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| 1 | Tectonics of South China Continent and its implications显示文摘This paper aims at exploring the tectonic characteristics of the South China Continent(SCC)and extracting the universal tectonic rules from these characteristics,to help enrich the plate tectonic theory and better understand the continental dynamic system.For this purpose,here we conduct a multi-disciplinary investigation and combine it with the previous studies to reassess the tectonics and evolution of SCC and propose that the tectonic framework of the continent comprises two blocks,three types of tectonic units,four deformation systems,and four evolutionary stages with distinctive mechanism and tectonic characteristics since the Neoproterozoic.The four evolutionary stages are:(1)The amalgamation and break-up of the Neoproterozoic plates,typically the intracontinental rifting.(2)The early Paleozoic and Mesozoic intracontinental orogeny confined by plate tectonics,forming two composite tectonic domains.(3)The parallel operation of the Yangtze cratonization and intracontinental orogeny,and multi-phase reactivation of the Yangtze craton.(4)The association and differentiation evolution of plate tectonics and intracontinental tectonics,and the dynamic characteristics under the Meso-Cenozoic modern global plate tectonic regime. | ZHANG GuoWei GUO AnLin WANG YueJun LI SanZhong DONG YunPeng LIU ShaoFeng HE DengFa CHENG ShunYou LU RuKui YAO AnPing | 2013 | Science China Earth Sciences2013，56，11： | 88 |
| 2 | Geochemistry and spatial distribution of late-Paleozoic mafic volcanic rocks in the surrounding areas of the Gonghe Basin: Implications for Majixueshan triple-junction and east Paleotethyan archipelagic ocean显示文摘The late-Paleozoic mafic volcanic rocks occurring in the surrounding areas of the Gonghe basin are distributed in the A'nyêmaqên ophiolite zone, Zongwulong tectonic zone and Kuhai-Saishitang volcanic zone. The mafic volcanics in the A'nyêmaqên zone formed an ancient ridge-centered hotspot around the Majixueshan OIB, the Kuhai-Saishitang mafic rocks consist of E-MORB and continental rift basalts and the Zongwulong volcanic rocks are enriched N-MORB. The regionally low Nb/U and Ce/Pb ratios reflect the influence of the OIB material on the mafic magma source. From geochemistry, spatial distribution and tectonic relationship of the mafic rocks, an ancient triple-junction centered at the Majixueshan can be inferred. The existence of the Kuhai-Saishitang aulacogen may have provided a tectonic channel for the Majixueshan OIB materials metasomatizing the magma source for the Zongwulong rocks. The formation of the triple-junction and the rifting of the Zongwulong zone have separated the orogens and massifs in the region. | GUO AnLin ZHANG GuoWei SUN YanGui CHENG ShunYou YAO AnPing | 2007 | Science China Earth Sciences2007，50，z2： | 8 |
| 3 | Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity显示文摘Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity has not been well-studied.This study aimed to establish a PDX repository for non-small cell lung cancer(NSCLC)and to further elucidate whether it could preserve the heterogeneity within and between tumors in patients.Methods:A total of 75 surgically resected NSCLC specimens were implanted into immunodeficient NOD/SCID mice.Based on the successful establishment of the NSCLC PDX model,we compared the expressions of vimentin,Ki67,EGFR,and PD-L1 proteins between cancer tissues and PDX models using hematoxylin and eosin staining and immunohistochemical staining.In addition,we detected whole gene expression profiling between primary tumors and PDX generations.We also performed whole exome sequencing(WES)analysis in 17 first generation xenografts to further assess whether PDXs retained the patient heterogeneities.Finally,paclitaxel,cisplatin,doxorubicin,atezolizumab,afatininb,and AZD4547 were used to evaluate the responses of PDX models to the standard-of-care agents.Results:A large collection of serially transplantable PDX models for NSCLC were successfully developed.The histology and pathological immunohistochemistry of PDX xenografts were consistent with the patients’tumor samples.WES and RNA-seq further confirmed that PDX accurately replicated the molecular heterogeneities of primary tumors.Similar to clinical patients,PDX models responded differentially to the standard-of-care treatment,including chemo-,targeted-and immuno-therapeutics.Conclusions:Our established PDX models of NSCLC faithfully reproduced the molecular,histopathological,and therapeutic characteristics,as well as the corresponding tumor heterogeneities,which provides a clinically relevant platform for drug screening,biomarker discovery,and translational research. | Xuanming Chen Cheng Shen Zhe Wei Rui Zhang Yongsheng Wang Lili Jiang Ke Chen Shuang Qiu Yuanli Zhang Ting Zhang Bin Chen Yanjun Xu Qiyi Feng Jinxing Huang Zhihui Zhong Hongxia Li Guowei Che Kai Xiao | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 4 | Which Inspection Approach Is Better to Prevent Drug Fraud: Announced or Unannounced?