | Neural Regeneration Research2024，19，3： | 0 |
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