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| 1 | Decrease in Serum Amyloid a Protein Levels Following Three-month Stays in Negatively Charged Particle-dominant Indoor Air Conditions显示文摘Objective The changes in serum adipokines and cytokines related to oxidative stress were examined during 3 months ‘Off to On' and ‘On to Off' periods using negatively charged particle-dominant indoor air conditions(NCPDIAC).Methods Seven volunteers participated in the study,which included ‘OFF to 3 months ON' periods(ON trials) for a total of 16 times,and ‘ON to 3 months OFF'(OFF trials) periods for a total of 13 times.Results With the exception of one case,serum amyloid A(SAA) levels decreased significantly during the ON trials.Conclusion Considering that SAA is an acute phase reactive protein such as C reactive protein(CRP),this observed decrease might indicate the prevention of cardiovascular and atherosclerotic changes,since an increase in high-sensitive CRP is associated with the subsequent detection of these events. | Suni Lee Shoko Yamamoto Yasumitsu Nishimura Hidenori Matsuzaki Kei Yoshitome Tamayo Hatayama Miho Ikeda YU Min Nagisa Sada Naoko Kumagai-Takei Takemi Otsuki | 2018 | Biomedical and Environmental Sciences2018，31，5： | 5 |
| 2 | High mobility group box-1 protein as a therapeutic target in perinatal hypoxic-ischemic brain injury显示文摘Perinatal hypoxic-ischemic(HI)brain injury is a leading cause of morbidity and longstanding disability in newborns(Millar et al.,2017).Improved neonatal intensive care has increased survival in infants with pregnancy and birth related complications.Nonetheless,many surviving neonates exhibit neurological abnormalities that can persist throughout life(Millar et al.,2017).Early neuroprotective strategies have the potential to improve neurological outcomes and attenuate developmental delay in neonates.However,hypothermia is the only currently approved intervention for HI encephalopathy in fullterm infants,which is only partially protective(Millar et al.,2017).Findings in preterm and full-term infants suggest that elevations in proinflammatory cytokines are important in the pathogenesis of HI-related brain injury(Millar et al.,2017).The high mobility group box-1(HMGB1),a representative damage associatedmolecular pattern(DAMP)protein,has been reported to be implicated in a variety of brain related inflammatory diseases including traumatic brain injury,epilepsy,and stroke(Nishibori et al.,2019).Anti-HMGB1 therapies have gained increasing interest to treat inflammation related disorders in the brain(Nishibori et al.,2019).However,there is a paucity of information regarding the pathology of HMGB1 in HI-related brain injury during the perinatal period.The current perspective discusses the potential contributions of HMGB1 to HI-related brain injury during the perinatal period and also addresses the potential of HMGB1 as a therapeutic target of the brain injury.Furthermore,this perspective emphasizes the potential for combinational therapeutics for hypothermia with anti-HMGB1 monoclonal antibodies(mAb)in perinatal HI brain injury. | Kazuki Hatayama Barbara S.Stonestreet | 2021 | Neural Regeneration Research2021，16，10： | 2 |
| 3 | An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements显示文摘 | Ken Itoh Tomoki Chiba Satoru Takahashi Tetsuro Ishii Kazuhiko Igarashi Yasutake Katoh Tatsuya Oyake Norio Hayashi Kimihiko Satoh Ichiro Hatayama Masayuki Yamamoto Yo-ichi Nabeshima | 1997 | Biochemical and Biophysical Research Communications1997，，2： | 2 |