显示文摘In recent years,there are many crimes related drug fraud occuring in China and many experts think that the main cause is that China Food and Drug Administration (CFDA)adopts announced inspection (AI).In order to circumvent this difficulty,CFDA has exploited unannounced inspection (UI)since 2014.In this paper,the authors study the problem of which one performs better, AI or UI.Specifically,the authors consider a supervisor,which decides the inspection approach,inspection strength and punishment to force the firm to put self-inspection effort to meet the requirements of Good Manufacturing Practice,and a firm,which produces a drug and decides its self-inspection effort. The authors use game theory to model this problem,characterize the equilibrium policies under AI, and compare the effects of the two approaches on preventing drug fraud under complete and incomplete information.The results show that under the complete information,UI performs better if the firm's technical level and the inspection cost are low and AI performs better otherwise.When the supervisor doesn't know the firm's technical level,if the low technical level is high,AI performs better.Otherwise, UI performs better if the inspection cost is low and AI performs better if the inspection cost is high. | ZHANG Manman ZHANG Juliang CHENG T.C.E. SALLAN Jose Maria HUA Guowei | 2018 | Journal of Systems Science & Complexity2018，31，6： | 3 |
| 5 | The Effect of Unannounced Inspection on Prevention of Drug Fraud显示文摘Alarge number of incidents related to fake/inferior-quality drugs have occurred in China in recent years. In order to reduce drug crimes, the China Food and Drug Administration (CFDA) has exploited the new supervision approach, i.e., unannounced inspection (UI), since September 2014. However, the effectiveness of UI in driving drug producers to put more effort into meeting the requirements of Good Manufacturing Practice (GMP) is yet to be ascertained. In this paper we apply game theory to study the effects of UI on the prevention of drug fraud, drug producers’ profits, and social welfare under scenarios of complete and incomplete information. We show that UI is not always an effective way of supervision. Specifically, if the upper bound on the punishment is not very large, UI can drive the firmto make the largest self-supervision effort only when the firm’s technical level is high and the supervision cost is low. Otherwise, UI cannot drive the firm to make the largest self-supervision effort. Under incomplete information, firms with a high technical level would adopt more self-supervision and make more profit than those with a low technical level. Moreover, we design a new mechanism under incomplete information that can incentive drug producers to make greater self-supervision effort to meet the requirements of GMP under certain conditions. | Manman Zhang Juliang Zhang T.C.E. Cheng Guowei Hua Xiaojie Yan Yi Liu | 2019 | Journal of Systems Science and Systems Engineering2019，28，1： | 3 |
| 6 | Managing carbon footprints in inventory management显示文摘 | Guowei Hua T.C.E. Cheng Shouyang Wang | 2011 | International Journal of Production Economics2011，，2： | 2 |
| 7 | On-line controlling system for nitrogen and phosphorus removal of municipal wastewater in a sequencing batch reactor (SBR)显示文摘The objectives of this study were to establish an on-line controlling system for nitrogen and phosphorus removal synchronously of municipal wastewater in a sequencing batch reactor(SBR).The SBR for municipal wastewater treatment was operated in sequences:filling,anaerobic,oxic,anoxic,oxic,settling and discharge.The reactor was equipped with on-line monitoring sensors for dissolved oxygen(DO),oxidation-reduction potential(ORP)and pH.The variation of DO,ORP and pH is relevant to each phase of biological process for nitrogen and phosphorus removal in this SBR.The characteristic points of DO,ORP and pH can be used to judge and control the stages of process that include:phosphate release by the turning points of ORP and pH;nitrification by the ammonia valley of pH and ammonia elbows of DO and ORP;denitrification by the nitrate knee of ORP and nitrate apex of pH;phosphate uptake by the turning point of pH;and residual organic carbon oxida-tion by the carbon elbows of DO and ORP.The controlling system can operate automatically for nitrogen and phosphorus efficiently removal. | Jun LI Yongjiong NI Yongzhen PENG Guowei GU Jingen LU Su WEI Guobiao CHENG Changjin OU | 2008 | Frontiers of Environmental Science & Engineering2008，2，1： | 2 |
