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| 1 | Ore-forming event and geodynamic setting of molybdenum deposit at Wenquan in Gansu Province,Western Qinling显示文摘The Wenquan molybdenum deposit is associated with a Triassic granite in this area.The Wenquan granite is enriched in LILE and LREE,poor in HFSE,and has significantly higher contents of alkali(K2O+Na2O) and Sr,Ba than those of the island arc volcanic rocks.These geochemical characteristics are similar to post-collisional granites in high K calc-alkaline series.Studies of major elements,trace elements,REEs and chronology of the Wenquan pluton show that,in the geodynamic transition stage of continent-continent convergence to extension,the partial melting of the enriched lithospheric mantle generated the basaltic magma and triggered the partial melting of the thickened lower crust which produceded the acidic magma,and the Wenquan pluton was formed by mixing of the two magmas.Molybdenite Re-Os isotopic dating gave Os model ages of 212.7±2.6 Ma to 215.1±2.6 Ma with a weighted mean of 214.1±1.1 Ma,and an Re-Os isochron age of 214.4±7.1 Ma.These ages are close to K-Ar ages(223 to 226 Ma) and a SHRIMP zircon U-Pb age(223±7 Ma) for the Wenquan granite within the error range,but relatively younger.This implies that the Mo mineralization occurred in a late stage of the magmatic intrusion,and the metallogenesis took place in the transition stage from syn-collision to post-collision in the tectonic setting of the Qinling Orogenic Belt(QOB) after continental collision be-tween the North China Block(NCB) and the South China Block(SCB).This process is also corre-sponding to the geological events of metamorphism and deformation in South Qinling,closure of the Mian-Lue oceanic basin,and exhumation of the Dabie-Sulu ultrahigh-pressure metamorphic rocks.The large-scale continent-continent collision between NCB and SCB in the middle Triassic triggered sig-nificant crustal thickening and exhumation of subducted slab.In the late Triassic,the tectonic setting was transformed to the transition stage from collision to extension.Materials from the asthenospheric mantle would ascend into the root of the lower crust,which could induce partial melting of the lower crust and generate Mo-enriched granitic magma.The ore-forming elements enriched in the fluid derived from the condensation and fraction of the magma resulted in the Mo mineralization.The Mo deposits in the QOB are mainly formed in two episodes,namely 220± Ma and 140± Ma.The two episodes of metal-logenesis were developed in the tectonic transition settings from compression to extension,but they were in the different stages of the tectonic evolution.The occurrence of the Wenquan Mo-bearing plu-ton indicates that the Triassic tectonic-magmatic belt of Western Qinling is another favorable region for Mo mineralization in the QOB.Therefore,it is significant to pay more attention to evaluation of the ore-forming potentiality in the Triassic granites in Western Qinling. | ZHU LaiMin DING ZhenJu YAO ShuZhen ZHANG GuoWei SONG ShiGang QU WenJun GUO Bo LEE Ben | 2009 | Chinese Science Bulletin2009，54，13： | 12 |
| 2 | SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflammatory response,known as cytokine storm,which may lead to death.Receptor-interacting serine/threonine-protein kinase 1(RIPK1)is an important mediator of inflammation and cell death.Here,we examined the interaction of RIPK1-mediated innate immunity with SARS-CoV-2 infection.We found evidence of RIPK1 activation in human COVID-19 lung pathological samples,and cultured human lung organoids and ACE2 transgenic mice infected by SARS-CoV-2.Inhibition of RIPK1 using multiple smallmolecule inhibitors reduced the viral load of SARS-CoV-2 in human lung organoids.Furthermore,therapeutic dosing of the RIPK1 inhibitor Nec-1s reduced mortality and lung viral load,and blocked the CNS manifestation of SARS-CoV-2 in ACE2 transgenic mice.Mechanistically,we found that the RNA-dependent RNA polymerase of SARS-CoV-2,NSP12,a highly conserved central component of coronaviral replication and transcription machinery,promoted the activation of RIPK1.Furthermore,NSP12323L variant,encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy,Italy,that