| 4 | Hydrogen-Rich University of Wisconsin Solution Attenuates Renal Cold Ischemia–Reperfusion Injury显示文摘 | Toyofumi Abe Xiao-Kang Li Koji Yazawa Naoyuki Hatayama Lin Xie Bunpei Sato Yoichi Kakuta Koichi Tsutahara Masayoshi Okumi Hidetoshi Tsuda Jun-ya Kaimori Yoshitaka Isaka Michiya Natori Shiro Takahara Norio Nonomura | 2012 | Transplantation Journal2012，，1： | 2 |
| 5 | Microvascular decompression for trigeminal neuralgia 显示文摘 | Hatayama T Ohkuma H | 2010 | No Shinkei Geka2010，38，4： | 1 |
| 6 | Coil embolisation for ruptured vertebral artery dissection distal to the origin of the poste- rior inferior cerebellar artery显示文摘 | Manabe H Hatayama T Hasegawa S | 2000 | Neuroradiology2000，42，12： | 1 |
| 7 | Hormonal regulation in the production of macrophage colony-stimulating factor and transforming growth factor-beta by human endometrial stromal cells in culture显示文摘 | Kanzaki H Hatayama H Narukawa S | 1995 | Horm Res1995，442，： | 1 |
| 8 | The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T 显示文摘 | HATAYAMA H WASHITA J KUWAJIMA | 2007 | Biochemical and Biophysical Research Communications2007，356，3： | 1 |
| 9 | Rational Design of Mn-salen Epoxidation Catalysts:Preliminary Results显示文摘 | Hosoya N Hatayama A Irie R | 1994 | Tetrahedron1994，50，15： | 1 |
| 10 | Application of electric discharge process in joining aluminum and stainless steel sheets 显示文摘 | MATSUGI K WANG Y HATAYAMA | 2003 | Journal of Materials Processing Technology2003，135，1： | 1 |
| 11 | Seventy- two- hour preservation, resuscitation, and transplantation of an isolated rat heart with high partial pressure carbon monoxide gas ( PCO = 400 hPa) and high partial pressure carbon dioxide (PCO2 = 1130 hPa) 显示文摘 | HATAYAMA N YOSHIDA Y SEKI K | 2010 | Cell Transplant2010，19，6： | 1 |
| 12 | The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T 显示文摘 | HATAYAMA H IWASHITA J KUWAJIMA A | 2007 | Biochem Biophys Res Commun2007，356，3： | 1 |
| 13 | A study on the perfusion preservation, resuscitation, and transplantation of a rat heart isola- ted for 96 hours显示文摘 | HATAYAMA N YOSHIDA Y SEKI K | 2009 | Cell Transplant2009，18，5： | 1 |
| 14 | Study on the preservation with CO ( PCO = 200 - 2, 000 hPa) , resuscitation, and heteroto- pic transplantation of an isolated rat heart 显示文摘 | YOSHIDA Y HATAYAMA N SEKI K | 2009 | Cell Transplant2009，18，5： | 1 |
| 15 | Impact properties of spark sintered titanium aluminides at elevated temperatures显示文摘 | MATSUGI K HATAYAMA T YANAGISAWA O | 1999 | Intermetallics1999，7，： | 1 |
| 16 | Robust cooperative control of two- link flexible manipulators on the basis of quasi-static equations显示文摘 | Matsuno F Hatayama M | 1999 | The International Journal of Robotics Research1999，18，4： | 1 |
| 17 | A case of endolymphatic sac tumor with long-term survival 显示文摘 | Asano K Sekiya T Hatayama T | 1999 | Brain Tumor Pathol1999，16，2： | 1 |
| 18 | Migration induced reorientation and anisotropic grating formation in photoreactive polymer liquid crystals显示文摘 | Ono H Hatayama A Emoto A | 2007 | Optical Materials2007，30，： | 1 |
| 19 | Uterine peristalsis in women with repeated IVF failures: possible therapeutic effect of hyoscine bromide显示文摘 | Kido A Togashi K Hatayama H | 2009 | Obstet Gynaecol Can2009，31，8： | 1 |
| 20 | Tunable onepot syntheses of hexagonal cublic and lamellar mesostructured vanadium phosphorus oxides 显示文摘 | Mizuno N Hatayama H Uchida S | 2001 | Chem Mater2001，13，： | 1 |
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