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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | DESIGN AND PREPARATION OF SILICON NITRIDE COMPOSITE WITH HIGH FRACTURE TOUGHNESS AND NACRE STRUCTURE显示文摘DESIGNANDPREPARATIONOFSILICONNITRIDECOMPOSITEWITHHIGHFRACTURETOUGHNESSANDNACRESTRUCTUREYHuang;H.NHao;Y.L.ChenandB.L.Zhou(1)De... | Y Huang H.N Hao Y.L. Chen and B.L.Zhou (1)Department of Materials Science and Engineering, Tsinghua University,Beijing 100084, China 2)Institute of Metal Research, Chinese Academy of Sciences,Shenyang 110015, China ) | 1996 | Acta Metallurgica Sinica(English Letters)1996，9，6： | 12 |
| 3 | Association between adiponectin concentrations and diabetic retinopathy in patients with type 2 diabetes: a meta analysis显示文摘 | Fan XH Wu QH Hao YH Ning N Kang Z Cui Y Liu RH | 2014 | Chinese Medical Journal2014，，4： | 8 |
| 4 | Tectonic framework of China and its relation with mineral resources——Cognition from geophysical data显示文摘TECTONIC and its evolution are theoretical basis of geology and summation in geosciences from investigation of the earth’s structure, composition, motion and history. Therefore, they are of great importance to the industrial activities. Various geological maps have been compiled in different scales after long-time observation of rock outcrops in mountains and torrents. These tectonic maps, which are obtained based upon the cognition and judgment of tectonic movements in different ages, are summarization regarding the regularity of geological phenomenon in terms of theory, and provide service of exploration and references for environmental protection and prevention and control of disaster. | Liu, GD Hao, TY Liu, Y | 1997 | Chinese Science Bulletin1997，42，2： | 5 |
| 5 | Association of polymorphisms in the vascular endothelial growth factor gene and its serum levels with diabetic retinopathy in Chinese patients with type 2 diabetes: A cross-sectional study显示文摘 | Fan XH Wu QH Li Y Hao YH Ning N Kang Z Cui Y Liu RH | 2014 | Chinese Medical Journal2014，，4： | 4 |
| 6 | An essential role for TAK1 in the contact hypersensitivity response显示文摘Contact hypersensitivity(CHS)is a delayed-type hypersensitivity that can be induced by haptens,such as 2,4-dinitrofluorobenzene(DNFB).Innate and adaptive immunities are both important for the development of CHS.To treat CHS-related diseases,such as allergic contact dermatitis,a disease prevalent in industrialized countries,ways of interfering with improper immune function during CHS responses need to be identified.Transforming growth factor-b-activated kinase-1(TAK1),a member of mitogen-activated protein kinase kinase kinase family,is important for both innate and adaptive immunities.We thus hypothesized that the CHS response could be inhibited by interfering with TAK1 activity.Using a mouse model in which TAK1 deletion can be locally induced,we observed that TAK deficiency led to an impaired CHS response and was associated with defective T-cell expansion,activation and interferon(IFN)-c production.In addition,we investigated the effect of deleting TAK1 specifically in dendritic cells(DC)on the CHS response.We found that when TAK1 is deficient in DC,the CHS response was abolished and hapten-elicited T-cell responses were defective.Collectively,this study demonstrates an essential role of TAK1 in the induction of CHS and suggests that targeting TAK1 could be a viable approach to treat CHS. | Yan G Zhao Yunqi Wang Weidong Hao Yisong Y Wan | 2011 | Cellular & Molecular Immunology2011，8，4： | 4 |
| 7 | 基于工作地点的分组干预对高血压控制的影响:一项随机临床研究显示文摘基于工作地点的干预可能为一种管理高血压的有效方法。但是目前缺少针对中国工作人群高血压控制情况的研究。本研究旨在评估基于工作地点的多组分别干预策略对改善血压控制的影响。研究设计及受试者:研究者在2013年1月至2014年12月于中国20个城区的60个工作地点进行了一系列高血压管理的随机临床试验。工作地点随机分为干预组(n=40)和对照组(n=20)。每个工作地点的受试者都需要完成一项横断面调查。 | 袁源(摘译) 叶鹏(审校) Wang Z Wang X Shen Y Li S Chen Z Zheng C Kang Y Jiang L Hao G Chang C Gao R | 2020 | 中华高血压杂志2020，28，6： | 3 |
| 8 | Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer显示文摘 | Zhang XM Miao XP Liang G Hao BT Wang YG Tan W Li Y Guo YL He FC Wei QY Lin DX | 2006 | 中国生物学文摘2006，20，4： | 2 |
| 9 | Sequence and analysis of rice chromosome 4显示文摘 | Feng Q Zhang Y Hao P | 2002 | Nature2002，420，： | 2 |
| 10 | 收缩压和舒张压变异性对脑卒中患者血管事件的不同影响显示文摘较高的血压变异性(blood pressure variability,BPV)是心血管病的危险因素。然而,在引发不同的血管事件时,收缩压变异性(systolic blood pressure variability,SBPV)和舒张压变异性(diastolic blood pressure variability,DBPV)是否存在不同作用仍不清楚。本研究旨在探讨SBPV或DBPV对急性缺血性脑卒中(acute ischaemic stroke,IS)或短暂性脑缺血发作(transient ischaemic attack,TIA)患者血管事件的作用是否存在区别。 | 周卫(译) 袁源(摘) 叶鹏(审校) Dai L Cheng A Hao X Xu J Zuo Y Wang A Meng X Li H Wang Y Zhao X Wang Y | 2020 | 中华高血压杂志2020，28，11： | 2 |
| 11 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 12 | Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption 显示文摘 | Guan Y Hao C Cha DR | 2005 | Nat Med2005，11，8： | 1 |
| 13 | Toughening modification of PS with n-BA/MMA/styrene coreshell structured copolymer from emulsifier-free emulsion polymerization 显示文摘 | Guo T Y Tang G L Hao G J | 2003 | Journal of Applied Science2003，90，： | 1 |
| 14 | A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer显示文摘 | Hao B Miao X Li Y | 2006 | Oncogene2006，25，25： | 1 |
| 15 | Changes in treatment of advanced laryngeal cancer 1985 -2001 显示文摘 | Chen Ay Schraq Hao Y | 2006 | Otolaryngology Head and Neck Surgery2006，135，： | 1 |
| 16 | New mutation points in 23Sr RNA gene associated with Helicobaeter pyiori resistance to clarithromycirt in northeast china 显示文摘 | HAO Q LI Y ZHANG Z J | 2004 | World Gastroenterol2004，10，7： | 1 |
| 17 | Electrophoretic motion of a charged spherical particle normal to a planar dielectric wall显示文摘 | Haber S | 1998 | Int J Multiphase Flow1998，24，5： | 1 |
| 18 | Changes in soil properties in southern Beijing municipality following land reform 显示文摘 | Zhang F R Hao X Y Wang R | 2004 | Soil & Tillage Research2004，75，2： | 1 |
| 19 | Effectiveness of first eight methadone maintenance treatment clinics in China显示文摘 | Pang L Hao Y Mi G | 2007 | AIDS2007，21，8： | 1 |
| 20 | Removal of Aflatoxin Bl from peanut milk inoculated with Flavobacterium aurantiacum 显示文摘 | Hao Y Y Brackett R E | 1988 | J Food Sci1988，，53： | 1 |
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