carries a Pro323Leu amino acid substitution in NSP12,showed increased ability to activate RIPK1.Inhibition of RIPK1 downregulated the transcriptional induction of proinflammatory cytokines and host factors including ACE2 and EGFR that promote viral entry into cells.Our results suggest that SARS-CoV-2 may have an unexpected and unusual ability to hijack the RIPK1-mediated host defense response to promote its own propagation and that inhibition of RIPK1 may provide a therapeutic option for the treatment of COVID-19. | Gang Xu Ying Li Shengyuan Zhang Haoran Peng Yunyun Wang Dekang Li Taijie Jin Zhuohao He Yilun Tong Chunting Qi Guowei Wu Kangyun Dong Jizhou Gou Yang Liu Tongyang Xiao Jing Qu Liang Li Liang Liu Ping Zhao Zheng Zhang Junying Yuan | 2021 | Cell Research2021，31，12： | 6 |
| 3 | Analysis of profit models for cross-border power interconnection projects显示文摘With the increasing demand worldwide for power grid interconnection,a growing number of related projects are under planning or construction.Despite the rapid growth of cross-border interconnection projects,the systematic research on profit models for these projects is insufficient.This paper first analyzes the profit sources of interconnection projects.Based on the analysis results,profit models are considered under different regulatory systems for three types of crossborder interconnection projects:fully market-oriented,semi-marketization,and fully supervised.Finally,measures for increasing the profitability and sustainable development of power interconnection projects are proposed. | Jing Li Guowei Gao Li Ma Tian Zhao Haoyuan Qu Fu Chen | 2019 | Global Energy Interconnection2019，2，5： | 4 |
| 4 | Dual reciprocity boundary element based block model for discontinuous deformation analysis显示文摘This paper presents a further development of the dual reciprocity boundary element method(DRBEM) with stepwise updating to pave the way for the introduction of boundary element mesh into the discontinuous deformation analysis(DDA). The advantage of the proposed method lies in its adoption of static fundamental solutions and reduction in the size of the governing equations by transforming the inertial term domain integrals to boundary integrals in the dynamic large displacement analysis. The unconditionally stable Newmark-β time integration method involving numerical damping to enhance the numerical stability is implemented for the dynamic analysis. In order to be coupled with the DDA to improve the deformability of the DDA block domains, a stepwise updating algorithm of the system variables is introduced. The stress updating in the analysis involved in the calculation of a domain integral and internal cells are used for the integration of the initial stress term. Several examples are used to verify the geometry-updated DRBEM model and satisfactory results have been obtained. | FU GuoYang MA GuoWei QU XiaoLei | 2015 | Science China(Technological Sciences)2015，58，9： | 2 |
| 5 | A Novel Fiber Bragg Grating with Triangular Spectrum and Its Application in Strain Sensor显示文摘A novel fiber Bragg grating with triangular spectrum is presented. A strain sensor based on this fiber grating is proposed. Experiments showed that the sensor has advantages of high sensitivity, wider measuring range and immunity to fluctuation of the light source power. | Rui Huang, Yingwu Zhou, Guowei Sun, Ronghui Qu, Zujie Fang Shanghai Institute of Optics and Fine Mechanics, CAS, P. R. China | 2003 | 光学学报2003，23，S1： | 2 |
| 6 | PEG conjugated N-octyl-O-sulfate chitosan micelles for delivery of paclitaxel:In vitro characterization and in vivo evaluation显示文摘 | Qu Guowei Yao Zhong Zhang Can | 2009 | European Journal of Pharmaceutical Sciences2009，37，： | 1 |
| 7 | Preparation and characterization of galactosylated chitosan coated BSA mi-crospheres containing 5-fiuorouracil显示文摘 | Can Zhang Yao Cheng Guowei Qu | 2008 | Carbohydrate Polym2008，72，： | 1 |
| 8 | PEG conjugated N-octyl-O-sulfate chitosan micelles for delivery of paclitaxel: In vitro characterization and in vivo evaluation显示文摘 | Guowei Qu Zhong Yao Can Zhang Xiaoli Wu Qineng Ping | 2009 | European Journal of Pharmaceutical Sciences2009，，2： | 1 |