| 8 | Price and lead time decisions in dual-channel supply chains显示文摘 | Guowei Hua Shouyang Wang T.C.E. Cheng | 2009 | European Journal of Operational Research2009，，1： | 1 |
| 9 | Bimetallic nickel cobalt sulfides with hierarchical coralliform architecture for ultrafast and stable Na-ion storage显示文摘A series of bimetallic nickel cobalt sulfides with hierarchical micro/nano architectures were fabricated via a facile synthesis strategy of bimetallic micro/nano structure precursor construction-anion exchange via solvothermal method. Among the nickel cobalt sulfides with different Ni/Co contents, the coral-like Ni1.01Co1.99S4 (Ni/Co, 1/2) delivers ultrafast and stable Na-ion storage performance (350 mAh·g−1 after 1,000 cycles at 1 A·g−1 and 355 mAh·g−1 at 5 A·g−1). The remarkable electrochemical properties can be attributed to the enhanced conductivity by co-existence of bimetallic components, the unique coral-like micro/nanostructure, which could prevent structural collapse and self-aggregation of nanoparticles, and the easily accessibility of electrolyte, and fast Na+ diffusion upon cycling. Detailed kinetics studies by a galvanostatic intermittent titration technique (GITT) reveal the dynamic change of Na+ diffusion upon cycling, and quantitative kinetic analysis indicates the high contribution of pseudocapacitive behavior during charge-discharge processes. Moreover, the ex-situ characterization analysis results further verify the Na-ion storage mechanism based on conversion reaction. This study is expected to provide a feasible design strategy for the bimetallic sulfides materials toward high performance sodium-ion batteries. | Yanyan He Caifu Dong Sijia He Huan Li Xiuping Sun Yuan Cheng Guowei Zhou Liqiang Xu | 2021 | Nano Research2021，14，11： | 1 |
| 10 | Price and lead time decisions in dual-channel supply chains 显示文摘 | Hua Guowei Wang Shouyang Cheng T C E | 2010 | European Journal of Operational Research2010，205，1： | 1 |
| 11 | Preparation and characterization of galactosylated chitosan coated BSA mi-crospheres containing 5-fiuorouracil显示文摘 | Can Zhang Yao Cheng Guowei Qu | 2008 | Carbohydrate Polym2008，72，： | 1 |
| 12 | Manag- ing carbon footprints in inventory management显示文摘 | Hua Guowei Cheng T C E Wang Shouyang | 2011 | In-ternational Journal of Production Economics2011，132，2： | 1 |
| 13 | Managing Carbon Footprints in Inventory Control 显示文摘 | Guowei Hua TCE Cheng Shouyang Wang | 2011 | Intemational Journal of Production Economics2011，132，： | 1 |
| 14 | Developing super-hydrophobic and corrosion-resistant coating on magnesium-lithium alloy via one-step hydrothermal processing显示文摘Formation of super-hydrophobic and corrosion-resistant coatings can provide significant corrosion protection to magnesium alloys.However,it remains a grand challenge to produce such coatings for magnesium-lithium alloys due to their high chemical reactivity.Herein,a one-step hydrothermal processing was developed using a stearic-acid-based precursor medium,which enables the hydrothermal conversion and the formation of low surface energy materials concurrently to produce the super-hydrophobic and corrosion-resistant coating.The multiscale microstructures with nanoscale stacks and microscale spheres on the surface,as well as the through-thickness stearates,lead to the super-hydrophobicity and excellent corrosion resistance of the obtained coating. | Guowei Wang Dan Song Yanxin Qiao Jiangbo Cheng Huan Liu Jinghua Jiang Aibin Ma Xiaolong Ma | 2023 | Journal of Magnesium and Alloys2023，11，4： | 1 |
| 15 | Manag-ing carbon footprints in inventory management显示文摘 | Hua Guowei Cheng 丁 C E Wang Shouyang | 2011 | In-ternational Journal of Production Economics2011，132，2： | 1 |
| 16 | Optimal or- der lot sizing and pricing with free shipping显示文摘 | Hua Guowei Wang Shouyang Cheng T C E | 2012 | Europe- an Journal of Operational Research2012，218，： | 1 |
| 17 | Optimal pricing and order quantity for the newsvendor problem with free shipping显示文摘 | Hua Guowei Wang Shouyang Cheng T C E | 2012 | International Journal of Produc tion Economics2012，135，1： | 1 |
| 18 | Optimal pricing and order quantity for the newsvendor problem with free shipping 显示文摘 | Hua Guowei Wang Shouyang Cheng T C E | 2012 | Production Economics2012，135，： | 1 |
| 19 | Managing carbon footprints in inventory management显示文摘 | Guowei Hua T.C.E. Cheng Shouyang Wang | 2011 | International Journal of Production Economics2011，，2： | 1 |
| 20 | Managing carbon footprints in inventory management显示文摘 | Guowei Hua T.C.E. Cheng Shouyang Wang | 2011 | International Journal of Production Economics2011，，2： | 1 |
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