| 9 | Preparation and charac- terization of galactosylated chitosan coated BSA microspheres con- taining 5 - fiuomuracil显示文摘 | Can Zhang Yao Cheng Guowei Qu | 2008 | Carbohydrate Polym2008，，： | 1 |
| 10 | Modeling of contact temperatures and their influence on the tribological performance of PEEK and PTFE in a dual-pin-ondisk tribometer显示文摘The direct blending of polyether ether ketone(PEEK)with a solid lubricant such as polytetrafluoroethylene(PTFE)improves its tribological performance,but compromises its outstanding mechanical properties and processability.While these negative effects might be circumvented via the hybrid wear method,the influence of the contact temperature between multiple sliding components acting together is not fully understood.Herein,an analytical temperature model considering the influence of both micro-and macro-thermal behavior is extended to predict the contact temperature of a dual-pin-on-disk hybrid wear system.The interactions between several heat sources are investigated and experimentally verified.The analytical results show that the nominal temperature rise of the shared wear track is determined by the combined effect of the heat generated by both pin components,while the rise in flash temperature at the region in contact with each pin component is dependent upon its individual characteristics and working conditions.Hence,while different temperature peaks can coexist in the shared wear track,the maximum value dominates the performance of the system.For the experimentally investigated PEEK–PTFE–steel hybrid wear system,the formation of tribofilms is blocked,and the hybrid wear system fails,when the peak temperature exceeds the glass transition temperature of both pins due to an increase in applied load. | Zhibin LIN Ting QU Ke ZHANG Qingbin ZHANG Shengdao WANG Guibin WANG Bingzhao GAO Guowei FAN | 2023 | Friction2023，11，4： | 0 |
| 11 | Enhanced Adhesion of Mussel-inspired Adhesive through Manipulating Contents of Dopamine Methacrylamide and Molecular Weight of Polymer显示文摘 | Xiong Xiong Yumei Liu Feng Shi Guowei Zhang Jie Weng Shuxin Qu | 2018 | Journal of Bionic Engineering2018，15，3： | 0 |
| 12 | Novel integrated three-port DC/DC converter for different operating modes between renewable energy,electrolyser and fuel cell/battery显示文摘Due to the slow dynamic power-regulation characteristics of the electrolyser(EL),a novel integrated three-port DC/DC converter topology based on a phase-shifted full-bridge converter and dual active-bridge converter is proposed in this paper.Especially,the proposed converter can achieve a fast auxiliary response to the EL.This topology has the features of single-stage conversion,high system integration and compatibility with multiple operation modes.The operational principles and a hybrid modulation scheme of the proposed converter are analysed in detail.In addition,the power-transmission characteristics of each port and the soft-switching range are researched.On these bases,six operation modes suitable for a hydrogen energy-storage system are designed.The simulation and a 2-kW scaled-down experimental prototype are established to verify the feasibility and effectiveness of the proposed topology in different operation modes. | Lilei Jiang Jianxin Qu Lingguo Kong Hejianuig Qian Chuang Liu Guowei Cai | 2023 | Clean Energy2023，7，1： | 0 |
| 13 | Pan-cancer immunogenic death analysis identifies key roles of CXCR3 and CCL18 in hepatocellular carcinoma显示文摘Immunogenic death is a form of programmed cell death that is common in the development and progression of cancer.However,its impact on tumor progression differs depending on the location of the tumor.Meanwhile,it also plays an important role in antitumor immunity because the process of immunogenic death can release substances that activate immunity.1 Therefore,in this study,the key mechanism of mediating immunogenic death in hepatocellular carcinoma(HCC)was found from the excavation of the immunogenic death characteristics of pan-cancer and the in-depth investigation of its effects on different tumor types(Fig.1A). | Jia Guo Xin Sun Guowei Pan Ce Li Xin He Xiaofang Che Zan Teng Xiujuan Qu Yunpeng Liu Bowen Yang | 2024 | Genes & Diseases2024，11，2： | 0 |
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